Keystone Symposia Conference | Fibrosis

Meeting Program

To view program in "24 hour" time (international) click here.

Tuesday, January 20
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 8:30 PM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Longs Peak
	Harry C. Dietz, Johns Hopkins University School of Medicine, USA TGF-beta, Microfibrils and Connective Tissue Homeostasis

Wednesday, January 21
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:15 AM	Cellular Basis of Fibrosis: Focus on the Lung Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Longs Peak
	* Moises Selman, Instituto Nacional de Enfermedades Respiratorias, Mexico
	David A. Schwartz, National Jewish Medical and Research Center, USA The Interplay of Environment and Genetics in Airway Fibrosis and Asthma
	Richard P. Phipps, University of Rochester, USA Fibroblast Heterogeneity and Fibrosis
	Harold A. Chapman, University of California, San Francisco, USA Epithelial Integrin alpha3beta1 Links beta-catenin and Smad Signaling to Promote Myofibroblast Formation and Pulmonary Fibrosis
	Boris Hinz, Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland Myofibroblasts and Mechanical Signal Transduction
	Manuela Funke, Massachusetts General Hospital, USA Short Talk: Lysophosphatidic Acid Contributes to an Apoptosis Paradox in Lung Fibrosis
	Usamah S. Kayyali†, Tufts Medical Center, USA Short Talk: MK2 Signaling in Fibroblast Biology and Pulmonary Fibrosis
Following Session is for Allergy and Asthma (J1)
8:00 - 11:15 AM	Risk Factors, Early Life Events and Innate Mechanisms Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Grays 1-3
	* Catherine M. Hawrylowicz, King's College London, UK
	Patrick G. Holt, University of Western Australia, Australia Early Life Events that Influence Allergic Status
	* Scott T. Weiss, Brigham and Women's Hospital, USA Vitamin D and Allergy/Asthma Prevalence
	David B. Lewis, Stanford University, USA Influence of viral infections on the development of asthma: Insights from a murine model of influenza A viral-induced allergen sensitization for allergic pathogenesis and its prevention by vaccination for influenza
	Marsha Wills-Karp, Cincinnati Children's Hospital Medical Center, USA Innate Immune Responses To Allergens
	René Teich†, Clinical Chemistry and Molecular Diagnostics, Germany Short Talk: Epigenetic Regulation of Asthma Protection Early in Life by the Non-Pathogenic Microbe Acinetobacter lwoffii F78
	Matthew E. Poynter†, University of Vermont, USA Short Talk: Airway Epithelial Activation of NF-ƒÛB is Sufficient to Promote Allergic Sensitization to an Innocuous Inhaled Antigen
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM- 1:00 PM	Poster Setup	Quandary 1-3
11:15 AM-	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
2:30 - 4:30 PM	Workshop 1: EMT, Plasticity and the Origin of Fibroblasts	Longs Peak
	Brandi Nicole Baird†, Brown Foundation Institute of Molecular Medicine, USA Identification and Characterization of Prospectively Isolated Candidate Stem/Progenitor Cells in the Adult Mouse Lung
	Ana P. Castano†, Brigham and Women's Hospital, USA Serum Amyloid P inhibits Renal Fibrosis through an Fc-gamma Receptor Dependent Mechanism
	Marianne E. Fairclough†, University of Birmingham, UK Diversity within Monocyte Derived Stromal Cells
	Darrell Pilling†, Rice University, USA Th-1 Cytokines Inhibit, and Th-2 Cytokines Promote Fibrocyte Differentiation
	Kirkwood A. Pritchard Jr.†, Medical College of Wisconsin, USA The Role of Matrix and Mesenchymal Transition in Fibrosis in Tight Skin Mice
	Peter H. S. Sporn†, Northwestern University Feinberg School of Medicine, USA Epithelial-Mesenchymal Transition in Normal Human Bronchial Epithelial Cells Triggered by TGF-â1, Eosinophils and Cyclic Mechanical Strain
	Gregory deHart†, FibroGen, Inc., USA Regulation of Epithelial to Mesenchymal Transition by Connective Tissue Growth Factor
	Shangxi Liu†, University of Western Ontario, Canada Role of Integrin beta1 in a Bleomycin-Induced Scleroderma Model: Using Fibroblast-Specific Integrin beta1-Knockout Mice
Following Workshop is for Allergy and Asthma (J1)
2:30 - 4:30 PM	Workshop 1: Genes and Gene: Environment Interactions and Innate Immunity Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Grays 1-3
	* Marsha Wills-Karp, Cincinnati Children's Hospital Medical Center, USA

