Fairmont Hotel Vancouver Floorplan

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This meeting took place in 2019



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Immunometabolism, Metaflammation and Metabolic Disorders (D6)


Organizer(s) Gökhan S. Hotamisligil, Ruslan M. Medzhitov and Karine Clément
April 14—18, 2019
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Discounted Abstract Deadline: Dec 18, 2018
Abstract Deadline: Jan 15, 2019
Scholarship Deadline: Dec 18, 2018
Discounted Registration Deadline: Feb 12, 2019

Supported by the Directors' Fund

Summary of Meeting:
Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlie the emergence of many pathologies, particularly chronic non-communicable diseases such as obesity and diabetes. Understanding the complex immunometabolic signaling networks and the cellular and molecular events that occur in the setting of altered nutrient and energy exposures has the potential to lead to tangible therapeutic advancements to promote health. This conference will engage scientists at the forefront of the efforts to translate this biology into clinical approaches, to discuss the successes and limitations of this work so far. This conference will cover the molecular mechanisms and physiological outcomes of immunometabolic interactions in the context of chronic metabolic diseases. Topics will range from the most evolutionarily conserved interactions studied in model organisms to human studies. There will be two sessions devoted to translational paths, covering both opportunities and challenges. Overall, this symposium will be an opportunity for experts in the fields of immunology and metabolism to come together to discuss and share their diverse perspectives on the integration of metabolism and immunity.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, April 14 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 18 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, April 19 in order to fully experience the meeting.

SUNDAY, APRIL 14

16:00—20:00
Arrival and Registration

British/Columbia Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

British/Columbia Foyer

MONDAY, APRIL 15

07:30—08:30
Breakfast

Pacific Ballroom
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Gökhan S. Hotamisligil, Harvard School of Public Health, USA

Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
C. elegans Surveillance of Conserved Cellular Components to Detect and Defend Pathogen Attacks, Real or Imagined

09:30—12:00
Immunometabolic Framework in Model Organisms
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
Laura Palanker Musselman, Binghamton University, USA
Increased Infection Susceptibility in Drosophila Insulin Resistance

Coffee Break

Heinrich Jasper, Genentech, Inc. & Buck Institute for Research on Aging, USA
Control of Metabolic and Immune Homeostasis by MANF

Antje Körner, University Children's Hospital Leipzig, Germany
Exploring Factors for Adipocyte Development and Adaptation in Human and Zebrafish

Bruno Guigas, Leiden University Medical Center, Netherlands
Short Talk: Phenotypically Distinct Alternatively-Activated Adipose Tissue Macrophages Induced by Helminth Molecules Differently Impact Metabolic Homeostasis

* Sally A. Clayton, University of Birmingham, UK
Short Talk: Electron Transport Chain Protein NDUFA4 is Regulated by Inflammatory Stimuli in Macrophages

12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
14:30—16:30
Workshop: Immunometabolic Regulators

British/Columbia Ballroom
* Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA

Duale A. Ahmed, Carleton University, Canada
Differential Modulation of Complex III Expression in Poly(I:C)-stimulated Macrophages Amplifies Interferon Signaling and Responses

Elizabeth Floyd, Pennington Biomedical Research Center, USA
Siah2 Contributes to Sex-Specific Remodeling of Metabolic and Inflammatory Signaling in Adipose Tissue

Anetta Svitorka Härtlova, University of Gothenburg, Sweden
MSR1 Triggers JNK-Mediated Lipid-Induced Inflammation and Promotes Obesity-Related Non-Alcoholic Liver Disease

Bastiaan Werner Lennert Maes, Ghent University VIB, Belgium
TAOK3 Modulates the Presence of T1ST2 T Regulatory Cells in Murine Obesity

Atsuko Nakatsuka, Okayama University Graduate School of Medicine, Japan
Vaspin Regulates Lysosome Function and Protects from Tubulopathy in Metabolic Syndrome

Christoph Wilhelm, University of Bonn, Germany
Lipid Droplet Formation Fuels Pathogenic ILC2 Responses in Airway Inflammation

Andreas Bergthaler, Austrian Academy of Sciences, Austria
CD8 T Cells Induce Cachexia in Chronic Viral Infection

16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—19:00
Components of Immunometabolic Interactions
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
Anna Mae Diehl, Duke University, USA
Immune Regulation of Liver Function and Response to Injury

Ajay Chawla, University of California, San Francisco, USA
Tissue Resident Macrophages in Metabolic Disease

Michael P. Czech, University of Massachusetts Medical School, USA
Immune Interactions that Drive Adipocyte Form and Function

Julie E. Gibbs, University of Manchester, UK
Short Talk: How Chronic Inflammatory Disease Affects Temporal Dynamics of the Gut Microbiome

* Agnieszka M. Kabat, Max Planck Institute of Immunobiology and Epigenetics, Germany
Short Talk: Adaptive Type 2 Responses in Mucosa-Associated Adipose Tissue

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
19:30—22:00
Poster Session 1

Pacific Ballroom

TUESDAY, APRIL 16

07:30—08:30
Breakfast

Pacific Ballroom
08:30—11:45
Immunometabolic Positioning of Innate versus Adaptive Immune Cells
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
Agnès C. Lehuen, Institut Cochin, France
MAIT Cells at the Crossroad of Microbiota, Inflammation and Diabetes

Barbara S. Nikolajczyk, University of Kentucky College of Medicine, USA
Mitochondrial Changes Synergize with Long Chain Fatty Acid Derivatives to Support Th17 Inflammation in Diabetes

Coffee Break

Diane Mathis, Harvard Medical School, USA
Adipose Tissue T-Regulatory Cells

Alexander Bartelt, Ludwig-Maximilians-University, Germany
Nfe2l1-Mediated Proteasomal Activity Secures ER Function in Adipocytes and Protects from Insulin Resistance in Mice and Humans

