| Tuesday, January 22 |
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3:00 - 7:30 PM
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Registration
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Foyer
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6:30 - 7:30 PM
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Refreshments
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Foyer
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7:30 - 9:30 PM
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Keynote Session
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Colorado Ballroom
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Mary-Elizabeth Patti,
Joslin Diabetes Center
and
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David E. Moller,
Eli Lilly and Company
Introductory Remarks
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C. Ronald Kahn,
Joslin Diabetes Center
Insulin Resistance, Obesity and Type 2 Diabetes: Which is the Chicken and Which is the Egg?
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Leif C. Groop,
Lund University
Searching for the Genetic Causes of Type 2 Diabetes
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| Wednesday, January 23 |
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7:00 - 8:00 AM
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Breakfast
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Summit Gallery
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8:00 - 11:15 AM
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Insulin Resistance and Diabetes Pathogenesis
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Colorado Ballroom
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Mary-Elizabeth Patti,
Joslin Diabetes Center
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Ele Ferrannini,
University of Pisa
Overview: Relative Role of Insulin Resistance vs. Beta Cell Dysfunction in Diabetes Pathogenesis
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Hannele Yki-Järvinen,
University of Helsinki
Role of Fatty Liver in the Pathogenesis of Metabolic Syndrome and Type 2 Diabetes
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Gerald I. Shulman,
HHMI, Yale University School of Medicine
Cellular Mechanisms of Insulin Resistance and the Role of Skeletal Muscle Insulin Resistance in the Pathogenesis of the Metabolic Syndrome
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Gökhan S. Hotamisligil,
Harvard University School of Public Health
Inflammation and ER Stress in Metabolic Disease
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Michael Ristow,
University of Jena
Short Talk: Impaired Oxidative Phosphorylation Induces Oxidative Stress, Decreases Life Span and Promotes Type 2 Diabetes and Obesity
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John Andrew Pospisilik,
Institute of Molecular Biology of the Austrian Academy of Sciences
Short Talk: Targeted Deletion of AIF Reduces OxPhos and Prevents Diabetes and Obesity
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9:20 - 9:40 AM
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Coffee Break
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Foyer
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11:15 AM - 1:00 PM
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Poster Setup
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Breckenridge Ballroom
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12:00 - 1:30 PM
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Meet the Professor Lunch: NIH Grant Application Process and Endo-Related Study Sessions
Box Lunches available for purchase. Advance sign-up will be required.
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Colorado Ballroom
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*
Mary-Elizabeth Patti,
Joslin Diabetes Center
Introduction
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Philip F. Smith,
NIDDK, National Institutes of Health
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1:00 - 10:00 PM
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Poster Viewing
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Breckenridge Ballroom
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4:30 - 5:00 PM
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Coffee Available
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Foyer
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5:00 - 7:00 PM
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Genetics and Syndromes Related to Type 2 Diabetes
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Colorado Ballroom
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Leif C. Groop,
Lund University
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Philippe Froguel,
Imperial College of London
Human Polygenic Severe Obesity Genes, What's New? What's Interesting?
