Keystone Symposia Conference | Frontiers of NMR in Biology

Meeting Program

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Sunday, February 15
3:00 - 7:30 PM	Registration	Promenade
6:30 - 7:30 PM	Refreshments	Promenade
7:30 - 9:30 PM	Keynote Session: Roles of NMR and X-ray in the Future of Biology Registered attendees for this meeting can view Abstracts for this session starting on 01/15/2009	Mesa Ballroom
	Peter E. Wright, The Scripps Research Institute, USA Beyond 3D Structure: Insights from NMR into Protein Disorder, Dynamics, and Interactions
	Wayne A. Hendrickson, Columbia University, USA Title to be Determined
Monday, February 16
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	New Methods Registered attendees for this meeting can view Abstracts for this session starting on 01/15/2009	Mesa Ballroom
	Ad Bax, NIDDK, National Institutes of Health, USA Proteins, Membranes, and Their Interaction Viewed by NMR
	Stephan Grzesiek, University of Basel, Switzerland Probing Protein Structure and Dynamics of Unfolded and Folded Proteins by NMR
	Christian Griesinger, Max Planck Institute for Biophysical Chemistry, Germany Recognition Dynamics from NMR Residual Dipolar Couplings
	Robert G. Griffin, Massachusetts Institute of Technology, USA Protein Structure Determination with Solid State NMR
	Erik R. P. Zuiderweg, University of Michigan, USA Short Talk: Structural Basis of the Allosteric Trigger of the Hsp70 Chaperone Proteins

9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM-	On Own for Lunch
11:00 AM- 1:00 PM	Poster Setup	Chamisa/Ortiz
1:00 - 10:00 PM	Poster Viewing	Chamisa/Ortiz
2:30 - 4:30 PM	Workshop 1: Tackling Membrane Proteins	Mesa Ballroom
	Mark Girvin, Albert Einstein College of Medicine, USA
	Francesca M. Marassi, Burnham Institute, USA NMR of Membrane Proteins in Lipid Bilayers, Bicelles, and Micelles
	Ichio Shimada, University of Tokyo, Japan Interaction Analyses between Membrane Proteins and Ligands
	Chad M. Rienstra, University of Illinois, USA Magic-Angle Spinning NMR for Membrane Protein Structure Determination
	Volker Dötsch, University of Frankfurt, Germany Combnation of Cell-Free Expresison and Liquid State NMR Spectroscopy for the Structural Investigation of Membrane Proteins
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:00 PM	Protein Folding and Dynamics Registered attendees for this meeting can view Abstracts for this session starting on 01/15/2009	Mesa Ballroom
	Charles R. Sanders, Vanderbilt University School of Medicine, USA NMR Studies of the Transmembrane C-Terminal Domain of the Amyloid Precursor Protein: Does APP Function as a Cholesterol Sensor?

	Brian F. Volkman, Medical College of Wisconsin, USA Native state interconversion between unrelated protein folds

	Robert Tycko, National Institutes of Health, USA Solid State NMR of Amyloid Fibrils and Freeze-Trapped Protein Folding Intermediates
	Anthony Mittermaier, McGill University, Canada Short Talk: Mapping the Energy Landscape of Protein Folding and Binding Using NMR and Calorimetry
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa/Ortiz
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 01/15/2009	Chamisa/Ortiz
Tuesday, February 17
7:00 - 8:00 AM	Breakfast	Chamisa
7:00 - 8:00 AM	Poster Setup	Chamisa/Ortiz
8:00 - 11:00 AM	Membrane Proteins Registered attendees for this meeting can view Abstracts for this session starting on 01/15/2009	Mesa Ballroom
	Ann E. McDermott, Columbia University, USA Solid State NMR of Protein Dynamics

	Lukas K. Tamm, University of Virginia, USA Structure and Dynamics of OmpG in Detergent Micelles
	Mei Hong, Iowa State University, USA Dynamic Conformation and Orientation of Membrane Proteins
	Stanley J. Opella, University of California, San Diego, USA Membrane Proteins Studied by Solid State NMR
	Daniel Nietlispach, University of Cambridge, UK Short Talk: Solution-NMR Structural Studies of the 7-Helix Transmembrane Receptor Sensory Rhodopsin pSRII
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM- 12:00 PM	Lunch	Chamisa
12:00 - 2:30 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 01/15/2009	Chamisa/Ortiz
2:30 - 4:30 PM	Workshop 2: Paramagnetic Relaxation Enhancement and Residual Dipolar Coupling	Mesa Ballroom
	Angela M. Gronenborn, University of Pittsburgh, USA
	Alexander Grishaev, NIDDK, National Institutes of Health, USA Combining RDC and Scattering Data for Structure Determination
	Lucia Banci, University of Florence, Italy Title to be Determined
	Rieko Ishima, University of Pittsburgh School of Medicine, USA Application of F-19 NMR to Study Protein Structure and Dynamics
	Rafael Bruschweiler, Florida State University, USA Structural Protein Dynamics Elucidated by Spin Relaxation, Dipolar Couplings, and Computation
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:00 PM	Protein Dynamics and Transient States Registered attendees for this meeting can view Abstracts for this session starting on 01/15/2009	Mesa Ballroom
	G. Marius Clore, NIDDK, National Institutes of Health, USA Visualizing Lowly-Populated Regions of the Free Energy Landscape of Macromolecular Complexes by Paramagnetic Relaxation Enhancement
	Dorothee Kern, Brandeis University, USA The Climb Over the Mountain – Molecular Pathways of Conformational Transitions
	Gary P. Drobny, University of Washington, USA Dynamics of Nucleic Acids
	Giuseppe Melacini, McMaster University, Canada Short Talk: Understanding cAMP-Dependent Allostery by NMR Spectroscopy
7:00 PM-	On Own for Dinner
Wednesday, February 18
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Human Disease Targets Registered attendees for this meeting can view Abstracts for this session starting on 01/15/2009	Mesa Ballroom

