Keystone Symposia Conference | Prevention of HIV/AIDS

Meeting Program

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Sunday, March 22
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 9:30 PM	Keynote Address (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Longs Peak / Grays Peak
	Francoise Barré-Sinoussi, Institut Pasteur, France HIV Diversity and Pathogenesis

	Rafi Ahmed, Emory University School of Medicine, USA Talk Title to be Determined
Monday, March 23
7:00 - 8:00 AM	Breakfast	Red Cloud / Shavano / Torreys
8:00 - 11:00 AM	Host Genomics and HIV Disease (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Longs Peak / Grays Peak
	Amalio Telenti, Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland Genomics and Vaccine Strategies
	Mary Carrington, National Cancer Institute, National Institutes of Health, USA Immunogenetics

	Speaker to be Announced,
	Bruce D. Walker, Massachusetts General Hospital, USA Genomics of Long-Term Progressors
	Short Talk to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Red Cloud / Shavano / Torreys
11:00 AM-	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Red Cloud / Shavano / Torreys
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	The Bigger Picture: Microbicides, Circumcision and Drugs for Prevention Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Longs Peak
	Melissa J. Robbiani (Pope), Population Council, USA Science of Microbicide Development
	Bertran Auvert, CHU Ambroise Paré, France Circumcision: Uptake and Impact
	Myron S. Cohen, University of North Carolina at Chapel Hill, USA ART for Prevention of the Sexual HIV Transmission of HIV
Following Session is for HIV Immunobiology (X4)
5:00 - 7:00 PM	Hiding from Immunity: Reservoirs and Latency Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Grays Peak
	Robert F. Siliciano, Johns Hopkins School of Medicine, USA Quantitative Analysis of the Control of HIV Replication by Drugs and Vaccines
	Joel Nee-lartey Blankson, Johns Hopkins School of Medicine, USA HIV Control in Elite Suppressors
	Dana H. Gabuzda, Dana Farber Cancer Institute, USA Macrophage Reservoirs
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Red Cloud / Shavano / Torreys
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Red Cloud / Shavano / Torreys
Tuesday, March 24
7:00 - 8:00 AM	Breakfast	Red Cloud / Shavano / Torreys
8:00 - 11:00 AM	Immune Control of HIV and Virus Escape (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Longs Peak / Grays Peak
	Francine E. McCutchan, USMHRP/Henry M. Jackson Foundation, USA Molecular Complexity of the Epidemic
	Philip J. Goulder, University of Oxford, UK HIV Escape and T Cell Control of HIV
	Giuseppe Pantaleo, Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland Immune Correlates of Protection to HIV
	George M. Shaw, University of Alabama at Birmingham, USA HIV Escape to Antibodies
	Short Talk to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Red Cloud / Shavano / Torreys
11:00 AM-	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Red Cloud / Shavano / Torreys
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	How to Improve Vaccine Efficacy? Adjuvants, Route of Administration... Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Longs Peak / Grays Peak
	Bali Pulendran, Emory University, USA Modulating Vaccine Responses with Innate Immunity
	Christopher J. Miller, University of California, Davis, USA Intra-Nasal/-Vaginal Mucosal Immunization
	Susan W. Barnett, Chiron Corporation, USA Mucosal Antibodies and Systemic Vaccine
	Short Talk to be Chosen from Abstracts,
Following Session is for HIV Immunobiology (X4)
5:00 - 7:00 PM	Models of HIV Immunobiology Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Grays Peak
	Guido Silvestri, University of Pennsylvania School of Medicine, USA SIV Infection of African Monkeys: A New Paradigm for AIDS Pathogenesis
	Cecilia Cheng-Mayer, Aaron Diamond AIDS Research Center, USA Coreceptor Switching in the SHIV/Macaque Model
	Sarah L. Rowland-Jones, MRC Laboratories, the Gambia, Gambia Lessons from HIV-2
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Red Cloud / Shavano / Torreys
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Red Cloud / Shavano / Torreys
Wednesday, March 25
7:00 - 8:00 AM	Breakfast	Red Cloud / Shavano / Torreys
8:00 - 11:00 AM	How to Generate Vaccine Efficacy against HIV? T Cell-Based and B-Cell Based Vaccines Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Longs Peak
	Barton F. Haynes, Duke University Medical Center, USA Keynote Address: What Does a Successful HIV-1 Vaccine Need To Do? Clues from Acute HIV Infection
	Dan H. Barouch, Beth Israel Deaconess Medical Center, USA Novel Adenovirus T Cell-Based Vaccines for HIV
	Dennis R. Burton, The Scripps Research Institute, USA Mechanisms of Antibody Protection Against HIV
	Peter D. Kwong, National Institutes of Health, USA Structure-Based Envelope Immunogens
Following Session is for HIV Immunobiology (X4)
8:00 - 11:00 AM	New Insights in HIV Replication Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Grays Peak
	Frank Kirchhoff, University of Ulm, Germany Role of Nef in vivo and in vitro

