Keystone Symposia Conference | Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota

Meeting Program

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Tuesday, January 13
3:00 - 7:30 PM	Registration	Chamisa Lobby
6:30 - 7:30 PM	Refreshments	Chamisa Ballroom 2
7:30 - 8:00 PM	Orientation	Chamisa Ballroom 2
Wednesday, January 14
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Protective Role of Innate Mucosal Immune Responses to Commensal Microbiota Registered attendees for this meeting can view Abstracts for this session starting on 12/13/2008	Chamisa Ballroom 1
	* Lloyd F. Mayer, Mount Sinai Medical Center, USA
	Scott Plevy, University of North Carolina, USA Protective Role of Heme Oxygenase and PI3 Kinase Isoforms
	Maria T. Abreu, University of Miami Miller School of Medicine, USA Mucosal TLR Regulation of Epithelial Integrity and Malignancy
	Eyal Raz, University of California, San Diego, USA Gut, Germs and Genes: The Tumorigenic Triad
	Andrea Cerutti, Weill Medical College of Cornell University, USA Regulation of IgA Switching by Epithelial Cells in Response to Bacterial Stimuli
	Sergio A. Lira, Mount Sinai School of Medicine, USA Short Talk: TLR Signaling in Small Intestinal Epithelium Promotes B Cell Recruitment and IgA Production in the Lamina Propria
	Nouara Lhocine, CGM-Centre National de la Recherche Scientifique, France Short Talk: PIMS Modulates Immune Tolerance by Negatively Regulating Drosophila Innate Immune Signaling
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM-	On Own for Lunch
11:15 AM- 1:00 PM	Poster Setup	Chamisa Ballroom 2
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 2
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Activation and Regulation of Mucosal NF-kappaB Registered attendees for this meeting can view Abstracts for this session starting on 12/13/2008	Chamisa Ballroom 1
	* Maria T. Abreu, University of Miami Miller School of Medicine, USA
	Christian Jobin, University of North Carolina at Chapel Hill, USA Host/Microbes Interaction: Lessons from Gnotobiotic Murine and Zebrafish NF-kB Reporter Gene System
	Averil I. Ma, University of California, San Francisco, USA Ubiquitin and Innate Immunity in Intestinal Homeostasis
	Maria del Carmen Alonso Cotoner, Massachusetts General Hospital and Harvard Medical School, USA Short Talk: GEF-H1 Mediates NOD1 Dependent NF-kB Activation Initiated by Shigella Flexneri Effectors
	Wen Zhou, University of Texas Southwestern Medical Center, USA Short Talk: FoxO4 inhibits NF-kappaB-Mediated Inflammatory Cytokine Expression and Protects Against Trinitrobenzene Sulfonic Acid-induced Colonic Injury and Inflammation in Mice
	Jun Sun, University of Rochester, USA Short Talk: Vitamin D Receptor Negatively Regulates in vivo NF-kappaB Activity in the Normal Colon and during Bacterial-Induced Intestinal Inflammation
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 12/13/2008	Chamisa Ballroom 2
Thursday, January 15
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Mechanisms of Bacterial Killing by Epithelial and Phagocytic Cells Registered attendees for this meeting can view Abstracts for this session starting on 12/13/2008	Chamisa Ballroom 1
	* R. Balfour Sartor, University of North Carolina at Chapel Hill, USA
	Ramnik Xavier, Massachusetts General Hospital, USA Crohn's Disease and Autophagy
	Jan Wehkamp, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Germany Mechanisms of Defensin Deficiency in IBD: From Epithelial Stem Cells to Chronic Inflammation
	Lora V. Hooper, University of Texas Southwestern Medical Center, USA Innate Immune Responses to Commensal Bacteria at the Gut Epithelial Surface
	Arlette Darfeuille-Michaud, Université d'Auvergne, France Crohn’s Disease-Associated Adherent-Invasive E. coli: Mechanisms of Intestinal Colonization, Evasion of Intracellular Killing and Development of Gut Inflammation
	Ye Yang, University of Oregon, USA Short Talk: Intestinal Alkaline Phosphatase Detoxifies LPS and Prevents Inflammation in Response to the Gut Microbiota
	Ajay S. Gulati, University of North Carolina, Chapel Hill, USA Short Talk: Effects of Murine Strain Variation on Intestinal Antimicrobial Peptide Expression
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM-	On Own for Lunch
11:15 AM- 1:00 PM	Poster Setup	Chamisa Ballroom 2
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 2
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Dendritic Cell Function at Mucosal Surfaces Registered attendees for this meeting can view Abstracts for this session starting on 12/13/2008	Chamisa Ballroom 1
	* Scott Plevy, University of North Carolina, USA
	Hans-Christian Reinecker, Massachusetts General Hospital, USA Regulatory Dendritic Cells in Control of Mucosal Inflammation and Restitution

