Clarion Hotel Sign Floorplan

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This meeting took place in 2016


Here are the related meetings in 2017:
B Cells and T Follicular Helper Cells – Controlling Long-Lived Immunity (D2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

B Cells at the Intersection of Innate and Adaptive Immunity (E3)


Organizer(s) Mikael C. I. Karlsson, Claudia Mauri, Eric Meffre and Andrea Cerutti
May 29—June 2, 2016
Clarion Hotel Sign • Stockholm, Sweden
Discounted Abstract Deadline: Jan 28, 2016
Abstract Deadline: Feb 29, 2016
Scholarship Deadline: Jan 28, 2016
Discounted Registration Deadline: Mar 29, 2016

Sponsored by AbbVie Inc. and BioLegend, Inc.

Summary of Meeting:
In the last few years, the role of B cells in the innate immune response and effector functions beyond antibody production has started to be appreciated. This meeting puts emphasis on newly discovered roles of B cells and discusses novel concepts in B cell biology that will open new venues to design B cell-directed treatments. It will thus highlight the function of B cells as general responders and regulators of inflammation and contrast this to their function and latest discoveries of their role as antibody producers.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, May 29 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 2 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, June 3 in order to fully experience the meeting.

SUNDAY, MAY 29

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, MAY 30

07:30—08:30
Breakfast

Individual Hotel
08:30—09:30
Welcoming Remarks and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

B1/B2
* Michel C. Nussenzweig, HHMI/Rockefeller University, USA

Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
Struggle for Life in the B Cell World

09:30—12:00
Creating and Maintaining the B Cell Repertoire
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

B1/B2
* Eric Meffre, Yale University School of Medicine, USA

* Tomohiro Kurosaki, WPI Immunology Frontier Research Center, Osaka University, Japan

Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Transcriptional Control of Late B Cell Development

Marcus R. Clark, University of Chicago, USA
BRWD1 Orchestrates Ig-kappa Recombination and Late B Cell Development

Deborah Dunn-Walters, University of Surrey, UK
The B Cell Repertoire and Immune Senescence

Trine A. Kristiansen, Lund University, Sweden
Short Talk: Cellular Barcoding Links B-1a B Cell Potential to a Reversible Fetal Hematopoietic Stem Cell State at the Clonal Level

Luka Mesin, Whitehead Institute, USA
Short Talk: Visualizing Clonal Selection in Germinal Centers

10:10—10:30
Coffee Break

Foyer/B3
12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

B3
13:00—22:00
Poster Viewing

B3
14:30—16:30
Workshop 1

B1/B2
* Deborah Dunn-Walters, University of Surrey, UK

* Michael P. Cancro, University of Pennsylvania, USA

Kathrin Pieper, Institute for Research in Biomedicine, Switzerland
A New Mechanism of Immunoglobulin Diversification Generates Broadly Reactive Antibodies to Plasmodium Falciparum

Caroline Rönnberg, Karolinska Institutet Solna, Sweden
A Prospective Study of B Cell Dynamics in Patients with Malaria using Mass Cytometry

Amit Saxena, Karolinska Institutet, Sweden
Reactive Oxygen Species Control Autoreactive B Cell Tolerance in a Mouse Model of Rheumatoid Arthritis

S. Rameeza Allie, University of Alabama, Birmingham, USA
Identification of Germinal Center Dependent, Lung Resident Memory B Cells after Influenza infection

Kristine Oleinika, University College London, UK
Regulatory B Cells Control Inflammation through the Induction of Suppressive Invariant Natural Killer T Cells

Marta E. Alarcón Riquelme, GENYO. Center for Genomics and Oncological Research, Spain
BANK1 Controls IgG Class Switching Through TLR7-Dependent STAT1 Activation

Peter P. Bönelt, Research Institute of Molecular Pathology, Austria
Autoimmunity Caused by Premature Blimp1 Expression during B Cell Development

16:30—17:00
Coffee Available

Foyer/B3
17:00—19:00
Innate B Cell Activation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

B1/B2
* Mikael C. I. Karlsson, Karolinska Institutet, Sweden

* Gunilla B. Karlsson Hedestam, Karolinska Institutet, Sweden

Andrea Cerutti, Mount Sinai School of Medicine, USA
Innate Signaling Networks in B Cell Activation

John F. Kearney, University of Alabama, Birmingham, USA
Effects of Neonatal Microbial Exposure on B Cell Development and Protection Against Allergic and Autoimmune Disease

Mikael C. I. Karlsson, Karolinska Institutet, Sweden
Short Talk: Neutrophils License NKT Cells to Regulate Self-Reactive B Cell Responses

