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This meeting took place in 2018



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Role of the Genital Tract Microbiome in Sexual and Reproductive Health (S6)


Organizer(s) Janneke van de Wijgert, Jeanne Marrazzo, Douglas Kwon and Jo-Ann Passmore
December 11—15, 2018
Southern Sun Cape Sun • Cape Town, Western Cape South Africa
Discounted Abstract Deadline: Aug 28, 2018
Abstract Deadline: Sep 12, 2018
Scholarship Deadline: Aug 28, 2018
Discounted Registration Deadline: Oct 11, 2018

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation

Summary of Meeting:
Bacteria and fungi residing in the female genital tract have been associated with elevated risks of HIV acquisition and transmission, pelvic inflammatory disease, miscarriage, preterm birth, and invasive maternal and neonatal infections. The increased availability of high-throughput genomic testing since the turn of the century has revealed a more detailed picture of these organisms than was possible when evaluation depended on microscopy and culture. The interrelationships between sexually transmitted infections, vaginal dysbiosis, vulvovaginal candidiasis, and vaginal pathobiont carriage are being elucidated, and their effects on the cervicovaginal mucosal barrier and immune system are being characterized. The mechanisms that may lead to adverse outcomes are being unraveled, and an increasing number of interventions are in clinical trials. In this meeting, the current understanding of female and male genital tract microbiology and immunology, including functional microbiology and biofilms, will be presented and knowledge gaps identified. Potential mechanisms leading to adverse outcomes, and a variety of potential prevention and/or treatment interventions, will be presented and discussed. The exponential progress made in recent years will hopefully lead to efficacious public health interventions to reduce the high prevalence of adverse sexual and reproductive health outcomes in women, especially in resource-poor settings.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Tuesday, December 11 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, December 15 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Sunday, December 16 in order to fully experience the meeting.

TUESDAY, DECEMBER 11

16:00—20:00
Arrival and Registration

3rd Floor Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

3rd Floor Lobby

WEDNESDAY, DECEMBER 12

08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

VOC North
* Janneke van de Wijgert, University of Liverpool and University Medical Center Utrecht, UK

* Jo-Ann S. Passmore, University of Cape Town, South Africa

* Douglas S. Kwon, Harvard Medical School, USA

Jeanne M. Marrazzo, University of Alabama at Birmingham, USA
Setting the Stage: An Overview of Advances and Controversies in Vaginal Microbiome Research

09:30—12:15
Vaginal Microbiology
Meeting has ended...abstracts no longer viewable online.

VOC North
* Janneke van de Wijgert, University of Liverpool and University Medical Center Utrecht, UK

* Jo-Ann S. Passmore, University of Cape Town, South Africa

Jacques Ravel, University of Maryland School of Medicine, USA
Progress Toward an In-Depth Understanding of the Vaginal Microbiome

Coffee Break

David Fredricks, Fred Hutchinson Cancer Research Center, USA
The Vaginal Microbiota and Bacterial Vaginosis

Mariya I. Petrova, KU Leuven, Belgium
Role of Lactobacillus Iners in the Vaginal Microbiota

Rosanne Y. Hertzberger, VU University Amsterdam, Netherlands
Short Talk: Lactobacillus crispatus Growth on Glycogen Is Dependent on its Type 1 Pullulanase Gene Variant

Michael France, University of Maryland Baltimore, USA
Short Talk: Identifying Factors that Influence the Temporal Stability of the Vaginal Microbiome

Matthew R. Hayward, Ragon Institute, USA
Short Talk: Cervicovaginal Microbial Strains Are Associated with Distinct Immunophenotypes

12:15—17:00
On Own for Lunch

12:15—13:00
Poster Setup

VOC South
13:00—22:00
Poster Viewing

VOC South
16:30—17:00
Coffee Available

3rd Floor Lobby
17:00—19:00
Genital Tract Microbiology and Metabolomics
Meeting has ended...abstracts no longer viewable online.

