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This meeting took place in 2016



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Noncoding RNAs in Health and Disease (Q5)


Organizer(s) Ramin Shiekhattar and Roberto Bonasio
February 21—24, 2016
Santa Fe Community Convention Center • Santa Fe, New Mexico USA
Discounted Abstract Deadline: Oct 20, 2015
Abstract Deadline: Nov 18, 2015
Scholarship Deadline: Oct 20, 2015
Discounted Registration Deadline: Dec 18, 2015

Sponsored by Cell Research and Journal of Molecular Cell Biology (JMCB)


Summary of Meeting:
Over the past decade, there has been a greater understanding of genomic complexity in eukaryotes ushered in by the immense technological advances in high-throughput sequencing of DNA and its corresponding RNA transcripts. This has resulted in the realization that beyond protein-coding genes, there are a large number of transcripts that do not encode for proteins and, therefore, may perform their function through RNA sequences and/or through secondary and tertiary structural determinants. This Keystone Symposia meeting is focused on the latest findings concerning different classes of noncoding RNAs that use different strategies to regulate transcription. These are exciting times for discovering the biological scope and the mechanism of action for these RNA molecules, which have roles in dosage compensation, imprinting, enhancer function and transcriptional regulation, with a consequently great impact in development and disease.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, February 21 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, February 24 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Thursday, February 25 in order to fully experience the meeting.

SUNDAY, FEBRUARY 21

16:00—20:00
Arrival and Registration

Sweeney Ballroom Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Sweeney F

MONDAY, FEBRUARY 22

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—09:30
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Sweeney Ballroom A-E
* Ramin Shiekhattar, University of Miami, USA

* Ali Shilatifard, Northwestern University, USA

Michael S. Levine, Princeton University, USA
Enhancers/Promoters and Regulation of Gene Expression

Eric N. Olson, University of Texas Southwestern Medical Center, USA
Modulation of Muscle Development and Disease by Noncoding RNAs

09:30—09:50
Coffee Break

Lobby
09:50—11:45
Noncoding RNAs in Heterochromatin and Dosage Compensation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Sweeney Ballroom A-B
* François Fuks, Université Libre De Bruxelles, Belgium

Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs

Joshua T. Mendell, HHMI/University of Texas Southwestern Medical Center, USA
Regulation of Genomic Stability by the Noncoding RNA NORAD

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
RNA Processing Machineries in Gene Silencing

Montserrat Anguera, University of Pennsylvania, USA
Short Talk: Unusual Maintenance of X-Chromosome Inactivation Predisposes Female Lymphocytes for Increased Expression from the Inactive X


Following Session is for Enhancer Malfunction in Cancer (Q6)

09:50—12:00
Enhancer Biology
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Sweeney Ballroom C-E
* Gerd A. Blobel, Children's Hospital of Philadelphia, USA

Dale Dorsett, St. Louis University School of Medicine, USA
RNA Binding Proteins Aid Association of Cohesin with Genes and Enhancers

Matthias Merkenschlager, Imperial College London, UK
The contribution of cohesin to enhancer connectivity and function.

Alexander Stark, Research Institute of Molecular Pathology - IMP, Austria
EMBO Young Investigator Lecture: Decoding Transcriptional Regulation

Julie Ahringer, University of Cambridge, UK
Short Talk: Properties and Activities of Enhancers

Beatriz Aranda-Orgilles, NYU School of Medicine, USA
Short Talk: Med12 Regulates Enhancer Dynamics in HSCs Independently of Mediator Kinase Activity

11:45—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts
11:45—16:00
On Own for Lunch

16:00—19:00
Noncoding RNAs and Enhancers in Development (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Sweeney Ballroom A-E
* Luciano Di Croce, Centre for Genomic Regulation, Spain

Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Noncoding RNAs and Transposition

Anindya Dutta, University of Virginia, USA
Short Talk: MUNC and DRAIC: lncRNAs Involved in Differentiation and in Repression of Metastasis

Robin D. Dowell, University of Colorado, USA
Enhancer RNAs Originate from Active Transcription Factor Binding

Gioacchino Natoli, IEO, European Institute of Oncology, Italy
Noncoding Transcription at Enhancers and Promoters: Genome-Wide Suppression by Early Termination

Gerd A. Blobel, Children's Hospital of Philadelphia, USA
A Hyperactive Transcriptional State Marks Genome Reactivation during Mitotic Exit

* Panagiotis Ntziachristos, Northwestern University, USA
Short Talk: Characterization of the Oncogenic Enhancer Repertoire in T Cell Leukemia using Chromatin Conformation Studies

17:30—17:50
Coffee Break

Lobby
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 1

Sweeney F, Main Level Breakouts

TUESDAY, FEBRUARY 23

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—11:15
Enhancer RNAs in Development and Disease (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Sweeney Ballroom A-E
* Anne Brunet, Stanford University, USA

* Julie Ahringer, University of Cambridge, UK

Ramin Shiekhattar, University of Miami, USA
Biogenesis and Mechanism of Action of Enhancer RNAs

Shelley L. Berger, University of Pennsylvania, USA
CBP Senses its Transcription Environment at Enhancers to Locally Modulate Acetyltransferase Activity

Christopher K. Glass, University of California, San Diego, USA
Mechanisms and Consequences of Enhancer Transcription

