Fairmont Banff Springs Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

Epigenetics and Human Disease (X5)

joint with the meeting on 3D Genome: Gene Regulation and Disease (X6)

Scientific Organizers: Cheryl H. Arrowsmith, Anne Schaefer and Mark A. Dawson


March 17—21, 2019

Fairmont Banff Springs, Banff, Alberta, Canada


Sponsored by Cell Research, Incyte Corporation, Novartis Institutes for BioMedical Research and Pfizer Inc.


Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.
BEWARE of booking lodging through companies unaffiliated with Keystone Symposia. Click here for more details.

Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.

Registered attendees of one meeting in a joint pair may participate in sessions of the other, pending space availability.

DEADLINES:
*All deadlines end at 11:59 PM US Mountain Standard Time
Scholarship Deadline: Nov 29, 2018 [details]
Discounted Abstract Deadline: Nov 29, 2018 [details]
Abstract Deadline: Dec 12, 2018 [details]
Discounted Registration Deadline: Jan 22, 2019 [details]

If you have missed a deadline due to the US government shutdown, please contact our office.

Click here to view Cancellation Policy

Register Yourself Deadlines and Fees

Rates and Deadlines listed below are for the 2019-X5 "Epigenetics and Human Disease" conference only.

*All deadlines end at 11:59 PM US Mountain Standard Time

Deadline Date Cost
Discounted Abstract Deadline
More details
Before and On November 29, 2018 100.00 USD*
- 50.00 USD discount
Abstract Deadline
More details
After November 29, 2018 until February 3, 2019 100.00 USD*
* 50.00 USD of Abstract fee deducted from your registration fee when you register for this meeting
Scholarship
More details
November 29, 2018 n/a
Discounted NON-STUDENT Registration
More details
Before and On January 22, 2019 945.00 USD
(includes 200.00 discount)
Regular NON-STUDENT Registration
More details
After January 22, 2019 1145.00 USD
Discounted STUDENT Registration
More details
Before and On January 22, 2019 720.00 USD
(includes 200.00 discount)
Regular STUDENT Registration
More details
After January 22, 2019 920.00 USD

* Changes in payment type that result in a refund are subject to a processing fee.
* Currency exchange gains/losses are the responsibility of the registrant and the Keystone Symposia will accept no liability for money loss through bank charges, transfers or currency fluctuations.




Discounted Abstract Deadline: November 29, 2018

*All deadlines end at 11:59 PM US Mountain Standard Time

Abstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register

Abstract Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadlines. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract early allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • accept your abstract online
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
(The Abstract Deadline: is December 12, 2018)

Global Health Travel Award Deadline:

*All deadlines end at 11:59 PM US Mountain Standard Time


Global Health Travel Award Details: You MUST complete your Global Health Travel Award appplication by the Global Health Travel Award Deadline and complete the other required steps (verify your contact information and submit a recommendation letter) to be considered for a travel award.


Click here to learn more about Global Health Travel Awards.

Scholarship Deadline: November 29, 2018

*All deadlines end at 11:59 PM US Mountain Standard Time


Scholarship Details: You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.

Click here to learn more about Scholarships.

Abstract Deadline: December 12, 2018

*All deadlines end at 11:59 PM US Mountain Standard Time


Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register

Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract by the Abstract Deadline allows us to:

  • submit your abstract to organizers to be considered for a short talk
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.

(Discounted Abstract Deadline: is November 29, 2018)

Discounted Registration Deadline: January 22, 2019

*All deadlines end at 11:59 PM US Mountain Standard Time


Registration Fee: 945.00 USD* (includes 200.00 USD discount)
Student Registration Fee: 720.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

After the Discounted Registration Deadline:


Registration Fee: 1145.00 USD*
Student Registration Fee: 920.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

Registration spaces are limited and may fill prior to discounted registration deadline.

Please be advised that some meeting participants have received calls and emails from a number of different housing services, including "Exhibitors Housing Services," “Expo Housing Services,” "Global Housing," etc. THESE COMPANIES ARE NOT AFFILIATED WITH KEYSTONE SYMPOSIA and are not authorized by Keystone Symposia to contact you. These companies may tell you that the meeting is filling, without any actual knowledge to that effect, and pressure you into giving them your credit card number to make a lodging reservation with them.

