Fairmont Hotel Vancouver Floorplan

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This meeting took place in 2018



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DNA and RNA Methylation (A7)


Organizer(s) Chuan He and Ting Wang
January 21—25, 2018
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Discounted Abstract Deadline: Sep 27, 2017
Abstract Deadline: Oct 27, 2017
Scholarship Deadline: Sep 27, 2017
Discounted Registration Deadline: Nov 28, 2017

Sponsored by Cell Research

Summary of Meeting:
The eukaryotic genome and transcriptome are not merely a static combination of A, T, C, G and U. Reversible DNA methylation is known to contribute significantly to gene expression regulation. In recent years, dynamic RNA methylation has also emerged as a major mode of post-transcriptional regulation of gene expression. DNA and RNA methylation is a field which is revolutionizing our knowledge on how the human genome functions, how cellular and environmental signals and stresses impact gene expression through DNA and RNA methylation, and how these inform our understanding of human disease mechanisms. This conference brings together an international group of scientists to present and discuss the emergence of and new developments in epigenomics/epitranscriptomics and their impacts on basic biology as well as human diseases, with a focus on DNA and RNA methylation. In addition, the conference provides hands-on workshops for junior and established scientists on key sequencing and computational methodologies and resources for epigenomics/epitranscriptomics research. These components will ultimately catalyze DNA and RNA methylation research and accelerate the pace of discovery. The conference will advance knowledge in the field by bringing together scientists who apply epigenomics/epitranscriptomics research to understand basic biology and human disease, thus catalyzing adoption of epigenomic/epitranscriptomic methods. Finally, it will foster scientific interactions that will ultimately accelerate the pace of discovery across multiple basic and disease-focused research areas.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 21 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 25 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 26 in order to fully experience the meeting.

SUNDAY, JANUARY 21

16:00—20:00
Arrival and Registration

British/Columbia Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

British/Columbia Foyer

MONDAY, JANUARY 22

07:30—08:30
Breakfast

Pacific Ballroom
08:00—08:30
Poster Setup

Pacific Ballroom
08:30—17:00
Poster Viewing

Pacific Ballroom
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Chuan He, University of Chicago, USA

Joseph R. Ecker, The Salk Institute for Biological Studies, USA
Single Cell Methylomes Reveal Neuronal Populations and Regulatory Elements in the Mammalian Brain

09:30—12:00
Global DNA Methylation
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Ting Wang, Washington University, USA

Dirk Schübeler, Friedrich Miescher Institute for Biomedical Research, Switzerland
Sensitivity of Transcription Factors to Chromatin and DNA Methylation

Coffee Break

Alexander Meissner, Max Planck Institute for Molecular Genetics, Germany
DNA Methylation

Steven E. Jacobsen, University of California, Los Angeles, USA
RNA-Directed DNA Methylation

Wei Xie, Tsinghua University, China
Short Talk: Dynamic Epigenetic Landscapes during Early Lineage Specification

Art Petronis, University of Toronto, Canada
Short Talk: Circadian DNA Modification Hallmarks of Aging and Disease

12:00—12:45
Lunch

Pacific Ballroom
12:00—14:30
Poster Session 1

Pacific Ballroom
14:30—16:30
Workshop 1: Epigenome and Computational Biology

British/Columbia Ballroom
* Ting Wang, Washington University, USA

Michael M. Hoffman, University of Toronto, Canada
Modeling Methyl-Sensitive Transcription Factor Motifs with an Expanded Epigenetic Alphabet

Wei Li, Baylor College of Medicine, USA
Cell Heterogeneity Adjusted Clonal Methylation (CHALM) Better Quantifies the Functional Consequences of DNA Methylation

Michael T. McManus, University of California, San Francisco, USA
Programmable de novo DNA Methylation in vivo

Jennifer M. SanMiguel, University of Pennsylvania, USA
Exploring the Role of Tet1 in Genomic Imprinting

Guifeng Wei, University of Oxford, UK
Nascent Epitranscriptome Profiling Reveals Widespread Intronic m6A in Mouse ES Cells

Bing Yao, Emory University, USA
DNA N6-Methyladenine Is Dynamically Modified in the Mouse Brain following Environmental Stress

Evangelos Kiskinis, Northwestern University Feinberg School of Medicine, USA
Dissecting DNA Methylation Dynamics during the Development and Function of The Human Spinal Cord

16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—19:00
Dynamic DNA Methylation
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Wei Xie, Tsinghua University, China

Wolf Reik, Babraham Institute, UK
Epigenetic Programming in Development and Aging

Joseph F. Costello, University of California, San Francisco, USA
Evolution of the Epigenome during Tumor Progression

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Active DNA Demethylation

Bing Zhu, Chinese Academy of Sciences, China
Short Talk: Regulation of de novo DNA Methylation during Oogenesis

19:00
On Own for Dinner
No registration fees are used to fund alcohol served at this function.