VOC North
* Sharon Hillier, University of Pittsburgh School of Medicine, USA

* Tania Crucitti, Centre Pasteur du Cameroun, Cameroon

Caroline M. Mitchell, Massachusetts General Hospital, USA
Microbiota of the Female Upper Genital Tract

Jessica L. Prodger, Western University, Canada
Male Genital Tract Microbiota: Insights into HIV Acquisition

Sujatha Srinivasan, Fred Hutchinson Cancer Research Center, USA
Metabolic Signatures of Bacterial Vaginosis

Praveen Thumbikat, Northwestern University, USA
Short Talk: Ubiquitous Gram-Positive Bacteria in the Male Urogenital Tract Are Disease-Causing Agents in Chronic Pelvic Pain

Gilda Tachedjian, Burnet Institute, Australia
Short Talk: Immune Modulatory Effects of Vaginal Microbiota Organic Acid Metabolites on Lower Female Reproductive Tract Epithelial Cells

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

3rd Floor Lobby
19:30—22:00
Poster Session 1

VOC South

THURSDAY, DECEMBER 13

08:30—11:45
Genital Tract Immunology
Meeting has ended...abstracts no longer viewable online.

VOC North
* Douglas S. Kwon, Harvard Medical School, USA

* Zenda Woodman, University of Cape Town, South Africa

Jo-Ann S. Passmore, University of Cape Town, South Africa
Interplay between Genital Immunity and Microbiota, Relevant to HIV Risk

Jordan K. Kyongo, LVCT Health, Kenya
Associations between Vaginal Microbiota and Immune Mediators in the Vaginal Biomarkers Study in Kenya, South Africa and Rwanda

Coffee Break

Rupert Kaul, University of Toronto, Canada
Impact of the Genital Microbiota and Microbiome-Focused Clinical Interventions on Mucosal Immunology and HIV Susceptibility

Nollaig M. Bourke, Trinity College Dublin, Ireland
The Role of IFN-ε in the Immune Homeostasis of the Female Genital Tract

Ryan Cheu, University of Miami, USA
Short Talk: The Impact of Vaginal Microbial Communities on Immune Cells Essential for Pathogen Protection and Epithelial Integrity

Heleen Schuster, Amsterdam University Medical Center, Netherlands
Short Talk: Exploring Microbe-Immune Crosstalk: Immunoglobulin Coating of Vaginal Microbiota.

Seth M. Bloom, Massachusetts General Hospital, USA
Short Talk: Modulation of Genital Tract CD4+ T Cell Subsets by Cervicovaginal Bacteria

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

VOC South
13:00—22:00
Poster Viewing

VOC South
16:30—17:00
Coffee Available

3rd Floor Lobby
17:00—19:00
Genital Tract Mucosal Defenses and Biofilms
Meeting has ended...abstracts no longer viewable online.

VOC North
* Lindi Masson, University of Cape Town Medical School, South Africa

* Thomas J. Hope, Northwestern University, USA

Melissa M. Herbst-Kralovetz, University of Arizona, USA
Human in vitro Systems to Study Genital Tract Mucosal Defenses

Hans Verstraelen, Ghent University, Belgium
Study of In Vivo Biofilms of the Female Genital Tract

Tania Crucitti, Centre Pasteur du Cameroun, Cameroon
Vaginal Microbiota and Biofilms in a Clinical Trial of the NuvaRing® in Rwanda

Rémy Froissart, Centre National de la Recherche Scientifique, France
Short Talk: Antibiotic Resistance Versus Biofilm Production in Gardnerella vaginalis

Laura K. Sycuro, University of Calgary, Canada
Short Talk: Morphotypic Variation of Vaginal Clue Cells Broadens Understanding of Vaginal Biofilms

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

3rd Floor Lobby
19:30—22:00
Poster Session 2

VOC South

FRIDAY, DECEMBER 14

08:30—11:45
Genital Tract Microbiota Associations with HIV/STIs
Meeting has ended...abstracts no longer viewable online.

VOC North
* Pamela Phumelele Gumbi, University of KwaZulu-Natal, South Africa

* Jorgen Skov Jensen, Statens Serum Institut, Denmark

Douglas S. Kwon, Harvard Medical School, USA
Genital Tract Microbiota Associations with HIV, Including Potential Mechanisms

Lindi Masson, University of Cape Town Medical School, South Africa
Metaproteomics Approaches to Understand Mucosal Inflammation and Target Cell Activation Associated with HIV Acquisition in African Women

Coffee Break

Nichole R. Klatt, University of Miami, USA
The Role of Vaginal Microbiota in Antiretroviral Drug Pharmacokinetics

Thomas J. Hope, Northwestern University, USA
Using Imaging Approaches to Gain Mechanistic Insights into HIV Transmission and Prevention

Rebecca M. Brotman, University of Maryland School of Medicine, USA
Short Talk: The Vaginal Microenvironment Prior to Incident STI

Lynette Denny, University of Cape Town, South Africa
Short Talk: Distinct Cervical Microbial Diversity and Community Structures by Human Papilloma Virus and Cervical Disease Status in HIV-Positive Women in South Africa

Erica L. Plummer, Melbourne Sexual Health Centre/ Central Clinical School, Monash University, Australia
Short Talk: Sexual Behaviors Impact the Vaginal Microbiota of Women Who Have Sex with Women

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

VOC South
13:00—22:00
Poster Viewing

VOC South
16:30—17:00
Coffee Available

3rd Floor Lobby
17:00—19:00
Genital Tract Microbiota Associations with Pregnancy and Neonatal Complications
Meeting has ended...abstracts no longer viewable online.

