Resort at Squaw Creek Floorplan

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This meeting took place in 2018



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iPSCs: A Decade of Progress and Beyond (C7)


Organizer(s) Shinya Yamanaka, Haruhisa Inoue and Yanhong Shi
March 25—29, 2018
Resort at Squaw Creek • Olympic Valley, California USA
Discounted Abstract Deadline: Dec 1, 2017
Abstract Deadline: Dec 21, 2017
Scholarship Deadline: Nov 30, 2017
Discounted Registration Deadline: Jan 18, 2018

Sponsored by California Institute for Regenerative Medicine (CIRM) and Cell Research

Summary of Meeting:
The breakthrough discovery of iPSCs has transformed our prospects for regenerative medicine. The use of disease-specific iPSCs provides great hope for developing surrogate models of human diseases, platforms for drug discovery, and stem cell-based cell replacement therapies. Cutting-edge iPSC technologies, including small molecule-induced reprogramming, efficient lineage-specific differentiation, targeted gene editing, and comprehensive disease modeling will be highlighted in this symposium. The overall goals are to: 1) Promote a further understanding of the application of iPSC technology to model human diseases and develop new therapies; 2) Facilitate the integration of the iPSC technology with emerging technologies, such as CRISPR/Cas9 gene editing technology; 3) Stimulate the development of new technologies; and 4) Promote collaborations among the scientists attending. In a year when the Nobel prize-winning iPSC technology reaches its 10th anniversary, the prospect of using iPSC technology to observe the development of human diseases in a dish and to develop cell replacement therapies is truly tantalizing. However, the iPSC technology is still facing many challenges. This symposium will present the most recent advances in this rapidly evolving research area to address the needs of the field. Due to the enormous potential of the iPSC technology in disease modeling, drug discovery and therapeutic development, this symposium will appeal to a wide community of researchers and clinicians alike.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 25 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 29 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 30 in order to fully experience the meeting.

SUNDAY, MARCH 25

16:00—20:00
Arrival and Registration

Lobby Alcove
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Cascades

MONDAY, MARCH 26

07:00—08:00
Breakfast

Cascades
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Haruhisa Inoue, Center for iPS Cell Research and Application, Kyoto University, RIKEN, Japan

* Yanhong Shi, Beckman Research Institute of City of Hope, USA

* Shinya Yamanaka, Gladstone Institute of Cardiovascular Disease, USA, Center for iPS Cell Research and Application, Kyoto University, Japan
iPSC Technology-The Past, Present and Future

09:00—11:30
iPSC-Based Disease Modeling
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Shinya Yamanaka, Gladstone Institute of Cardiovascular Disease, USA, Center for iPS Cell Research and Application, Kyoto University, Japan

Fred (Rusty) H. Gage, The Salk Institute for Biological Studies, USA
Applications of iPS Cells to Reveal Insights into Biological Psychiatry

Coffee Break

Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Stem Cells and Epigenetic Regulation in Development and Disease

Yanhong Shi, Beckman Research Institute of City of Hope, USA
Modeling Neurological Diseases Using Patient iPSCs

Ji Hyeon Ju, Catholic University of Korea, South Korea
Short Talk: Disease Modeling using Induced Pluripotent Stem Cells of Patients with Systemic Sclerosis

Aparna Venkatesh, Agency for Science and Technology Singapore, Singapore
Short Talk: Advances in Down Syndrome Disease Modeling Using hiPSC

11:30—11:45
Overview of CIRM's Programs/Funding Opportunities
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Kelly A. Shepard, California Institute for Regenerative Medicine, USA

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Alpine Ballroom
13:00—22:00
Poster Viewing

Alpine Ballroom
16:30—17:00
Coffee Available

Sierra Prefunction
17:00—19:00
Drug Discovery using iPSC Platforms
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Yanhong Shi, Beckman Research Institute of City of Hope, USA

