Keystone Symposia Conference | Axonal Connections: Molecular Cues for Development and Regeneration

Meeting Program

To view program in "24 hour" time (international) click here.

Tuesday, February 17
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 8:30 PM	Keynote Address (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Grays Peak / Longs Peak


	Michael E. Greenberg, Harvard Medical School, USA Signaling Networks that Regulate Synapse Development and Cognitive Function
	Huda Y. Zoghbi, Howard Hughes Medical Institute, Baylor College of Medicine, USA Pathogenic Mechanisms in Neurodevelopment and Neurodegenerative Disorders
Wednesday, February 18
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:00 AM	Molecular Cues for Axon Guidance Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Grays Peak
	* Rüdiger Klein, Max Planck Institute of Neurobiology, Germany

	Marc Tessier-Lavigne, Genentech, Inc., USA Axon Guidance at the Spinal Cord Midline
	Yimin Zou, University of California, San Diego, USA Wnt Signaling and Axon Guidance Along the CNS Anteroposterior Axis
	Dietmar Schmucker, Dana-Farber Cancer Institute, Harvard Medical School, USA Functional and Molecular Studies of the Hypervariable Receptor Dscam

	Hitoshi Sakano, University of Tokyo, Japan Talk Title to be Determined
	Short Talk(s) to be Chosen from Abstracts,
Following Session is for Neurodegenerative Diseases (J5)
8:00 - 11:00 AM	Autophagy - Common Themes in Neurodegenerative Disease? Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Longs Peak
	* Richard I. Morimoto, Northwestern University, USA
	Ana Maria Cuervo, Albert Einstein College of Medicine, USA Autophagy in the Nervous System
	David C. Rubinsztein, Cambridge Institute for Medical Research, UK Autophagy Induction: A Possible Therapeutic Strategy for Neurodegenerative Diseases Caused by Aggregate-Prone Intracytoplasmic Proteins

	Masaaki Komatsu, Tokyo Metropolitane Institute of Medical Science, Japan Autophagy and Neurodegeneration
	Ron R. Kopito, Stanford University, USA Macroautophagy in Neurodegenerative Diseases
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Quandary 1-3
11:00 AM-	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Axon Degeneration (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Grays Peak / Longs Peak
	* Marie T. Filbin, Hunter College, USA

	Freda D. Miller, Hospital for Sick Children, University of Toronto, Canada p75 and Axon Degeneration: From Pruning to Injury
	Marc R. Freeman, University of Massachusetts Medical School, USA Mechanisms of Axon Degeneration in Drosophila
	Wenbiao Gan, Skirball Institute Program of Molecular Neurobiology, USA Imaging Neuronal Injury and Repair
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Quandary 1-3
Thursday, February 19
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:00 AM	Signaling Pathways in Neural Connectivity Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Grays Peak
	* Stephen M. Strittmatter, Yale University, USA

	David G. Ginty, Johns Hopkins School of Medicine, USA Talk Title to be Determined

	Alex L. Kolodkin, Johns Hopkins University School of Medicine, USA Molecular Mechanisms of Growth Cone Guidance in Drosophila and Mammals
	Rüdiger Klein, Max Planck Institute of Neurobiology, Germany Bi-Directional Regulation of Axon Guidance and Plasticity by Ephrins
	Yi Rao, Peking University, China Slit and Netrin
	Short Talk to be Chosen from Abstracts,
Following Session is for Neurodegenerative Diseases (J5)
8:00 - 11:00 AM	Proteostasis in Neurodegenerative Disease: Chaperones and Protein Misfolding Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Longs Peak
	* Ana Maria Cuervo, Albert Einstein College of Medicine, USA
	Richard I. Morimoto, Northwestern University, USA Proteostatis and Neurodegenerative Disease
	Heather Leigh True-Krob, Washington University, USA Yeast Prions as a System to Study Protein Misfolding and Chaperones
	Speaker to be Announced,

	Andrew G. Dillin, The Salk Institute for Biological Studies, USA Title to be Determined
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Quandary 1-3
11:00 AM-	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	RNA and Regulated Protein Expression in Axon Guidance Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Grays Peak
	* Michael E. Greenberg, Harvard Medical School, USA

