Keystone Resort Floorplan

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This meeting took place in 2018


Here are the related meetings in 2019:
Long Noncoding RNAs: From Molecular Mechanism to Functional Genetics (X2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Noncoding RNAs: Form, Function, Physiology (C2)


Organizer(s) Joshua T. Mendell, Igor Ulitsky and Sohail F. Tavazoie
February 25—March 1, 2018
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 24, 2017
Abstract Deadline: Nov 21, 2017
Scholarship Deadline: Oct 24, 2017
Discounted Registration Deadline: Dec 19, 2017

Sponsored by Ionis Pharmaceuticals, Inc.

Summary of Meeting:
Recent research has revealed pervasive transcription of eukaryotic genomes outside of protein-coding genes. The resulting noncoding RNA transcripts come in many forms, perform diverse functions and play critical roles in organismal health and disease. Tens of thousands of noncoding RNAs have been identified so far, but we are still at the earliest stages of understanding their regulation and function. Such knowledge will be critical in order to harness the full potential of noncoding RNAs for the diagnosis and treatment of human diseases. To address this gap in our understanding, this conference aims to: 1) Bring together a multi-disciplinary group of scientists at all career stages to share their latest research in this field; 2) Provide a forum for the presentation of cutting-edge data on noncoding RNA structure, function and their roles in physiology and disease; and 3) Offer junior scientists outstanding mentoring and networking opportunities through close interactions with senior investigators. It is anticipated that the interactions of participants with diverse backgrounds, expertise and experimental models will spur new lines of investigation and collaborations that will lead to breakthroughs in our understanding of the noncoding transcriptome.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, February 25 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 1 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 2 in order to fully experience the meeting.

SUNDAY, FEBRUARY 25

16:00—20:00
Arrival and Registration

Longs Peak Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, FEBRUARY 26

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Joshua T. Mendell, HHMI/University of Texas Southwestern Medical Center, USA

Caroline Dean, John Innes Centre, UK
Antisense-Mediated Chromatin Silencing at FLC

09:00—11:15
Evolution and Structure of Noncoding RNAs
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Joshua T. Mendell, HHMI/University of Texas Southwestern Medical Center, USA

Igor Ulitsky, Weizmann Institute of Science, Israel
Sequences Enriched in Alu Repeats Drive Nuclear Localization of Long RNAs in Human Cells

Coffee Break

Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs

Kevin Weeks, University of North Carolina, USA
Structure-Based Discovery of New Functions in Large RNAs

Yashar Niknafs, University of Michigan, USA
Short Talk: Oncogenic Role of THOR, a Conserved Cancer/Testis Long Noncoding RNA

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Prokaryotic and Viral Noncoding RNAs
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Howard Y. Chang, Stanford University, USA

Jörg Vogel, University of Würzburg, Germany
Grad-seq Discovers the Third Domain of Small RNA-mediated Gene Regulation in Bacteria

Ronald R. Breaker, Yale University, USA
Comprehensive Discovery of Ribozymes and Riboswitches

Joan A. Steitz, Yale University, United States Minor Outlying Islands
Nuclear Noncoding RNAs: More Surprises

Roee Amit, Technion - Israel Institute of Technology, Israel
Short Talk: Short CU-Rich Motifs Insulate Bacterial Genes from Transcriptional Read-Through

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 1

Longs/Quandary Peaks

TUESDAY, FEBRUARY 27

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:15
Noncoding RNAs in Epigenetic Regulation
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* John L. Rinn, University of Colorado Boulder, USA

Jeannie T. Lee, Massachusetts General Hospital, USA
How RNA Recruits Epigenetic Complexes to the X-Chromosome

Neil Brockdorff, University of Oxford, UK
Chromosome Silencing by Xist RNA

Coffee Break

Roberto Bonasio, University of Pennsylvania, USA
Regulation of Chromatin Complexes by Protein–RNA Interactions

Xiaohua Shen, Tsinghua University, China
Cis-Acting lncRNAs in Transcription and Chromatin Regulation

Chen Davidovich, Monash University, Australia
Short Talk: Mechanism for RNA-Mediated Regulation of the Histone Methyltransferase Polycomb Repressive Complex 2 (PRC2)

Amanda J. Whipple, Massachusetts Institute of Technology, USA
Short Talk: Neuronal Functions of Imprinted, Noncoding RNAs

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
14:30—16:30
Workshop: Highlights of Submitted Abstracts

Longs/Quandary Peaks
* Susan B. Carpenter, University of California, Santa Cruz, USA

* David L. Spector, Cold Spring Harbor Laboratory, USA

Amanda Louise Gervaise, Baylor College of Medicine, USA
Global Profiling Identifies Germline miRNAs Functioning During Oogenesis in C. elegans

Yunsun Nam, University of Texas Southwestern Medical Center, USA
Heme Enables Proper Positioning of Drosha and DGCR8 on Primary microRNAs

Yoo Jane Han, University of Chicago, USA
Circular RNAs Expressed from the BRCA1 Pseudogene Regulates the DNA Damage Response through SERBP1 RNA-Binding Protein