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Leslie J. Baier,
National Institutes of Health
The Search for Type 2 Diabetes and Obesity Susceptibility Genes in Pima Indians
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Andrea Dunaif,
Northwestern University Feinberg School of Medicine
PCOS and Type 2 Diabetes – Insights from Genetic Studies
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Jeremy B.M. Jowett,
Baker IDI Heart and Diabetes Institute
Short Talk: A Systems Biology Approach to Determining the Biological Consequences of Genetic Variation in Humans: The PPAR gamma Pro12Ala Variant
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Breckenridge Ballroom
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7:30 - 10:00 PM
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Poster Session 1
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Breckenridge Ballroom
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| Thursday, January 24 |
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7:00 - 8:00 AM
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Breakfast
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Summit Gallery
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8:00 - 11:15 AM
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Adipose and Inflammatory Links to Insulin Resistance
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Colorado Ballroom
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*
Michael P. Czech,
University of Massachusetts Medical School
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Isaac (Zak) S. Kohane,
Harvard Medical School, Children's Hospital
Getting Better and More Numbers for Discovery Research in the Genomic Era
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Lily Q. Dong,
University of Texas Health Science Center
Short Talk: “Ying-Yang” Regulation of Adiponectin Signaling by APPL Isoforms
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Rosalind A. Coleman,
University of North Carolina at Chapel Hill
Lipogenic Pathways: Links to Diabetes Risk
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Steven E. Shoelson,
Harvard Medical School
Potent Roles of the Immune System in Obesity Induced T2DM and CVB
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Mitchell A. Lazar,
University of Pennsylvania School of Medicine
Transcriptional Networks Leading From Obesity to Insulin Resistance
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David A. Bernlohr,
University of Minnesota
Short Talk: Role of Adipose Protein Carbonylation in Insulin Resistance; The HNE Pathway
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9:20 - 9:40 AM
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Coffee Break
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Foyer
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11:15 AM - 1:00 PM
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Poster Setup
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Breckenridge Ballroom
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12:00 - 1:30 PM
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Meet the Professor Lunch: Clinical DM for PhDs
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Colorado Ballroom
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*
Mary-Elizabeth Patti,
Joslin Diabetes Center
Introduction
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Martin J. Abrahamson,
Harvard Medical School
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1:00 - 10:00 PM
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Poster Viewing
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Breckenridge Ballroom
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4:30 - 5:00 PM
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Coffee Available
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Foyer
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5:00 - 7:15 PM
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Epigenetic and Metabolic Determinants of Insulin Resistance and Diabetes Risk
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Colorado Ballroom
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*
Mitchell A. Lazar,
University of Pennsylvania School of Medicine
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Miguel Constância,
University of Cambridge
Epigenetics: Basic Mechanisms and Potential Links to Developmental Origins of Adult Disease
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Kevin L. Grove,
Oregon National Primate Research Center
Short Talk: Maternal High Fat Diet Causes Fetal Lipotoxicity
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Mary-Elizabeth Patti,
Joslin Diabetes Center
Genetic and Environmental Pathways to Human Diabetes Risk
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Don Ayer,
University of Utah
Short Talk: Glucose Sensing and Regulation of Glucose-Dependent Transcription
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Assam El-Osta,
Baker Heart Research Institute
Short Talk: Transient Hyperglycemia Induces Persistent Transcriptional Activity; Insights into Epigenetic Change and Glycemic Memory
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Breckenridge Ballroom
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7:30 - 10:00 PM
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Poster Session 2
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Breckenridge Ballroom
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| Friday, January 25 |
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7:00 - 8:00 AM
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Breakfast
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Summit Gallery
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8:00 - 11:15 AM
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Searching for New Therapeutic Targets
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Colorado Ballroom
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David E. Moller,
Eli Lilly and Company
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Alan D. Attie,
University of Wisconsin-Madison
Multidimensional Approaches to DM Gene Discovery
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Michael P. Czech,
University of Massachusetts Medical School
Systems Biology Approaches to Metabolic Disease
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Alexei Kharitonenkov,
Eli Lilly and Company
Metabolic Actions of FGF-21
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D. Grahame Hardie,
University of Dundee
AMP-Activated Protein Kinase as a Drug Target in Type 2 Diabetes and Metabolic Syndrome
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Carsten Schmitz-Peiffer,
Garvan Institute of Medical Research
Short Talk: Inhibition of PKCepsilon is a Potential Therapy for Type 2 Diabetes by Reconstituting Glucose-Stimulated Insulin Secretion and Reducing Insulin Clearance
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Joseph S. Grimsby,
Hoffmann-La Roche, Inc.
Short Talk: Antidiabetic Effects of Glucokinase Activators: From Benchside to Bedside
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9:20 - 9:40 AM
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Coffee Break
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Foyer
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11:15 AM - 1:00 PM
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Poster Setup
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Breckenridge Ballroom
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1:00 - 10:00 PM
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Poster Viewing
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Breckenridge Ballroom
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2:30 - 4:30 PM
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Drug Discovery Workshop
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Colorado Ballroom
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*
David E. Moller,
Eli Lilly and Company
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Jin-Long Chen,
Amgen Inc.
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Ranabir Sinha Roy,
Merck & Co. Inc.