	* Donata Vercelli, University of Arizona, USA Epigenetic Signatures of Environmental Exposures
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Liver Fibrosis Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Longs Peak
	* Thomas A. Wynn, National Institutes of Health, USA
	Anna Mae Diehl, Duke University Medical Center, USA The Cellular Biology and Clinical Spectrum of Liver Fibrosis
	John P. Iredale, University of Edinburgh, Scotland Liver Fibrosis: A dynamic model of inflammation and repair
	Scott L. Friedman, Mount Sinai School of Medicine, USA Genetic Determinants of Fibrosis Progression
	Margaret M. Mentink-Kane†, NIAID, National Institute of Health, USA Short Talk: Accelerated Liver Fibrosis in the Combined Absence of Interleukin-13 Regulatory Molecules: IL-13 Receptor Alpha 2, IL-10 and IL-12
Following Session is for Allergy and Asthma (J1)
5:00 - 7:00 PM	Structural and Resident Cells of the Lung Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Grays 1-3
	* Stephen T. Holgate, Southampton General Hospital, UK
	* Michael J. Holtzman, Washington University, USA New Immune Pathways for Allergy and Asthma
	Steven F. Ziegler, Benaroya Research Institute, USA TSLP and Allergic Inflammation
	Maria do Carmo Leite-de-Moraes, CNRS, UMR 8147, France NKT Cells in the Lung

	Hamida Hammad, Ghent University, Belgium Short Talk: TLR4 Expression on Airway Stromal Cells is Crucial for Innate and Adaptive Immunity to House Dust Mite Allergen
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Quandary 1-3
Thursday, January 22
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:15 AM	The Immunology and Cell Biology of Fibrosis Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Longs Peak
	* John Varga, Northwestern University, Feinberg School of Medicine, USA
	Thomas A. Wynn, National Institutes of Health, USA Regulation and Function of IL-13 Signaling in Inflammation and Fibrosis
	Rebecca G. Wells, University of Pennsylvania, USA Liver Fibrosis: The Intersection of Soluble and Mechanical Factors
	Paul W. Noble, Duke University, USA Regulation and Lung Injury and Repair: Toll Like Receptors and Innate Immunity
	Victor J. Thannickal, University of Michigan, USA Apoptosis and Fibroblast Survival in Fibrogenesis
	Anna P. Lam, Northwestern University, USA Short Talk: Activated Canonical Wnt/beta-catenin Signaling Mediates Lung Fibroblast Migration and Proliferation
	Susan K. Mathai, Yale University School of Medicine, USA Short Talk: Profibrotic Monocyte Subsets in Pulmonary Fibrosis
Following Session is for Allergy and Asthma (J1)
8:00 - 11:15 AM	Effector Mechanisms and Cells Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Grays 1-3
	* Bart N. Lambrecht, Ghent University, Belgium
	Sally E. Wenzel, University of Pittsburgh, USA Asthma Phenotypes: Are we closing the loop to pathobiology
	* K. Frank Austen, Harvard Medical School, USA Leukotrienes as Therapeutic Targets in Asthma

