Keystone Symposia Conference | Malaria: Immunology, Pathogenesis and Vaccine Perspectives

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Sunday, June 8
3:00 - 7:30 PM	Registration	Otto Molden Foyer
6:30 - 7:30 PM	Welcome	Otto Molden Foyer
7:30 - 8:30 PM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 05/08/2008	Erwin Schrödinger Hall
	* Michael F. Good, Queensland Institute of Medical Research, Australia
	Stephen L. Hoffman, Sanaria, USA The Role of an Attenuated Sporozoite Vaccine in a Changing Malaria World

Monday, June 9
7:00 - 8:00 AM	Breakfast	Your Lodging Location
8:00 - 11:45 AM	Immunology I Registered attendees for this meeting can view Abstracts for this session starting on 05/08/2008	Erwin Schrödinger Hall
	* Mary Margaret Stevenson, Montreal University Health Center Research Institute, Canada Dissecting the Innate Immune Response to Malaria in a Mouse Model
	Jean Langhorne, National Institute for Medical Research, UK Antigen Presentation, Inflammatory Monocytes and CD4 T Cell Responses in a Blood-Stage Malaria Infection
	* Eleanor M. Riley, London School of Hygiene and Tropical Medicine, UK Innate Immunity to Malaria
	Isabella A. Quakyi, University of Ghana, Ghana Acquired Immunity and Biomarkers of Functional Relevance in Plasmodium falciparum Malaria
	Greta Weiss, NIAID, National Institutes of Health, USA Short Talk: The Impact of P. falciparum Infection on the Development and Maintenance of Memory B Cells
	Tonia Woodberry, Menzies School of Health Research, Australia Short Talk: Human T Cell Recognition of the Novel Vaccine Target Plasmodium HGXPRT following Natural Parasite Exposure
	Diane Wallace Taylor, University of Hawaii, USA Short Talk: Are Antimalarial Immune Responses Altered in Pregnant Women?
	Shazia Khanam, Tata Institute of Fundamental Research, India Short Talk: Murine Malarial Infections Affect Thymic T Cell Development
9:20 - 9:40 AM	Coffee Break	Otto Molden Foyer
11:45 AM- 1:00 PM	Poster Setup	Otto Molden Foyer
11:45 AM-	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Otto Molden Foyer
4:30 - 5:00 PM	Coffee Available	Otto Molden Foyer
5:00 - 7:00 PM	Worms and Malaria Registered attendees for this meeting can view Abstracts for this session starting on 05/08/2008	Erwin Schrödinger Hall
	* Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands The Immunological Consequences of Malaria and Helminth Coinfection
	Christian Engwerda, Queensland Institute of Medical Research, Australia The Pathogenesis of Experimental Cerebral Malaria during Schistosoma mansoni Infection
	Pierre Druilhe, Institut Pasteur, France Worms Worsen Malaria: Understanding Human-P. falciparum Immune Interactions Uncovers the Immunological Role of Worms
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Otto Molden Foyer
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 05/08/2008	Otto Molden Foyer
Tuesday, June 10
7:00 - 8:00 AM	Breakfast	Your Lodging Location
7:00 - 8:00 AM	Poster Setup	Otto Molden Foyer
8:00 - 11:30 AM	Immunology II Registered attendees for this meeting can view Abstracts for this session starting on 05/08/2008	Erwin Schrödinger Hall
	* James W. Kazura, Case Western Reserve University, USA Natural Evolution of Adaptive Immunity to MSP1 during Childhood in Holoendemic Malaria: Relation to Resistance to Blood Stage Plasmodium falciparum in vivo
	* Susan K. Pierce, NIAID, National Institutes of Health, USA The Generation and Maintenance of B Cell Immunological Memory in Response to Plasmodium falciparum
	William R. Heath, Walter and Eliza Hall Institute of Medical Research, Australia Murine Blood-Stage Plasmodium berghei Infection Induces Pathogen-Specific CD8+ Cytotoxic T cell Immunity
	Hajime Hisaeda, Kyushu University, Japan Short Talk: Malaria Parasites Require Toll-Like Receptor 9 Signaling for Immune Evasion by Activating Regulatory T Cells
	Maria Sophia Mackroth, Case Western Reserve University, USA Short Talk: Human Cord Blood CD4+CD25hi Regulatory T Cells Suppress Prenatally Acquired T Cell Response to Plasmodium falciparum Antigens