We highly recommend that you not make a reservation with these companies or any other housing service! These companies' representations to participants have been misleading. Please report any calls or correspondence you might have received to Keystone Symposia and book only through lodging links in your Keystone Symposia account, an established travel agency or directly with the hotel(s) listed on our website.
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 17 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 21 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 22 in order to fully experience the meeting.

SUNDAY, MARCH 17

16:00—20:00
Arrival and Registration

Van Horne Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Van Horne Foyer

MONDAY, MARCH 18

07:00—08:00
Breakfast

Mezzanine 2
08:00—09:30
Welcome and Keynote Session (Joint)
Registered attendees can view abstracts starting on 02/17/2019

Van Horne A/B
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Transcriptional Regulation, Epigenetics and Disease

Wendy A. Bickmore, University of Edinburgh, UK
Spatial Organisation of the Human Genome in Disease and Senescence

Coffee Break

09:50—12:00
3D Epigenome/Epigenetics and Disease (Joint)
Registered attendees can view abstracts starting on 02/17/2019

Van Horne A/B
Matthias Merkenschlager, Imperial College London, UK
Quantitative Approaches to Cohesin-Dependent Regulation of Transcription

Mathieu Lupien, University Health Network, Canada
Epigenetics Variants in Cancer

Joanna Wysocka, Stanford University School of Medicine, USA
Epigenetic Regulation of Craniofacial Development

John Alan Wildenthal, NCI, National Institutes of Health, USA
Short Talk: Elucidating Enhancers Governing Human Pancreas Cell Identity and Function

Yin Shen, University of California, San Francisco, USA
Short Talk: Charting Cell-Specific 3D Epigenomes During Corticogenesis to Understand Human Brain Development and Complex Disorders

Evgeny Kvon, Lawrence Berkeley National Laboratory, USA
Short Talk: Saturation Mutagenesis Reveals Functional Impact of Enhancer Mutations In Vivo

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
14:30—16:30
Workshop 1: Epigenetic Memory and Inheritance in Health and Disease

Van Horne A/B
* Johnathan R. Whetstine, Fox Chase Cancer Center, USA
Epigenetics: A Gatekeeper to DNA Amplification and Drug Response

Berkley Eric Gryder, NCI, National Institutes of Health, USA
Chemical Disruption of Core Regulatory Architecture in Rhabdomyosarcoma

Navneet Matharu, University of California, San Francisco, USA
CRISPRa Mediated Activation of Promoter or Enhancer Corrects Haploinsufficiency

Benjamin A. Nacev, Memorial Sloan Kettering Cancer Center, USA
Expanding the Landscape of 'Oncohistone' Mutations in Human Cancers

Kirsten C. Sadler, New York University Abu Dhabi, United Arab Emirates
Epigenetic Compensation Promotes Liver Regeneration

Lan-Hsin Wang, National Defense Medical Center, Taiwan
Critical Roles of the MLL4 Complex in Establishing an Active enhancer Landscape in Normal and Pathological Conditions

14:30—16:30
Workshop 1: 4DN Nucleome Consortium Resources
In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them.

Van Horne C
Judy Mietz, NCI, National Institutes of Health, USA
4DN Current Scope and Outlook

Olivier Blondel†, NIDDK, National Institutes of Health, USA
4DN Current Scope and Outlook

Burak H. Alver, Harvard Medical School, USA
4DN Data Portal

Feng Yue†, Pennsylvania State University, USA
Introduction to 4DN Joint Analysis

Nick Gilbert, University of Edinburgh, UK
Chromatin-Associated RNA Recycling by XRN2 Regulates Transcription and Chromosome Structure

Rieke Kempfer, Max Delbrück Center, Germany
Higher-Order Chromatin Contacts and Regulatory Networks in the ESC Genome.

* Sheng Zhong†, University of California, San Diego, USA
RNA as Proximity Labeling Media for Connecting Microscopic and Omics Data of Nuclear Organization

Zhen Chen, City of Hope, USA
Endothelial functional Regulation by Enhancer-Associated Long Non-Coding RNAs

Xiaoyi Cao†, University of California, San Diego, USA
How to Incorporate 4DN Data in your Personal Website

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Epigenetic Dysregulation in Neurobiology
Registered attendees can view abstracts starting on 02/17/2019

Van Horne A/B
Anne Schaefer, Mount Sinai School of Medicine, USA
Epigenetic Regulation of Neurodevelopment and Neurodegeneration

Danny F. Reinberg, HHMI/New York University, USA
The Epigenetic Status of some Histone Post-Translational Modifications