	Stephanie C. Eisenbarth, Yale University, USA The Role of Inflammasomes in Vaccination and Allergic Disease
	Frances E. Lund, University of Rochester Medical Center, USA CD38: Modulator of the NAD Metabolome and Regulator of Inflammation
	Hiroshi Watarai, Riken Research Center for Allergy and Immunology, Japan Short Talk: A novel Subset of Mouse NKT Cells Bearing the IL-17 Receptor B Responds to IL-25 and Contributes to Airway Hyperreactivity
	Pierre Bruhns†, Institut Pasteur, France Short Talk: FcgammaRIV as a Murine Equivalent of FcepsilonRI Expressed by Macrophages from Human Atopics in IgE-Induced inflammation
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM- 1:00 PM	Poster Setup	Quandary 1-3
11:15 AM-	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
2:30 - 4:30 PM	Workshop 2: Model Systems for Studying Fibrosis	Longs Peak
	Shizhong S. Bu†, Medical University of South Carolina, USA DhS1P has a Potent Anti-Fibrotic Effect in Scleroderma Fibroblasts via Modulation of PTEN Levels
	Daniel Alejandro Cabrera†, Pontificia Universidad catolica, Chile Induction of Fibrosis by Exercise on Dystrophic Muscles: Role of CTGF
	Tomoko Hayashida, Feinberg School of Medicine, Northwestern University, USA Lack of beta1 Integrin Enhances TGF-beta Stimulated Type I Collagen Synthesis via Rac1 Mediated ERK Activity that Phosphorylates Smad Linker Region
	Andreas Guenther, Pulmonary & Critical Care, Germany Role of defective surfactant processing and transport in Hermansky-Pudlak-Syndrome associated Interstitial Pneumonia (HPSIP) and Idiopathic Pulmonary Fibrosis (IPF)
	Scott R. Manson†, Washington University, USA BMP-7 Counters the TGF-beta Pathway and Promotes Renal Recovery from Ureteral Obstruction-Induced Renal Fibrosis
	Sybille van den Brule†, Université catholique de Louvain, Belgium Activation of the D Prostanoid Receptor 1 (DP1) Regulates Fibroblast Proliferation and Lung Fibrosis
	Joe (Jia-hui) Wang†, King's College London, UK Antisense Inhibition of Kirsten-Ras Expression Reduces Fibrosis in a Rat Model of Unilateral Ureteric Obstruction
Following Workshop is for Allergy and Asthma (J1)
2:30 - 4:30 PM	Workshop 2: Intercellular and Intracellular Signaling Mechanisms Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Grays 1-3
	* Paul B. Rothman, University of Iowa, USA
	* Bart N. Lambrecht, Ghent University, Belgium
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Renal Fibrosis Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Longs Peak
	* Michael Zeisberg, Beth Israel Deaconess Medical Center & Harvard Medical School, USA
	Jeffrey B. Kopp, National Institutes of Health, USA Overview of Renal Fibrosis
	Agnes Fogo, Vanderbilt University Medical Center, USA Animal Models and the Reversibility of Fibrosis
	H. William Schnaper, Northwestern University, USA TGF-beta Signaling in Renal Fibrogenesis
	Ana P. Castano, Brigham and Women's Hospital, USA Short Talk: Serum Amyloid P inhibits Renal Fibrosis through an Fc-gamma receptor dependent mechanism.
	Jeremy S. Duffield, Harvard Medical School, USA Short Talk: Genetic Lineage Analysis Indicates that the Pericyte, not Epithelial to Mesenchymal Transition, Generates Myofibroblasts in the Obstructive Model of Kidney Fibrosis
Following Session is for Allergy and Asthma (J1)
5:00 - 7:00 PM	Immune Regulation Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Grays 1-3
	* Steven F. Ziegler, Benaroya Research Institute, USA
	Valerie Julia, INSERM, France Breast Milk-Mediated Transfer of an Antigen Induces Tolerance and Protection from Allergic Asthma

	* Catherine M. Hawrylowicz, King's College London, UK Regulatory T Cells in Allergy and Asthma: The Role of the Vitamin D Pathway
	Yong-Jun Liu, University of Texas MD Anderson Cancer Center, USA Immune Regulation by Dedritic Cells, TSLP and Cytokines
	Hiromasa Inoue, Kyushu University, Japan Short Talk: Pulmonary SOCS1 as a Central Endogenous Inhibitor of Allergic Asthma
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Quandary 1-3
Friday, January 23
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:00 AM	Asthma, Allergy and Tissue Remodeling (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Longs Peak / Grays Peak
	Stephen J. Galli, Stanford University, USA Mast Cells and Tissue Remodeling
	Speaker to be Announced,
	James J. Lee, Mayo Clinic Scottsdale, USA Eosinophils Orchestrate Allergic Pulmonary Responses: Who’s your Daddy Now T Cells!
	Jack A. Elias, Yale School of Medicine, USA Insights from Transgenic Models of Lung Fibrosis
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Quandary 1-3
11:00 AM-	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Environmental Cues and Cellular Responses Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Longs Peak
	* Luisa A. DiPietro, University of Illinois at Chicago, USA
	Rik Derynck, University of California, San Francisco, USA Mesenchymal Cell Plasticity, EMT Transition and TGF-beta




