Beaver Run Resort Floorplan

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This meeting took place in 2017



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Precision Genome Engineering (A2)


Organizer(s) J. Keith Joung, Emmanuelle Charpentier and Olivier Danos
January 8—12, 2017
Beaver Run Resort • Breckenridge, Colorado USA
Discounted Abstract Deadline: Sep 19, 2016
Abstract Deadline: Oct 6, 2016
Scholarship Deadline: Sep 19, 2016
Discounted Registration Deadline: Nov 9, 2016

Sponsored by Biogen, Editas Medicine, Inc., Merck & Co., Inc., Novo Nordisk A/S, Regeneron Pharmaceuticals, Inc., Sangamo Therapeutics, Inc. and Thermo Fisher Scientific Inc.

Summary of Meeting:
Precision genome engineering technologies enable targeted, highly efficient alteration of DNA sequences in living cells or organisms. Given their customizable nature, these technologies promise to be broadly useful both as biomedical research tools and as novel therapeutics for gene-based diseases. Given the rapidity with which this field moves, it is challenging for both newcomers and experts alike to stay updated with all of the latest advances. Furthermore, genome engineering necessarily encompasses a broad range of scientific expertise that includes fundamental mechanisms of DNA repair, basic science studies of bacterial-derived systems that form the basis of many of these technologies, innovations with genome engineering tool platforms, a wide variety of research applications spanning from model organisms to plants and mammalian cells, and pre-clinical and clinical studies aimed at translation into human therapeutics. The goal of this Keystone Symposia meeting is to bring together scientists from academia and industry with diverse but relevant expertise in a setting conducive to discussion of new results and potential collaborative efforts. Invited talks will cover a wide range of topics ranging from fundamental basic science through to clinical translation studies. Attendees of this meeting will have the opportunity to hear about the latest findings in this fast-paced field and to establish collaborations with scientists who have complementary expertise.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 12 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 13 in order to fully experience the meeting.

SUNDAY, JANUARY 8

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, JANUARY 9

07:00—08:00
Breakfast

Summit Gallery
08:00—09:00
Welcome & Keynote Address
Meeting has ended...abstracts no longer viewable online.
Provide an overview of ongoing clinical trials that are based on or utilize genome-editing technologies. Discuss on-going and future challenges to further translation.

Colorado Ballroom
* J. Keith Joung, Massachusetts General Hospital, USA

Luigi M. Naldini, San Raffaele Telethon Institute, Italy
Precision Genome Engineering of Human Hematopoiesis for Treating Genetic Disease and Cancer

09:00—11:30
(Basic) Science of Recombination & DNA Repair
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* J. Keith Joung, Massachusetts General Hospital, USA

David R. Liu, Harvard University, USA
Base Editing: Genome Editing without Double-Stranded DNA Cleavage

Coffee Break

Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
DNA Repair Mechanisms and Genome Engineering

Frederick W. Alt, Boston Children's Hospital, USA
Recurrent DNA Break Cluster Genes in Neural Development, Diversification and Disease: Potential Analogies to Lymphocyte Rearrangement Processes

Jean-Yves Masson, Laval University Cancer Research Center, Canada
Short Talk: Regulation of the Tumor Suppressor PALB2: A Critical Player for Homologous Recombination at a CRISPR/Cas9-Induced DNA Double-Strand Break

Katherine S. Pawelczak, NERx Biosciences, USA
Short Talk: Chemical Enhancement of CRISPR/Cas9 Mediated Site-Specific Genome Engineering using Novel Inhibitors of the Ku-DNA Interaction

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
14:30—15:30
Workshop 1: In vivo Delivery of Genome Editing Nucleases
Workshop participants will discuss outstanding issues such as mode of delivery, formulation, routes of administration, dose definition, genotoxicity and immune responses. The goal will be to define the gaps in developing genome editing reagents as injectable drugs.