VOC North
* Hans Verstraelen, Ghent University, Belgium

* Caroline M. Mitchell, Massachusetts General Hospital, USA

Gregory A. Buck, Virginia Commonwealth University, USA
The Microbiome of the Female Reproductive Tract and Pregnancy

David MacIntyre, Imperial College London, UK
The Relationship between Vaginal Microbiota Composition and Poor Pregnancy Outcomes

David M. Aronoff, Vanderbilt University, USA
Leveraging New Tissue Models to Explore Host-Microbial Interactions in Chorioamnionitis

Muchaneta Mugabe, University of Cape Town, South Africa
Short Talk: Vaginal Microbiome and Birth Weight in a Zimbabwean Cohort

Anna Sandager Hansen, Aarhus University Hospital, Denmark
Short Talk: Subclinical Vaginal Infections and Adverse Pregnancy Outcome

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

3rd Floor Lobby
19:30—22:00
Poster Session 3

VOC South

SATURDAY, DECEMBER 15

08:30—11:45
Vaginal Dysbiosis Prevention and Treatment Interventions I
Meeting has ended...abstracts no longer viewable online.

VOC North
* Jeanne M. Marrazzo, University of Alabama at Birmingham, USA

* Lenka A. Vodstrcil, Monash University, Australia

Jennifer E. Balkus, University of Washington, USA
Overview of Antibiotic and Antifungal Interventions

Janneke van de Wijgert, University of Liverpool and University Medical Center Utrecht, UK
Vaginal Probiotics: Results of a Randomized Pilot Trial and Systematic Review

Coffee Break

Craig R. Cohen, UCSF, USA
Update on Live Biotherapeutic Trials to Prevent Vaginal Dysbiosis and HIV

Catriona S. Bradshaw, Monash University, Australia
Partner Treatment Studies

Florencia A.T. Boshier, Fred Hutchinson Cancer Research Center, USA
Short Talk: Complementing 16S rRNA Gene Amplicon Sequencing with Estimates of Total Bacterial Load Can Infer Absolute Bacterial Species Concentrations as Measured by Targeted Assays in the Vaginal Microbiome

Jeanne Tamarelle, Université Versailles-Saint-Quentin-en-Yvelines, France
Short Talk: Long-Lasting Impact of Antibiotic Treatment for Chlamydia trachomatis on the Vaginal Microbiome in Young Women

Kelly Li, Thermo Fisher Scientific Inc., USA
Short Talk: Developing A Large Collection of Vaginal Microbiota Assays Using TaqManTM Chemistry on High-Throughput Nano-Microfluidic OpenArrayTM

11:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

3rd Floor Lobby
17:00—18:45
Vaginal Dysbiosis Prevention and Treatment Interventions II
Meeting has ended...abstracts no longer viewable online.

VOC North
* Jo-Ann S. Passmore, University of Cape Town, South Africa

* Jennifer E. Balkus, University of Washington, USA

Sharon Hillier, University of Pittsburgh School of Medicine, USA
Effect of Sex Hormones on the Vaginal Microbiota and Multipurpose Prevention Technologies

Lenka A. Vodstrcil, Monash University, Australia
The Oral Contraceptive Pill Favorably Influences the Vaginal Microbiota but Sexual Activity Drives BV Recurrence

Adam J. Ratner, New York University School of Medicine, USA
Targeting Perinatal Pathogens in the Vaginal Microbiome

Gregor Reid, Lawson Health Research Institute, Canada
Short Talk: Probiotic Fermented Food for Africa

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions
Meeting has ended...abstracts no longer viewable online.

VOC North
* Janneke van de Wijgert, University of Liverpool and University Medical Center Utrecht, UK

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

3rd Floor Lobby
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

VOC South

SUNDAY, DECEMBER 16

 
Departure


*Session Chair †Invited, not yet responded.



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