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This meeting took place in 2018



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Heart Failure: Crossing the Translational Divide (A1)


Organizer(s) Yibin Wang, Joseph A. Hill and Carolyn Lam
January 14—18, 2018
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Sep 21, 2017
Abstract Deadline: Oct 19, 2017
Scholarship Deadline: Sep 21, 2017
Discounted Registration Deadline: Nov 20, 2017

Sponsored by Amgen Inc.

Summary of Meeting:
Heart failure is a major human disease that afflicts millions of people worldwide. Intensive research in the past decade has yielded many exciting new mechanistic insights into the pathogenesis of heart failure, but progress toward successful therapies to prevent, halt and reverse heart failure has been painfully slow. The overall goal of this Keystone Symposia conference is to focus on heart failure and highlight the scientific advances in basic discovery and early-phase therapeutic development in this fast-moving field. The symposium will provide the field with an opportunity for robust discussion about the major issues crossing the translational divide from basic discovery to therapies.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 14 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 18 with a closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Friday, January 19 in order to fully experience the meeting.

SUNDAY, JANUARY 14

16:00—20:00
Arrival and Registration

Shavano Peak Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Shavano Peak Foyer

MONDAY, JANUARY 15

07:00—08:00
Breakfast

Shavano/Torreys
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Yibin Wang, University of California, Los Angeles, David Geffen School of Medicine, USA

* Joseph A. Hill, University of Texas Southwestern Medical Center, USA

David C. Page, Whitehead Institute for Biomedical Research, USA
Sex and Disease: Do Males and Females Read their Genomes Differently?

09:00—11:30
HFrEF: Ischemic Heart Disease (I/R Injury and Cell Death)
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Issei Komuro, Tokyo University Graduate School, Japan

* Zhao Wang, University of Texas Southwestern Medical Center, USA

Laura Mauri, Brigham and Women's Hospital, USA
What Ischemic HFrEF Looks like Clinically and What I Wish I Had in My Toolbox

Coffee Break

Richard N. Kitsis, Albert Einstein College of Medicine, USA
Understanding and Therapeutically Manipulating Cell Death in the Heart

Junichi Sadoshima, Rutgers New Jersey Medical School, USA
Autosis Mediates Myocardial Cell Death During Ischemia/Reperfusion

Yusuke Morita, Kyoto University, Japan
Short Talk: Spatiotemporal and Integrative Analysis of the Transcriptome and Metabolome Response to Systemic Energetic Starvation with Cardiac Dysfunction

Dipayan Chaudhuri, University of Utah, USA
Short Talk: Mitochondrial Cardiomyopathies Feature Compensatory Increases in Mitochondrial Calcium

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
14:30—16:30
Workshop and Panel 1: Does an X or Y Make a Difference for the Heart?

Crestone/Red Cloud
* Joseph A. Hill, University of Texas Southwestern Medical Center, USA
Does XX or XY Make the Heart Grow Fonder?

Leslie A. Leinwand, University of Colorado Boulder, USA
A Woman is Not a Small Man: Sex Differences in the Heart

David C. Page, Whitehead Institute for Biomedical Research, USA
Translate Mechanism to Practice: For Sex Differences in HF

* Vera Regitz-Zagrosek, Charité - University Medicine Berlin, Germany
Translational Aspects of Sex Differences in Myocardial Ischemia and Hypertrophy

Carolyn Lam, Duke-NUS Medical School, Singapore
Sex Differences in HF-Clinical Trial

16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Inflammation (Non-Ischemic) HFrEF
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Donald R. Menick, Medical University of South Carolina, USA

* Merry L. Lindsey, University of Mississippi Medical Center, USA

Douglas L. Mann, Washington University School of Medicine, USA
What Inflammatory Cardiomyopathy Looks like Clinically and What I Wish I Had in My Toolbox

Peter Liu, University of Ottawa Heart Institute, Canada
Immune System as Sensor/Mediator for Progression in Heart Failure – Translational Considerations

Georg Daniel Duerr, University of Bonn, Germany
Short Talk: Post-Conditioning with CpG-Containing TLR9 Ligand 1668-thioate Attenuates Inflammatory Response and Remodeling Leading to Less Fibrosis and Better Left Ventricular Function in Murine Myocardial Infarction