Elodie Picarda, Albert Einstein College of Medicine, USA
Short Talk: The Immune Checkpoint B7-H3 (CD276) Protects against Obesity

* Lin Wu, Skirball Institute, NYU School of Medicine, USA
Short Talk: Selective Redundancy in Metabolism Network Allows Specific in vivo Inhibition of Inflammatory but Not Homeostatic Th17 Cells

Julian Mervyn Yabut, McMaster University, Canada
Short Talk: Inhibition of Mast Cell Serotonin Synthesis Reduces Obesity and Insulin Resistance by Potentiation of White Adipose Tissue Browning in Mice

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—19:00
Signaling Networks Regulating Immunometabolic Responses
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Interfacing Immune Response and Metabolism

Roger J. Davis, HHMI/University of Massachusetts Medical School, USA
Stress Signaling Pathways in Immunometabolism

Vishwa Deep Dixit, Yale University, USA
Aging and the Metabolic Inflammasome

* Maria Luisa Balmer, University Basel, Switzerland
Short Talk: Accumulation of Acetate at Sites of Infection Improves Pathogen Clearance and Protects from Immunopathology by Re-Programming Memory CD8+ T Cells

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
19:30—22:00
Poster Session 2

Pacific Ballroom

WEDNESDAY, APRIL 17

07:30—08:30
Breakfast

Pacific Ballroom
08:30—11:45
Organelle Dynamics and Function in Immunometabolism
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
Gökhan S. Hotamisligil, Harvard School of Public Health, USA
Immunometabolic Components of Age- and Obesity-Associated Pathologies

Gerald S. Shadel, The Salk Institute for Biological Studies, USA
Adaptive Responses to Mitochondrial Stress

Coffee Break

Shawn C. Burgess, University of Texas Southwestern Medical Center, USA
Mitochondrial Metabolism in Fatty Liver Disease

Ling Yang, University of Iowa, USA
Lysosomal Nitric Oxide Bioactivity Contributes to Obesity-Associated Insulin Resistance

Aparajita Madhavan, The Scripps Research Institute, USA
Short Talk:Pharmacologic targeting of IRE1 Signaling to Alleviate Metabolic Dysfunction

Feyza Engin, University of Wisconsin-Madison, USA
Short Talk: Beta Cell IRE1α Deficiency Protects Mice Against Type 1 Diabetes

* Guang Gao, University of British Columbia, Canada
Short Talk: STED Super-Resolution Microscopy Reveals Reticulon and CLIMP-63 Dependent Peripheral ER Tubule Nanodomain Organization

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—19:15
Nutrients and Metabolites Critical for Immunometabolic Responses
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Immunometabolic Regulation by Novel Lipid Species

Christopher K. Glass, University of California, San Diego, USA
Roles of Tissue Environment in Shaping Macrophage Identities

Tony K.T. Lam, Toronto General Research Institute, Canada
Nutrient Sensing in the Gut

Benan Pelin Sermikli, Institute of Pasteur Lille, France
Short Talk: Role of Myeloid-Expressed RORα in Metabolic Diseases

* Jaswinder K. Sethi, University of Southamptom, UK
Short Talk: Inflammation-Linked Adaptations in Dermal Microvascular Reactivity Accompany the Development of Obesity and Type 2 Diabetes

Martin Valdearcos, University of California, San Francisco, USA
Short Talk: Microglia Mediate Neonatal Weight Gain and Early-Life Programming of Adult Glucose Control

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
19:30—22:00
Poster Session 3

Pacific Ballroom

THURSDAY, APRIL 18

07:30—08:30
Breakfast

Pacific Ballroom
08:30—11:30
Translation of Immunometabolism
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
Marc Y. Donath, University Hospital Basel, Switzerland
Targeting Inflammation in Metabolic Disease

Armelle Yart, INSERM, France
Study on Rare Disease Uncovers New Determinants of Inflammation-Dependent Insulin Resistance

Coffee Break

Elif A. Oral, University of Michigan, USA
Crosstalk Between Metabolic and Immune Signals at the Sites of Energy Storage: Translational Lessons

Lale Ozcan, Columbia University, USA
Short Talk: Regulation of LDL-Cholesterol by Glucagon-Mediated Lysosomal Degradation of PCSK9

* Kacey J. Prentice, Harvard University, USA
Short Talk: Targeting Circulating FABP4 Prevents Type 1 Diabetes by Promoting β Cell Function and Survival

Emma Borgeson, University of Gothenburg, Sweden
Short Talk: Therapeutic Potential of Pro-Resolving Lipids in Human Cardiometabolic Disease

11:30—17:00
On Own for Lunch

16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—18:45
Immunometabolic Links in Human Studies
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
* Karine Clément, INSERM/Sorbonne Universite, France
The Role of Microbiota in Human Metabolic Disease

Gerald I. Shulman, Yale University School of Medicine, USA
Linking White Adipocyte Inflammation to Alterations in Hepatic Mitochondrial Metabolism and Type 2 Diabetes

Evan D. Rosen, Harvard University, USA
Multifunctional Roles of Interferon Regulatory Factors (IRFs) in Metabolism

Esperanza Perucha, King's College London, UK
Short Talk: The Cholesterol Biosynthesis Pathway Regulates IL-10 Expression in Human CD4+ T Cells

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

British/Columbia Ballroom
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Pacific Ballroom

FRIDAY, APRIL 19

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support from these exhibitors at this conference:

MilliporeSigma
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK121500-01




We gratefully acknowledge additional support for this conference from:

GeneTex, Inc. InSphero Inc.
Sabri Ülker Foundation
 

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

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Phone:+1 970-262-1179