Keystone Symposia Conference | Structural Biology and Activation Mechanisms of Membrane Receptors

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Tuesday, September 16
3:00 - 7:30 PM	Registration	Palmerston Foyer
6:30 - 7:30 PM	Refreshments	Palmerston Foyer
7:30 - 9:30 PM	Keynote Session Registered attendees for this meeting can view Abstracts for this session starting on 08/16/2008	Palmerston
	* Pierre De Meyts, Hagedorn Research Institute, Novo Nordisk A/S, Denmark
	Michael C. Lawrence, Walter and Eliza Hall Institute of Medical Research, Australia Structural Insights into Ligand Binding in the Insulin Receptor Family
	Brian K. Kobilka, Stanford University, USA Structure and Dynamics of the Human beta 2 Adrenergic Receptor
Wednesday, September 17
7:30 - 8:30 AM	Breakfast	Golden Cliff/Eagles
7:30 - 11:30 AM	Poster Setup	Superior/Superior Lobby/Wasatch/Maybird
8:30 - 11:30 AM	Structural Biology of Ligands and Receptors of the Insulin/IGF Peptide Families Registered attendees for this meeting can view Abstracts for this session starting on 08/16/2008	Ballroom 2-3
	* Tom L. Blundell, University of Cambridge, UK
	Michael A. Weiss, Case Western Reserve University, USA How Insulin Binds: Studies with Photoaffinity Crosslinking
	Jonathan Whittaker, Case Western Reserve University, USA Insights into Insulin and IGF-I Ligand-Receptor Interactions from Mutational Analysis
	Briony E. Forbes, University of Adelaide, Australia IGF Structural Determinants Involved in Receptor and Binding Protein Binding
	Yvonne Jones, University of Oxford, UK Crystal Structure of the IGF-II/Mannose-6-Phosphate Receptor Complex
9:40 - 10:00 AM	Coffee Break	Ballroom Lobby
11:30 AM- 12:30 PM	Lunch	The Hall
12:30 - 2:30 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 08/16/2008	Superior/Superior Lobby/Wasatch/Maybird
2:30 - 4:30 PM	Workshop 1: New Structures or Structural Aspects	Palmerston
	Brian M. Baker, University of Notre Dame, USA T Cell Receptor Cross-Reactivity via Cooperative Conformational Plasticity
	* Tim R. Hercus, Hanson Institute, Australia The Structure of the GM-CSF Receptor Complex Reveals a New Mode of Cytokine Receptor Activation

