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This meeting took place in 2016



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Positive-Strand RNA Viruses (N1)


Organizer(s) Raul Andino and Peter D. Nagy
May 1—5, 2016
Hyatt Regency Austin • Austin, Texas USA
Discounted Abstract Deadline: Jan 6, 2016
Abstract Deadline: Feb 3, 2016
Scholarship Deadline: Jan 6, 2016
Discounted Registration Deadline: Mar 2, 2016

Sponsored by Merck & Co., Inc.

Summary of Meeting:
Positive-stranded RNA viruses are significant and emerging human pathogens worldwide. Virus-host interactions and innate responses by the host are intensively studied areas, which promise novel, broad-range and durable antiviral approaches. Topics covered by the meeting include basic advances in research on viral replication structures, virus entry and virus evolution; virus-host interactions, discussed from the virus view on changing the host (including systems biology) and host responses and defense mechanisms; and emerging therapeutics. It is anticipated that rapidly emerging new concepts on virus-host interactions will help the participants to test various host factors for a large number of positive-strand RNA viruses to expand the arsenal of antiviral approaches. This meeting will bring together experts on positive-stranded RNA viruses that will facilitate the rapid progress and dissemination of new concepts in the complex field of virus-host interactions. Also, speakers who are expert with other groups of viruses will be invited to facilitate cross-talk with other areas in virology. Among the speakers will be interdisciplinary scientists who would not normally meet with this group of researchers. Virology, cell biology, genetics, evolution, macromolecular structures/assembly, systems biology and imaging will all be brought together.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, May 1 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 5 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, May 6 in order to fully experience the meeting.

SUNDAY, MAY 1

16:00—20:00
Arrival and Registration

Zilker North Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Zilker North Lobby

MONDAY, MAY 2

07:30—08:30
Breakfast

Zilker 1-2
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Zilker 3-4
* Raul Andino, University of California, San Francisco, USA

Anna Marie Pyle, Yale University, USA
Viral RNA Structure and its Recognition by Host and Viral Proteins

09:30—11:45
Systems Biology: From “Omics” to Function
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Host-virus interaction uncovered by integration of large data sets (genomics, proteomics, functional genomics, etc.).

Zilker 3-4
* Peter D. Nagy, University of Kentucky, USA

Priya S. Shah, University of California, San Francisco, USA
Proteomics, Functional Genomics, eMAPs on Dengue Virus Replicating in Humans and Mosquitoes

Shin-Ru Shih, Chang Gung University, Taiwan
Host-Factors Involved in Enterovirus Replication

Benjamin R. tenOever, Icahn School of Medicine at Mount Sinai, USA
Functional Antiviral Genomics through in vivo RNAi Screens

Jan E. Carette, Stanford University, USA
Short Talk: Genetic Knockout Screens Identify Host Genes Required For Dengue Virus Replication

Sunnie R. Thompson, University of Alabama, Birmingham, USA
Short Talk: Identification of Host Factors that Interact with Dengue Virus RNA in Cell Culture

10:00—10:20
Coffee Break

Zilker North Lobby
11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Zilker 1-2
13:00—22:00
Poster Viewing

Zilker 1-2
14:30—16:30
Workshop 1: Recombination and Replication Fidelity, RdRp Structure

Zilker 3-4
* Karla A. Kirkegaard, Stanford University School of Medicine, USA

David J. Barton, University of Colorado School of Medicine, USA
Polymerase Structure-Function and Picornavirus RNA Recombination

Patrick T. Dolan, Stanford University, USA
Population Sequencing Reveals the Host-Specific Adaptive Landscapes of Dengue Virus

Gonzalo Moratorio, Institut Pasteur, France
Cornering RNA Viruses by Constraining their Sequence Space

Craig E. Cameron, Pennsylvania State University, USA
New, Functional Forms of HCV NS5A Protein in vivo?