TUESDAY, JANUARY 23

07:30—08:30
Breakfast

Pacific Ballroom
08:30—11:45
DNA Methylation in Diseases
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Joseph F. Costello, University of California, San Francisco, USA

Peter A. Jones, Van Andel Research Institute, USA
Awakening Endogenous Retroviruses for Cancer Therapy

Ting Wang, Washington University, USA
Transposable Elements in Normal and Cancer Epigenome

Coffee Break

Margaret A. Goodell, Baylor College of Medicine, USA
DNA Methylation in Leukemia

Dana C. Dolinoy, University of Michigan School of Public Health, USA
Longitudinal Effects of Developmental Exposures on Age-Related DNA Methylation and Hydroxymethylation

Kirsten C. Sadler, New York University Abu Dhabi, United Arab Emirates
Short Talk: Cell Cycle Arrest, Apoptosis and Immune Surveillance as Mechanisms to Eliminate Cells with DNA Hypomethylation

Yong Cheng, St. Jude Children's Research Hospital, USA
Short Talk: Characterizing the Functions of Dynamic DNA Methylation between Adult and Fetal Erythroid Cells

11:45—12:15
Meet the Editors

British/Columbia Ballroom
* Chuan He, University of Chicago, USA

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
14:30—16:30
Hands-On Workshop: Engaging Roadmap, ENCODE, and 4DN Data Using the WashU Epigenome Browser
Advances in next-generation sequencing technology have reshaped the landscape of genomic and epigenomic research as well as human genetics studies. Annotating the non-coding, regulatory genome with genomic and epigenomic data has provided new venues to interpret the functional consequences of genetic variants associated with human complex traits. Large consortiums such as ENCODE and Roadmap Epigenomics project have generated tens of thousands sequencing-based genome-wide datasets, creating a reference and resource for the scientific community. There is a great need for investigators to effectively engage with this resource in the context of analyzing investigators’ own data. This interactive workshop will introduce The WashU Human Epigenome Browser and associated tools (http://epigenomegateway.wustl.edu/). The WashU Epigenome Browser hosts data from ENCODE, Roadmap Epigenomics, IHEC as well as 4D Nucleome Consortia, and supports navigation of the data and its interactive visualization, integration, comparison, and analysis. Attendees will gain hands-on experience with exploring the most current epigenomic and 3D chromatin structure resources, and with advanced visual-bioinformatics tools including gene set view, genome juxtaposition, and chromatin-interaction display, inventions unique to the WashU Epigenome Browser. Through specific examples the workshop will demonstrate the power of annotating genetic variants with epigenomic data, and how it can be easily achieved with the Epigenome Browser.

British/Columbia Ballroom
* Ting Wang, Washington University, USA

16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—19:00
Other DNA Methylation
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Bing Zhu, Chinese Academy of Sciences, China

Yang Shi, Children's Hospital Boston, Harvard Medical School, USA
DNA 6mA Methylation

Andrew Xiao, Yale University, USA
The Recent Expansion of Epigenetic Regulatory Repertoire in Mammals

Chunxiao Song, University of Oxford, UK
Using Epigenetic Signatures in Cell-Free DNA for Cancer Detection

Silvia Monticelli, Institute for Research in Biomedicine, Switzerland
Short Talk: Dynamics of DNA Methylation and Hydroxymethylation in Human T Cell Responses

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
19:30—22:00
Poster Session 2

Pacific Ballroom

WEDNESDAY, JANUARY 24

07:30—08:30
Breakfast

Pacific Ballroom
08:30—11:45
Dynamic RNA Methylation
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Pedro J. Batista, NCI, National Institutes of Health, USA

Chuan He, University of Chicago, USA
RNA Methylation in Gene Expression Regulation

Gideon Rechavi, Tel Aviv University, Israel
Biological Implications of Epitrancriptomics