Haruhisa Inoue, Center for iPS Cell Research and Application, Kyoto University, RIKEN, Japan
Human Pluripotent Stem Cells in Neurological Drug Discovery

Ricardo E. Dolmetsch, Novartis Institutes for BioMedical Research, USA
Using Stem Cell to Develop Drugs in Pediatric Neurology

David Piper, Thermo Fisher Scientific, USA
Removing Inherent Bottlenecks in the Genome Engineering of iPSCs to Build Relevant Disease Models for Target and Compound Screening

Rik van der Kant, Vrije Universiteit, Netherlands
Short Talk: A Drug Screen in iPSC-Alzheimer's Disease Neurons Identifies Cholesterol Metabolism as an Aβ Independent Regulator of Tau Dysfunction

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Cascades
19:30—22:00
Poster Session 1

Alpine Ballroom

TUESDAY, MARCH 27

07:00—08:00
Breakfast

Cascades
08:00—11:15
3D Modeling Using Organoids
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Haruhisa Inoue, Center for iPS Cell Research and Application, Kyoto University, RIKEN, Japan

Madeline Lancaster, Medical Research Council Laboratory of Molecular Biology, UK
Studying Human Brain Development and Evolution in Cerebral Organoids

Guo-li Ming, University of Pennsylvania, USA
Brain-Region-Specific Organoids for Modeling Neurodevelopment and Disease

Coffee Break

Flora M. Vaccarino, Yale University School of Medicine, USA
Integrative Multi-Omics Analyses of iPSC-Derived Brain Organoids Identify Early Determinants of Human Cortical Development

Hongjun Song, University of Pennsylvania, USA
Epitranscriptomic Regulation in the Nervous System

Mark A. Skylar-Scott, Harvard University, USA
Short Talk: Embedded 3D Bioprinting of Vascularized Organ-Specific Tissues at Scale

Kapil Bharti, National Institutes of Health, USA
Short Talk: Patient-Specific 3D Bioprinted Eye Tissue to Understand and Treat Macular Degeneration

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Alpine Ballroom
13:00—22:00
Poster Viewing

Alpine Ballroom
14:30—16:30
Workshop 1

Grand Sierra Ballroom A-B
* Hongjun Song, University of Pennsylvania, USA

Narae Park, Catholic University of Korea, South Korea
Autoimmune Disease Modeling in vitro with Combination of iPSC-Derived Cardiomyocytes and Disease-Active Serum

Ellis Kim, University of Chicago, USA
iPSC-Derived Cardiomyocytes Highlight the Differences between Myotonic Dystrophy Subtypes

Masayuki Yazawa, Columbia University, USA
Human iPSC-Based Screen for FDA Drug Repurposing to Rescue Severe Cardiac Arrhythmia

Yibing Qyang, Yale University, USA
Human Tissue-Engineered Blood Vessels Derived from Induced Pluripotent Stem Cells

Ksenia Blinova, Food and Drug Administration, USA
Human iPSC-Derived Myocytes for Preclinical Assessment of Drug-Induced Cardiac Toxicities

Alma Forsman, Biomedicine at Gothenburg University, Sweden
Cartilage Mimics Generation by 3D Bioprinting of Induced Pluripotent Stem Cells in a Modified Bioink

Ilyas Singec, National Institutes of Health, USA
GMP-Compatible Robotic Cell Expansion, Combinatorial Small Molecule Screening, and Directed Differentiation of Human iPS Cells into Multiple Cells

16:30—17:00
Coffee Available

Sierra Prefunction
17:00—19:00
Gene Editing of Stem Cells
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Fred (Rusty) H. Gage, The Salk Institute for Biological Studies, USA

Ruwanthi N. Gunawardane, Allen Institute for Cell Science, USA
Systematic Gene Tagging with CRISPR/Cas9 to Illuminate Stem Cell Organization and Dynamics