Alexander E. Gorbalenya, Leiden University Medical Center, Netherlands
NiRAN, Nidovirus RdRp-Associated Nucleotidyltransferase: First Enzyme Exclusively Associated with an Order of +RNA Viruses

James Bert Flanegan, University of Florida, USA
Poliovirus Multifunctional Precursor Proteins Required for Replication Complex Assembly, VPgpUpU Synthesis and RNA Replication

Kay Choi, University of Texas Medical Branch, USA
Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface

Chloé Jaubert, Universite de Bordeaux, France
RNA Genomic Dimerization and Hepatitis C Virus Replication

16:30—17:00
Coffee Available

Zilker North Lobby
17:00—19:00
Entry, Trafficking and Exiting
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Virus receptor interactions, intracellular trafficking, and mechanisms of egress.

Zilker 3-4
* Andres Merits, University of Tartu, Estonia

Félix Rey, Institut Pasteur, France
Eliciting Cross-Reactive Antibodies Neutralizing Dengue Virus: A Structural View

Carolyn B. Coyne, University of Pittsburgh, USA
Roadblocks: Polarized Cells as Barriers to RNA Virus Entry and Infection

Julie K. Pfeiffer, University of Texas Southwestern Medical Center, USA
Enteroviruses and the Microbiota

Maria Guadalupe Martinez, Albert Einstein College of Medicine, USA
Short Talk: Alphavirus Budding: How Viruses Remodel the Cell During Exit

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Zilker 1-2
19:30—22:00
Poster Session 1

Zilker 1-2

TUESDAY, MAY 3

07:30—08:30
Breakfast

Zilker 1-2
08:00—08:30
Poster Setup

Zilker 1-2
08:30—17:00
Poster Viewing

Zilker 1-2
08:30—11:30
Replication Organelles, Membranes, Proteins, Lipids and Stuff...
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
How do virus construct alter the cell architecture to create a RNA replication favorable environment.

Zilker 3-4
* Raul Andino, University of California, San Francisco, USA

Ralf Bartenschlager, University of Heidelberg, Germany
Cell Biology of Viral Replication Cycles: A Comparison of Hepatitis C Virus and Dengue Virus

Richard J. Kuhn, Purdue University, USA
Structure-Function Studies of Flavivirus Replication Proteins

Frank van Kuppeveld, Utrecht University, Netherlands
Short Talk: An Enterovirus Mutant that can Replicate in the Absence of Replication Organelles

Paul Ahlquist, University of Wisconsin-Madison, USA
Protein, RNA and Membrane Interactions in Positive-Strand RNA virus Genome Replication

Michael S. Diamond, Washington University School of Medicine, USA
A Genome-Wide CRISPR/Cas9 Screen Identifies Novel Host Factors Required for Flavivirus Infection

Hongliang Wang, University of Michigan, USA
Short Talk: Pulse-Chase Imaging Reveals Continuous and Rapid Turnover of Hepatitis C Virus Replication Organelles

09:50—10:10
Coffee Break

Zilker North Lobby
11:30—12:30
Lunch

Zilker 1-2
12:00—14:30
Poster Session 2

Zilker 1-2
16:30—17:00
Coffee Available

Zilker North Lobby
17:00—19:00
Replication Enzymes and Other Factors
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Both viral and cellular proteins and RNAs catalyzing the formation of RNA progeny.

Zilker 3-4
* Richard William Hardy, Indiana University, USA

K. Andrew White, York University, Canada
Regulation of Tombusvirus Processes by Long-range RNA-RNA Interactions

Eric J. Snijder, Leiden University Medical Center, Netherlands
An Unprecedented Protein-Stimulated -2/-1 Ribosomal Frameshift Mechanism in Arteriviruses

John T. Patton, University of Maryland, USA
How Rotaviruses Do It? RNA Synthesis in Double-Stranded RNA Viruses

Tero Ahola, University of Helsinki, Finland
Short Talk: There is One Defined Pathway for Alphavirus RNA Replication

Eric Poeschla, University of Colorado School of Medicine, USA
Short Talk: Broad Spectrum Antiviral Protection via Positive Strand RNA Virus RdRp-Mediated Stable Activation of RIG-I-Like Receptor-dependent Innate Immunity

19:00
On Own for Dinner


WEDNESDAY, MAY 4

07:30—08:30
Breakfast

Zilker 1-2
08:30—11:30
Virus Modulations of Host Pathways
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Host-virus interactions.

