| Tuesday, March 25 |
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3:00 - 7:30 PM
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Registration
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Grand Foyer
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6:30 - 7:30 PM
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Refreshments
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Grand Foyer
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7:30 - 9:30 PM
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Keynote Session
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Sea to Sky Ballroom BC
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Judy Lieberman,
Harvard Medical School
and
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Phillip A. Sharp,
Massachusetts Institute of Technology
Introductions
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Craig C. Mello,
University of Massachusetts Medical School
Small RNA Pathways and Germline in C. elegans
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Gregory J. Hannon,
Cold Spring Harbor Laboratory
Conserved Roles of Small RNAs in Genome Defense
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| Wednesday, March 26 |
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7:00 - 8:00 AM
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Breakfast
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Sea to Sky Ballroom A, Lower Level
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8:00 - 11:00 AM
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MicroRNAs and Their Targets (Vertebrate). Session Supported by Regulus Therapeutics
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Sea to Sky Ballroom BC
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David P. Bartel,
Massachusetts Institute of Technology
MicroRNAs and their Targets
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Carlo M. Croce,
Ohio State University
MicroRNA Genes and Cancer
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Eric N. Olson,
University of Texas Southwestern Medical Center
microRNAs Control of Muscle Development and Disease
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V. Narry Kim,
Seoul National University
lin 28-Mediated Terminal Uridylation of pre-let-7
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Joel G. Belasco,
New York University School of Medicine
Short Talk: Importance of Translational Repression and non-Nucleolytic Ago Isoforms for on-Target RNA Interference
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9:20 - 9:40 AM
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Coffee Break
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Grand Foyer
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11:00 AM - 1:00 PM
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Poster Setup
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Sea to Sky Ballroom A, Foyer
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11:00 AM -
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On Own for Lunch
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1:00 - 10:00 PM
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Poster Viewing
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Sea to Sky Ballroom A, Foyer
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4:30 - 5:00 PM
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Coffee Available
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Grand Foyer
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5:00 - 7:15 PM
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MicroRNAs and Their Targets (Plants and Invertebrates). Session Supported by Regulus Therapeutics
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Sea to Sky Ballroom BC
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Victor Ambros,
University of Massachusetts
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Stephen M. Cohen,
Temasek Life Sciences Laboratory
MicroRNA Functions
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Oliver Hobert,
Columbia University Medical Center
The Regulatory Architecture of a miRNA-Controlled 3'UTR
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Molly C. Hammell,
University of Massachusetts Medical School
Short Talk: mirWIP: microRNA Target Prediction Based on miRNP Enriched Transcripts
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Marcelo A. German,
Delaware Biotechnology Institute
Short Talk: Global Identification of miRNA-Target RNA Pairs by Parallel Analysis of RNA Ends (PARE)
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Eric C. Lai,
Sloan-Kettering Institute
Short Talk: Biogenesis and Function of Hairpin RNAs
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Alla Grishok,
Columbia University Medical Center
Short Talk: Targets of Endogenous RNAi Processes in C. elegans
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Sea to Sky Ballroom A, Foyer
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7:30 - 10:00 PM
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Poster Session 1
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Sea to Sky Ballroom A, Foyer
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| Thursday, March 27 |
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7:00 - 8:00 AM
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Breakfast
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Sea to Sky Ballroom A, Lower Level
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8:00 - 11:15 AM
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RNA Interference: Regulation of Transcription
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Sea to Sky Ballroom BC
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Danesh Moazed,
Harvard Medical School
Role of Non-Coding RNAs in Heterochromatin Assembly
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Marjori Ann Matzke,
Gregor Mendel Institute of Molecular Plant Biology Austrian Academy of Sciences
RNA-Directed DNA Methylation in Arabidopsis
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Alexei A. Aravin,
Cold Spring Harbor Laboratory
Small RNA Pathways in Mouse Germline
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Rene Ketting,
Hubrecht Institute
TRF-Like Terminal Transferases affect RNAi and Chromosome Segregation in C. elegans
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Michel A. J. Georges,
University of Liège
Small RNAs and Imprinting
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9:20 - 9:40 AM
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Coffee Break
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Grand Foyer
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11:15 AM - 1:00 PM
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Poster Setup
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Sea to Sky Ballroom A, Foyer
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11:15 AM -
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On Own for Lunch
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1:00 - 10:00 PM
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Poster Viewing
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Sea to Sky Ballroom A, Foyer
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4:30 - 5:00 PM
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Coffee Available
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Grand Foyer
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5:00 - 7:00 PM
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Non-coding RNAs
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Sea to Sky Ballroom BC
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Thomas R. Gingeras,
Affymetrix, Inc.