Lieselotte Sarah Maria Kreuk, University of California, Berkeley, USA
Short Talk: Characterizing the Ontogeny and Downstream Immunological Significance of Anti-Commensal IgG with the Use of an IgG3 Reporter Mouse

Andrew Getahun, University of Colorado School of Medicine, USA
Short Talk: Continuous Inhibitory Signaling by Both SHP-1 and SHIP-1 Pathways is Required to Maintain Unresponsiveness of Autoreactive B Cells

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

B3/Atrium
19:30—22:00
Poster Session 1

B3

TUESDAY, MAY 31

07:30—08:30
Breakfast

Individual Hotel
08:30—11:30
B Cell Subsets
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

B1/B2
* Thomas L. Rothstein, Feinstein Institute for Medical Research, USA

* Joan Yuan, Lund University, Sweden

Marc K. Jenkins, University of Minnesota Medical School, USA
Tracking Protein Antigen-specific Memory B Cells

Nicole Baumgarth, University of California, Davis, USA
B-1 Cells and Immune Protection

Jean-Claude Weill, Institut Necker-Enfants Malades, INSERM U1151, France
Mouse B Cell Memory Responses to External or Internal Challenges

Bart N. Lambrecht, VIB, Ghent University, Belgium
New Insights in Marginal Zone B Cell Development by Analysis of Taok3 Deficient Mice

Lars Nitschke, University of Erlangen, Germany
Short Talk: Siglec-G, an Inhibitory Receptor on B Cells

09:50—10:10
Coffee Break

Foyer/B3
11:30—17:00
On Own for Lunch

Atrium
11:30—13:00
Poster Setup

B3
13:00—22:00
Poster Viewing

B3
14:30—16:30
Workshop 2

B1/B2
* Lisa Westerberg, Karolinska Institutet, Sweden

* Troy D. Randall, University of Alabama at Birmingham, USA

Heike Schmitt, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany
Siglec-H Protects from (Herpes-) Virus Triggered Severe Systemic Autoimmunity

Edina Andrea Schweighoffer, Francis Crick Institute - Mill Hill Laboratory, UK
BCR – TLR Crosstalk in the LPS Response of B Cells

Gabriel Kristian Pedersen, Karolinska Institutet, Sweden
TACI Expression is Impaired in the Absence of Functional IkappaBNS

Kai-Ting Chuang Shade, Massachusetts General Hospital, USA
A Single Glycan on IgE is Indispensable for Initiation of Anaphylaxis

Vera Greiner, Dana-Farber Cancer Institute, USA
Genome Editing of the Human B Cell Receptor with CRISPR/Cas9

Jourdan K. Posner, University of Hawaii, Manoa, USA
Pattern Recognition Receptor Ligands Drive the Differentiation and Activation of Human B Cell Subsets

Soren E. Degn, Harvard Medical School, USA
Autoreactive Germinal Center Dynamics and the Evolution of Autoreactive B Cells

16:30—17:00
Coffee Available

Foyer/B3
17:00—19:15
B Cell Tolerance
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

B1/B2
* Ann Marshak-Rothstein, University of Massachusetts Medical School, USA

* Frances E. Lund, University of Alabama at Birmingham, USA

Eric Meffre, Yale University School of Medicine, USA
Resetting Early B Cell Tolerance Checkpoints Defective in Patients with Autoimmune Diseases

Christopher Sundling, Garvan Institute of Medical Research, Australia
Plasma Cell Differentiation from Conventional and Rogue GC B Cells

Michael P. Cancro, University of Pennsylvania, USA
Age Associated B Cells: T-bet Driven Effectors of Protective and Autoimmune Responses

David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA
B Cell-Intrinsic Signals Critical for T Cell-Dependent vs. Independent Loss of Tolerance

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

B3/Atrium
19:30—22:00
Poster Session 2

B3

WEDNESDAY, JUNE 1

07:30—08:30
Breakfast

Individual Hotel
08:30—11:45
Antibody Effector Functions and Antigen Recognition by the BCR
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

B1/B2
* Lill Martensson, University of Gothenburg, Sweden

* Birgitta Heyman, Uppsala University, Sweden

Michel C. Nussenzweig, HHMI/Rockefeller University, USA
The Germinal Center Reaction

Maureen McGargill, St Jude Children's Research Hospital, USA
Generation of Antibodies to Conserved Influenza A Epitopes

Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
The IgM Fc-Receptor

Jeffrey V. Ravetch, Rockefeller University, USA
Diversification of Antibody Effector Function

Michael Reth, Max Planck Institute of Immunobiology and Epigenetics, Germany
Molecular Requirements for the Sensing of Monovalent Antigens by the Oligomeric B cell Antigen Receptor