	Gabriela Minigo, Monash University, Australia Short Talk: Mechanisms of Induction of Unconventional CD25- Regulatory T Cells and Conventional Treg and Association with Parasitemia in Malaria Infection
	Michael Walther, Medical Research Council Laboratories, Fajara, Gambia Short Talk: Immunoregulation in Uncomplicated and Severe P. falciparum Malaria

	John T. Harty, University of Iowa, USA Short Talk: Numerical Requirements for Long-Term CD8+ T Cell Immunity to P. berghei Sporozoite Challenge
9:20 - 9:40 AM	Coffee Break	Otto Molden Foyer
11:30 AM- 12:30 PM	Lunch	Otto Molden Foyer
12:30 - 2:30 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 05/08/2008	Otto Molden Foyer
2:30 - 4:30 PM	Pathogenesis I Registered attendees for this meeting can view Abstracts for this session starting on 05/08/2008	Erwin Schrödinger Hall

	Kamija Phiri, College of Medicine, University of Malawi, Malawi Pathogenesis of Severe Anaemia in Malawian Children Living in a Malaria Endemic Area
	* Louis Schofield, Walter and Eliza Hall Institute of Medical Research, Australia Immunological Mechanisms Controlling Erythropoietic Suppression and Severe Anaemia in Experimental Malaria Infections
	Douglas Golenbock, University of Massachusetts Medical School, USA The Basis of Fever and Proinflammatory Cytokinemia in Acute Malaria
	Constance A. Finney, University of Toronto, Canada Short Talk: TLR Involvement during Experimental Malaria: Implications at both Ends of the Clinical Spectrum of Human Disease
4:30 - 5:00 PM	Coffee Available	Otto Molden Foyer
5:00 - 7:00 PM	Pathogenesis II - Cerebral Malaria Registered attendees for this meeting can view Abstracts for this session starting on 05/08/2008	Erwin Schrödinger Hall

	Dan Milner, Harvard School of Public Health, USA Pediatric Cerebral Malaria: Insights from the Ongoing Autopsy Study in Blantyre, Malawi
	Isabelle Medana, Oxford University, UK The Pathology and Pathophysiology of Cerebral Malaria in Adults

	* Georges E. R. Grau, University of Sydney, Australia Cerebral Malaria: Malarial Antigen Transfer by Microparticles or Trogocytosis as Effectors of Microvascular Endothelial Lesions
	Gregory S. Park, University of Minnesota, USA Short Talk: von Willebrand Factor, but not sVCAM-1 or sICAM-1, Effectively Discriminates between Cerebral and Uncomplicated Malaria in Ugandan Children
7:00 PM-	On Own for Dinner
Wednesday, June 11
7:00 - 8:00 AM	Breakfast	Your Lodging Location
8:00 - 11:30 AM	Pathogenesis III Registered attendees for this meeting can view Abstracts for this session starting on 05/08/2008	Erwin Schrödinger Hall
	Nicholas Beare, Royal Liverpool University Hospital, UK Retinal Microvasculature and the Pathophysiology of Cerebral Malaria
	* Nick M. Anstey, Menzies School of Health Research, Australia Impaired Nitric Oxide Bioavailability and Endothelial Dysfunction in Severe Malaria: A Target for Adjunctive Therapy?