Rui Zhou, Johns Hopkins University School of Medicine, USA
The Circular RNA Edis Modulates Innate Immunity and Neurodevelopment in Drosophila

Andre Verdel, Institut Albert Bonniot, France
A New lncRNA-based Mechanism Controlling Sexual Differentiation and Heterochromatin Gene Silencing in Fission Yeast

Martina Rossi, University of Genoa, Italy
LncRNA EPR Orchestrates Epithelial Gene Expression Program in Mammary Gland Cells

Musaddeque Ahmed, Princess Margaret Cancer Centre, Canada
CRISPRi Screening of Susceptibility Regulatory Regions and Long Noncoding RNAs in Prostate Cancer

Joon H. Choi, University of Texas at Austin, USA
The Triphosphatase DUSP11 Controls the Level and Immunostimulatory Activity of Alu Transcripts

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Noncoding RNAs in Subcellular Organization
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Jeannie T. Lee, Massachusetts General Hospital, USA

Tetsuro Hirose, Hokkaido University, Japan
Dissection of Elements and Machinery of Architectural Noncoding RNAs

David L. Spector, Cold Spring Harbor Laboratory, USA
Targeting Long Noncoding RNAs to Impact Breast Cancer Progression

John L. Rinn, University of Colorado Boulder, USA
High-Throughput Identification of RNA Nuclear Enrichment Sequences

Miha Modic, Helmholtz Zentrum München, Germany
Short Talk: Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 2

Longs/Quandary Peaks

WEDNESDAY, FEBRUARY 28

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:15
Transcriptional and Post-Transcriptional Regulation by Noncoding RNAs
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Matthias W. Hentze, European Molecular Biology Laboratory, Germany

Reuven Agami, Netherlands Cancer Institute, Netherlands
Transcriptional Control by lncRNAs

Susan B. Carpenter, University of California, Santa Cruz, USA
Genetic Models Reveal Cis and Trans Functions for LincRNA-Cox2

Coffee Break

Joshua T. Mendell, HHMI/University of Texas Southwestern Medical Center, USA
Noncoding RNAs in Post-Transcriptional Regulatory Circuits

Irene Bozzoni, University La Sapienza, Rome, Italy
Long Noncoding RNAs and Circular RNAs in the Control of Muscle Differentiation

Olof S. Dallner, Rockefeller University, USA
Short Talk: Quantitative Regulation of the Leptin Gene by a Fat-Specific lncRNA

Ramesh S. Pillai, University of Geneva, Switzerland
Short Talk: Regulation of m6A Transcripts by YTHDC2 Is Essential for Meiosis in the Mammalian Germline

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Non-Canonical Roles of tRNAs, snoRNAs, and Repetitive RNAs
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Irene Bozzoni, University La Sapienza, Rome, Italy

Sohail F. Tavazoie, Rockefeller University, USA
tRNA Fragments in Hypoxic Response and Cancer Progression

Britt Glaunsinger, University of California, Berkeley and HHMI, USA
Repetitive Noncoding RNAs in Viral Pathogenesis

Matthias W. Hentze, European Molecular Biology Laboratory, Germany
Regulation of Selective Autophagy by the Small Noncoding Vault RNA1-1

Benjamin R. Hawley, Weill Cornell Medicine, USA
Short Talk: Drosha Drives the Formation of DNA:RNA Hybrids around DNA Break Sites to Facilitate DNA Damage Repair

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 3

Longs/Quandary Peaks

THURSDAY, MARCH 1

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:15
Noncoding RNAs in Disease
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Sohail F. Tavazoie, Rockefeller University, USA

Stefanie Dimmeler, University of Frankfurt, Germany
Noncoding RNAs in Cardiovascular Diseases

Nadya Dimitrova, Yale University, USA
Investigation of Long Noncoding RNAs in Tumorigenesis

Coffee Break

Caroline Woo, Translate Bio, USA
Targeting lncRNAs for Gene Upregulation Using Oligonucleotides as a Therapeutic Modality

Stefano Gustincich, Italian Institute of Technology, Italy
SINEUPs: A Versatile Tool to Increase Protein Synthesis

Ashish Lal, NCI, National Institutes of Health, USA
Short Talk: Regulating the Regulator: Long Noncoding RNAs in the p53 Network in Colorectal Cancer

Doug Hanniford, New York University Langone Medical Center, USA
Short Talk: CDR1as Arises from a lncRNA Transcript which Is Epigenetically Silenced to Drive Melanoma Metastasis

11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:45
Unconventional RNA Form and Function
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Igor Ulitsky, Weizmann Institute of Science, Israel

Jeremy E. Wilusz, University of Pennsylvania, USA
Controlling Circular RNA Levels

Lingling Chen, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Biogenesis of Circular RNAs

Antonio J. Giraldez, Yale University School of Medicine, USA
Noncoding RNAs and Peptides in Zebrafish Development

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grays Peak
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Longs/Quandary Peaks

FRIDAY, MARCH 2

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Ionis Pharmaceuticals, Inc.

We gratefully acknowledge additional support from these exhibitors at this conference:

Arraystar Inc.
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge additional support for this conference from:

Integrated DNA Technologies Oncotarget

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Translate Bio


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676