Shelley L. Berger, University of Pennsylvania, USA
Epigenetic Pathways as Targets in Human Cancer

Gonçalo Castelo-Branco, Karolinska Institutet, Sweden
Short Talk: Single-Cell Transcriptomics and Epigenomics Reveal Disease-Specific States of Oligodendroglia in Multiple Sclerosis

Lorna Farrelly, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Glutamine 5 Serotonylation on Histone H3 is a Permissive Modification that Functions Combinatorially with H3K4me3 to Potentiate Gene Expression

17:00—19:15
Single Cell Analysis of Genome Architecture
Registered attendees can view abstracts starting on 02/17/2019

Van Horne C
Alistair Boettiger, Stanford University, USA
Visualizing 3D Genome Architecture and Gene Expression during Embryogenesis

Peter Fraser, Florida State University, USA
Cell Cycle Dynamics of Chromosomal Organisation at Single-Cell Resolution

Ibrahim Cissé, Massachusetts Institute of Technology, USA
Super-Resolution Imaging of Transcription in Live Mammalian Cells

Blanca Pijuan-Sala, University of Cambridge, UK
Short Talk: Using Single-Cell Chromatin Accessibility Profiling to Study the Regulatory Mechanisms Underlying Early Mouse Organogenesis

Akihito Harada, Medical Institute of Bioregulation, Kyushu University, Japan
Short Talk: High-Throughput Single Cell Epigenomic Profiling using Chromatin Integration Labeling-Sequence

Jesse M. Engreitz, Harvard University and Broad Institute, USA
Short Talk: Activity-by-Contact Model of Enhancer Specificity from Thousands of CRISPR Perturbations

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
19:30—22:00
Poster Session 1

Mezzanine 2

TUESDAY, MARCH 19

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:30
Understanding and Targeting Epigenetic Dysregulation
Registered attendees can view abstracts starting on 02/17/2019

Van Horne A/B
Mark A. Dawson, Peter MacCallum Cancer Centre, Australia
Mechanisms of Epigenetic Therapeutics in Leukemia

Johannes Zuber, Research Institute of Molecular Pathology, Austria
Decoding and Exploiting Chromatin-associated Dependencies in Leukemia

Coffee Break

Cheryl Arrowsmith, University of Toronto, Canada
Probing the Epigenome for Therapeutic Opportunities

Marie Classon, , USA
Epigenetic Mechanisms of Drug Resistance

Sarah Attwell, Zenith Epigenetics Corp., Canada
Short Talk: The BET Inhibitor ZEN-3694 Blocks Multiple Tumor Immune Suppressive Factors and has the Potential to Increase the Efficacy of Anti-PD1 Treatment

M. Ryan Corces, Stanford University, USA
Short Talk: The Chromatin Accessibility Landscape of Primary Human Cancers

Céline Vallot, Institut Curie, France
Short Talk: Single-Cell Chromatin Profiling Reveals Heterogeneity of Chromatin States in Breast Cancer

08:00—11:15
Analysis of 3D Genome with Advanced Microscopy
Registered attendees can view abstracts starting on 02/17/2019

Van Horne C
Cornelis Murre, University of California, San Diego, USA
The Role of Non-Coding Transcription in Compartmentalization

Jan Ellenberg, European Molecular Biology Laboratory, Germany
Imaging Chromosome Structure and Dynamics in Single Cells by Quantitative Live and Super-Resolution Imaging

Hanhui Ma, Shanghaitech University, China
Short Talk: “CRISPRadius” Reveals that DNA and Histone Modifications Cooperatively Regulate Heterochromatin Condensates

Coffee Break

Andrew S. Belmont, University of Illinois at Urbana-Champaign, USA
Nuclear Speckle Association Modulates Transcription Revealed through Live-Cell Imaging

Clodagh C. O'Shea, The Salk Institute for Biological Studies, USA
Cracking the Nucleus: Visualizing the Higher Coding Structures of DNA

Magda Bienko†, Karolinska Institutet, Sweden
Short Talk: Radial Organization of the Genome Revealed by GPSeq

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
14:30—16:30
Workshop 2: Novel Modifications of Chromatin & RNA; Detection, Quantification and Functional Significance

Van Horne A/B
* François Fuks, Université Libre de Bruxelles, Belgium
Transcriptome-Wide Distribution and Function of RNA Modifications

Adriana Z. Corvalan, University of California, Los Angeles, USA
Understanding the Role of H4K20me3 and Suv4-20h2 in Cellular Quiescence

