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This meeting took place in 2018



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Endoderm Development and Disease: Cross-Organ Comparison and Interplay (C3)


Organizer(s) Xin Sun, Kat Hadjantonakis and Didier Stainier
February 25—March 1, 2018
Sagebrush Inn & Suites • Taos, New Mexico USA
Discounted Abstract Deadline: Oct 25, 2017
Abstract Deadline: Nov 28, 2017
Scholarship Deadline: Oct 25, 2017
Discounted Registration Deadline: Dec 20, 2017

Supported by the Directors' Fund

Summary of Meeting:
Organs do not function in isolation. In contrast to the majority of existing meetings that focus on individual organs (lung, pancreas, intestines, etc.), or individual pathways (FGF, WNT, Hippo, etc.), this conference offers a unique cross-organ perspective on development, homeostasis, repair, regeneration and pathogenesis. The endoderm is an ideal setting as it gives rise to the majority of our internal organs such as the thyroid, thymus, lungs, liver, pancreas, esophagus, stomach, intestine and prostate, etc. Associated with these organs is a wide spectrum of diseases, including asthma, diabetes, fibrosis, obesity, infections and cancer. This conference aims to achieve the following goals: 1) Synthesize similarities and differences of mechanisms of specification, morphogenesis, maturation, regeneration and pathogenesis across organs; 2) Use the simplicity of the developing organs to uncover complex disease mechanisms; 3) Investigate organ development and function in the context of other organs, the immune system and the nervous system; 4) Consider organ physiology and metabolism under the influence of the environment: bacteria, viruses, allergen, pollutants and circadian control; and 5) Share successful technologies across organ systems. Such a cross-sectional perspective brings together researchers across scientific disciplines who do not normally meet. The conference will link development with physiology and help to establish a community of the next generation of researchers who will approach their scientific investigation with a broad, multi-systems view.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, February 25 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 1 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 2 in order to fully experience the meeting.

SUNDAY, FEBRUARY 25

16:00—20:00
Arrival and Registration

Sagebrush Lobby & Cantina
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Sagebrush Lobby & Cantina

MONDAY, FEBRUARY 26

07:00—08:00
Breakfast

Sagebrush Lobby & Cantina
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Kat Hadjantonakis, Sloan Kettering Institute, USA

* Xin Sun, University of California, San Diego, USA

* Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany

James M. Wells, Cincinnati Children's Hospital Research Foundation, USA
Using Pluripotent Stem Cell-Derived Organoids to Study Gastrointestinal Development and Disease

09:00—11:30
Specification and Morphogenesis: In the Embryo and the Dish
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Brigid L. M. Hogan, Duke University Medical Center, USA

Elizabeth J. Robertson, University of Oxford, UK
Specification of the Definitive Endoderm and Midline Progenitors in the Early Post-Implantation Mouse Embryo

Coffee Break

Kat Hadjantonakis, Sloan Kettering Institute, USA
Single-Cell Dynamics and the Emergence of the Endoderm in the Mouse Embryo

Ophir Klein, University of California, San Francisco, USA
Diverse Regenerative Strategies of the Intestinal Epithelium

Francesca M. Spagnoli, Max Delbrück Center for Molecular Medicine, Germany
Short Talk: Similarities and Differences Underlying Cell Identity Acquisition in Liver and Pancreas

P. Duc Si Dong, Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Direct in vivo Lineage Conversion of Muscle into Pancreatic Endoderm-Like Cells

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop 1: Emerging Technologies

Chamisa Ballroom 1
* Mitsuru Morimoto, RIKEN, Center for Developmental Biology, Japan

Stéphane Boutet, 10x Genomics, USA
Single Cell Transcriptomics for Characterization of Normal and Diseased Endodermal Tissues

Sonja Nowotschin, Sloan Kettering Institute, USA
Ontogeny of the Endoderm in the Mouse: A Single-Cell Transcriptomic Analysis

Pamela A. Hoodless, British Columbia Cancer Agency, Canada
Delineating Cell Diversity in the Mouse Liver Bud and Early Embryonic Liver through Single-Cell Expression Profiling

Nadav Sharon, Harvard University, USA
A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets

Hirofumi Kiyokawa, RIKEN, Center for Developmental Biology, Japan
The Dynamic Epithelial Transition of Developing Trachea Unveiled by Single Cell RNA-Seq

Jacob Enriquez, Cincinnati Children's Hospital Medical Center, USA
Enteroendocrine Cell Differentiation and Dynamics during Homeostatic and Altered Nutrient Conditions