	Jonathan K. Tyzack†, Trends in Biochemical Sciences, UK Dragging (and Zooming and Rotating) Publication of 3D Molecular Structures into the 21st Century
	Marie Parat, University of Montreal, Canada Molecular Analysis of Natriuretic Peptide Receptor: A Transmembrane Signal Transduction
	Lennart Zabeau, Ghent University, Belgium A Model for a Hexameric 2:4 Leptin:Leptin Receptor Complex
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby
5:00 - 7:00 PM	Evolution of the Insulin/IGF Receptor Systems Registered attendees for this meeting can view Abstracts for this session starting on 08/16/2008	Ballroom 2-3
	* Donald F. Steiner, University of Chicago, USA
	Pierre De Meyts, Hagedorn Research Institute, Novo Nordisk A/S, Denmark Structure, Function and Evolution of Ligands and Receptors of the Insulin Peptide Family
	Shu-Jin Chan, University of Chicago, USA Where Insulin Binds: Mapping Contact Points in the Insulin:Insulin Receptor Complex
	Robert S. Garofalo, Pfizer Global Research and Development, USA Insulin Receptors and Signaling in Drosophila
7:00 PM-	On Own for Dinner
Thursday, September 18
7:30 - 8:30 AM	Breakfast	Golden Cliff/Eagles
8:30 - 11:30 AM	From Receptor Structure to Activation Mechanism Registered attendees for this meeting can view Abstracts for this session starting on 08/16/2008	Ballroom 2-3
	* Joseph Schlessinger, Yale University School of Medicine, USA Cell Signaling by Receptor Tyrosine Kinases: From Basic Principles to Cancer Therapy
	Michael J. Waters, University of Queensland, Australia The Mechanism of Growth Hormone Receptor Activation Revisited
	Krzysztof Palczewski, Case Western Reserve University, USA Oligomerization and Activation of GPCRs: Insights from Rhodopsin Structures
	Wayne A. Hendrickson, Columbia University, USA Dimeric Associations in G-Protein Coupled Receptors
9:40 - 10:00 AM	Coffee Break	Ballroom Lobby
11:30 AM-	On Own for Lunch
4:30 - 5:00 PM	Coffee & Snacks Available	Palmerston Foyer
5:00 - 7:00 PM	The Proximal Steps of Receptor Activation and Signaling Registered attendees for this meeting can view Abstracts for this session starting on 08/16/2008	Ballroom 2-3
	* Kenneth Siddle, University of Cambridge, UK
	Linda J. Pike, Washington University School of Medicine, USA Negative Cooperativity in EGF Receptor Signaling
	Stevan R. Hubbard, New York University School of Medicine, USA Mechanisms of Protein Recruitment to the Insulin Receptor
	Tarik Issad, Institut Cochin-Institute de Recherches Biomédicales, France Dynamics of Insulin and IGF-I Receptor Partnerships using BRET (Bioluminescence Resonance Energy Transfer)
7:00 PM-	On Own for Dinner
Friday, September 19
7:30 - 8:30 AM	Breakfast	Golden Cliff/Eagles
7:30 - 11:30 AM	Poster Setup	Superior/Superior Lobby/Wasatch/Maybird
8:30 - 11:30 AM	Structure, Function and Crosstalk of G-Protein-Coupled Receptors (GPCRs) Registered attendees for this meeting can view Abstracts for this session starting on 08/16/2008	Ballroom 2-3
	* Gilbert Vassart, Université Libre de Bruxelles, Belgium
	Robert J. Lefkowitz, Howard Hughes Medical Institute at Duke University Medical Center, USA beta-Arrestin Biased Agonism at Seven Transmembrane Receptors
	Ross A.D. Bathgate, University of Melbourne, Australia Structural Relationships of the INSL/Relaxin Ligands and their G-Protein Coupled Receptors
	Sabine Costagliola, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Belgium Functional Significance of Oligomerization and Negative Cooperativity in Glycoprotein Hormone Receptors
	Ilpo Huhtaniemi, Imperial College London, UK In vivo Validation of LH Receptor Dimerization by Complementation in Knockout Mice
9:40 - 10:00 AM	Coffee Break	Ballroom Lobby
11:30 AM- 12:30 PM	Lunch	The Hall
12:30 - 2:30 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 08/16/2008	Superior/Superior Lobby/Wasatch/Maybird
2:30 - 4:30 PM	Workshop 2: New Methodological Approaches	Palmerston
	* Fariba M. Assadi-Porter, University of Wisconsin-Madison, USA Direct NMR Detection of the Binding of Functional Ligands to the Human Sweet Receptor, a Heterodimeric Family 3 GPCR
	Helen L. Attrill, University of Oxford, UK Characterising The Multimerization Of The Neurotensin Receptor Type I In Model Lipid Membrane Bilayers
	Nancy E. Caceres, Ludgwig Institute for Cancer Research, Belgium Investigating the Stoichiometry of the Active G-CSF Receptor (G-CSFR) Complex by Testing the Activity of coiled coil-G-CSFR Fusion Proteins
	Anja Krippner-Heidenreich, University of Newcastle, UK Efficient Activation of the Tumour Necrosis Factor (TNF) Receptor is Highly Determined by the Stalk Region
	Philippe Rondard, Institut de Génomique Fonctionnelle, France Molecular Functioning of the GABAB Receptor Revealed by Glycan Wedge Scanning
	Johannes van Agthoven, Biological NMR and Crystallography, France The Stoichiometry and Stability of the Prolactin/Prolactin Receptor Complex is Influenced by its N-Terminus
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby
5:00 - 7:00 PM	From Receptor Activation to Signal Transduction: Quantitative Approaches Registered attendees for this meeting can view Abstracts for this session starting on 08/16/2008	Ballroom 2-3
	* Ralph A. Bradshaw, University of California, San Francisco, USA
	Blagoy Blagoev, University of Southern Denmark, Denmark Quantitative Proteomics: Analysis of Signal Transduction Networks
	James Faeder, University of Pittsburgh School of Medicine, USA Structure-Based Modeling of EGF Receptor Signal Transduction