	Speaker to be Announced,
	Christopher Aiken, Vanderbilt University School of Medicine, USA Cyclophilin A and HIV-1 Capsid Function
	Nathaniel R. Landau†, NYU School of Medicine, USA Vpr and DNA Damage
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Red Cloud / Shavano / Torreys
11:00 AM-	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Red Cloud / Shavano / Torreys
2:30 - 4:30 PM	Workshop 1: Which Immune Correlates of Protection against HIV? How to Measure T Cell and B Cell Correlates?	Longs Peak
	Short Talks to be Chosen from Abstracts, , USA
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	HIV at the Mucosa: Portal of Entry and Front-Line Defense (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Longs Peak
	Ashley T. Haase, University of Minnesota, USA Keynote Address: HIV at Mucosal Front Lines
	Ronald S. Veazey, Tulane National Primate Research Center, USA HIV and Intestinal Lymphoid Tissue
	Alison Simmons, Weatherall Institute of Molecular Medicine, UK HIV and Dendritic Cell Activation
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Red Cloud / Shavano / Torreys
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Red Cloud / Shavano / Torreys
Thursday, March 26
7:00 - 8:00 AM	Breakfast	Red Cloud / Shavano / Torreys
8:00 - 11:00 AM	Lessons from Clinical Trials of Preventative Vaccines Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Longs Peak
	Scott M. Hammer, Columbia University, USA Keynote Address: Challenges in Preventative Vaccine Development
	Speaker to be Announced,
	M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA Lessons from the HIV-Ad5 Vaccine Phase II Clinical Trial
	Merlin L. Robb†, Walter Reed Army Institute of Research, USA Results from the HIV-Canarypox Vaccine Phase III Clinical Trial
	Short Talk to be Chosen from Abstracts,
Following Session is for HIV Immunobiology (X4)
8:00 - 11:00 AM	Innate Antiviral Immunity Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Grays Peak
	Michael H. Malim, King's College London School of Medicine, UK Antiviral Cytidine Deaminases
	Warner C. Greene, Gladstone Institute of Virology and Immunology, USA APOBEC and Early Block to HIV Infection

	Greg J. Towers, University College London, UK Talk Title to be Determined
	Paul D. Bieniasz, Aaron Diamond AIDS Research Center, USA Post-Entry Blocks
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM-	On Own for Lunch
2:30 - 4:30 PM	Workshop 2: Challenges in Study Design	Longs Peak
	Short Talks to be Chosen from Abstracts, , USA
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Prevention of AIDS: What can we Learn from Therapeutic Vaccines? Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Longs Peak
	Brigitte Autran, Hôpital Pitié-Salpétrière, UPMC, France Lessons for Therapeutic Vaccines against HIV for Immune Correlates of Protection against HIV
	Susan P. Buchbinder†, San Francisco Department of Public Health, USA Comparison between Preventative and Therapeutic Vaccine Trials using Adenovirus 5 Vectors

	Speaker to be Announced,
	Short Talk to be Chosen from Abstracts,
Following Session is for HIV Immunobiology (X4)
5:00 - 7:00 PM	Virus Spread Registered attendees for this meeting can view Abstracts for this session starting on 02/22/2009	Grays Peak
	Olivier Schwartz, Institut Pasteur, France T Cell-T Cell Transfer
	Thomas J. Hope, Northwestern University, Feinberg School of Medicine, USA Visualizing the Infectious Synapse
	Vincent Piguet, University Hospital of Geneva, Switzerland Mechanisms of DC-T Cell HIV-1 Transmission via an Infectious Synapse
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Red Cloud / Shavano / Torreys
8:00 - 11:00 PM	Entertainment	Red Cloud / Shavano / Torreys
Friday, March 27
	Departure
*=Session Chair †=Speaker invited, not yet responded.

Keystone Symposia would like to thank the sponsor of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:

GenVec, Inc.

We gratefully acknowledge the companies that provide Keystone Symposia with additional meeting support, including marketing and advertising...

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Most recent research efforts on the prevention of HIV and AIDS has focused on T cell-based vaccines but it is admitted this approach will not prevent HIV and needs to be strengthened by novel approaches to generate HIV neutralizing antibodies. The recent successes or failures of alternative methods of HIV prevention (e.g., microbicides, circumcision), or of AIDS prevention (therapeutic vaccines) should help better understand how HIV vaccines can be used, and require sharing basic understanding and results with the prophylactic vaccine field. However the recent negative results of a major HIV vaccine trial have substantially disorganized the field and limit preparation of a definitive program a year and a half in advance. The goals of the meeting are therefore to focus on the most recent key advances in the understanding of (1) how HIV can be controlled at entry and after infection in 3 joint sessions with the concurrent “HIV Immunobiology” meeting, (2) how T cell-based or antibody-based HIV vaccines can be improved, and (3) what are the results of the current vaccine trials and those of alternative methods of HIV or AIDS prevention and how can they help at re-orientating vaccine researches. Two workshops will provide key information on the definition of immune correlates of protection and their analysis in clinical trials.

Prevention of HIV/AIDS (X3)