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Organogenesis: Building a Functional Organ in the Context of the Other Tissues
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* David M. Ornitz, Washington University School of Medicine, USA

Xin Sun, University of California, San Diego, USA
Consider the Lung as a Sensory Organ

Sarah Knox, University of California, San Francisco, USA
Salivary Gland Development and Repair

Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany
Genetics of Endoderm Development and Disease

Talia Nasr, Cincinnati Children's Hospital, USA
Short Talk: Modeling Tracheoesophageal Birth Defects: The Role of Hedgehog/Gli Signaling in Foregut Morphogenesis

Elke A. Ober, University of Copenhagen, Denmark
Short Talk: Cellular and Biomechanical Mechanisms of Liver Morphogenesis

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

TUESDAY, FEBRUARY 27

07:00—08:00
Breakfast

Sagebrush Lobby & Cantina
08:00—11:15
Stem/Progenitor Cells: Similarities and Differences Across Organs
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany

Edward E. Morrisey, University of Pennsylvania, USA
Generating and Regenerating the Lung Alveolus

Lucy Erin O'Brien, Stanford University School of Medicine, USA
Collective Dynamics of Drosophila Intestinal Stem Cells

Coffee Break

Markus Grompe, Oregon Health & Science University, USA
Injury Responses in the Liver

Brigid L. M. Hogan, Duke University Medical Center, USA
Stem Cells and Lung Repair: Deconstructing the Alveolar Niche

Stijn De Langhe, University of Alabama at Birmingham, USA
Short Talk: Mesenchymal-Epithelial Fgf10-Fgfr2b Signaling Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Bleomycin Injury

Norris Ray Dunn, Institute of Medical Biology, Singapore
Short Talk: Mutated in Colorectal Cancer (Mcc): A Novel Centrosomal Protein Involved in Adult Intestinal Homeostasis

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop 2: Manipulating Cell Fate

Chamisa Ballroom 1
* Chris Wright, Vanderbilt University Medical Center, USA

Li-Fang Chu, University of Wisconsin-Madison, USA
Comparative, High-Temporal Resolution Transcriptomic Analysis of Human and Mouse Embryonic Stem Cells Differentiation towards Definitive Endoderm Reveals Conserved and Unique Coding and Noncoding Gene Expression Repertoire

Stephen Trisno, Cincinnati Children's Hospital Medical Center, USA
Directed Differentiation of Human Pluripotent Stem Cells to Esophageal Organoids

Erin M. McAuley, University of Chicago, USA
Sox2 Expression Marks Castration-Resistant Progenitor Cells in the Adult Murine Prostate

Federica Michielin, University of Padova, Italy
Investigating Liver Disease Heterogeneity in Alpha1-Antitrypsin Deficiency with hiPSCs Populations

Nikolay Ninov, Technical University Dresden, Germany
Beta Cells Come in Different Flavors: The Role of Developmental History in Shaping Proliferative and Functional Heterogeneity

Gregory Wiessner, Columbia University Medical Center, USA
Retinoid Signaling Suppresses Squamous Differentiation in the Developing Urothelium

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Genetics and Epigenetics: Homing in on Causality
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Gerd Walz, University Freiburg Medical Center, Germany

Chris Wright, Vanderbilt University Medical Center, USA
Pancreatic Endocrine-Cell Birth: Focal Cell-Intrinsic Neurog3-Independent Morphogenetic Programs Linked to Epithelial Feedback, and Lineage-Priming as a Progenitor-Partitioning Mechanism

Lori Sussel, University of Colorado, USA
Regulating Islet Cell Identity

Maike Sander, University of California, San Diego, USA
Deconstructing Pancreatic Development and Disease with Human Pluripotent Stem Cells

Dario Nicetto, Perelman School of Medicine, University of Pennsylvania, USA
Short Talk: Genome-Wide Depletion of H3K9me3 Heterochromatin during Endoderm Development Reveals Regulatory Dynamics at Hepatic and Pancreatic-Specific Genes

Alan C. Mullen, Harvard Medical School, USA
Short Talk: lncRNA DIGIT Interacts with Chromatin Readers to Regulate Endoderm Differentiation

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

WEDNESDAY, FEBRUARY 28

07:00—08:00
Breakfast

Sagebrush Lobby & Cantina
08:00—11:15
Endoderm Organ Function: Physiology, Metabolism and Pathology
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Susan Thibeault, University of Wisconsin-Madison, USA

Michael J. Welsh, University of Iowa, USA
Abnormal Submucosal Gland Mucus Impairs Mucociliary Transport in Cystic Fibrosis Airways