09:50—10:10
Coffee Break

Foyer/B3
11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

B3
13:00—22:00
Poster Viewing

B3
14:30—16:30
Workshop 3

B1/B2
* Lars Nitschke, University of Erlangen, Germany

* Stephen Malin, Karolinska Institute, Sweden

Feng Feng, Boston University, USA
An Autoreactive Memory-Derived Plasmablast Response Precedes the Immunogen-Specific Response in the Repeated Anthrax Vaccine in Humans

Hermann Eibel, University Medical Center Freiburg, Germany
Differential Signaling and Processing of BAFF-Receptor in B Cells

Tam Quách, NSLIJ The Feinstein Medical Research Institute, USA
Human B-1 And B-2 Cells Come From A Lin-CD34+CD38lo Progenitor Population

Selina Keppler, Francis Crick Institute, UK
WIP-ing B cells: CD19 as a Generic Hub for PI3K Signaling

Hedda Wardemann, German Cancer Research Center, Germany
Clonal Selection of Memory B Cells Upon Human Malaria Infection

Almudena R. Ramiro, Centro Nacional de Investigaciones Cardiovasculares, Spain
Non-Hodgkin Lymphoma Therapeutics by MicroRNA-28 Replacement

Patricia J. Gearhart, NIA, National Institutes of Health, USA
DNA Breaks in Variable Regions Are Predominantly Single Stranded and Generated by UNG and MSH6 Pathways

16:30—17:00
Coffee Available

Foyer/B3
17:00—19:15
Mucosal B Cell Responses
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

B1/B2
* Andrea Cerutti, Mount Sinai School of Medicine, USA

* Eduardo J. Villablanca, Karolinska Institute, Sweden

Jeffrey J. Bunker, University of Chicago, USA
Specificity of IgA Responses

Sergei A. Nedospasov, Engelhardt Institute of Molecular Biology, Russia
ILC3, IgA, Cytokines and Beyond

Claudia Berek, Deutsches Rheuma Forschungszentrum, Germany
A Key Role of Eosinophils for the Normal Organization of the Gut Immune Compartment

Duane R. Wesemann, Brigham and Women's Hospital, Harvard Medical School, USA
Short Talk: Microbes Regulate Primary Ig Repertoire Polyreactivity

Yang Yang, Stanford University School of Medicine, USA
Short Talk: Distinct Mechanisms Define Murine B Cell Lineage Immunoglobulin Heavy Chain (IgH) Repertoires

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

B3/Atrium
19:30—22:00
Poster Session 3

B3

THURSDAY, JUNE 2

07:30—08:30
Breakfast

Individual Hotel
08:00—08:30
Poster Set Up

B3
08:30—15:30
Poster Viewing

B3
08:30—11:30
B Cells as Regulators of the Immune Response
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

B1/B2
* Paolo Casali, University of Texas School of Medicine, USA

Frances E. Lund, University of Alabama at Birmingham, USA
Cytokine-Dependent Induction of Novel Human Plasma Cell Precursors in Autoimmune Mice and Humans

* Claudia Mauri, University College London, UK
Generation of Systemic and Mucosal B Regulatory Cells

Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA
Maintenance of Self-Reactive Memory B Cells by FDC

Yi Hao, Huazhong University of Science & Technology, China
Short Talk: Persistent Germinal Centers and Circulating Antigen-Specific Antibodies Modulate B Cell Memory Responses

Kai Kisand, University of Tartu, Estonia
Short Talk: High-Affinity Disease-Ameliorating Autoantibodies in Patients with Defective Central T Cell Tolerance

Melissa Marie Walker, University of Colorado, USA
Short Talk: Cyclic-di-Nucleotides as STING-Dependent Adjuvants and B Cell Activators

09:50—10:10
Coffee Break

Foyer/B3
11:30—13:00
On Own for Lunch

13:00—15:30
Poster Session 4

B3
16:30—17:00
Coffee Available

Foyer/B3
17:00—18:45
Targeting B Cells for Treatment
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

B1/B2
* Kristina Lejon, Umeå University, Sweden

* Elizabeth A. Leadbetter, Trudeau Institute, USA

Simone Cenci, University Vita Salute Fondazione Centro San Raffaele del M.te Tabor, Italy
Autophagy in Plasma Cell Pathophysiology

Andrew C. Chan, Genentech, Inc., USA
B Cell Immunotherapy: 2016 and Beyond

Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Broadly Neutralizing Antibodies and a New Mechanism of Diversification

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

B1/B2
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

B3/Atrium
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

B3

FRIDAY, JUNE 3

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

AbbVie Inc. BioLegend, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI124357-01

Funding for this conference was made possible [in part] by 1 R13 AI 124357 - 01 from the National Institute of Allergy and Infectious Diseases and the National Institute of Arthritis and Musculoskeletal and Skin Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676