	Andrew D. Luster, Massachusetts General Hospital, USA Inflammation and Fibrosis - Chemokines, LPA
	Luisa A. DiPietro, University of Illinois at Chicago, USA Scar Formation in the Healing Wound

	Keith C. Olsen, University of Rochester, USA Short Talk: Tissue Transglutaminase as a Novel Modulator of and Potential Therapeutic Target in Pulmonary Fibrosis
	Florian Rieder, Lerner Research Institute, USA Short Talk: Endothelial-to-Mesenchymal Transition of Intestinal Mucosal Microvascular Cells: A Novel Mechanism of Intestinal Fibrosis
Following Session is for Allergy and Asthma (J1)
5:00 - 7:00 PM	Lipid Mediators, Proteases and Cytokines in Tissue Remodeling Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Grays 1-3
	* Joshua A. Boyce†, Brigham and Women's Hospital, Harvard Medical School, USA
	* Juan Rivera, NIAMS, National Institutes of Health, USA Sphingosine-1-phosphate in Allergy and Asthma

	Clare M. Lloyd, Imperial College London, UK Cytokine regulation of Allergic Airway Inflammation and Remodelling
	Gunnar Pejler, Swedish University of Agricultural Sciences, Sweden Mast cell chymase- a friend or foe?
	Cara MM Williams, Wyeth, USA Short Talk: Cytosolic Phospholipase A2alpha Orchestrates Allergic Disease
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Quandary 1-3
Saturday, January 24
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:15 AM	Novel Therapeutic Targets and Biomarkers Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Longs Peak
	* Michael Gilman, Stromedix, Inc., USA
	Howard Y. Chang, Stanford University, USA Genomic encoding of positional identities: Implications for fibrosis
	Ronald M. duBois, National Jewish Health, USA Genetics of diffuse lung fibrosis: lessons learned
	Shelia M. Violette, Stromedix, USA Therapeutic Potential of a Function Blocking alphavbeta6 Antibody in Fibrosis and Oncology
	Scott M. Lonning, Genzyme Corporation, USA Prospects and Challenges of TGFb Neutralization for the Treatment of Pathologic Fibrosis
	Joanna Busquets†, Thomas Jefferson University, USA Short Talk: Quantitative Assessment of Tissue Fibrosis in Skin Biopsies from Patients with Systemic Sclerosis Employing Confocal Laser Scanning Microscopy (CLSM). An Objective Outcome Measure for Clinical Trials
	Naftali Kaminski†, University of Pittsburgh Medical Center, USA Short Talk: Title to be Determined
Following Session is for Allergy and Asthma (J1)
8:00 - 11:00 AM	Conventional and Novel Targets for Intervention Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Grays 1-3
	* Robert L. Coffman, Dynavax Technologies, USA
	John A. Cidlowski, NIEHS, National Institutes of Health, USA The Glucocorticoid Receptor: One Gene, Many Proteins – New Mechanisms for Tissue Specific Anti-Inflammatory Actions of Glucocorticoids in Health and Disease.
	* Jean-Pierre Kinet, Beth Israel Deaconess Medical Center and Harvard Medical School, USA IgE and the High Affinity IgE Receptor: Structure, Function and Targets of Therapy
	Marco Conti, University of California, San Francisco, USA Cyclic AMP-specific phosphodiesterase regulation as a critical compoenent of the airway inflammatory responses