	Yuko Saeki, RIKEN, Genomic Sciences Center, Japan Crosstalk between Signaling and Transcription Produces Switch-like Response in ErbB Receptor Network
7:00 PM-	On Own for Dinner
Saturday, September 20
7:30 - 8:30 AM	Breakfast	Golden Cliff/Eagles
8:30 - 11:30 AM	Challenges in Structural Biology of Membrane Receptors Registered attendees for this meeting can view Abstracts for this session starting on 08/16/2008	Ballroom 2-3
	* Wayne A. Hendrickson, Columbia University, USA

	Gebhard F. X. Schertler, Medical Research Council, UK Structure of a Conformationally Stabilized beta1 Adrenergic G Protein-Coupled Receptor
	Ulf Skoglund, Karolinska Institutet, Sweden Studies on Proteins, Membrane Proteins and Receptors using Molecular Electron Tomography
	Milka Vrecl, Univerza v Ljubljani, Slovenia The Use of Bioluminescence Resonance Energy Transfer 2 (BRET2) to Study G-Protein-Coupled Receptor (GPCR) Partner Interactions
	Marisa Martin-Fernandez, Daresbury Laboratory, UK ErbB1 Inside-Out Signalling Regulates Global Ectodomain Orientation and Oligomer Topology
9:40 - 10:00 AM	Coffee Break	Ballroom Lobby
11:30 AM-	On Own for Lunch
4:30 - 5:00 PM	Coffee & Snacks Available	Palmerston Foyer
5:00 - 7:00 PM	Receptor Structural Biology and Drug Discovery Registered attendees for this meeting can view Abstracts for this session starting on 08/16/2008	Ballroom 2-3
	Maja Jensen, Plougmann and Vingtoft, Denmark Allosteric and Biological Properties of Insulin Mimetic and Antagonist Peptides Targeting the Insulin Receptor Binding Sites
	* Alexander Levitzki, Hebrew University of Jerusalem, Israel Developments in Signal Transduction Therapy of Cancer
	Tom L. Blundell, University of Cambridge, UK Targeting Membrane Receptors and Signalling Systems for Drug Discovery

7:00 - 7:30 PM	Social Hour	The Hall
7:30 - 8:30 PM	Dinner	The Hall
8:00 - 11:00 PM	Entertainment	Ballroom 2-3
Sunday, September 21
	Departure
*=Session Chair †=Speaker invited, not yet responded.

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Considerable progress has been made in understanding the structure and function of membrane receptors and receptor signaling complexes since the first radioligand binding studies nearly four decades ago. The structures of the extracellular domains of many receptors in diverse classes are now available. However, the structural data have not always provided unambiguous information as to what the relevant physiological structure is or the precise nature of the binding and activation mechanism. To get the full picture, it is necessary to integrate structural information, biochemical and molecular biology approaches such as site-directed mutagenesis, photoaffinity crosslinking and bioluminescence resonance energy transfer, kinetics, and mathematical modeling. This symposium brings together experts in these various disciplines, both seasoned and fresh, for an open-minded debate on how to realize this integrative approach. A strong theme of the meeting is that there are more similarities than previously estimated between the mechanisms of activation of various classes of receptors. The study of the biological evolution of the ligand and receptor families and signal transduction mechanisms also provides key information on highly conserved modules. Finally, the promises and challenges in translating our knowledge of the structural biology of membrane receptor signaling to drug discovery will be discussed.

Structural Biology and Activation Mechanisms of Membrane Receptors (S1)