Keystone Symposia Conference | Metabolism and Cardiovascular Risk

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Meeting Program

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Tuesday, September 23
3:00 - 7:30 PM	Registration	Foyer
6:30 - 7:30 PM	Refreshments	Foyer
7:30 - 8:30 PM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 08/23/2008	Peak 5
	* E. Dale Abel, University of Utah, USA

8:30 - 9:00 PM	Orientation for New Attendees and New Investigators Registered attendees for this meeting can view Abstracts for this session starting on 08/23/2008 NOTE: Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a "What to Expect during your Attendance" for interested delegates.	Peak 5
Wednesday, September 24
7:00 - 8:00 AM	Breakfast	Peaks 1-4
8:00 - 11:15 AM	New Genetic Insights Linking Metabolism and Cardiovascular Risk Registered attendees for this meeting can view Abstracts for this session starting on 08/23/2008	Peak 5




	Markku Laakso, Kuopio University Central Hospital, Finland Genetics of Type 2 Diabetes
	Ruth McPherson, University of Ottawa Heart Institute, Canada Genetic Insights into Coronary Artery Disease
	* Alan D. Attie, University of Wisconsin-Madison, USA Genes, Gene Networks, and Type 2 Diabetes




	Aldons J. Lusis, University of California, Los Angeles, USA Systems Biology of Cardiovascular Disease
	Zhiguang Su, The Jackson Laboratory, USA Short Talk: Obesity, Adiponectin, and HDL are Controlled by Common Genetic Factors in the Mouse
	Sudha Biddinger, Harvard University, USA Short Talk: Hepatic Insulin Resistance Suppresses Cholesterologenic Gene Expression by Inhibiting SREBP-2
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM- 1:00 PM	Poster Setup	Peaks 1-4
11:15 AM-	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Peaks 1-4
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Adipocytokines and Cardiovascular Risk Registered attendees for this meeting can view Abstracts for this session starting on 08/23/2008	Peak 5
	* Scott A. Summers, University of Utah, USA
	Kenneth Walsh, Boston University School of Medicine, USA Adiponectin and Cardiac Injury
	Daniel T. Eitzman, University of Michigan, USA Visceral Adipose Tissue and Atherosclerosis
	Cuihua Zhang, University of Missouri-Columbia, USA TNF-Alpha and Vascular Dysfunction
	Anne Marie Minihane, Hugh Sinclair Nutrition Group, UK Short Talk: Influence of a Leptin Receptor Gene Variant on Postprandial Triglyceride Metabolism: Impact of Gender
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Peaks 1-4
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 08/23/2008	Peaks 1-4
Thursday, September 25
7:00 - 8:00 AM	Breakfast	Peaks 1-4
8:00 - 11:15 AM	Insulin and Akt Signaling in the Heart and Vasculature Registered attendees for this meeting can view Abstracts for this session starting on 08/23/2008	Peak 5
	* Kenneth Walsh, Boston University School of Medicine, USA
	E. Dale Abel, University of Utah, USA Insulin and Growth Factor Regulation of Cardiac Mitochondria
	Anthony Rosenzweig, Beth Israel Deaconess Medical Center, USA Akt and SGK Signaling in the Heart
	William C. Sessa, Yale University School of Medicine, USA Role of Akt in the vasculature
	Paul L. Huang, Massachusetts General Hospital, USA eNOS, Metabolic Diseases, and Cardiovascular Risk
	Elena Galkina, Eastern Virginia Medical School, USA Short Talk: Accelerated Atherosclerosis in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous ApoE Knockout Mice
	Carlos Fernandez-Hernando, Yale School of Medicine, USA Short Talk: Endothelial Caveolin-1 Regulates the Progression of Atherosclerosis by Controlling LDL Infiltration, Expression of Vascular Adhesion Molecules and Production of Nitric Oxide
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM- 12:00 PM	Lunch	Peaks 1-4
12:00 - 2:30 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 08/23/2008	Peaks 1-4
2:30 - 4:30 PM	Workshop: Hot Topics in Cardiac and Vascular Metabolism	Peak 5
	* Ira J. Goldberg, Columbia University, USA
	* Karin E. Bornfeldt, University of Washington School of Medicine, USA