Yadong Huang, Gladstone Institute of Neurological Disease, USA
Alzheimer's Disease Modeling and Drug Screening Using Gene-Edited Human iPSCs

Alysson R. Muotri, University of California, San Diego, USA
Applications of Brain-Model Technology

Kathleen Worringer, Novartis Institutes for BioMedical Research, USA
Short Talk: CRISPR Screening in Human Pluripotent Stem Cells and Neurons

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Cascades
19:30—22:00
Poster Session 2

Alpine Ballroom

WEDNESDAY, MARCH 28

07:00—08:00
Breakfast

Cascades
08:00—11:00
Organ Generation from iPSCs
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Ronald M. Evans, HHMI/The Salk Institute, USA

Juan Carlos Izpisua-Belmonte, The Salk Institute for Biological Studies, USA
In vitro and in vivo Approaches for Cell and Tissue Generation

Hiromitsu Nakauchi, Stanford University, USA
Interspecies Cell/Organogenesis: In vivo Generation of Functional Cells and Organs from iPS Cells

Coffee Break

Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
Cellular Reprogramming Approaches for Cardiovascular Disease

Peter Loskill, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Germany
Short Talk: Stem Cell-Based Microphysiological Organ-on-a-Chip Systems as in vitro Models of Human Tissue with Physiological Structure and Function

Vivian M. Lee, STEMCELL Technologies, Inc., Canada
Short Talk: The STEMdiffTM Cerebral Organoid Kit Generates Organoids that Recapitulate Early Brain Development

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Alpine Ballroom
13:00—22:00
Poster Viewing

Alpine Ballroom
14:30—16:30
Workshop 2

Grand Sierra Ballroom A-B
* Guo-li Ming, University of Pennsylvania, USA

Masashi Miyauchi, Graduate School of Medicine, University of Tokyo, Japan
Patient-Derived Induced Pluripotent Stem Cells Identify ADAM8 as an Antigen of TKI-Resistant Chronic Myeloid Leukemia Cells

David F. Fischer, Charles River, UK
Use of Pluripotent Stem Cells and Stem Cells-Derived Neurons in Support of Drug Discovery and Target Validation

Michela Deleidi, German Center for Neurodegenerative Diseases, Germany
Enhancing Mitochondrial Biogenesis via NAD+ Precursors Rescues Mitochondrial Function and Neurodegeneration in iPSC and Fly Models of Parkinson's Disease

Chunli Zhao, Stanford University, USA
Defining the Pathogenesis of Undiagnosed Diseases Using iPSC

Paul George, Stanford University, USA
Engineered Cerebral Cortex-like Conductive Scaffold Generates Functional Neurons

Zachary Pappalardo, Xcell Biosciences, USA
Application of Atmospheric Pressure and Hypoxia during Culture Promotes Neural Induction of iPSCs and Subsequent Differentiation into Adult Neurons

Taewan Kim, Memorial Sloan Kettering Cancer Center, USA
Derivation of Enriched Engraftable Midbrain Dopamine Neurons from hPSC in a cGMP-Qualified Condition

Karen Litwa, East Carolina University, USA
Cytoskeletal Regulation of Neurodevelopment in an hIPSC-Derived Autism Model

16:30—17:00
Coffee Available

Sierra Prefunction
17:00—19:00
Stem Cell Therapeutic Development
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA

Ronald M. Evans, HHMI/The Salk Institute, USA
Therapeutic Development for Diabetes Using Personalized Insulin-Producing Cells

Ole Isacson, Harvard Medical School/McLean Hospital, USA
Functional Connectivity from iPSC-Derived Dopamine Neurons and the Use of Primate Models of Parkinson’s Disease

Christine L. Mummery, Leiden University Medical Center, Netherlands
Cardiovascular Diseases and Drugs: Where Are We with hiPSC Models?

