Keystone Symposia Conference | The Neurobiology of Pain and Analgesia

Meeting Program

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Sunday, February 22
3:00 - 7:30 PM	Registration	Promenade
6:30 - 7:30 PM	Refreshments	Promenade
7:30 - 9:30 PM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2009	Mesa A-B
	* Clifford J. Woolf, Massachusetts General Hospital, USA

	Michael J. Detke, Eli Lilly and Company, USA New Treatments for Pain: Starting with the End in Mind – Market, Regulatory, and Development Challenges, and How These Relate to Neurobiology
	Xinzhong Dong, Johns Hopkins University, USA Short Talk: Regulation of TRP Channels by Pirt

	Samer Eid, Merck & Co., Inc., USA Short Talk: To Feel or not to Feel - Targeting the Heat Sensor TRPV1 for Pain Treatment
Monday, February 23
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Nociceptor Transduction and Plasticity Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2009	Mesa A-B
	* Ardem Patapoutian, The Scripps Research Institute, USA
	Jon Levine, University of California, San Francisco, USA Kinases - Nociceptors Pain Switches
	Peter McNaughton, University of Cambridge, UK Sensitization in Nociceptors
	David Shelton, Rinat Laboratories, Pfizer Global Research and Development, USA NGF and Anti-NGF: The Ying and Yang of Pain
	Stephen B. McMahon, King's College London, UK Nociceptor Mechano-Sensitisation Induced by UVB Irradiation in Human and Rodent Skin
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM-	On Own for Lunch
11:00 AM- 1:00 PM	Poster Setup	Ortiz
1:00 - 10:00 PM	Poster Viewing	Ortiz
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:00 PM	TRP Channels Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2009	Mesa A-B
	* Stephen B. McMahon, King's College London, UK
	Ardem Patapoutian, The Scripps Research Institute, USA Molecular Mechanisms of Thermosensation
	David Julius, University of California, San Francisco, USA From Peppers to Peppermints: Natural Products as Probes of the Pain Pathway
	Magdalene Moran, Hydra Biosciences, USA TRPs as Analgesic Drug Targets
	Cheryl L. Stucky, Medical College of Wisconsin, USA Short Talk: TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons via Neuronal and Keratinocyte Expression
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Ortiz
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2009	Ortiz
Tuesday, February 24
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Synaptic Plasticity Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2009	Mesa A-B
	* David Julius, University of California, San Francisco, USA
	Robert W. Gereau, Washington University Pain Center, USA Postsynaptic Mechanisms of Plasticity in Dorsal Horn Neurons
	Sandra Garraway, Texas A & M, USA Activation of Neuronal ERK2 is Required for Inflammation-Induced Pain
	Frank Porreca, University of Arizona, USA Modulating Descending Modulation
	Hans Ulrich Zeilhofer, University of Zurich, Switzerland GABA-A Receptor Subunit-Specific Analgesia
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM-	On Own for Lunch
11:00 AM- 1:00 PM	Poster Setup	Ortiz
1:00 - 10:00 PM	Poster Viewing	Ortiz
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:00 PM	Sodium and Calcium Channels Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2009	Mesa A-B
	* Frank Porreca, University of Arizona, USA
	Peter W. Reeh, University of Erlangen - Nurnberg, Germany Nociceptor Sodium Channels – Few but Decisive