Investigations of the Functional Roles of the Pervasive Transcription Observed for Genomes
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Gene W. Yeo,
The Salk Institute
Short Talk: Analysis of Small RNAs in Stem Cell Development
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Dinshaw J. Patel,
Memorial Sloan-Kettering Cancer Center
Structural Biology of Riboswitch-Mediated Gene Regulation and Argonaute-Mediated Gene Silencing
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Nikolaus Rajewsky,
Max Delbruck Center for Molecular Medicine
Identifying MicroRNAs and Their Targets
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Sea to Sky Ballroom A, Foyer
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7:30 - 10:00 PM
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Poster Session 2
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Sea to Sky Ballroom A, Foyer
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| Friday, March 28 |
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7:00 - 8:00 AM
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Breakfast
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Sea to Sky Ballroom A, Lower Level
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7:00 - 8:00 AM
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Poster Setup
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Sea to Sky Ballroom A, Foyer
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8:00 - 11:00 AM
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RNA Interference: Newly Emerging Biology
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Sea to Sky Ballroom BC
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Phillip D. Zamore,
University of Massachusetts Medical School
Germline and Somatic Small RNAs
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Thomas Tuschl,
Rockefeller University
miRNA Profiling and in Situ Hybridization to Examine Their Cell-Type Specific Expression Patterns
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Haifan Lin,
Yale University
Epigenetic Function of Piwi and piRNAs
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Phillip A. Sharp,
Massachusetts Institute of Technology
miRNA Silencing by Translational Inhibition and mRNA Degradation
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Elisa Izaurralde,
MPI for Developmental Biology
Short Talk: Mechanism of miRNA-Mediated Gene Silencing
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9:20 - 9:40 AM
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Coffee Break
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Grand Foyer
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11:00 AM - 12:00 PM
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Lunch
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Sea to Sky Ballroom A, Foyer
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12:00 - 2:30 PM
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Poster Session 3
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Sea to Sky Ballroom A, Foyer
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2:30 - 4:30 PM
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Workshop 1: New Approaches to shRNA-Based Screening and Therapy
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Sea to Sky Ballroom BC
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David E. Root,
Broad Institute
Pooled shRNA Screens for Functional Fingerprinting
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Edward Harlow,
Harvard Medical School
shRNA Screens to Identify Targets for Cancer Drug Development
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Michael T. Hemann,
Massachusetts Institute of Technology
In Vivo Screens to Identify Mechanisms of Drug Resistance
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Mark A. Kay,
Stanford University
Functional Evidence for Restricting MicroRNA Targets to the 3' Untranslated Region of mRNAs
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John J. Rossi,
Beckman Research Institute of the City of Hope
Applying RNAi for the treatment of HIV infection
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4:30 - 5:00 PM
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Coffee Available
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Grand Foyer
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5:00 - 7:00 PM
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RNA Interference: Mechanisms and Cell Biology
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Sea to Sky Ballroom BC
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Matthias W. Hentze,
European Molecular Biology Laboratory
Mechanism of Translational Inhibition by miRNAs
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Carl D. Novina,
Dana Farber Cancer Institute
Short Talk: MicroRNA-Targeted mRNAs Contain 40S, but not 60S Components
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Witold Filipowicz,
Friedrich Miescher Institute for Biomedical Research
Role of Dicer in miRNA Pathways and Beyond
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Jennifer A. Doudna,
University of California, Berkeley/HHMI
Mechanisms of Small RNA Processing
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7:00 PM -
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On Own for Dinner
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| Saturday, March 29 |
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7:00 - 8:00 AM
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Breakfast
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Sea to Sky Ballroom A, Lower Level
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7:00 - 8:00 AM
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Poster Setup
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Sea to Sky Ballroom A, Foyer
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8:00 - 11:00 AM
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RNAi-Based Screening
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Sea to Sky Ballroom BC
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Gary B. Ruvkun,
Massachusetts General Hospital, Harvard Medical School
The Protein Coding Cofactors of miRNAs and siRNAs
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Anjana Rao,
Harvard Medical School
RNAi Screen for Mammalian Biology and a Bit About Eri-1
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Reuven Agami,
Netherlands Cancer Institute
Dead End 1 Blocks microRNA Access to Target mRNA
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Scott M. Hammond,
University of North Carolina at Chapel Hill
Regulation of microRNA Biogenesis by Lin-28
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9:20 - 9:40 AM
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Coffee Break
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Grand Foyer
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11:00 AM - 12:00 PM
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Lunch
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Sea to Sky Ballroom A, Foyer
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12:00 - 2:30 PM
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Poster Session 4
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Sea to Sky Ballroom A, Foyer
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2:30 - 4:30 PM
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Workshop 2: Translating RNAi
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Sea to Sky Ballroom BC
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Lee Lim,
Rosetta Inpharmatics LLC
Using Profiling to Study miRNAs
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Muthiah Manoharan,
Alnylam Pharmaceuticals Inc.
Cellular Delivery of siRNAs and Antagomirs Using Chemical
Conjugation and Complexation Strategies
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C. Frank Bennett,
ISIS Pharmaceuticals, Inc.
Therapeutic Approaches for Modulating Gene Expression Utilizing Single Stranded Oligonucleotides
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David L. Lewis,
Mirus Bio Corporation
Dynamic PolyConjugates: A Rationally Designed, Modular Platform for Systemic siRNA Delivery
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Fumitaka Takeshita,
National Cancer Center Research Institute
Systemic microRNA Therapy for Cancer Metastasis
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4:30 - 5:00 PM
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Coffee Available
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Grand Foyer
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5:00 - 7:00 PM
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RNAi-Based Therapy
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Sea to Sky Ballroom BC
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Beverly L. Davidson,
University of Iowa
RNAi and Neurodegenerative Diseases
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Judy Lieberman,
Harvard Medical School
Silent Treatment for Cancer
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Markus Stoffel,
Institut f. Molekulare Systembiologie
Molecular Mechanisms of Cellular Uptake of Cholesterol-Conjugated RNAs
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Morten Lindow,
Santaris Pharma
Short Talk: LNA-Mediated microRNA Silencing in non-Human Primates
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Sea to Sky Ballroom A, Foyer
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8:00 - 11:00 PM
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Entertainment
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Sea to Sky Ballroom A, Foyer
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| Sunday, March 30 |
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Departure
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