	R. William DePaolo, University of Chicago, USA Short Talk: TLR6-Dependent Infectious Tolerance Mediated by a Yersinia Virulence Factor
	Peter Velázquez, Skirball Institute, USA Short Talk: Delineating Mucosal Dendritic Cell Networks via Intravital Microscopy
	Jacqueline Perrigoue, University of Pennsylvania, USA Short Talk: Delineating Requirements for Antigen Presentation in the Intestine
	Ting Feng, University of Alabama Birmingham, USA Short Talk: Regulation of Toll-like Receptor 5 Gene Expression in Mucosal Dendritic Cells
	InYoung Kim, University of Chicago, USA Short Talk: Extracellular Heat Shock Protein 70 is a Negative Regulator of the Innate Immune System
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 12/13/2008	Chamisa Ballroom 2
Friday, January 16
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Effector T Cell Responses in Intestinal Inflammation Registered attendees for this meeting can view Abstracts for this session starting on 12/13/2008	Chamisa Ballroom 1
	* Charles O. Elson, University of Alabama, USA
	Casey T. Weaver, University of Alabama at Birmingham, USA TH17 Responses in Intestinal Inflammation
	Fiona M. Powrie, University of Oxford, UK Mechanisms of T Cell-Mediated Experimental Colitis
	Bana Jabri, University of Chicago, USA Intraepithelial NK Lymphocytes
	Jesús Rivera-Nieves, University of Colorado Health Sciences Center, USA Recruitment of T Cells to Chronically Inflamed Small Bowel
	Anisa Ismail, University of Texas, Southwestern Medical Center, USA Short Talk: Interactions between Commensal Bacteria and gamma delta Intraepithelial Lymphocytes during Mucosal Injury
	Kim Phung Le Nguyen, University of California, San Diego, USA Short Talk: Cholera Toxin Induces cAMP-Dependent Th17 Differentiation by Dendritic Cells
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM-	On Own for Lunch
11:15 AM- 1:00 PM	Poster Setup	Chamisa Ballroom 2
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 2
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Microbial Activation of Immune-Mediated Intestinal Inflammation Registered attendees for this meeting can view Abstracts for this session starting on 12/13/2008	Chamisa Ballroom 1
	* Casey T. Weaver, University of Alabama at Birmingham, USA
	Charles O. Elson, University of Alabama, USA Flagellin-Specific T Cell Responses in Experimental Colitis
	Sandra Kim, University of North Carolina at Chapel Hill, USA Bacterial and Host Specificity in Immune - Mediated Experimental Colitis
	Jochen Mattner, Cincinnati Children's Hospital Medical Center, USA The Role of Alphaproteobacteria in the Induction of Autoimmunity
	Wendy S. Garrett, Harvard School of Public Health, USA Short Talk: Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 12/13/2008	Chamisa Ballroom 2
Saturday, January 17
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Regulation of Mucosal Immune Response to Microbial Components Registered attendees for this meeting can view Abstracts for this session starting on 12/13/2008	Chamisa Ballroom 1

	Craig L. Maynard, University of Alabama at Birmingham, USA Tracking T Regulatory Cells in the Intestine
	Yasmine Belkaid, NIAID, National Institutes of Health, USA Commensal DNA Limits Regulatory T Cell Conversion and is a Natural Adjuvant of Intestinal Immune Responses
	Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA Role of TGF-beta in Regulating the Balance between Pathogenic and Regulatory T Cells
	William A. Faubion, Mayo Clinic, USA The Functional Relevance of Pathogen Recognition Receptor Expression in Human T Regulatory Cells
	Betsy C. Taylor, University of Pennsylvania, USA Short Talk: TSLP-TSLPR Interactions Regulate Intestinal Immunity and Inflammation

9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM-	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Translation of Basic Research to Biomedical Applications Registered attendees for this meeting can view Abstracts for this session starting on 12/13/2008	Chamisa Ballroom 1
	* Scott Plevy, University of North Carolina, USA
	Rene de Waal Malefyt, Schering-Plough, USA The Role of IL-23 and Th17 Cells in Chronic Immune Mediated Inflammatory Diseases

	Kevan C. Herold, Yale University, USA Induction of CD8+ Regulatory T Cells with Anti-CD3 Monoclonal Antibody
	Huabao Xiong, Mount Sinai School of Medicine, USA Blocking the TLR Signaling Pathway using TLR Peptides in the Treatment of Colitis
	Edwin F. de Zoeten, Children's Hospital of Philadelphia, USA Short Talk: Regulation of Foxp3+ Regulatory T Cells (Treg) by Small Molecule Targeting of HDAC6, Enhances Treg Function and Ameliorates Development of IBD in Murine Models
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
8:00 - 11:00 PM	Entertainment	Chamisa Ballroom 2
Sunday, January 18
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:

	Schering-Plough Research Institute
United European Gastroenterology Federation

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI079896-01

The contents of this program are solely the responsibility of the Conference Organizers and their speakers and do not necessarily represent the official views of the National Institutes of Health.

We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

Click here to view these companies

Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the pathophysiology of chronic intestinal inflammation such as Crohn’s disease, ulcerative colitis and pouchitis and emphasize innate and adaptive immunoregulatory mechanisms that mediate mucosal homeostasis in a hostile environment. Major unresolved issues in mucosal immunology are as follows: (1) understanding how epithelial cells coexist with commensal intestinal bacteria, yet recognize the pathogenic organisms; (2) understanding how effector mechanisms in innate immune cells and T cells are appropriately downregulated; and (3) how understanding of basic immune regulation and inflammation can lead to the development of novel therapeutic agents for chronic inflammatory bowel diseases. This meeting presents state of the art lectures on the most recent research on innate, adaptive and regulatory immune responses to commensal bacteria, promotes interdisciplinary research interactions and explores several novel therapeutic approaches derived from recent pathogenic insights.

Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6)