Keystone Symposia Conference | The Biology of RNA Silencing

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Saturday, April 25
3:00 - 7:30 PM	Registration	Palm Court
6:30 - 7:30 PM	Refreshments	Palm Court
7:30 - 9:30 PM	Keynote Session Registered attendees for this meeting can view Abstracts for this session starting on 03/25/2009	Crystal Ballroom
	* Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland
	* Erik Sontheimer, Northwestern University, USA Welcoming Remarks


	Andrew Fire, Stanford University, USA Adventures in the Small RNA-ome
	David P. Bartel, Massachusetts Institute of Technology, USA MicroRNAs and Other Small Regulatory RNAs
Sunday, April 26
7:00 - 8:00 AM	Breakfast	Crystal Ballroom
8:00 - 11:30 AM	Mechanism of Small RNAs I Registered attendees for this meeting can view Abstracts for this session starting on 03/25/2009	Salon B-C
	* David C. Baulcombe, University of Cambridge, UK
	V. Narry Kim, Seoul National University, South Korea Biogenesis of miRNAs
	Gunter Meister, Max Planck Institute of Biochemistry, Germany Regulation of Argonaute Function

	Qinghua Liu, University of Texas Southwestern Medical Center, USA Short Talk: C3PO Promotes Drosophila RNAi by Enhancing RISC Activity
	Bruce M. Paterson, National Cancer Institute, National Institutes of Health, USA Short Talk: Identification of an RNA-Dependent RNA Polymerase in Drosophila Involved in RNAi and Transposon Suppression
	Erik Sontheimer, Northwestern University, USA CRISPR Interference in Bacteria
	Dinshaw J. Patel, Memorial Sloan-Kettering Cancer Center, USA Structural Biology of Argonaute-Mediated RNA Silencing
	Jin-Biao Ma, University of Alabama at Birmingham, USA Short Talk: Structural Insights into the Molecular Mechanism of the Small RNA Methyltransferase HEN1
9:20 - 9:40 AM	Coffee Break	Prefunction, Level 2
11:30 AM-	On Own for Lunch
11:30 AM- 1:00 PM	Poster Setup	Salon A
1:00 - 10:00 PM	Poster Viewing	Salon A
4:30 - 5:00 PM	Coffee Available	Prefunction, Level 2
5:00 - 7:15 PM	Chromatin Silencing and Modification Registered attendees for this meeting can view Abstracts for this session starting on 03/25/2009	Salon B-C
	* Irene Bozzoni, University La Sapienza, Rome, Italy
	Shiv I. S. Grewal, National Institutes of Health, USA Epigenetic Genome Control by RNAi and Transposon-Derived Proteins
	Nicholas J. Proudfoot, University of Oxford, UK Autoregulation of Convergent RNAi Genes by Transient Heterochromatin Formation in S. pombe
	Thomas A. Volpe, Northwestern University, Feinberg School of Medicine, USA Short Talk: RNA-Dependent RNA Polymerase Links Assembly of Heterochromatin Domains to Secondary siRNA Synthesis
	Steven E. Jacobsen, HHMI/University of California, Los Angeles, USA DNA Methylation on Arabidopsis
	Andrzej T. Wierzbicki, Washington University, USA Short Talk: RNA Polymerase V Transcription Recruits AGO4 to Chromatin
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Salon A
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 03/25/2009	Salon A
Monday, April 27
7:00 - 8:00 AM	Breakfast	Crystal Ballroom
7:00 - 8:00 AM	Poster Setup	Salon A
8:00 - 11:30 AM	Mechanism of Small RNAs II Registered attendees for this meeting can view Abstracts for this session starting on 03/25/2009	Salon B-C
	* Javier A. Martinez, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria

	Scott G. Kennedy, University of Wisconsin, USA siRNAs Initiate a NRDE-2-Dependent Co-Transcriptional Gene Silencing Program that Regulates RNAP II Elongation
	Craig C. Mello, University of Massachusetts Medical School, USA Complexity of RNA Silencing in C. elegans
	Thomas F. Duchaine, McGill University, Canada Short Talk: Architecture of the ERI endoRNAi Initiation Machinery in C. elegans
	David C. Baulcombe, University of Cambridge, UK Imprinted Expression of siRNA loci in Arabidopsis
	Peter Sarnow, Stanford University School of Medicine, USA Modulation of Hepatitis C Virus RNA Abundance by Liver-Specific microRNA miR-122
	Yukihide Tomari, University of Tokyo, Japan Short Talk: Dissection of Ago1-RISC Assembly Pathway in Drosophila
	Eric C. Lai, Sloan-Kettering Institute, USA Short Talk: Sorting of miRNA Strands in Drosophila*
9:20 - 9:40 AM	Coffee Break	Prefunction, Level 2
11:30 AM- 12:30 PM	Lunch	Salon A
12:00 - 2:30 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 03/25/2009	Salon A
12:00 - 7:15 PM	Poster Viewing
2:30 - 4:30 PM	Workshop 1: Identification of New miRNA Targets	Salon B-C
	* Mihaela Zavolan, Biozentrum, University of Basel, Switzerland Sequence and Structure Determinants of miRNA Targeting Specificity
	Daehyun Baek, Whitehead Institute for Biomedical Research, USA The Impact of microRNAs on Protein Output
	Artemis G. Hatzigeorgiou, BSRC "Al. Fleming", Greece DIANA-MicroT 4: Machine Learning based microRNA Target Prediction
	Markus Hafner, Rockefeller University, USA PURE-CLIP - Transcriptome-Wide Identification of miRNA Targets and RNA Targets and Binding Sites of RNA-Binding Proteins
	Dimitrios G. Zisoulis, University of California, San Diego, USA Massive Identification of miRNA Target Sites in Endogenous mRNAs
	Vincenzo Alessandro Gennarino, Telethon Institute of Genetics and Medicine, Italy MicroRNA Target Prediction by Expression Analysis of Host Genes
	Francesca Moretti, European Molecular Biology Laboratory, Germany Positional Effects of microRNA-Mediated Translational Regulation and their Mechanistic Basis
	Yevgeniy Grigoryev, The Scripps Research Institute, USA The Role of miRNAs in Regulating Human T and B Lymphocyte Activation
4:30 - 5:00 PM	Coffee Available	Prefunction, Level 2
5:00 - 7:15 PM	Intersection of RNAi/miRNA Silencing with Other Cellular Pathways Registered attendees for this meeting can view Abstracts for this session starting on 03/25/2009	Salon B-C
	* Brenda L. Bass†, University of Utah, USA
	Olivier Voinnet, Institut de Biologie Moléculaire des Plantes, France RNAi and Pathogen Defense in Plants
	Bryan R. Cullen, Duke University Medical Center, USA Viruses, microRNAs and RNA Interference
	Craig P. Hunter, Harvard University, USA Intercellular RNA Transporters in Worms and Vertebrates
	Raul Andino, University of California, San Francisco, USA Short Talk: Antiviral Immunity in Drosophila Requires Systemic RNAi Spread
	Yi Liu, University of Texas Southwestern Medical Center, USA Short Talk: A Novel Type of Small Interference RNA Induced by DNA Damage
7:15 PM-	On Own for Dinner
Tuesday, April 28
7:00 - 8:00 AM	Breakfast	Crystal Ballroom
8:00 - 11:30 AM	Regulation of Translation and Stability by miRNAs Registered attendees for this meeting can view Abstracts for this session starting on 03/25/2009	Salon B-C
	* Haruhiko Siomi, Keio University School of Medicine, Japan
	Elisa Izaurralde, MPI for Developmental Biology, Germany GW182 Proteins are Essential for miRNA-mediated Gene Silencing in Animal Cells
	Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland Mechanism and Regulation of miRNA Repression in Mammalian Cells
	Xiaozhong Alec Wang, Northwestern University, USA Short Talk: Genetic Analysis of Argonaute Function in ES Cells
	Nahum Sonenberg, McGill University, Canada Dissecting microRNA Mechanisms of Action in vitro
	Joan A. Steitz, Howard Hughes Medical Institute, Yale University, USA MicroRNPs: Versatile Regulators of Translation in Vertebrate Cells
	Sara R. Cherry, University of Pennsylvania, USA Short Talk: Ars2 Regulates both miRNA- and siRNA-Dependent Silencing and Suppresses RNA Virus Infection in Drosophila
	Helge Großhans, Friedrich Miescher Institute (FMI), Switzerland Short Talk: Active Turnover Modulates Mature microRNA Activity in C. elegans
9:20 - 9:40 AM	Coffee Break	Prefunction, Level 2
11:30 AM-	On Own for Lunch
11:30 AM- 1:00 PM	Poster Setup	Salon A
1:00 - 10:00 PM	Poster Viewing	Salon A
2:30 - 4:30 PM	Workshop 2: Lessons from Deep Sequencing	Salon B-C
	* Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany Dynamic Small RNA Expression in Precisely Staged Early C. elegans Embryos and the Planarian Small RNAome
	Thomas Hohn, University of Basel, Switzerland RNA-Based Silencing Suppression
	Nicholas D. Socci, Memorial Sloan Kettering Cancer Center, USA Analysis of SmallRNA Expression Profiles in Liposarcoma via Deep Sequencing
	Priyamvada Rajasethupathy, Columbia University, USA Characterization of Small RNAs in Aplysia Reveals Neuronal piRNAs and a Neuron-Specific miRNA that Constrains Long-Term Synaptic Plasticity
	Xiaoming Zhang, University of California, Riverside, USA Diverse Classes of Endogenous siRNAs with Distinct Biogenesis Pathways Identified from Bacterial-Challenged Arabidopsis
	Michael Thomas McManus, University of California, San Francisco, USA EXPANDed RNAi Libraries for High-Throughput Deep Screening
	Constance Ciaudo, Institut de Biologie Moleculaire des Plantes, France Highly Dynamic and Sex-Specific Expression of Micro RNAs during Early ES Cell Differentiation
	Hervé Seitz, CNRS, France The Spectacular Diversity of Small Silencing RNAs in Animals is Ancient and not a Vertebrate Innovation
4:30 - 5:00 PM	Coffee Available	Prefunction, Level 2
5:00 - 7:15 PM	RNA Silencing in the Germline Registered attendees for this meeting can view Abstracts for this session starting on 03/25/2009	Salon B-C
	* Richard W. Carthew, Northwestern University, USA
	Gregory J. Hannon, Cold Spring Harbor Laboratory, USA Conserved Roles of Small RNAs in Genome Defense
	Mikiko C. Shiomi, Keio University School of Medicine, Japan PiRNA Biogenesis Systems in Drosophila Germline Cells
	Rene Ketting, Hubrecht Institute, Netherlands RNAi and Chromosome Segregation
	Yohei Kirino, University of Pennsylvania School of Medicine, USA Short Talk: Methylation of Piwi Proteins is Conserved across Phyla and in D. melanogaster it is Catalyzed by PRMT5 and Required for Ago3 and Aub Stability
	Michael Reuter, EMBL, France Short Talk: Loss of the Mili-Associated Tudor Domain Containing Protein 1 Specifically Derepresses LINE1 Transposons
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Salon A
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 03/25/2009	Salon A
Wednesday, April 29
7:00 - 8:00 AM	Breakfast	Crystal Ballroom
8:00 - 11:30 AM	MicroRNAs in Development Registered attendees for this meeting can view Abstracts for this session starting on 03/25/2009	Salon B-C
	* Olivier Voinnet, Institut de Biologie Moléculaire des Plantes, France
	Richard W. Carthew, Northwestern University, USA Silencing by Small RNAs is Linked to Endosome Trafficking
	Victor Ambros, University of Massachusetts, USA MicroRNA Pathways in Animal Development
	Antonio J. Giraldez, Yale School of Medicine, USA The Role of microRNAs during Zebrafish Development
	Gerhard Schratt, University of Heidelberg, Germany Short Talk: microRNA Regulation of Dendritic and Synaptic Plasticity
	Eran Hornstein, Weizmann Institute of Science, Israel Short Talk: Loss of miRNA Activity in Pathogenesis of ALS-like Motor Neuron Disease
	Hun-Way Hwang, Johns Hopkins University, USA Short Talk: Cell-Cell Contact Globally Activates microRNA Biogenesis
	Yang Yu, Case Western Reserve University, USA Short Talk: Enhanced Magnitude of miRNA-Mediated Regulation Upon Muscle Differentiation
	Joel Neilson, Massachusetts Institute of Technology, USA Short Talk: 3' UTR Dynamics in Cellular Activation and Transformation
9:20 - 9:40 AM	Coffee Break	Prefunction, Level 2
11:30 AM-	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Prefunction, Level 2
5:00 - 7:30 PM	Small RNAs in Medicine Registered attendees for this meeting can view Abstracts for this session starting on 03/25/2009	Salon B-C