Zilker 3-4
* Ralf Bartenschlager, University of Heidelberg, Germany

Peter D. Nagy, University of Kentucky, USA
Tombusvirus Replicase Complex Usurps the Glycolytic Pathway for Robust Replication

Sean P. Whelan, Harvard Medical School, USA
VSV Polymerase Architecture and Activity Regulated by Host Cell Factors

William Jackson, University of Maryland School of Medicine, USA
Short Talk: A Novel Signaling Mechanism Induces Autophagy in Poliovirus-Infected Cells

Karla A. Kirkegaard, Stanford University School of Medicine, USA
Noncoding RNAs and Virus Infection

Michael Gale, Jr., University of Washington, USA
Pathogen Sensing and Response in RNA Virus Infection

Tristan X. Jordan, University of Chicago, USA
Short Talk: AMPK Inhibition of mTOR Activity is Required for Dengue Virus-Induced Lipophagy

09:50—10:10
Coffee Break

Zilker North Lobby
11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Zilker 1-2
13:00—22:00
Poster Viewing

Zilker 1-2
14:30—16:30
Workshop 2: Emerging Concepts and Landscapes

Zilker 3-4
* Eva Harris, University of California, Berkeley, USA

Craig B. Wilen, Washington University, USA
Discovery of a Proteinaceous Cellular Receptor for a Norovirus

Sue E. Crawford, Baylor College of Medicine, USA
Human Noroviruses Replicate in Stem-cell Derived Human Intestinal Enteroids

Jason Mackenzie, University of Melbourne, Australia
Norovirus Translation: Control at the Stress Granule-PKR-p-elf2Alpha axis

Alexandra Schäfer, University of North Carolina at Chapel Hill, USA
The Epigenetic Landscape during MERS-CoV Infection

Mohsan Saeed, Rockefeller University, USA
Development of an Efficient Pan-Genotype Cell Culture System for Hepatitis C Virus

Ann Palmenberg, University of Wisconsin-Madison, USA
Atomic Resolution Structures of Rhinovirus C15a by Cryo-EM Show Unique Topographies and Virion Properties

Jessica L. Smith, Oregon Health and Sciences University, USA
A microRNA Screen Identifies the miR-34 Family as Potent Inhibitors of Flavivirus Infection and Reveals an Intersection Between the Wnt and Interferon Signaling Pathways

Shangmei Hou, University of Alberta, Canada
Flavivirus Infection Impairs Peroxisome Biogenesis and Early Anti-Viral Signaling

16:30—17:00
Coffee Available

Zilker North Lobby
17:00—19:15
Evolution, Adaptation and Virus Fitness
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Experimental and theoretical approaches to understanding mechanisms of virus evolution.

Zilker 3-4
* Craig E. Cameron, Pennsylvania State University, USA

Claus Wilke, University of Texas at Austin, USA
Next-Gen Virology: Use of Microfluidics and Live-Cell Imaging to Study Poliovirus Replication at the Single-Cell Level

Paul Turner, Yale University, USA
Rate of Novel Host Invasion affects Adaptability of Evolving RNA Virus Lineages

Raul Andino, University of California, San Francisco, USA
RNA Virus Population Dynamics and the Mechanisms of Adaptation

Johan Neyts, University of Leuven, Belgium
Towards Antivirals against Flavi-, Picorna-, Alpha- and Noroviruses