Dian Cao, University of Texas Southwestern Medical Center, USA
Short Talk: Cytosolic DNA Sensing Governs Myocardial Ischemic Injury by Promoting Macrophage Transformation

Shey-Shing Sheu, Thomas Jefferson University, USA
Short Talk: Mitochondrial Fission Protein Drp1 Clustered at the Sarcoplasmic Reticulum-Mitochondria Junctions to Regulate Cardiac Excitation-Contraction-Energetics Coupling

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
19:30—22:00
Poster Session 1

Shavano/Torreys

TUESDAY, JANUARY 16

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
HFrEF: Hypertensive Heart Disease (Hypertrophy, Fibrosis)
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Hina Chaudhry, Mount Sinai School of Medicine, USA

* Dan Tong, University of Texas Southwestern Medical Center, USA

Joseph A. Hill, University of Texas Southwestern Medical Center, USA
What Hypertensive HFrEF Looks Like and What I Wish I Had in my Toolbox

Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA
Fibroblast Dynamics in the MI-Injured Heart

Coffee Break

Mark E. Anderson, Johns Hopkins University School of Medicine, USA
CaMKII as a Therapeutic Target in Heart Failure and Arrhythmias

Timothy A. McKinsey, University of Colorado Denver, USA
Epigenetic Regulation of Heart Failure

Toshiyuki Ko, University of Tokyo, Japan
Short Talk: Single-Cell Analysis of Non-Cardiomyocytes Reveals a Critical Regulator of Cardiac Homeostasis

Rajan Jain, University of Pennsylvania, School of Medicine, USA
Short Talk: The Role of Nuclear Architecture in Myocyte Determination and Genetic Cardiomyopathy

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
14:30—16:30
Workshop and Panel 2: Big Data and Precision Medicine for Heart Failure
-Precision medicine: What does it mean? -Conceptual foundation of precision medicine -Precision medicine in HF clinical practice -Precision medicine in drug discovery and clinical trials

Crestone/Red Cloud
* Thomas Vondriska, University of California, Los Angeles, USA

Peipei Ping, University of California, Los Angeles, USA
Data Science in CV Biology and Medicine

Elizabeth M. McNally, Northwestern University, USA
Genomic Solutions to Precision Medicine

Daniel P. Kelly, University of Pennsylvania, USA
Integrated Profiling Approaches to Delineating the Metabolic Origins of Heart Failure

16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:15
PH and RV Failure
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Kristina Lorenz, Leibniz Institute for Analytical Sciences- ISAS, Germany

Wai Hong Wilson Tang, Cleveland Clinic, USA
What Pulmonary Hypertension and Right Heart Failure Looks like Clinically and What I Wish I Had in My Toolbox

Stephan Rosenkranz, Klinik III für Innere Medizin, Germany
Novel Targets in Pulmonary Vascular Disease and RV Dysfunction

Yibin Wang, University of California, Los Angeles, David Geffen School of Medicine, USA
Role of Stress-Signaling in Post-Natal RV Development and Maturation

Yingjie Chen, University of Minnesota, USA
Short Talk: Harnessing the T Cell Function as a New Direction in Attenuating the Transition from Left Heart Failure to Right Heart Failure through Modulating Lung Inflammation

* Edda Spiekerkoetter, Stanford University, USA
Short Talk: Increasing BMPR2 Signaling with FK506 (Tacrolimus) Reduces Cardiac Fibrosis and Improves Right Ventricular Adaptation in Pulmonary Hypertension

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
19:30—22:00
Poster Session 2

Shavano/Torreys

WEDNESDAY, JANUARY 17

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
HFrEF and Metabolism
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Chen Gao, University of California, Los Angeles, USA

* Gemma Figtree, Kolling Institute, University of Sydney, Australia

E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Mitochondrial Metabolism and Signaling Mechanisms in Heart Failure

Peipei Ping, University of California, Los Angeles, USA
The O-PTM Fingerprints of Mitochondrial Proteome: Molecular Signature and Functional Phenotype

Coffee Break

Daniel P. Kelly, University of Pennsylvania, USA
Mitochondrial Remodeling in Heart Failure

Rong Tian, University of Washington, USA
Metabolic Modulation of Cardiac Hypertrophy