	John Wood, University College London, UK Sodium Channels, MicroRNAs and Peripheral Pain Thresholds"
	Diane Lipscombe, Brown University, USA Nociceptors Modulate Calcium Channel Activity by Alternative Splicing.
	Sarah E. Canetta, Columbia University, USA Short Talk: Type III Nrg1-erbB Signaling Affects Peripheral Nociception
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Ortiz
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2009	Ortiz
Wednesday, February 25
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Discovering Pain Targets Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2009	Mesa A-B
	* Simon Tate, GlaxoSmithKline, UK
	Clifford J. Woolf, Massachusetts General Hospital, USA Finding Novel Analgesic Targets
	Qiufu Ma, Dana Farber Cancer Institute, USA Regulation of Nociceptor Phenotype and Pain Behavior
	Benjamin F. Cravatt III, The Scripps Research Institute, USA Modulating Pain by Blockade of Endocannabinoid Metabolism
	Gary R. Lewin, Max-Delbruck Center for Molecular Medicine, Germany Mechanostransducers as Targets for Pain Therapy
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM-	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:00 PM	Pain Circuits Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2009	Mesa A-B
	* Robert W. Gereau, Washington University Pain Center, USA
	Mark Zylka, University of North Carolina, USA Biochemical Modulation of Nociceptive Circuits
	Allan I. Basbaum, University of California, San Francisco, USA Nociceptive Pathways
	Joyce A. DeLeo, Dartmouth-Hitchcock Medical Center, USA Glial-Neuronal Circuits
	Sarah Ross, Harvard Medical School, USA Short Talk: Bhlhb5 Is Critical for the Formation of Nociceptive Circuits in the Developing Spinal Cord
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Ortiz
Thursday, February 26
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Validating Pain Targets and Developing Analgesics Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2009	Mesa A-B
	* Allan I. Basbaum, University of California, San Francisco, USA
	Simon Tate, GlaxoSmithKline, UK Progressing Pain Targets: A Focus on in vitro Screening
	Rohini Kuner, University of Heidelberg, Germany Murine Analgesic Target Validation
	Prisca Honore, Abbott Laboratories, USA Analgesia - Pharmacological Validation
	Kenneth M. Verburg, Pfizer Inc., USA Pain Therapeutics: Focus on Development
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM-	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:00 PM	Pain Genetics Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2009	Mesa A-B
	* John Wood, University College London, UK
	Annemieke Kavelaars, University Medical Center Utrecht, The Netherlands Short Talk: GRK2 Deficiency Prolongs PGE2-Induced Hyperalgesia via a Switch in Signaling from PKA to ERK
	Michele Hummel, Wyeth Research, USA Short Talk: Corticotropin Releasing Factor1 Receptors Mediate Inflammatory- and Neuropathic-Like Pain
	Achim Schmidtko, University of Frankfurt, Germany Short Talk: Reduced Inflammatory and Neuropathic Pain in Mice Lacking Nitric Oxide-Sensitive Guanylyl Cyclase

	Jeff S. Mogil, McGill University, Canada Genetics of Pain in the Laboratory Mouse
	Luda Diatchenko, University of North Carolina School of Dentistry, USA Expansion of the Human ì-Opioid Receptor Gene Locus: Novel Functional Variants
7:00 - 7:15 PM	Concluding Remarks Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2009	Mesa A-B
	Clifford J. Woolf, Massachusetts General Hospital, USA
	Simon Tate, GlaxoSmithKline, UK
	Ardem Patapoutian, The Scripps Research Institute, USA
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Mesa Ballroom
8:00 - 11:00 PM	Entertainment	Mesa Ballroom
Friday, February 27
	Departure
*=Session Chair †=Speaker invited, not yet responded.

Keystone Symposia would like to thank the sponsors of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:

Eli Lilly and Company	GlaxoSmithKline
Pfizer Global Research & Development	Pfizer Inc.

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS064604-01

The contents of this program are solely the responsibility of the Conference Organizers and their speakers and do not necessarily represent the official views of the National Institutes of Health.

We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

Click here to view these companies

This symposium will highlight the substantial advances made in our understanding of the neurobiology and pathophysiology of pain and the enormous opportunities these present for identifying and exploiting new targets for therapy. Current therapy is largely empirical and is based on suppressing symptoms. The future offers treatment targeted at the specific neural mechanisms responsible. This requires understanding the mechanisms, being able to identify which mechanism operates in which patient, and having pharmacological tools to act on the molecular targets that drive these mechanisms. Furthermore, we need to identify which patient is at risk of developing pain and develop preventative disease-modifying treatments to abort the establishment of pain. This symposium will address how these goals can be achieved by the combined effort of academics and industry.

The Neurobiology of Pain and Analgesia (C2)