	Peter C. Lucas, University of Michigan, USA The CARMA3-Bcl10-MALT1 Signalosome as a mediator of Angiotensin II-dependent NF-kappaB activation and atherogenesis
	Jenny E. Kanter, University of Washington, USA Macrophage Long-Chain acyl-CoA Synthetase 1 Plays an Important Role in Lipid Loading by Inhibiting Cholesterol Efflux via ATP-Binding Cassette Transporter 1

	Heiko Bugger, University of Utah School of Medicine, USA Increased Myocardial Fatty Acid Uptake by Acyl-CoA Synthetase 1 Impairs Mitochondrial Function and Dynamics
	Xiaoyue Pan, SUNY Downstate Medical Center, USA Clock is Required for Diurnal and Food-Entrained Regulation of Plasma Lipids and Lipoproteins
	Zoltan P. Arany, Dana Farber Cancer Institute, USA Regulation of VEGF and Angiogenesis by the Transcriptional Coactivator PGC-1alpha
	Denis J. Glenn, University of California, San Francisco, USA Transgenic Expression of DGAT1 in Cardiac Myocytes Results in Cardiac Steatosis
	Adam Raymond Wende, University of Utah, USA Short-term, Cardiac Specific Overexpression of GLUT4 does not Rescue Metabolic and Contractile Dysfunction in the Diabetic Heart
	Leo Timmers, University Medical Center Utrecht, The Netherlands Cardioprotective Effects of Exenatide, a Glucagon-Like Peptide 1 Receptor Agonist
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Signaling Mechanisms Regulating Mitochondrial Function and Metabolism Registered attendees for this meeting can view Abstracts for this session starting on 08/23/2008	Peak 5
	* Margaret P. Chandler, Case Western Reserve University, USA
	Daniel P. Kelly, Burnham at Lake Nona, USA PGC1, Mitochondria and Cardiac Dysfunction in Insulin Resistance and Diabetes
	Jiandie Lin, University of Michigan Medical School, USA Transcriptional Networks in the Control of Energy Metabolism
	Martin E. Young, Baylor College of Medicine, USA Circadian Clocks and Cardiac Metabolism
	Michael N. Sack, National Institutes of Health, USA Short Talk: PGC-1alpha Integrates Insulin Signaling, Mitochondrial Regulation and Bioenergetic Function in Skeletal Muscle
7:00 PM-	On Own for Dinner
Friday, September 26
7:00 - 8:00 AM	Breakfast	Peaks 1-4
8:00 - 11:15 AM	Inflammation, Lipids and Other Risk Factors Registered attendees for this meeting can view Abstracts for this session starting on 08/23/2008	Peak 5

	Christopher K. Glass, University of California, San Diego, USA Transcriptional Regulation of Macrophage Function

	* Ajay Chawla, Stanford University Medical Center, USA Macrophage activation in obesity and insulin resistance
	Kitt F. Petersen, Yale University School of Medicine, USA Lipid-Mediated Insulin Resistance

	Li Wang, University of Utah, USA Nuclear Receptor SHP in Metabolic Regulation

	Michael G. Usher, University of Michigan, USA Short Talk: The Mineralocorticoid Receptor Controls Macrophage Polarization in Cardiovascular Inflammation
	Ming-Dong Wang, University of Ottawa Heart Institute, Canada Short Talk: SR-BI Deficiency in Macrophage Labeled with LDL-Derived Cholesterol Leads to Reduced in vivo Reverse Cholesterol Transport
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM- 1:00 PM	Poster Setup	Peaks 1-4
11:15 AM-	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Peaks 1-4
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:15 PM	Vascular Metabolism Registered attendees for this meeting can view Abstracts for this session starting on 08/23/2008	Peak 5
	* Alan R. Tall, Columbia University, USA
	Ira J. Goldberg, Columbia University, USA Glucose and Lipids in Cardiovascular Diseases
	Clay F. Semenkovich, Washington University School of Medicine, USA Vascular Metabolism and Atherosclerosis