Harrison W. Gabel, Washington University School of Medicine, USA
Non-CG DNA Methylation in Neurodevelopmental Disorders

Simão Teixeira Rocha, Instituto de Medicina Molecular Joao Lobo Antunes, Portugal
Exploring the Role of Polycomb Recruitment in Xist-Mediated Silencing of the X Chromosome in ES Cells

Rohan Nishant Shah, University of Chicago, USA
Quantitative Studies of Histone Modifications

Zibo Zhao, Northwestern University, USA
Regulation of MLL/COMPASS Stability Through Its Proteolytic Cleavage by Taspase1 as a Possible Approach for Clinical Therapy of Leukemia

14:30—16:30
Workshop 2: ENCODE Consortium Resources
The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium.

Van Horne C
Michael J. Pazin, NHGRI, National Institutes of Health, USA
Overview of ENCODE project

Zhiping Weng, University of Massachusetts, USA
ENCODE DAC

Ting Wang†, Washington University, USA
WashU Epigenome Browser

Jie Xu†, Pennsylvania State University, USA
Talk Title to be Announced

Jian Ma, Carnegie Mellon University, USA
Comparing 3D Genome Organization in Multiple Species using Phylo-HMRF

Yanxiao Zhang, Ludwig Institute for Cancer Research, USA
Primate-Specific Retrotransposon HERV-H Demarcates Chromatin Domains in Lineage Specification and Evolution

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Infectious Diseases and Autoimmunity
Registered attendees can view abstracts starting on 02/17/2019

Van Horne A/B
Ido Amit, Weizmann Institute, Israel
The Power of ONE: Immunology in the Age of Single Cell Genomics

Eric A. Miska, University of Cambridge, UK
RNA Modifications and Novel Antiviral Response

Alexander Tarakhovsky, Rockefeller University, USA
I-BET, Inflammation, Histone Mimicry in Pathogens, Antiviral Response

Madle Sirel, Karolinska Institutet, Sweden
Short Talk: Epigenetics of Parasites Causing Placental Malaria

Colby Zaph, Monash University, Australia
Short Talk: Regulatory T Cell Stability is Controlled by the Lysine Methyltransferase G9a Independently of DNA Methylation

17:00—19:15
Chromatin and Epigenetics
Registered attendees can view abstracts starting on 02/17/2019

Van Horne C
Bas van Steensel, Netherlands Cancer Institute, Netherlands
Lamina Associated Domains

Mitchell Guttman, California Institute of Technology, USA
3D Genome Organization and X Chromosome Inactivation

Joseph R. Ecker, The Salk Institute for Biological Studies, USA
Single Cell Analysis of DNA Methylation

Chen-Yu Wang, Massachusetts General Hospital, USA
Short Talk: SMCHD1 Regulates the Folding of the Inactive X Chromosome and Select Autosomal loci

Candice Byers, Tufts University, USA
Short Talk: Cellular Systems Genetics Implicates KRAB Zinc Finger Proteins in Mediating Variation in Chromatin State in Pluripotent Stem Cells

Marc Bühler, Friedrich Miescher Institute for Biomedical Research, Switzerland
Short Talk: A Transcription Factor Implicated in Autism Locally Constrains Chromatin Looping

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
19:30—22:00
Poster Session 2

Mezzanine 2

WEDNESDAY, MARCH 20

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:30
Chromatin Signaling and Epigenetic Mechanisms
Registered attendees can view abstracts starting on 02/17/2019

Van Horne A/B
Christopher Vakoc, Cold Spring Harbor Laboratory, USA
Transcriptional Addiction in Cancer

Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School, USA
Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease

Coffee Break

Paola Scaffidi, Francis Crick Institute, UK
Epigenetics and Functional Intratumor Heterogeneity

Xiaobing Shi, Van Andel Institute, USA
Novel Histone Marks and Reader Domains

Kelly Barnett, Vanderbilt University, USA
Short Talk: ATAC-Me Captures Spatiotemporal Dynamics of DNA Methylation Across the Chromatin Accessible Genome during A Monocyte to Macrophage Transition

Susan J. Clark, Garvan Institute of Medical Research, Australia
Short Talk: DNA Hypermethylation Encroachment at CpG Island Borders in Cancer is Predisposed by H3K4 Mono-Methylation Patterns