Coffee Break

Samie Jaffrey, Weill Medical College of Cornell University, USA
Encoding the Fate and Function of mRNA with Reversible Epitranscriptomic Modifications at Internal Sites and in mRNA Caps

Tao Pan, University of Chicago, USA
M6A-dependent RNA Interaction with a Low-complexity Protein Regulates Co-transcriptional Gene Expression

Chengqi Yi, Peking University, China
Short Talk: Mapping the Functional Mammalian Epitranscriptome

Patrick Paddison, Fred Hutchinson Cancer Research Center, USA
Short Talk: N6-Methyladenosine Regulates Translation of Key Genes Required for Human Erythroid Lineage Specification

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—19:00
RNA Methylation in Development and Cellular Processes
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Chengqi Yi, Peking University, China

Jianjun Chen, Beckman Research Institute of City of Hope, USA
N6-Methyladenosine in Acute Myeloid Leukemia

Hani Goodarzi, University of California, San Francisco, USA
Targeted Regulation of Transcript Stability through RNA Methylation and Intron Retention

Yunsun Nam, University of Texas Southwestern Medical Center, USA
Structural Studies of RNA Methylation

Pedro J. Batista, NCI, National Institutes of Health, USA
Short Talk: The Rna Helicase Ythdc2/Bgcn Regulates the Transition from Proliferation to Differentiation in the Germline Stem Cell Lineage

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
19:30—22:00
Poster Session 3

Pacific Ballroom

THURSDAY, JANUARY 25

07:30—08:30
Breakfast

Pacific Ballroom
08:30—11:45
RNA Methylation in Diseases
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Patrick Paddison, Fred Hutchinson Cancer Research Center, USA

Tariq M. Rana, University of California, San Diego, USA
RNA Methylation during Viral Infections

Stacy M. Horner, Duke University Medical Center, USA
RNA Methylation in Flaviviridae Virus Infection

Coffee Break

Suyun Huang, MD Anderson Cancer Center, USA
RNA Methylation in Glioma

Yanhong Shi, Beckman Research Institute of City of Hope, USA
RNA Modification in Glioblastoma

Housheng Hansen He, Princess Margaret Cancer Centre, Canada
Short Talk: The Dynamic N6-Methyladenosine Epitranscriptomic Landscape in Lung Adenocarcinoma

Pooja Yadav, University of Texas Health Science Center, USA
Short Talk: N6 Methyladenosine RNA Demethylase Regulates Osteosarcoma Growth and DNA Damage Response

11:45—17:00
On Own for Lunch

14:30—16:30
Workshop 2: DNA and RNA Methylation in Diseases

British/Columbia Ballroom
* Chuan He, University of Chicago, USA

Humaira Gowher, Purdue University, USA
Biological Outcomes of the Catalytic Specialization of DNA Methyltransferases

Bryan Tsutomu Harada, University of Chicago, USA
m6A mRNA Methylation Regulates the Proliferation and Tumorigenicity of Endometrial Cancer

Hong Ji, University of California, Davis, USA
Diesel Exhaust and House Dust Mite Allergen Alter TET1 Expression and Lead to Common Changes in Airway DNA Methylation

Brittany A. Elliott, Duke University, USA
Box C/D Small Nucleolar RNAs Regulate Gene Expression by Guiding 2 O-Methylation of mRNA

Marco Morselli, University of California, Los Angeles, USA
Bisulfite RNA-seq: Detection and Analysis of 5-methyl Cytosine in polyA-RNA with Next Generation Sequencing

Hyung Joo Lee, Washington University School of Medicine, USA
Cell Type-Specific DNA Methylation Is Associated with Cell Fate Restriction during Zebrafish Fin Regeneration

16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—18:45
Other RNA Methylation
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Housheng Hansen He, Princess Margaret Cancer Centre, Canada

Michaela Frye, Deutsches Krebsforschungszentrum, Germany
Regulatory Potential of Cytosine-5 Methylation in RNA

François Fuks, Université libre de Bruxelles, Belgium
Transcriptome-Wide Distribution and Function of RNA Modifications

Juan Alfonzo, Ohio State University, USA
Bridging the Gap between RNA Editing and Modification: A 10-Year Solution to a 20-Year Problem

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Pacific Ballroom

FRIDAY, JANUARY 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


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Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Cell Research

We gratefully acknowledge additional support for this conference from:

Abcam plc

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