DPP-4 Inhibitors and Next-Generation Insulin Secretagogues
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Bryan Goodwin,
GlaxoSmithKline
Orphan Nuclear Receptors and Beyond in the Treatment of Metabolic Disease
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Cord Dohrmann,
DeveloGen AG
Identifying Drug Targets Regulating Metabolism in Drosophila
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Brian P. Zambrowicz,
Lexicon Genetics Incorporated
Using Mouse Genetics to Understand Gene Function and Identify Targets for Drug Discovery
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4:30 - 5:00 PM
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Coffee Available
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Foyer
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5:00 - 7:00 PM
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Novel Pathways in Diabetes and Metabolic Syndrome
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Colorado Ballroom
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*
Barbara B. Kahn,
Beth Israel Deaconess Medical Center
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Philipp E. Scherer,
University of Texas Southwestern Medical Center
Separating “Good” from “Bad” Adipose
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Juleen R. Zierath,
Karolinska Institute
Down-Regulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance
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Pere Puigserver,
Dana-Farber Cancer Institute, Harvard Medical School
Sirtuins and Transcriptional Control in Hepatic Metabolism
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Maziyar Saberi,
University of California, San Diego
Short Talk: Novel Liver-Specific TORC2 siRNA Corrects Hyperglycemia in Rodent Models of Type 2 Diabetes
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Breckenridge Ballroom
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7:30 - 10:00 PM
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Poster Session 3
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Breckenridge Ballroom
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| Saturday, January 26 |
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7:00 - 8:00 AM
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Breakfast
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Summit Gallery
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8:00 - 11:30 AM
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New Molecular Mechanisms of Insulin Resistance
|
Colorado Ballroom
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*
Philipp E. Scherer,
University of Texas Southwestern Medical Center
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Barbara B. Kahn,
Beth Israel Deaconess Medical Center
RBP4 and Insulin Resistance
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Deborah M. Muoio,
Duke University
Lipid-Induced Mitochondrial Stress and Insulin Resistance in Skeletal Muscle
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Joyce J. Repa,
University of Texas Southwestern Medical Center
The Oxysterol Nuclear Receptors and Glucose Homeostasis
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Johan Auwerx,
Institut de Génétique et Biologie Moléculaire et Cellulaire
A Cofactor Network that Controls PGC-1alpha Activity and Energy Homeostasis
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Alexander Banks,
Dana Farber Cancer Institute
Short Talk: Metabolic Mimicry of Calorie Restriction by SirT1 Gain-of-Function in Mice
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Matthias Mann,
Max-Planck Institute for Biochemistry
Short Talk: Mapping the Mitochondrial Proteome – Implications for Insulin Action and Diabetes
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Mark A. Febbraio,
Baker Heart Research Institute
Short Talk: Activating HSP72 Protects against Obesity-Induced Insulin Resistance
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9:20 - 9:40 AM
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Coffee Break
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Foyer
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12:00 - 1:30 PM
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Meet the Professor Lunch: Perspectives of Science in Drug Discovery and Careers in Industry
Box Lunches available for purchase. Advance sign-up will be required.
|
Colorado Ballroom
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David E. Moller,
Eli Lilly and Company
Introduction
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Rebecca A. Taub,
VIA Pharmaceuticals, Inc
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Thomas A. Gustafson,
Eli Lilly
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4:30 - 5:00 PM
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Coffee Available
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Foyer
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5:00 - 7:00 PM
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Transcriptional Interface between Lipid and Glucose Metabolism
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Colorado Ballroom
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*
Anna Krook,
Karolinska Institutet
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Marc R. Montminy,
The Salk Institute for Biological Studies
The TORC Family of CREB Coactivators: Regulators of Energy Balance
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Markus Stoffel,
Institut f. Molekulare Systembiologie
Cross-Talk between Insulin Signaling and FOXA2 in the Liver and Lateral Hypothalamus
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Bruce M. Spiegelman,
Harvard Medical School
Transcriptional Control of Brown Fat Determination by PRDM16: A Co-Regulator of the PGC-1s and Nuclear Receptors
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Jiandie Lin,
University of Michigan Medical School
Short Talk: Decoding the PGC-1 Transcriptional Network through Genome-Wide Coactivation Analyses
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Breckenridge Ballroom
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8:00 - 11:00 PM
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Entertainment
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Breckenridge Ballroom
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| Sunday, January 27 |
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Departure
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