Irene Miguel-Aliaga, Imperial College London, UK
Sex Differences in Intestinal Plasticity

Coffee Break

Stacey S. Huppert, Cincinnati Children’s Hospital Medical Center, USA
Building a Functional Biliary System via Hepatocyte Plasticity

Stephen Liberles, Harvard Medical School, USA
Molecular and Genetic Analysis of the Vagus Nerve

Ahmad N. Nabhan, Stanford University, USA
Short Talk: Single Cell Wnt Signaling Niches Maintain Stemness of Alveolar Type 2 Cells

Giovanni Giuseppe Giobbe, University College London, UK
Short Talk: From Stem Cell to Hepatocyte: Reconstructing a Functional Liver

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Endoderm Cancers: Not All Generated Equal
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Lijian Hui, Shanghai Institutes of Biological Sciences, China

Matthias Hebrok, University of California, San Francisco, USA
Pancreatic Cancer

Vishva M. Dixit, Genentech, Inc., USA
Lung and Pancreatic Cancer

Michael M. Shen, Columbia University, USA
Progenitor Cells and the Origin of Prostate Cancer

Kyra A. Campbell, University of Sheffield, UK
Short Talk: Colorectal Cancer and Metastasis, a Novel Model in Adult Drosophila Demonstrates a Key Role for Cell Plasticity

Joe Ouadah, Stanford University School of Medicine, USA
Short Talk: A Subpopulation of Pulmonary Neuroendocrine Cells Function as Reserve Stem Cells and Initiate Small Cell Lung Cancer

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

THURSDAY, MARCH 1

07:00—08:00
Breakfast

Sagebrush Lobby & Cantina
08:00—11:15
Interaction with the Environment: A Part of Life
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* David Riches, National Jewish Health, USA

Michael J. Holtzman, Washington University in St. Louis, USA
Endoderm Reaction to Infection

Karen Guillemin, University of Oregon, USA
Teaming with Microbes: Lessons from the Zebrafish Intestine

Coffee Break

Jianwen Que, Columbia University, USA
Living in Limbo: Transitional Basal Cells at the Gastroesophageal Junction

Joseph S. Takahashi, HHMI/University of Texas Southwestern Medical Center, USA
Circadian Rhythm in Endoderm Organs

Yu Hsuan Carol Yang, Max Planck Institute for Heart and Lung Research, Germany
Short Talk: Unraveling the Role of Endocrine Pancreas Innervation through in vivo Time-Lapse Imaging and Optogenetic Control of Nerve Activity

Gustavo Mostoslavsky, Boston University, USA
Short Talk: Novel Intestinal Differentiation Approach from Human Induced Pluripotent Stem Cells Gives Rise to Intestinal Organoids Devoid of Mesenchymal Support

11:15—17:00
On Own for Lunch

14:30—16:30
Workshop 3: Endoderm Crosstalk: Novel Insights

Chamisa Ballroom 1
* Barak Blum, University of Wisconsin, USA

Andrew S. Hagan, Washington University in St. Louis, USA
FGF18 Signaling in Postnatal Alveologenesis

Randee Young, University of California, San Diego, USA
Investigating the Role of Airway Smooth Muscle during Branching Morphogenesis of the Mammalian Lung

Kazushige Shiraishi, University of Tokyo, Japan
Transcriptome Analysis of Lung Epithelial Cells and Fibroblasts during Alveologenesis Revealed Stage-Specific Transcriptional Signatures and Epithelial-Fibroblast Interactions

Melissa T. Adams, University of Wisconsin-Madison, USA
Roundabout Receptors Control Spatial Organization and Endocrine Cell Type Ratio in the Islets of Langerhans

Caitlin Braitsch, University of Texas Southwestern Medical Center, USA
Lats1/2 Kinases Are Required to Coordinate Epithelial Proliferation and Morphogenesis via NFκB Signaling Pathway

Vlasta Lungova, University of Wisconsin, USA
Beta-Catenin Signaling is Essential for Mammalian Larynx Recanalization and Establishment of Vocal Fold Progenitor Cells

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—18:45
Endoderm Diseases: Lessons from Development
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Xin Sun, University of California, San Diego, USA

Lijian Hui, Shanghai Institutes of Biological Sciences, China
Cell Identity Conversion and Liver Regeneration

Norbert Perrimon, Harvard Medical School, USA
Interorgan Communication

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Chamisa Ballroom 2

FRIDAY, MARCH 2

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

eLife March of Dimes Foundation, Grant No. 4-FY18-826

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676