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NOTE: This meeting occurs in 2009 (June 5 - 10, 2009)

LANGUAGE NOTE: This meeting will be conducted in English.
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Meeting Program

To view program in "24 hour" time (international) click here.


Friday, June 5
3:00 - 7:30 PM Registration Longs Peak Foyer
6:30 - 7:30 PM Refreshments Longs Peak Foyer
7:30 - 8:30 PM Keynote Address
Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009 		Grays/Long Peak
Kenneth A. Dill, University of California, San Francisco, USA
Protein Structure and Dynamics - Energy Landscapes
Saturday, June 6
7:00 - 8:00 AM Breakfast Quandary Peak
8:00 - 11:00 AM Dynamics, Energy Landscapes and Evolutionary Selection
Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009 		Grays/Long Peak
Hans Frauenfelder, Los Alamos National Laboratory, USA
The Role of Structure, Energy Landscape, Dynamics, and Allostery in the Enzymatic Function of Myoglobin
Cecilia Clementi, Rice University, USA
Folding Landscape of Monomeric Lactose Repressor: Quantitative Comparison of Theory and Experiment
Shoshana Wodak, Hospital for Sick Children, Canada
Evolutionary Selection and Allostery
Michele Vendruscolo, University of Cambridge, UK
Encoding Conformational Shifts in Sequences
Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM Coffee Break Longs Peak Foyer
11:00 AM- 1:00 PM Poster Setup Quandary Peak
11:00 AM- On Own for Lunch
1:00 - 10:00 PM Poster Viewing Quandary Peak
2:30 - 4:30 PM Workshop
 Grays/Long Peak
Short Talks to be Chosen from Abstracts, , USA
4:30 - 5:00 PM Coffee Available Longs Peak Foyer
5:00 - 7:00 PM Catalysis and Allostery
Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009 		Grays/Long Peak
Patrick Loria, Yale University, USA
Dynamic Requirements for a Functional Protein Hinge
Sebastian Doniach, Stanford University, USA
Mechanism of Dynamical Couplings and Translocation in Hepatitis C Virus NS3 Helicase Using Elastic Network Model
Susan S. Taylor, University of California, San Diego, USA
Allostery and Kinase Functions
Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM Social Hour w/ Lite Bites Quandary Peak
7:30 - 10:00 PM Poster Session 1
Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009 		Quandary Peak
Sunday, June 7
7:00 - 8:00 AM Breakfast Quandary Peak
8:00 - 11:00 AM Allosteric Events in Membrane Proteins
Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009 		Grays/Long Peak
Jean-Pierre Changeux, Institut Pasteur, France
Keynote Address: The Nicotinic Acetylcholine Receptor: A Membrane Allosteric Protein Engaged in Neuronal Communications
D. Peter Tieleman, University of Calgary, Canada
Coupling between Nucleotide Binding and Transmembrane Domains in ABC Transporters
Ivet Bahar, University of Pittsburgh, USA
Allosteric Dynamics of Glutamate Transporters: Insights from Multiscale Computations
Heidi E. Hamm, Vanderbilt University School of Medicine, USA
Using EPR Spectra for Mapping Allosteric Connections from the Receptor to the Nucleotide-Binding Pocket of Heterotrimeric G Proteins
Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM Coffee Break Longs Peak Foyer
11:00 AM- 1:00 PM Poster Setup Quandary Peak
11:00 AM- On Own for Lunch
1:00 - 10:00 PM Poster Viewing Quandary Peak
4:30 - 5:00 PM Coffee Available Longs Peak Foyer
5:00 - 7:00 PM Dynamics and Biomolecular Machines
Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009 		Grays/Long Peak
Ada Yonath, Weizmann Institute of Science, Israel
Ribosomal Machinery: Peptide Bond Formation, Chaperone Assistance, and Antibiotics Inactivation
Devarajan Thirumalai, University of Maryland, USA
Common Themes in the Dynamics of Allosteric Transitions in Molecular Machines
Amnon Horovitz, Weizmann Institute of Science, Israel
Pathway(s) of the ATP-Induced Allosteric Transitions of GroEL
Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM Social Hour w/ Lite Bites Quandary Peak
7:30 - 10:00 PM Poster Session 2
Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009 		Quandary Peak
Monday, June 8
7:00 - 8:00 AM Breakfast Quandary Peak
8:00 - 11:00 AM Signal Propagation in Molecular and Cellular Systems I
Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009 		Grays/Long Peak
Vincent J. Hilser, University of Texas Medical Branch, USA
Allostery in Ensembles
Kevin Donald Ridge, University of Texas, Houston, USA
Signaling via Structure Change: GPCR Mediated G Protein Signaling
Michael Grabe, University of Pittsburgh, USA
Structure Prediction for the Down State of a Potassium Channel Voltage Sensor
Lila M. Gierasch, University of Massachusetts Amherst, USA
The Changing Landscape of Protein Allostery
Short Talk(s) to be Chosen from Abstracts,
Hot Topics
9:20 - 9:40 AM Coffee Break Longs Peak Foyer
11:00 AM- 1:00 PM Poster Setup Quandary Peak
11:00 AM- On Own for Lunch
1:00 - 10:00 PM Poster Viewing Quandary Peak
4:30 - 5:00 PM Coffee Available Longs Peak Foyer
5:00 - 7:00 PM Signal Propagation in Molecular and Cellular Systems II
Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009 		Grays/Long Peak
Rama Ranganathan, University of Texas Southwestern Medical Center, USA
A Global Analysis of Cross-talk in a Mammalian Cellular Signaling Network - or - Natural-like Function in Artificial WW Domains
David A. Agard, University of California, San Francisco, USA
Dramatic Nucleotide-Dependent Conformational Rearrangements in the E. coli hsp90
Andrew Hopkins†, University of Dundee, UK
Network Pharmacology
Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM Social Hour w/ Lite Bites Quandary Peak
7:30 - 10:00 PM Poster Session 3
Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009 		Quandary Peak
Tuesday, June 9
7:00 - 8:00 AM Breakfast Quandary Peak
8:00 - 11:00 AM Novel Methods for Dynamics and Allostery
Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009 		Grays/Long Peak
Carol V. Robinson, University of Cambridge, UK
Role of Mass Spectrometry in Structure Elucidation of Dynamic Protein Complexes
G. Marius Clore, National Institutes of Health, USA
Open-to-Closed Transition in Apo Maltose-Binding Protein Visualized by Paramagnetic NMR
Ruben Abagyan, The Scripps Research Institute, USA
Induced Fit in Ligand Binding - Drug Design and Docking
Ad Bax, NIDDK, National Institutes of Health, USA
Talk Title to be Determined
Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM Coffee Break Longs Peak Foyer
11:00 AM- On Own for Lunch
4:30 - 5:00 PM Coffee Available Longs Peak Foyer
5:00 - 7:00 PM Novel Methods for Equilibrium Fluctuations
Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009 		Grays/Long Peak
Elliot L. Elson, Washington University School of Medicine, USA
Microseconds Dynamics Measured by Fluorescence Correlation Spectroscopy
Susan Marqusee†, University of California, Berkeley, USA
Exploring Conformational Landscapes Using Optical Tweezers
Patrice Vachette, IBBMC, France
Synchotron SAXS Detection of Pre-Existing Structural Equilibrium for a Mutant of Allosteric Aspartate Transcarbamoylase
Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM Social Hour w/ Lite Bites Quandary Peak
8:00 - 11:00 PM Entertainment
Wednesday, June 10
Departure
      *=Session Chair     †=Speaker invited, not yet responded.




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With recent progress in exploring biomolecular systems dynamics, an emerging view is that of the ‘intrinsic ability’ of biomolecular systems to populate an ensemble of fluctuating conformations, or alternative states, which include, in particular, the functional forms stabilized upon ligand/substrate binding or protein-protein interactions. Allosteric changes in conformations, or signal transduction mechanisms, thus emerge as properties encoded by the structure and energy landscape, which are evolutionarily selected due to their functional predisposition. Of particular interest is to elucidate the mechanisms of information flow, not only at the level of residue interactions, but also between the components of biomolecular machines or cell signaling networks. This Keystone Symposia meeting will provide a forum for researchers from diverse fields to explore the basic principles underlying allosteric responses at the molecular level, and their higher (cellular) level consequences, and to exchange expertise on methods to illuminate key dynamic properties of biomolecular systems.