Colorado Ballroom
* Olivier Danos, Biogen, USA

15:30—16:30
Workshop 2: Ex vivo or in vitro Delivery of Genome Editing Nucleases

Colorado Ballroom
* Luigi M. Naldini, San Raffaele Telethon Institute, Italy

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Latest Advances in Genome-Editing Nuclease Technologies I
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* J. Keith Joung, Massachusetts General Hospital, USA

Edward J. Rebar, Sangamo Therapeutics, Inc., USA
New Zinc Finger Nuclease Architectures for Precision Genome Engineering

Jay Ashok Shendure, University of Washington, USA
Applications of Genome Editing in Developmental Biology and Human Genetics

Amit Choudhary, Harvard Medical School, USA
Short Talk: Chemical Control of CRISPR-Cas9 in Cells and Organisms

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 1

Breckenridge Ballroom

TUESDAY, JANUARY 10

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Latest Advances in Genome-Editing Nuclease Technologies II
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Jennifer A. Doudna, HHMI/University of California, Berkeley, USA

Jonathan S. Weissman, University of California, San Francisco, USA
Applications of CRISPR-Cas9-Based Gene Regulatory Proteins

Andy May, Chan Zuckerberg Biohub, USA
DNA Repair Outcomes Following Cas9 Double-Stranded Breaks

Coffee Break

J. Keith Joung, Massachusetts General Hospital, USA
Defining, Optimizing and Changing the Specificities of CRISPR-Cas Nucleases

Rolf Turk, Integrated DNA Technologies, USA
Short Talk: Efficient Homology-Directed Repair using Long Single-Stranded DNA Templates

Channabasavaiah B. Gurumurthy, University of Nebraska Medical Center, USA
Short Talk: Easi-CRISPR: A Simple and Efficient Method for Creating Reporter and Conditional Knockout Animal Models

Fuqiang Chen, MilliporeSigma, USA
Short Talk: Improvement of CRISPR Activity and Specificity via Proximal Binding of Multiple CRISPR/Cas Systems (proxy-CRISPR)

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
14:30—15:30
Workshop 3: Genome-Wide Specificities & Off-Target Effects of Genome Editing Nucleases
This workshop will briefly review the various methods that currently exist for determining genome-wide off-target effects. Time will also be provided for a general question and answer session and discussion of best practices for off-target determination.

Colorado Ballroom
* J. Keith Joung, Massachusetts General Hospital, USA

15:30—16:30
Workshop 4: Design of Individual gRNAs and Genome-Wide Libraries of gRNAs for CRISPR-Cas Nucleases
This workshop will discuss what you need to know for designing guide RNAs for both small-scale experiments and genome-wide screening. We will look under the hood of available computational tools in order to understand the principles behind the choices baked into these design algorithms. Additionally, we will discuss how the 'optimal' design may vary based on model system and experimental intent.

Colorado Ballroom
* John G. Doench, Broad Institute of MIT and Harvard University, USA

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Biology of CRISPR Systems
Meeting has ended...abstracts no longer viewable online.
Updates on cutting-edge basic science studies of CRISPR systems. Not just Cas9 but extend to other aspects of the system (e.g., Cas1/Cas2, sequence-specific ribonucleases).

Colorado Ballroom
* Maria Jasin, Memorial Sloan Kettering Cancer Center, USA

Feng Zhang, Broad Institute of MIT and Harvard University, USA
Expanding the CRISPR-Cas Genome Engineering Toolbox

Eugene V. Koonin, National Institutes of Health, USA
Discovery of Novel CRISPR-Cas Systems by Genome and Metagenome Sequence Database Mining and Evolution of Adaptive Immunity in Prokaryotes

Joshua Keith Young, Dupont Pioneer, USA
Short Talk: Identification and Characterization of Novel Cas9 Endonucleases

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 2

Breckenridge Ballroom

WEDNESDAY, JANUARY 11

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Research Applications of Genome & Epigenome Engineering I
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Barbara J. Meyer, University of California, Berkeley, USA

Angelo Lombardo, San Raffaele Telethon Institute for Gene Therapy, Italy
Therapeutic Applications of Epigenome Editing

Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
Mechanism and Delivery of RNA-Guided Genome Engineering Proteins