Hatice S. Kaya-Okur, Fred Hutchinson Cancer Research Center, USA
Short Talk: CUT&Tag for Efficient Epigenomic Profiling of Small Samples and Single Cells

08:00—11:30
3D Genome and Gene Regulation
Registered attendees can view abstracts starting on 02/17/2019

Van Horne C
Bing Ren, Ludwig Institute for Cancer Research, USA
Regulation of Enhancer/Promoter Interactions

Gerd A. Blobel, Children's Hospital of Philadelphia, USA
Re-Configuration of Chromatin Structure During the Mitosis-G1 Phase Transition

Coffee Break

Jennifer E. Phillips-Cremins, University of Pennsylvania, USA
3D Genome Reconfiguration in Neurological Disorders

Stavros Lomvardas, Columbia University, USA
3D Chromatin Organization of the Olfactory Receptor Locus

Seungsoo Kim, University of Washington, USA
Short Talk: A Combination of Transcription Factors Mediates Inducible Interchromosomal Contacts

David Hawkins, University of Washington, USA
Short Talk: Epigenome Annotation and Three-Dimensional Genome Architecture Reveal Candidate Silencer Elements for the Human and Mouse Genomes

11:00—12:00
Roundtable Discussion: Women in Science (Joint)

Van Horne A/B
Cheryl Arrowsmith, University of Toronto, Canada

Anne Schaefer, Mount Sinai School of Medicine, USA

Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
14:30—16:30
Workshop 3: Emerging Therapies to Chromatin and RNA Modifying Enzymes

Van Horne A/B
* Nada Jabado, McGill University Health Centre, Canada
Therapeutic Vulnerability of the K27M Oncohistone: Finding Achilles' Heel in Gliomas?

Danielle Bozek, University of Calgary, Canada
DOT1L Epigenetically Regulates Glioblastoma Cancer Stem Cell Properties

Patrizia Casaccia, Advanced Science Research Center, USA
DNA Hydroxymethylation Impacts Age-Dependent Myelin Regeneration in the Central Nervous System

Bilal N. Sheikh, Max Planck Institute for Immunobiology and Epigenetics, Germany
Neural Metabolic Defects lead to Inflammation and Brain Haemorrhage

Art Petronis, University of Toronto, Canada
Circadian DNA Modification Hallmarks of Aging and Disease

Andreas R. Pfenning, Carnegie Mellon University, USA
Epigenomic Profiling of Major Human Brain Cell Types Reveals Sex Specific Differences in Hippocampal Oligodendrocyte Gene Regulation in Alzheimer's Disease

Emmanuelle Vire, University College London, UK
Altered DNA Methylation Signatures to Better Detect, Classify, and Understand Human Prion Diseases

14:30—16:30
Workshop 3: International Human Epigenome Consortium
The IHEC consortium is an international consortium of investigators dedicated to the study of epigenomes in normal and disease cells. It has made major contributions to the development of new technologies and generation of valuable datasets to the field of epigenomics. This workshop will feature short presentations and tutorials aimed at facilitating the dissemination of resources and tools from the IHEC consortium.

Van Horne C
16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Metabolic Diseases and Aging
Registered attendees can view abstracts starting on 02/17/2019

Van Horne A/B
Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA
Role of Mutations in Epigenetic Regulators in Pathogenesis of AML

Steve Horvath, University of California, Los Angeles, USA
Epigenetic Aging Clock versus Gene Regulation

Anne Brunet, Stanford University, USA
Epigenetic Regulation of Aging

Louis Coussement, University Ghent, Belgium
Short Talk: The Aging Genome: CpG Depletion throughout Human Evolution

Anita Oest, Linkoping University, Sweden
Short Talk: Diet-Sensitive Fragmentation of Sperm tRNA

17:00—19:15
Genome Architecture and Development
Registered attendees can view abstracts starting on 02/17/2019

Van Horne C
Wei Xie, Tsinghua University, China
Chromatin Reprogramming in Mammalian Gametogenesis and Early Development

Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany
Genome Architecture Mapping: Discovering Chromatin Contacts in Rare Cell Types

X. Sunney Xie, Peking University, China
Decoding the 3D Genome

Sajad Hamid, University of California, San Francisco, USA
Short Talk: Mapping of Nuclear Lamina-Associated Genome Organization in Developing Mouse and Human Brain

Xiong Ji, Peking University, China
Short Talk: RNAPII Condensates Connect Genome Organization and Gene Regulation