Mark R. Denison, Vanderbilt University Medical Center, USA
Short Talk: Identification of Coronavirus Fidelity Determinants Following Long-Term Passage of Murine Hepatitis Virus Lacking nsp14-ExoN Mediated Fidelity

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Zilker 1-2
19:30—22:00
Poster Session 3

Zilker 1-2

THURSDAY, MAY 5

07:30—08:30
Breakfast

Zilker 1-2
08:30—11:30
Immunity and Stress Responses
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Virus are under pressure to replicate and in doing so cell host detect them inducing innate immunity. Is stress involved in the process? How viruses deal with stress and innate immunity responses?

Zilker 3-4
* Michael Gale, Jr., University of Washington, USA

Ana Fernandez-Sesma, Mount Sinai School of Medicine, USA
Innate Immunity to Dengue Virus

Nihal Altan-Bonnet, NHLBI, National Institutes of Health, USA
Intercellular Transmission of Viral Populations with Vesicles

Scott Benjamin Biering, University of Chicago, USA
Short Talk: Replication Complexes of Positive-Strand RNA Viruses are Disrupted by Interferon-Gamma Inducible GTPases

Richard E. Lloyd, Baylor College of Medicine, USA
Enterovirus Antagonism of RNA Granules

Maria-Carla Saleh, Institut Pasteur, France
Systemic Spread of Antiviral RNAi Immunity through Extracellular Vesicles Containing Viral RNAs

Eva Harris, University of California, Berkeley, USA
Short Talk: Mechanisms of Dengue Virus NS1-Induced Endothelial Permeability and Vascular Leak

09:50—10:10
Coffee Break

Zilker North Lobby
11:30—17:00
On Own for Lunch

15:00—16:30
Workshop 3: Discussion on the Emergence of ZIKA Virus and Other Flaviviruses

Zilker 3-4
* Michael S. Diamond, Washington University School of Medicine, USA

Nicholas Barrows, Duke University, USA
Repurposed Drug Candidates to Treat Zika Virus Infection in Pregnancy

Bryan C. Mounce, Institut Pasteur, France
Interferon-induced Spermidine-spermine N1-Acetyltransferase and Polyamine Depletion Restrict Chikungunya and Zika Virus Transcription and Translation

Hengli Tang, Florida State University, USA
Zika Virus Infection Leads to Cell Cycle Arrest and Stunted Growth of Human Cortical Neural Progenitors

Douglas G. Widman, University of North Carolina at Chapel Hill, USA
A Reverse Genetics Platform to Generate Zika Virus Infectious Clones and Evaluate Viral Determinants of Pathogenesis

Devika Sirohi, Purdue University, USA
The Cryo-EM Structure of Zika Virus

16:30—17:00
Coffee Available

Zilker North Lobby
17:00—18:45
Therapeutic Interventions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Novel interventions targeting virus and host factors.

Zilker 3-4
* Maria-Carla Saleh, Institut Pasteur, France

Judith Frydman, Stanford University, USA
Host Protein Homeostasis Machinery as an Antiviral Target

Susan C. Baker, Loyola University Chicago, USA
Targeting Coronavirus Papain-like Proteases to Block Viral Replication and Pathogenesis

Matthew Frieman, University of Maryland, USA
Short Talk: Identification and Characterization of ABL Kinase Inhibitors as Potent Inhibitors of SARS-CoV and MERS-CoV Fusion

Ying Kai Chan, Harvard Medical School, USA
Short Talk: Dengue Virus NS3 Antagonizes Innate Immunity Using a Phosphomimetic-Based Mechanism

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Zilker 3-4
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Zilker 1-2
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Zilker 1-2

FRIDAY, MAY 6

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Merck & Co., Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:


International Symposium on Positive Strand RNA Viruses

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI124477-01

Funding for this conference was made possible [in part] by 1 R13 AI 124477 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676