	Jerry L. Nadler, Eastern Virginia Medical School, USA Inflammatory Mechanisms Linking Metabolic Changes and Atherosclerosis
	Cecilia M. Giachelli, University of Washington, USA Regulation of Vascular Calcification
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Peaks 1-4
7:30 - 10:00 PM	Open Viewing Poster Sessions 1 & 2 Registered attendees for this meeting can view Abstracts for this session starting on 08/23/2008	Peaks 1-4
Saturday, September 27
7:00 - 8:00 AM	Breakfast	Peaks 1-4
8:00 - 11:15 AM	Lipid Signaling and Lipotoxicity Registered attendees for this meeting can view Abstracts for this session starting on 08/23/2008	Peak 5
	* M. Mahmood Hussain†, SUNY Downstate Medical Center, USA
	Rudolf Zechner, University of Graz, Austria Adipose Triglyceride Lipase
	* Jean E. Schaffer, Washington University School of Medicine, USA Lipotoxicity: Mapping the Response to Metabolic Stress
	Jay W. Heinecke, University of Washington School of Medicine, USA Proteomics Implicates a Macrophage Sterol-Regulated Network in Atherogenesis
	Scott A. Summers, University of Utah, USA Ceramides, Insulin Resistance, and Metabolic Disease
	Luuk Jon Rijzewijk, Vrije Universiteit University Medical Center, The Netherlands Short Talk: The Phenotype of Human Diabetic-Lipotoxic Cardiomyopathy and the Effects of Anti-Steatotic PPARgamma-Agonist Therapy: Studies with PET and MRI/MRS
	Babak Razani, Washington University School of Medicine, USA Short Talk: Cardiac Fatty Acid Synthase Mediates Survival with Acute Stress
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM-	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Molecular Mechanisms of Atherosclerosis Registered attendees for this meeting can view Abstracts for this session starting on 08/23/2008	Peak 5

	Alan R. Tall, Columbia University, USA Anti-Atherogenic Mechanisms of HDL
	* Karin E. Bornfeldt, University of Washington School of Medicine, USA Diabetes-Accelerated Atherosclerosis: Evidence from a Mouse Model
	Edward Allen Fisher, New York University School of Medicine, USA Regulation of Atherosclerosis Regression in Novel Mouse Models and the Effects of Hyperglycemia
	Jason Voogt, KineMed, Inc., USA Short Talk: In vivo Effects of Two ApoA-1 Mimetics on Plasma Cholesterol Flux, de novo Cholesterol Synthesis and Reverse Cholesterol Transport
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Peaks 1-4
8:00 - 11:00 PM	Entertainment	Peaks 1-4
Sunday, September 28
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK076500-03

The contents of this program are solely the responsibility of the Conference Organizers and their speakers and do not necessarily represent the official views of the National Institutes of Health.

We gratefully acknowledge the companies that provide Keystone Symposia with additional meeting support, including marketing and advertising...

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Cardiovascular disease is the major cause of mortality in developed countries and emerging economies worldwide. Important risk factors include diabetes, obesity, and dyslipidemia. Given the growing worldwide epidemic of obesity and the metabolic syndrome, there is a critical need to understand the biological mechanisms that confer this increased risk. The most current research in this area has identified important mechanisms linking dyslipidemia and inflammation to the development of atherosclerosis, the role of adipokines in linking metabolic dysfunction and cardiovascular disease, and the role of insulin resistance and mitochondrial dysfunction in the pathogenesis of cardiac dysfunction. Recent genome-wide association studies have identified novel genetic loci that may link metabolic disorders with increased risk. The goals of this meeting are to present the latest data on: (1) genetic studies linking metabolism and cardiovascular risk; (2) new insights into the mechanisms linking insulin resistance with atherosclerosis and cardiac dysfunction; and (3) new insights into the role of altered insulin signaling and lipotoxicity in promoting cardiovascular disease in individuals with diabetes and the metabolic syndrome. The program will catalyze interactions that are likely to lead to new approaches to tackle the translation of fundamental observations to the prevention of cardiovascular disease in these vulnerable populations.

Metabolism and Cardiovascular Risk (S2)