	Prescott G. Woodruff†, UCSF, USA Short Talk: Presence or Absence of IL-13-Driven Inflammation Defines Major Sub-Phenotypes of Asthma
	Joshua A. Boyce†, Brigham and Women's Hospital, Harvard Medical School, USA Short Talk: Leukotriene E4-Induced Pulmonary Inflammation is Mediated by the P2Y12 Receptor
	Heidi Campos Schilter, Garvan Institute of Medical Research, Australia Short Talk: A Role for Fatty Acid Binding Proteins in Airway Immune Responses
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM-	On Own for Lunch
2:30 - 4:30 PM	Workshop 3: Therapeutic Targets and Biomarkers	Longs Peak
	April A. Cox, Array Biopharma, USA Preclinical Efficacy of a PDGFR inhibitor, ARRY-768, in a Rat Model of Gadolinium-Induced Fibrosis
	Francesco Del Galdo†, Thomas Jefferson University, USA A Pattern of Shared Alterations in the Secretome of Dermal Fibroblasts from Systemic Sclerosis and Nephrogenic Systemic Fibrosis: A Biomarker Signature for Fibrotic Diseases
	Qin Hu†, King's College London, UK Discovery of Herbal Compounds with in vitro Anti-Fibrotic Activities
	Jadranka Milosevic, Simmons Center for Interstitial Lung Disease, USA The Role of miR-154 microRNA Family in IPF
	Jennifer Laurente Sargent, Dartmouth Medical School, USA Overlapping and Distinct Gene Targets of TGFbeta, IL13 and IL4 in Dermal Fibroblasts are Expressed in Distinct Molecular Subsets of Systemic Sclerosis
	Timothy W. Schacker†, University of Minnesota, USA Lymph Node Fibrosis Is A Significant Factor In HIV Pathogenesis And Limits Immune Reconstitution Despite Antiretroviral Therapy Suppression of Viral Replication
	Georg Wick†, Division of Experimental Pathology and Immunology, AUSTRIA Immune Mechanisms Involved in Peri-Silicone Mammary Implant (SMI) Fibrosis
Following Workshop is for Allergy and Asthma (J1)
2:30 - 4:30 PM	Workshop 3: Effector Cells and Mechanisms in Asthma Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Grays 1-3
	* Gianni Marone†, University of Naples Federico II School of Medicine, Italy
	* Stephen J. Galli, Stanford University, USA
	Short Talks to be Chosen from Abstracts, , USA
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Novel Therapies Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Longs Peak
	* Scott M. Lonning, Genzyme Corporation, USA

	Bruce N. Cronstein, New York University School of Medicine, USA Adenosine Receptors as Targets for Fibrosis Therapy
	Mark Lupher, Jr., Promedior, Inc., USA Regulating Fibrosis with the Natural Innate Response Modifier, SAP

	Claire L. Emson, KineMed, Inc., USA Measurement of Collagen Synthesis by Heavy Water Labeling and its Application for Indentifying Anti-Fibrotic Therapies.
	Ruchi Bansal, University of Groningen, The Netherlands Short Talk: A Mimetic Peptide of Interferon gamma (IFNgamma) as a Novel Anti-Fibrotic Agent
Following Session is for Allergy and Asthma (J1)
5:00 - 7:00 PM	Immune Intervention Registered attendees for this meeting can view Abstracts for this session starting on 12/20/2008	Grays 1-3
	* Yong-Jun Liu, University of Texas MD Anderson Cancer Center, USA
	Robert L. Coffman, Dynavax Technologies, USA The Th2 Concept: Emergence through Clinical Applications
	Bart N. Lambrecht, Ghent University, Belgium Targeting dendritic cells
	* Anthony J. Coyle, MedImmune, Inc., USA Cytokine Antagonists
	Lawren C. Wu, Genentech, Inc., USA Short Talk: Reduction of Serum IgE by Depletion of the IgE B Cell Lineage – a Novel Approach for the Treatment of Allergic Diseases
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
8:00 - 11:00 PM	Entertainment	Quandary 1-3
Sunday, January 25
	Departure
*=Session Chair †=Speaker invited, not yet responded.

Keystone Symposia would like to thank the sponsor of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:

	KineMed, Inc.
Promedior, Inc.

We gratefully acknowledge the companies that provide Keystone Symposia with additional meeting support, including marketing and advertising...

Click here to view these companies

Fibrosis is a major cause of morbidity worldwide, can affect nearly all tissues, and is a dominant feature of diseases ranging from pulmonary fibrosis to glomerulosclerosis and cancer. Current treatments targeting the inflammatory cascade are ineffective in fibrosis. On-going research focuses on the role of innate immunity, and intrinsic mesenchymal cell alterations, plasticity, and progenitor cell differentiation in the pathogenesis. Experimental models, genetics and functional genomics have uncovered novel aspects of fibrosis, and innovative therapies are entering clinical trials. However, consensus on robust outcome measures or appropriate biomarkers for evaluating therapeutic effectiveness is lacking. This meeting brings together academic clinicians, researchers and pharmaceutical industry representatives from a variety of fields (1) to identify themes shared among the different fibrosing disorders, (2) to delineate promising novel molecular and cellular targets and treatment strategies, and (3) to discuss outcome measures and biomarkers for clinical trials. Opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting “Allergy and Asthma”, which will share a session with this meeting.

Fibrosis (J2)