Jiandong Liu, University of North Carolina at Chapel Hill, USA
Short Talk: Lin28a Regulates Pathological Hypertrophic Growth through Pck2-Mediated Enhancement of Anabolic Synthesis

Gregory Aubert, Northwestern University, USA
Short Talk: SUR2 as a Regulator of Cardiac Metabolism Plasticity

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
14:30—16:30
Workshop and Panel 3: Pharma for HF, How NOT to Get Lost in Translation

Crestone/Red Cloud
* Christine E. Seidman, Harvard Medical School, USA

* Daria Mochly-Rosen, Stanford University, USA

Russell A. Miller, Pfizer Inc., USA

Anthony J. Muslin, Sanofi, USA

Robert N. Willette, GlaxoSmithKline, USA

Aarif Y. Khakoo, Amgen, USA

Yan G. Ni, Regeneron, USA

16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:15
HFrEF: Genetics and Epigenetics
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Lisa Wilsbacher, Northwestern University, USA

* Ferhaan Ahmad, University of Iowa, USA

Elizabeth M. McNally, Northwestern University, USA
How Genetics Informs the Care of HF

Christine E. Seidman, Harvard Medical School, USA
Genetics of Cardiomyopathy: Insights into Cardiac Physiology and Disease

Thomas Thum, Medical School Hannover, Germany
Noncoding RNAs and Other Therapeutic Approaches in Cardiac Remodeling

Manuel Rosa-Garrido, University of California, Los Angeles, USA
Short Talk: Elucidation of Gene Regulation Paradigms by Integrating Chromatin Architecture, Histone Marks and DNA Methylation in Failing Hearts

Anant Chopra, Boston University, USA
Short Talk: From Tissues to Cells: Dissecting the Mechanisms of Genetic Cardiomyopathy using in vitro Engineered Disease Models

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
19:30—22:00
Poster Session 3

Shavano/Torreys

THURSDAY, JANUARY 18

07:00—08:00
Breakfast

Shavano/Torreys
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Carolyn Lam, Duke-NUS Medical School, Singapore

Daria Mochly-Rosen, Stanford University, USA
Cardiac Disease: Crossing the Translational Divide

09:00—11:30
HFpEF (Mechanisms and Therapy)
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Robert S. Danziger, University of Illinois at Chicago, USA

David A. Kass, Johns Hopkins Hospital, USA
Dissecting Mechanisms of HFpEF - A Multiscale Approach

Coffee Break

Carolyn Lam, Duke-NUS Medical School, Singapore
HFpEF Exists -- We Just Don’t Know What to Call It

Wolfgang A. Linke, University of Munster, Germany
Targeting Cardiomyocyte Structure and Function in HFpEF

Gabriele G. Schiattarella, University of Texas Southwestern Medical Center, USA
Short Talk: XBP1s-FoxO1 Axis Regulates Lipid Metabolism and Cardiac Performance in Heart Failure with Preserved Ejection Fraction

Florin Despa, University of Kentucky, USA
Short Talk: Diabetic HFpEF in a Rat Model of Systemic Amylin Dyshomeostasis

11:30—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:15
HFrEF (Cellular and Molecular Therapy)
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Lior Zangi, Icahn School of Medicine at Mount Sinai, USA

* Lina A. Shehadeh, University of Miami Miller School of Medicine, USA

Roger J. Hajjar, Mount Sinai School of Medicine, USA
Gene Therapy for Heart Failure & Pulmonary Hypertension

Hesham A. Sadek, University of Texas Southwestern Medical Center, USA
Rethinking the Effect of Hypoxia on Cardiomyocytes

Joseph C. Wu, Stanford University School of Medicine, USA
Genomics and Stem Cells for Precision Cardiovascular Medicine

Erik A. Blackwood, San Diego State University, USA
Short Talk: Pharmacologic ATF6 Activation Reprograms Cellular Proteostasis to Mitigate Pathology in a Heart Disease Model

Carmine Gentile, University of Sydney, Australia
Short Talk: Cardiac Spheroid-Based Therapy for Heart Failure Patients

19:15—19:30
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Shavano/Torreys

FRIDAY, JANUARY 19

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Amgen Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 HL140913-01

Funding for this conference was made possible (in part) by 1 R13 HL140913-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Cytokinetics, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676