Coffee Break

Alister Funnell, Altius Institute for Biomedical Sciences, USA
Short Talk: Functional Characterization of Putative Regulatory Elements by Precision Genome Engineering

Robert J. Ihry, Novartis Institutes for BioMedical Research, USA
Short Talk: p53 Inhibition Enhances CRISPR/CAS9 Engineering in Human Pluripotent Stem Cells by Blocking DSB-Induced Toxicity

Shashank Patel, NCI, National Institutes of Health, USA
Short Talk: A Genome-Scale CRISPR Screen to Identify Essential Genes for T Cell Based Cancer Therapies

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Research Applications of Genome & Epigenome Engineering II
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Angelo Lombardo, San Raffaele Telethon Institute for Gene Therapy, Italy

Barbara J. Meyer, University of California, Berkeley, USA
Genome Editing of C. elegans and Other Non-Model Organisms

Daniel F. Voytas, University of Minnesota, USA
Precise Engineering of Plant Genomes

Andrea Crisanti, Imperial College London, UK
Building and Testing CRISPR-Based Gene Drives for Population Control in the Malaria Mosquito

Alex Marson, University of California, San Francisco, USA
Short Talk: Discovery of an Autoimmunity-Associated IL2RA Enhancer by Unbiased Targeting of Transcriptional Activation

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 3

Breckenridge Ballroom

THURSDAY, JANUARY 12

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Novel Technologies for Therapeutic Application of Genome Engineering
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Olivier Danos, Biogen, USA

Vic E. Myer, Editas Medicine, USA
Advancing CRISPR Technologies for Therapeutic Application

Daniel G. Anderson, Massachusetts Institute of Technology, USA
Nucleic Acid Delivery Systems for RNA Therapy and Gene Editing

Coffee Break

Mark A. Kay, Stanford University, USA
rAAV-Mediated Genome Editing without the Use of Nucleases

Bin Li, Ohio State University, USA
Short Talk: Lipid-like Nanoparticles for mRNA Delivery in vivo

Knut Woltjen, CiRA, Kyoto University, Japan
Short Talk: Simultaneous Derivation of Disease-Relevant Point-Mutants and Concordant Isogenic Clones from Human Induced Pluripotent Stem Cells

11:15—17:00
On Own for Lunch

14:30—16:30
Workshop 5: Ethics & Human Rights

Colorado Ballroom
* George J. Annas, Boston University School of Public Health, USA
Why Precision Genome Engineering Should Not Be Used to (Try to) Make a "Better Baby"

Peter Dabrock, FAU Erlangen-Nürnberg, Germany
“Do Not Throw the Baby Out with the Bathwater” – Societal, Ethical and Governance Challenges of Precision Genome Engineering for Science and Society

Evelyne Shuster, Veterans Affairs Medical Center, USA
Editing the “Book of Life”: Too Early to Prescribe?

16:30—17:00
Coffee Available

Foyer
17:00—18:45
Therapeutic Applications of Genome Engineering
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Mark A. Kay, Stanford University, USA

Andrew M. Scharenberg, University of Washington, USA
Translational Genome Editing

Philippe N. Duchateau, Cellectis SA, France
TALEN®-Based Targeted Genome Modifications for Improved CAR T-Cell Adoptive Immunotherapy

Linhong Li, MaxCyte, Inc., USA
Short Talk: Mutation Correction of X-linked Chronic Granulomatous Disease

Sateesh Krishnamurthy, University of Iowa, USA
Short Talk: Correction of CFTR Splicing Mutation by Using CRISPR/Cas9 Genome Editing and Non-Homologous End Joining

18:45—19:00
Meeting Wrap-Up: Outcomes & Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources. Novo Nordisk A/S funding is not being used for this function.

Breckenridge Ballroom

FRIDAY, JANUARY 13

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Biogen Editas Medicine, Inc.
Merck & Co., Inc. Novo Nordisk A/S
Regeneron Pharmaceuticals, Inc. Sangamo Therapeutics, Inc.
Thermo Fisher Scientific Inc.
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Charles River MYcroarray
Synthego
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Editas Medicine, Inc.


Sangamo Therapeutics, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676