	Torleif Hard, University of Gothenburg, Sweden An Engineered Monomer Binding Protein Eliminates Alzheimer Amyloid-Beta Peptide Neurotoxicity



	Michael F. Summers, University of Maryland Baltimore County and HHMI, USA Structural Basis for Trafficking of HIV-1 and HIV-2 Proteins to Virus Assembly Sites
	Michael K. Rosen, University of Texas Southwestern Medical Center, USA Dynamic Origins of Interdomain Cooperativity in the Vav1 Proto-Oncoprotein
	Juli Feigon, University of California, Los Angeles, USA Structure and Function of Human Telomerase and H/ACA RNA
	Christopher B. Marshall, Ontario Cancer Institute, Canada Short Talk: Characterization of Intrinsic and TSC2 GAP-Accelerated GTPase Activity of Rheb by Real-Time NMR
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM-	On Own for Lunch
11:00 AM- 1:00 PM	Poster Setup	Chamisa/Ortiz
1:00 - 10:00 PM	Poster Viewing	Chamisa/Ortiz
2:30 - 4:30 PM	Workshop 3: Automation and Refinement Methods	Mesa Ballroom
	John L. Markley, University of Wisconsin, Madison, USA Approaches to the Investigation of More Challenging Proteins and Protein Complexes
	Masatsune Kainosho, Nagoya University, Japan Applications of the Residue-Selective SAIL Approach for Structures and Dynamics of Proteins
	David A. Case, Rutgers University, USA Building Better Models for Rotational Diffusion in Biomolecular NMR
	Alexandre M.J.J. Bonvin, Universiteit Utrecht, Netherlands Information-Driven Modeling of Biomolecular Complexes
	Vladislav Orekhov, Gothenburg University, Sweden Hyper-Dimensional NMR Spectroscopy with Multi Dimensional Decomposition
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:00 PM	Macromolecular Interactions Registered attendees for this meeting can view Abstracts for this session starting on 01/15/2009	Mesa Ballroom
	Robert B. Russell, EMBL-Heidelberg, Germany Discovery of New Peptides Mediating Interaction Networks

	James Jeiwen Chou, Harvard Medical School, USA NMR Studies of Viral Proton Channels
	Gerhard Wagner, Harvard Medical School, USA Topology and Regulation of the eIF4A/4G/4H Helicase Complex in Translation Initiation
	Masayori Inouye†, University of Medicine and Dentistry of New Jersey, USA Short Talk: Production and Isotopic Enrichment of a Single Membrane Protein in E. coli for NMR Studies without Purification
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa/Ortiz
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 01/15/2009	Chamisa/Ortiz
Thursday, February 19
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Drug Discovery and Chemical Biology Registered attendees for this meeting can view Abstracts for this session starting on 01/15/2009	Mesa Ballroom
	Maurizio Pellecchia, Burnham Institute, USA NMR Based Drug Discovery: Screening and Design of Novel Chemical Probes

	Patricia J. LiWang, University of California, Merced, USA Structural and Functional Studies of Chemokines: Blocking HIV-1 and Stopping Inflammation
	Wolfgang Jahnke, Novartis Institutes for BioMedical Research, Switzerland NMR in Drug Discovery: The Blessing and Curse of Versatility
	Benjamin F. Cravatt III, The Scripps Research Institute, USA Activity-Based Proteomics
	Timothy A. Cross, Florida State University, USA Short Talk: Solid State NMR: A Novel Approach for Membrane Protein Drug Screening
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM-	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:00 PM	Large Systems and New Methods Registered attendees for this meeting can view Abstracts for this session starting on 01/15/2009	Mesa Ballroom
	Patrik Lundstrom, University of Toronto, Canada Short Talk: Accurate Measurement of Protein Excited State Chemical Shifts by Relaxation Dispersion NMR Spectroscopy

	Charalampos Kalodimos, Rutgers University, USA NMR of the Transcription Machinery
	James H. Prestegard, University of Georgia, USA Sparse Labeling and Resonance Assignments for Structural Studies of Large and Glycosylated Proteins
	Kurt Wüthrich, ETH Zurich/The Scripps Research Institute, Switzerland Automation in NMR Structure Determination of Proteins in Solution
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mesa C
8:00 - 11:00 PM	Registered attendees for this meeting can view Abstracts for this session starting on 01/15/2009	Mesa C
Friday, February 20
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:


	Anatrace, Inc.
Isotec, a member of the Sigma-Aldrich Group	New Era Enterprises, Inc.

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM086958-01

The contents of this program are solely the responsibility of the Conference Organizers and their speakers and do not necessarily represent the official views of the National Institutes of Health.

We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

Click here to view these companies

Over the past several decades Nuclear Magnetic Resonance (NMR) spectroscopy has become an indispensable tool in structural and molecular biology, with most recent contributions to genomics, proteomics and metabolomics. Advances in NMR technology would not be possible without our continued efforts to develop new methodologies and applications. This symposium will focus on the latest technological advances in NMR spectroscopy as well as recent biological discoveries made through NMR studies. Emphasis will be placed on the investigation of large biological systems, membrane proteins, folding and dynamics, and transient states of enzymatic reactions or protein interactions. As such, those using NMR have been extending its application to more complex and challenging systems in combination with other biophysical tools such as X-ray crystallography and electron microscopy. The purpose of this symposium is to provide a forum for discussion on these and other new trends in biological NMR.

Frontiers of NMR in Biology (B8)