Stacey S. Gallegos, University of California, Los Angeles, USA
Short Talk: Glial-Enriched Progenitor Cells: A Novel Cell-Based Therapy for White Matter Stroke

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Cascades
19:30—22:00
Poster Session 3

Alpine Ballroom

THURSDAY, MARCH 29

07:00—08:00
Breakfast

Cascades
08:00—11:00
Clinical Applications of Stem Cells
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Joseph C. Wu, Stanford University School of Medicine, USA

Lorenz Studer, Memorial Sloan Kettering Cancer Center, USA
Clinical Applications of Pluripotent Stem Cells

Misao Fujita, Kyoto University, Japan
The Ethical, Social and Legal Aspects of iPSC Applications

Coffee Break

Keiko Muguruma, RIKEN, Japan
Construction of Brain Tissues from iPSCs for Investigation of Disease Mechanisms

Dominik Eckardt, Miltenyi Biotec GmbH, Germany
Short Talk: Fully Integrated, Closed System for Expansion and Differentiation of Pluripotent Stem Cells toward Clinically Relevant Cell Populations and Scales

Katja Gabriele Weinacht, Stanford School of Medicine, USA
Short Talk: Human iPSC-Derived Thymic Epithelial Progenitor Cells as Stem Cell-Based Therapy to Restore Thymic Function in Hematopoietic Stem Cell Transplant Recipients

11:00—17:00
On Own for Lunch

14:30—16:30
Workshop 3

Grand Sierra Ballroom A-B
* Yadong Huang, Gladstone Institute of Neurological Disease, USA

Osvaldo Antonio Miranda, California State University, Northridge, USA
Derivation and Characterization of Rett iPSC Cerebral Organoids

Wei Niu, University of Michigan, USA
Modeling Protocadherin-19 Female Limited Epilepsy in iPSC-Derived Neurons and Cerebral Organoids

Guoqiang Sun, City of Hope, USA
Studying Microcephaly Induced by Human Cytomegalovirus (hCMV) in a Human iPSC-Derived 3D Biosystem

Li Li, City of Hope, USA
Modeling Alexander Disease using Patient iPSC-Derived Astrocytes

Zhexing Wen, Emory University, USA
Modeling Zika Virus Exposure and Screening Therapeutic Compounds with Human iPSC-Derived Neural Cells

Beate Winner, Friedrich-Alexander University Erlangen-Nürnberg, Germany
Th17 Lymphocyte-Induced Neuronal Cell Death in Parkinson's Disease using an Autologous Human Stem Cell Based Model

Katharina Meyer, Harvard Medical School, USA
Neural Progenitor Cell Function in Alzheimer's Disease

William T. Hendriks, Massachusetts General Hospital, USA
Human iPSC-Based Disease Modeling Reveals a Retrotransposon with Repeat Expansion as the Causal Mechanism of X-Linked Dystonia Parkinsonism

16:30—17:00
Coffee Available

Sierra Prefunction
17:00—18:45
Manufacturing and Commercialization
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
* Lorenz Studer, Memorial Sloan Kettering Cancer Center, USA

Eugenia M. Jones, Cellular Dynamics International, USA
Human iPSC Creation and Biobanking

Joseph C. Wu, Stanford University School of Medicine, USA
Cardiac iPSCs for Precision Medicine and Clinical Trial in a Dish

Mahendra S. Rao, New York Stem Cell Foundation, USA
Consideration and Concerns in Manufacturing iPSC -Derived Products

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom A-B
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Alpine Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Alpine Ballroom

FRIDAY, MARCH 30

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

California Institute for Regenerative Medicine (CIRM) Cell Research

We gratefully acknowledge additional support from these exhibitors at this conference:

PeproTech, Inc. Xcell Biosciences
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge additional support for this conference from:

American Society of Gene & Cell Therapy (ASGCT) eLife
March of Dimes Foundation, Grant No. 4-FY18-826 STEMCELL Technologies, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Thermo Fisher Scientific Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676