	John G. Flanagan, Harvard Medical School, USA RNA-Based Regulation Mechanisms in Axon Development
	Gary Bassell, Emory University, USA Mechanisms of mRNA Transport and Local Protein Synthesis in Neuronal Development and Regeneration
	Oliver Hobert, Columbia University Medical Center, USA Molecular Mechanisms of Maintaining Neuronal Architecture
Following Session is for Neurodegenerative Diseases (J5)
5:00 - 7:00 PM	Models of Neurodegenerative Diseases Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Longs Peak
	* Fred H. Gage, The Salk Institute for Biological Studies, USA
	Susan L. Ackerman, HHMI/ The Jackson Laboratory, USA Novel Neurodegenerative Pathways from Studies of Mutant Mice: Chaperones and Protein Misfolding in Neurodegeneration
	Adriano M. Aguzzi, University Hospital of Zurich, Switzerland The Prion Protein in Health and Disease
	Karen Hsiao Ashe, University of Minnesota, USA Animal Models of Alzheimer's Disease - What Have They Taught Us?
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Quandary 1-3
Friday, February 20
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:00 AM	Axon Regeneration (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Grays Peak / Longs Peak
	* Liqun Luo, Stanford University, USA
	Stephen M. Strittmatter, Yale University, USA Nogo and NgR as Regulators of Axon Plasticity, Sprouting and Regeneration
	Mark H. Tuszynski, University of California, San Diego, USA Promoting Axonal Regeneration after Chronic Spinal Injury
	Zhigang He, Children's Hospital, Boston, USA Intrinsic Mechanisms in Axon Regeneration
	Marie T. Filbin, Hunter College, USA Signaling Axonal Regeneration in the CNS
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Quandary 1-3
11:00 AM-	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Synapse Formation Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Grays Peak
	* Marc Tessier-Lavigne, Genentech, Inc., USA

	Kang Shen, Stanford University, USA Regulators of Synapse Formation in C. elegans
	Vivian Budnik, University of Massachusetts, USA Wnt Signaling in Synapse Assembly and Plasticity
	Ben A. Barres, Stanford University, USA How do Astrocytes Induce CNS Synapse Formation?
Following Session is for Neurodegenerative Diseases (J5)
5:00 - 7:00 PM	RNA Actions in Neurodegeneration Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Longs Peak
	* Ted M. Dawson, Johns Hopkins School of Medicine, USA

	Bart De Strooper, Center for Human Genetics, Belgium MicroRNA's in Neurodegeneration
	Shai Shaham, Rockefeller University, USA A New C. elegans Cell Death Pathway
	Valina L. Dawson, Johns Hopkins School of Medicine, USA Survival and Death Choices Regulated by MiR's
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Quandary 1-3
Saturday, February 21
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:00 AM	Stem Cells (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Grays Peak / Longs Peak
	* David M. Holtzman, Washington University, USA
	Fred H. Gage, The Salk Institute for Biological Studies, USA Stem Cells in the Adult Brain
	Fiona Doetsch, Columbia University, USA Stem Cells: From Epigenetics to MicroRNAs
	Hongjun Song, Johns Hopkins University School of Medicine, USA Extrinsic and Intrinsic Mechanisms Regulating Adult Neural Stem Cells and Neurogenesis
	Lorenz Studer, Memorial Sloan Kettering Cancer Center, USA Embryonic Stem Cell-Derived Neurons Form Functional Networks: Lessons for Therapy of Neurodegenerative Disease
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM-	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Dendrite Patterning and Complex Circuits Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Grays Peak
	* Ben A. Barres, Stanford University, USA


	Liqun Luo, Stanford University, USA Assembly of the Olfactory Circuit in the Fly Brain
	Yuh-Nung Jan, University of California, San Francisco, USA Genetic Control of Dendrite Arborization Patterns
	Catherine C. Dulac, Harvard University, USA Talk Title to be Determined

Following Session is for Neurodegenerative Diseases (J5)
5:00 - 7:00 PM	New Therapeutic Approaches Registered attendees for this meeting can view Abstracts for this session starting on 01/17/2009	Longs Peak
	* Adriano M. Aguzzi, University Hospital of Zurich, Switzerland
	David M. Holtzman, Washington University, USA Fluid Biomarkers of Antecedent Alzheimer's Disease and New Therapies and Methods to Assess Treatments in Neurodegenerative Disease
	Berislav Zlokovic, University of Rochester, USA Blood-Brain Barrier in Neurodegenerative Disease and Stroke
	Tim Miller, Washington University School of Medicine, USA Anti-Sense to Treat ALS
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
8:00 - 11:00 PM	Entertainment	Quandary 1-3
Sunday, February 22
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:

Genentech, Inc.

We gratefully acknowledge the companies that provide Keystone Symposia with additional meeting support, including marketing and advertising...

Click here to view these companies

The functioning of the nervous system depends on formation of a complex pattern of connections during development. If these connections are subsequently lost through injury or degeneration, axons in the adult CNS fail to regenerate, creating a major clinical challenge. The last several years have seen tremendous progress in identifying molecular mechanisms for axon development and regeneration, although much remains to be learned about these complex processes. Rapid progress is being made in identifying new classes of extracellular regulators, understanding the mechanisms by which this extracellular information is transduced by the neuron into appropriate responses, and learning the underlying molecular logic for the formation of neural connectivity. This meeting will bring together researchers in the fields of axon development, degeneration and regeneration. The meeting will promote exchange of ideas, information and collaboration among these fields, and will train young scientists in the questions, approaches, and opportunities in these exciting and topical research areas. It will also promote scientific and translational goals of understanding the basic mechanisms for the formation of neural circuits, and developing new strategies for therapeutic repair.

Axonal Connections: Molecular Cues for Development and Regeneration (J6)