	* Patrick E. Duffy, Seattle Biomedical Research Institute, USA Maternal and Fetal Factors Predict Malaria Outcomes during Infancy
	Adrian V.S. Hill, Jenner Institute, Oxford University, UK Immunogenetics of Disease Susceptibility
	Gabriele S.V. Campanella, Massachusetts General Hospital, USA Short Talk: Chemokine Receptor CXCR3 and its Ligands CXCL9 and CXCL10 are Required for the Development of Murine Cerebral Malaria
	Brendan J. McMorran, University of Tasmania, Australia Short Talk: Platelets have a Protective Role in Erythrocytic Stage Malaria Infection
	Katsuyuki Yui, Nagasaki University, Japan Short Talk: Malaria-Specific and Non-Specific Activation of CD8+ T-Cells during Blood Stage of Plasmodium berghei Infection
9:20 - 9:40 AM	Coffee Break	Otto Molden Foyer
11:30 AM- 1:00 PM	Poster Setup	Otto Molden Foyer
11:30 AM-	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Otto Molden Foyer
2:30 - 4:30 PM	Workshop: Presentations by Travel Scholarship Awardees	Erwin Schrödinger Hall
	Ana Maria Pamplona Santos, Instituto de Medicina Molecular, Portugal Heme Oxygenase-1 and Carbon Monoxide Suppress the Pathogenesis of Experimental Cerebral Malaria
	Patti Kiser, Colorado State University, USA IL-10-Producing CD4+T-Cells Mitigate Malaria-Associated Anemia
	Bernd Lepenies, Swiss Federal Institute of Technology Zurich, Switzerland Ligation of B and T Lymphocyte Attenuator (BTLA) Protects Mice from Cerebral Malaria during P. berghei ANKA Infection
	* Ian A. Cockburn, Johns Hopkins Bloomberg School of Public Health, USA Long-Term Antigen Presentation Following Exposure to Plasmodium Sporozoites may Induce T Cell Dysfunction
	Olivia Finney, London School of Hygiene and Tropical Medicine, UK Regulatory T Cells are Upregulated after Natural Exposure to Plasmodium falciparum
	Indu Malhotra, Case Western Reserve University, USA Effect of Prenatal Exposure to Malaria on the Susceptibility to Infection during Childhood
4:30 - 5:00 PM	Coffee Available	Otto Molden Foyer
5:00 - 7:15 PM	Vaccines I Registered attendees for this meeting can view Abstracts for this session starting on 05/08/2008	Erwin Schrödinger Hall
	Adrian V.S. Hill, Jenner Institute, Oxford University, UK Vectored Malaria Vaccines


	* Thomas L. Richie, Naval Medical Research Center, USA Developing a Multi-Stage, Multi-Antigen Adenovirus-Vectored Vaccine against P. falciparum Malaria
	Joe D. Cohen, GlaxoSmithKline Biologicals, Belgium The RTS,S. Malaria Vaccine Candidate: From Phase II to Phase III
	Alessandro D. Sette, La Jolla Institute for Allergy & Immunology, USA Short Talk: Meta-Analysis of Immune Epitope Data for Plasmodium Species: Overview and Applications for Malarial Immunobiology and Vaccine-Related Issues

	Sope Omowale Olugbile, Institut de Biochimie, Switzerland Short Talk: Novel Polyepitope Malaria Vaccine Candidate
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Otto Molden Foyer
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 05/08/2008	Otto Molden Foyer
Thursday, June 12
7:00 - 8:00 AM	Breakfast	Your Lodging Location
8:00 - 11:30 AM	Vaccines II Registered attendees for this meeting can view Abstracts for this session starting on 05/08/2008	Erwin Schrödinger Hall
	* Louis H. Miller, National Institutes of Health, USA Why a Malaria Vaccine is Possible
	Brendan S. Crabb, Burnet Institute, Australia New Insights into Merozoite Invasion and Post-Invasion Events
	Denise L. Doolan, Queensland Institute of Medical Research,, Australia Plasmodium falciparum Immunomics and Vaccine Development
	* Sanjai Kumar, Food and Drug Administration, USA Considerations for Whole Parasite Based Malaria Vaccines