Tae-Kyung Kim, University of Texas Southwestern Medical Center, USA
Functional Mechanisms of Neuronal Enhancers

Franziska Petermann, NIAMS, National Institutes of Health, USA
Short Talk: Deletion of NeST Reduces IFN-gamma Expression and Chromosomal Looping at the Ifng locus

Daniel R. Larson, NCI, National Institutes of Health, USA
Short Talk: Coordinate Regulation of Estrogen-Responsive Genes and eRNA in Single Cells

09:20—09:40
Coffee Break

Lobby
11:15—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Lobby
17:00—19:00
Enhancer Chromatin and Noncoding RNAs (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Sweeney Ballroom A-E
* Karen Adelman, NIEHS, National Institutes of Health, USA

* Dale Dorsett, St. Louis University School of Medicine, USA

Ali Shilatifard, Northwestern University, USA
Enhancer Malfunction in Cancer

Tony Kouzarides, University of Cambridge, UK
Role of ncRNAs in Transcription and Cancer

Harinder Singh, Cincinnati Children's Hospital Medical Center, USA
Single-Cell Analysis of Mixed-Lineage Transcriptional States Leading to a Binary Cell Fate Choice

Jesse M. Engreitz, Broad Institute of Harvard and MIT, USA
Short Talk: Many Promoters of lncRNAs and mRNAs Act as Enhancers in Local Gene Regulatory Networks

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 2

Sweeney F, Main Level Breakouts

WEDNESDAY, FEBRUARY 24

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—11:15
Noncoding RNAs in Epigenetics
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Sweeney Ballroom A-B
* Roberto Bonasio, University of Pennsylvania, USA

François Fuks, Université Libre De Bruxelles, Belgium
Mechanisms of TETs and Hydroxymethylation

Anne Brunet, Stanford University, USA
Epigenetic Regulation of Longevity

Chris Marine, Vlaams Instituut voor Biotechnologie, Belgium
Cancer Cell Addiction to lncRNAs

Gozde Korkmaz, Netherlands Cancer Institute, Netherlands
Short Talk: Functional Genetic Screens for Enhancer Elements in the Human Genome Using CRISPR-Cas9

Luciano Di Croce, Centre for Genomic Regulation, Spain
Polycomb Orchestrates Gene Regulation Dynamics in Cell Differentiation and Cancer

Madoka Chinen, NIDDK, National Institutes of Health, USA
Short Talk: Structure-Function Analysis of Drosophila Argonaute2 in Chromatin Insulator Activity


Following Session is for Enhancer Malfunction in Cancer (Q6)

08:00—11:00
Enhancers and Regulatory Networks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Sweeney Ballroom C-E
* Dale Dorsett, St. Louis University School of Medicine, USA

Ann Dean, NIDDK, National Institutes of Health, USA
Enhancer Mechanisms Underlying the Erythroid Transcriptome

Warren S. Pear, University of Pennsylvania, USA
Modular Domains within a Super Enhancer Determine Drug Resistance in T-Cell Leukemia

W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Molecular Mechanisms for the Assembly and Function of Cell Type-Specific Enhancers

Denes Hnisz, Whitehead Institute, USA
Enhancer Structure and Function in Health and Disease

Sarah Pyfrom, Washington University in St. Louis, USA
Short Talk: Defining and Targeting Pathogenic Enhancers in B Cell Cancers

09:20—09:40
Coffee Break

Lobby
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Lobby
17:00—19:00
Noncoding RNAs and Nuclear Architecture
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Sweeney Ballroom A-B
* Howard Y. Chang, Stanford University, USA

John L. Rinn, Harvard University, USA
Function and Evolution of Local Repeats in the FIRRE Locus

Eric A.J. Simko, Johns Hopkins University, USA
Short Talk: Nuclear Paraspeckle Disruption by C9orf72 Repeat RNA

Karen Adelman, NIEHS, National Institutes of Health, USA
Pol II Pausing and Elongation at Noncoding RNA Loci

Roberto Bonasio, University of Pennsylvania, USA
RNA-Mediated Regulation of Chromatin-Associated Proteins


Following Session is for Enhancer Malfunction in Cancer (Q6)

17:00—19:00
Chromatin Structure and Enhancer Promoter Communications
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Sweeney Ballroom C-E
* Ann Dean, NIDDK, National Institutes of Health, USA

Nadav Ahituv, University of California, San Francisco, USA
Functional Characterization of Gene Regulatory Elements

Robert E. Kingston, Massachusetts General Hospital, USA
Alterations in Nucleosome Accessibility during Regulation

Blaine Bartholomew, University of Texas MD Anderson Cancer Center, USA
Short Talk: Auto-Regulation of SWI/SNF in Cancer and its Relationship to Enhancers

Sharon Y.R. Dent, University of Texas MD Anderson Cancer Center, USA
Short Talk: A SAGA of GCN5 and USP22 in Development and Disease

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions

Sweeney Ballroom A-B
* Ramin Shiekhattar, University of Miami, USA

* Roberto Bonasio, University of Pennsylvania, USA


Following Session is for Enhancer Malfunction in Cancer (Q6)

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Sweeney Ballroom C-E
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sweeney F, Main Level Breakouts
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sweeney F, Main Level Breakouts

THURSDAY, FEBRUARY 25

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Research Journal of Molecular Cell Biology (JMCB)

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Exiqon A/S

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HG008828-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676