Fulai Jin, Case Western Reserve University, USA
Short Talk: Multi-Scale 3D Genome Analyses in Human Neurogenesis and Brain Tissues with Easy Hi-C

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
19:30—22:00
Poster Session 3

Mezzanine 2

THURSDAY, MARCH 21

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:30
Epigenetic Regulation in Immunoncology and Cancer Therapeutics
Registered attendees can view abstracts starting on 02/17/2019

Van Horne A/B
Daniel De Carvalho, University Health Network, Canada
DNA Methylation, Viral Mimicry, Epigenetic Therapy

Rab K. Prinjha, GlaxoSmithKline, UK
Drug Discovery and Clinical Progression or Epigenetic Therapies

Coffee Break

Benjamin Nicholson, Merck Research Laboratories, USA
Epigenetics and Immune Modulation in Cancer

Ricky W. Johnstone, Peter MacCallum Cancer Centre, Australia
Epigenetic Modulation of the Immune System for Cancer Treatment

Ali Chomiak, Van Andel Research Institute, USA
Short Talk: Polycomb Signaling as a Therapeutic Axis for Enhancing Epigenetic Therapy in Colorectal Cancer

Colum P. Walsh, University of Ulster, UK
Short Talk: UHRF1 is Required to Suppress Viral Mimicry through Both DNA Methylation-Dependent and -Independent Mechanisms

Andrew Morton, Case Western Reserve University, USA
Short Talk: Lineage-Specific Enhancers are Co-Opted on Focal Oncogenic Amplifications in Solid Tumors

08:00—11:00
Computational Analysis of 3D Genome
Registered attendees can view abstracts starting on 02/17/2019

Van Horne C
Erez Lieberman-Aiden, Baylor College of Medicine, USA
A 3D Code in the Human Genome

X. Shirley Liu, Dana-Farber Cancer Institute, Harvard School of Public Health, USA
Epigenomic Analysis of Cancer Cells

Coffee Break

Frank Alber, University California, Los Angeles, USA
Computational Modeling of 3D Genome

Mario Nicodemi, Universita' di Napoli Federico II, Italy
Polymer Physics Predicts the Effects of Structural Variants on Chromatin Architecture

Jill E. Moore, University of Massachusetts Medical School, USA
Short Talk: Evaluating Computational Methods for Predicting Enhancer-Gene Interactions

Ferhat Ay, La Jolla Institute, USA
Short Talk: FitHiChIP: Identification of Chromatin Loops from HiChIP/PLAC-Seq Data

Kathleen Keough, Gladstone Institutes, University of California, San Francisco, USA
Short Talk: A Role for Enhancer Hijacking in the Emergence of Human Accelerated Regions

11:00—17:00
On Own for Lunch

11:00—12:00
Roundtable Discussion: Careers in Industry (Joint)

Van Horne A/B
Bing Ren, Ludwig Institute for Cancer Research, USA

Richard A. Young, Whitehead Institute for Biomedical Research, USA

Rab K. Prinjha, GlaxoSmithKline, UK

Benjamin Nicholson, Merck Research Laboratories, USA

Marie Classon, , USA

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
3D Genome and Disease (Joint)
Registered attendees can view abstracts starting on 02/17/2019

Van Horne A/B
Xiaowei Zhuang, Harvard University, USA
Single-Cell Transcriptome and Chromosome Imaging

Bradley E. Bernstein, Massachusetts General Hospital, USA
Epigenetic Plasticity and Selection in Tumorigenesis

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
TET Loss-of-Function and Oncogenesis

Zuzana Tothova, Dana-Farber Cancer Institute, USA
Short Talk: Chromatin Architecture in Leukemia Through the Lens of Cohesin Complex Mutations

Jesse Dixon, The Salk Institute for Biological Studies, USA
Short Talk: Identification of Recurrent TAD Fusion Events as a Result of Structural Variation in Cancer Genomes

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Registered attendees can view abstracts starting on 02/17/2019

Van Horne A/B
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Registered attendees can view abstracts starting on 02/17/2019

Van Horne C
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Mezzanine 2

FRIDAY, MARCH 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Research Incyte Corporation
Novartis Institutes for BioMedical Research Pfizer Inc.

We gratefully acknowledge additional support from these exhibitors at this conference:

EpiCypher Illumina
10x Genomics
 
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge additional support for this conference from:

American Society of Gene & Cell Therapy (ASGCT) Chroma Technology Corporation
Zymo Research Corporation
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



GlaxoSmithKline


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676