	Arturo Reyes-Sandoval, Jenner Institute ORCRB, UK Short Talk: A Phase I Study to Assess the Safety and Immunogenicity of New Malaria Vaccine Candidate AdCh63 ME-TRAP, Alone and with MVA ME-TRAP, using a Prime-Boost Delivery Schedule

	Edmond Joseph Remarque, Biomedical Primate Research Centre, The Netherlands Short Talk: Diversity-Covering Immunization with Plasmodium falciparum AMA1 (PfAMA1) Induces Broader Allelic Recognition and Growth Inhibition Responses in Rabbits and Rhesus
	Toshihiro Horii, Research Institute for Microbial Diseases, Japan Short Talk: Learning from Interfacing Studies on SE36: A Candidate Malaria Vaccine that Targets the Achilles’ Heel Antigen of Plasmodium falciparum
9:20 - 9:40 AM	Coffee Break	Otto Molden Foyer
11:30 AM-	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Otto Molden Foyer
5:00 - 7:15 PM	Whole Parasite Vaccines Registered attendees for this meeting can view Abstracts for this session starting on 05/08/2008	Erwin Schrödinger Hall
	* Stephen L. Hoffman, Sanaria, USA Progress Toward Development of a Metabolically Active, Non Replicating Plasmodium falciparum Sporozoite Vaccine
	Stefan H.I. Kappe, Seattle Biomedical Research Institute, USA Genetically Engineered Malaria Parasite Vaccines

	Michael F. Good, Queensland Institute of Medical Research, Australia Could a Whole Parasite Vaccine be Effective Against the Blood Stages?
	Meta Roestenberg, Radboud University Medical Center Nijmegen, The Netherlands Short Talk: Sterile Protection against P. falciparum Challenge in Human Volunteers after Repeated Exposure to Sporozoites under Chloroquine Prophylaxis
	Kavita Singh, National Institutes of Health, USA Short Talk: Structures of the Plasmodium falciparum VAR2CSA DBL3x Domain and its Complex with Chondroitin Sulfate A that is Implicated in Pregnancy-Associated Malaria
7:15 - 7:30 PM	Closing Remarks Registered attendees for this meeting can view Abstracts for this session starting on 05/08/2008	Erwin Schrödinger Hall
	Nick M. Anstey, Menzies School of Health Research, Australia
7:30 - 8:30 PM	Social Hour w/ Lite Bites	Otto Molden Foyer
8:00 - 11:00 PM	Entertainment	Otto Molden Foyer
Friday, June 13
	Departure
*=Session Chair †=Speaker invited, not yet responded.

Keystone Symposia would like to thank the sponsor of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:

Sanaria Inc.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI078721-01

The contents of this program are solely the responsibility of the Conference Organizers and their speakers and do not necessarily represent the official views of the National Institutes of Health.

We gratefully acknowledge the companies that provide Keystone Symposia with additional meeting support, including marketing and advertising...

Click here to view these companies

Our increased knowledge in basic immunology is having dramatic repercussions on our understanding of the immune responses to the malaria parasite and how these contribute to parasite resistance and to immunopathogenesis. Consequently, we are refining our classical approach to malaria vaccine development which has been based centrally on production of recombinant proteins of the merozoite or sporozoite surface. While these still represent the major pathway, we can now evaluate our approaches in terms of adjuvants, vectors and prime boost approaches to optimize immune responses and chances of success. Simultaneously, we are re-evaluating approaches based on whole parasites (sporozoites, red cell stages) using attenuated and inactivated organisms. The meeting will bring together world leaders in the three inter-related sub themes and update all attendees on the complex interactions between induction of immune responses and the consequences, both positive (i.e. immunity) and negative (immune dysregulation and disease). We will hear the latest reports on clinical trials for both the leading subunit and whole organismal vaccines in a venue which will see scientists from both developed countries and malaria-endemic countries sharing ideas and planning strategic research collaborations.

Malaria: Immunology, Pathogenesis and Vaccine Perspectives (E3)