	* Anastasia Khvorova, RXi Pharma, USA
	John Van der Oost, Wageningen University, Netherlands Interference by Small CRISPR RNA in Prokaryotes
	Gunther Hartmann, Universitätsklinikum Bonn, Germany RIG-I Immunorecognition of siRNA and Application for Tumor Therapy
	Beverly L. Davidson, University of Iowa, USA Noncoding RNAs and Huntington’s disease.

	Tariq M. Rana, Burnham Institute for Medical Research, USA Short Talk: Role of P-Bodies and microRNAs in Modulating Host-HIV-1 Interactions

	Kumi Sakurai, City of Hope Graduate School of Biological Sciences, USA Short Talk: Characterization and in vivo Application of a Dual Inhibitory Aptamer-siRNA Delivery System for HIV-1 Therapy
	Sakari Kauppinen, Santaris Pharma, Denmark Short Talk: Therapeutic Silencing of microRNA-122 in Primates with Chronic HCV Infection
7:30 - 8:30 PM	Social Hour w/ Lite Bites	Crystal Ballroom
8:00 - 11:00 PM	Entertainment	Crystal Ballroom
Thursday, April 30
	Departure
*=Session Chair †=Speaker invited, not yet responded.

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During the past decade, a set of pathways collectively known as “RNA silencing” has been shown to use small RNA molecules to regulate gene expression and protect cells from pathogens. RNA silencing pathways control an ever-expanding range of biological phenomena, and defects in these pathways lead directly to disease. In addition, small RNAs hold great promise as therapeutic agents. The physiological mechanisms of RNA silencing are only partially understood. Furthermore, small RNAs are known to affect gene expression at many different levels, but the ways in which these different levels of silencing are integrated remain obscure. Our ability to harness RNA silencing for therapeutic purposes depends critically on our knowledge of the underlying biology. The goals of this meeting are to bring together leading researchers working on different branches of RNA silencing to share their findings and facilitate a deeper understanding of the breadth and complexity of small RNA-related phenomena.

The Biology of RNA Silencing (D6)