Resort at Squaw Creek Floorplan

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This meeting took place in 2018



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Natural Products and Synthetic Biology: Parts and Pathways (J1)


Organizer(s) Jon Clardy, Yi Tang and Sean F. Brady
January 21—24, 2018
Resort at Squaw Creek • Olympic Valley, California USA
Discounted Abstract Deadline: Sep 25, 2017
Abstract Deadline: Oct 23, 2017
Scholarship Deadline: Sep 25, 2017
Discounted Registration Deadline: Nov 21, 2017

Sponsored by Merck & Co., Inc.

Summary of Meeting:
Natural products, the structurally diverse family of small molecules produced by living organisms in an idiosyncratic fashion, have provided the basis for the majority of our therapeutic agents used to treat infectious diseases, cancer and immune disorders. Whole genome sequencing of producing organisms, especially bacteria and fungi, reveals that we have discovered only a fraction of these biosynthetically derived small molecules; a substantial fraction of natural product chemical space still represents “dark matter” (i.e., molecules predicted by bioinformatics analysis that have yet to be observed experimentally). Diversity springs from variations in genetically encoded biosynthetic enzymes, environmental stimuli that regulate expression of these genes and the inherent combinatorial expansion resulting from multi-enzyme biosynthetic pathways. Closing this gap between our current inventory and the genomic potential has become an important goal for basic and applied science; synthetic biology coupled with bioinformatic analysis has become the primary research tool for this effort. Bioinformatic mining continues to reveal the enzymes and pathways that nature uses, and synthetic biology has begun to reassemble or refactor these pathways to produce known and unknown products in new hosts. This conference brings together researchers in fields ranging from microbiology to botany, bioinformatics, gene synthesis and assembly, covering the spectrum from basic to industrial applications.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 21 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, January 24 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Thursday, January 25 in order to fully experience the meeting.

SUNDAY, JANUARY 21

16:00—20:00
Arrival and Registration

Lobby Alcove
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Alpine Ballroom

MONDAY, JANUARY 22

07:00—08:00
Breakfast

Alpine Ballroom
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
* Jon Clardy, Harvard Medical School, USA

Chaitan Khosla, Stanford University, USA
Structure and Mechanism of Assembly Line Polyketide Synthases

09:00—11:30
Mining the Human Microbiome
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
* Mohamed S. Donia, Princeton University, USA

Michael A. Fischbach, Stanford University, USA
Small Molecules from the Human Microbiota

Coffee Break

Emily P. Balskus, Harvard University, USA
Deciphering the Human Microbiota with Chemistry

Jason M. Crawford, Yale University, USA
Harnessing Cellular Stress for Metabolite Discovery in Bacterial Pathogens

David Zeevi, Rockefeller University, USA
Short Talk: Towards Mining the Gut Microbiome for Therapeutic Targets

Yuki Sugimoto, Princeton University, USA
Short Talk: Discovery of Drug-Like Molecules from the Human Microbiome

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Alpine Ballroom
13:00—22:00
Poster Viewing

Alpine Ballroom
16:30—17:00
Coffee Available

Alpine Prefunction
17:00—19:00
Mining Environmental Genomes
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
* Jason M. Crawford, Yale University, USA

Jon Clardy, Harvard Medical School, USA
Unknown Unknowns

Tadhg Begley, Texas A&M, USA
Mechanistic Studies on the Futalosine-Dependent Menaquinone Biosynthetic Pathway

Bradley Moore, University of California, San Diego, USA
Biosynthesis in Toxic Marine Microalgae

Jeremy George Owen, Victoria University of Wellington, New Zealand
Short Talk: The Natural Products of Mycale hentscheli Bacterial Symbionts

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Alpine Ballroom
19:30—22:00
Poster Session 1

Alpine Ballroom

TUESDAY, JANUARY 23

07:00—08:00
Breakfast

Alpine Ballroom
08:00—11:15
Fungal and Plant I
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
* Anne E. Osbourn, John Innes Centre, UK

Sarah O’Connor, John Innes Centre, UK
Biocatalysts from Alkaloid Producing Plants

Elizabeth Sattely, Stanford University, USA
Discovery and Engineering of Plant Chemistry for Plant and Human Health

Coffee Break

Reshma Shetty, Ginkgo Bioworks, Inc., USA
The Emerging Organism Engineering Industry

Jaclyn Winter, University of Utah, USA
Developing Heterologous Expression Platforms for Elucidating Fungal Natural Product Biosynthesis

Sagar Changdev Gore, Leibniz Institute for Natural Product Research and Infection Biology, Germany
Short Talk: Phylogenetic and Binding Pocket Analysis of Fungal Adenylation Domains

Roland D. Kersten, Massachusetts Institute of Technology, USA
Short Talk: Genome Mining of Plant Ribosomal Peptides

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Alpine Ballroom
13:00—22:00
Poster Viewing

Alpine Ballroom
16:30—17:00
Coffee Available

Alpine Prefunction
17:00—19:15
Fungal and Plant II
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
* Jaclyn Winter, University of Utah, USA

Yi Tang, University of California, Los Angeles, USA
Bioactive Natural Product Discovery Using the Self-Resistance Gene as a Lead

Adam L. Meadows, Amyris, Inc, USA
Next-Generation Platforms for Strain Optimization: Reducing the Cost and Time for Commercializing Natural Products

Axel A. Brakhage, Friedrich Schiller University, Germany
Activation of Natural Product Gene Clusters by Microbial Communication and Synthetic Biology

Brandon Pfannenstiel, University of Wisconsin-Madison, USA
"Reading" the Histone Code of Secondary Metabolism

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Alpine Ballroom
19:30—22:00
Poster Session 2

Alpine Ballroom

WEDNESDAY, JANUARY 24

07:00—08:00
Breakfast

Alpine Ballroom
08:00—11:00
Plant and Other Pathways
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
* Elizabeth Sattely, Stanford University, USA

Christina D. Smolke, Stanford University, USA
A Microbial Biomanufacturing Platform for Natural and Semisynthetic Opioids

Anne E. Osbourn, John Innes Centre, UK
Plant Metabolic Clusters – From Genetics to Genomics

Coffee Break

Francis Stewart, Technische Universitaet Dresden, Germany
Direct Cloning and Recombineering of Biosynthetic Gene Clusters

Sibongile Mafu, University of Massachusetts, USA
Short Talk: Discovery of Plant Based Natural Phytochemicals through Elicitation of Calli Cultures

Radin Sadre, Michigan State University, USA
Short Talk: Boosting Terpenoid and Oil Production in Photosynthetic Tissues of Plants

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Alpine Prefunction
17:00—18:45
Microbial Pathways
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
* Tadhg Begley, Texas A&M, USA

Sean F. Brady, Rockefeller University, USA
Culture-Independent Discovery of Natural Products from Soil Metagenomes

Christopher Voigt, Massachusetts Institute of Technology, USA
High-Throughput Mining of Natural Products

Alessandra S. Eustaquio, University of Illinois, USA
Bacterial Genome Mining and Biosynthetic Engineering for Natural Product Drug Discovery and Development

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grand Sierra Ballroom C-D
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Alpine Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Alpine Ballroom

THURSDAY, JANUARY 25

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Merck & Co., Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health
National Center for Complementary and Integrative Health (NCCIH)

Grant No. 1 R13 AT009821-01

Funding for this conference was made possible (in part) by 1 R13 AT009821-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

eLife

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676