Keystone Symposia Conference | Protein Dynamics, Allostery and Function

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Friday, June 5
3:00 - 7:30 PM	Registration	Shavano Peak Foyer
6:30 - 7:30 PM	Refreshments	Shavano Peak Foyer
7:30 - 8:30 PM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009	Red Cloud Peak
	Kenneth A. Dill, University of California, San Francisco, USA Protein Folding: Physical Approaches to Predicting Structures and Stabilities
Saturday, June 6
7:00 - 8:00 AM	Breakfast	Crestone Peak
8:00 - 11:00 AM	Dynamics, Energy Landscapes and Evolutionary Selection Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009	Red Cloud Peak



	Hans Frauenfelder, Los Alamos National Laboratory, USA A Unified Model of Protein Dynamics
	Cecilia Clementi, Rice University, USA Prediction of Protein Functional States by Multi-Resolution Protein Modeling

	Michele Vendruscolo, University of Cambridge, UK Advances in the use of NMR Spectroscopy to Characterize Free Energy Landscapes of Proteins
	Walter Englander, University of Pennsylvania, USA Short Talk: How Proteins Fold
	Matthias Buck, Case Western Reserve University, Medical School, USA Short Talk: Conformational Coupling in an Effector-GTPase Interaction: Differences in the Complex Formation of the Plexin GTPase Binding Domain with Rac1 and Rnd1
9:20 - 9:40 AM	Coffee Break	Shavano Peak Foyer
11:00 AM-	On Own for Lunch
11:00 AM- 1:00 PM	Poster Setup	Crestone Peak
1:00 - 10:00 PM	Poster Viewing	Crestone Peak
2:30 - 4:30 PM	Workshop	Red Cloud Peak
	* Ada Yonath, Weizmann Institute of Science, Israel
	Chad M. Petit, University of North Carolina, USA Entropically Modulated Function in a PDZ domain

	Miles A. Pufall, University of California-San Francisco, USA Modulating Protein Function: DNA as an Allosteric Effector of Glucocorticoid Receptor Activity
	Paula Therese Lang, University of California, Berkeley, USA Ghosts in the Machines: Using Novel X-Ray Crystallographic Methods to Identify Side Chain Polymorphism in Protein-Ligand Interactions
	Jianpeng Ma, Baylor College of Medicine, USA Minimalist Network Model (MNM): A Novel Coarse-grained Normal Mode Analysis
	Eileen K. Jaffe, Fox Chase Cancer Center, USA Dynamic Dissociating Homo-Oligomers and Allosteric Regulation
	Ahmet Bakan, University of Pittsburgh, USA Effect of Inhibitor Binding on Protein Structure and Dynamics: Intrinsic Dynamics or Induced Dynamics?
	Gail E. Fanucci, University of Florida, USA Monitoring Motions and Flexibility of HIV-1 Protease with Pulsed EPR Spectroscopy
	Michelle A. Markus, Wyeth Pharmaceuticals, USA Identifying Novel, Non-Chelating Inhibitors of MMP-9 using Virtual Screening, NMR Spectroscopy, and X-Ray Crystallography
4:30 - 5:00 PM	Coffee Available	Shavano Peak Foyer
5:00 - 7:00 PM	Catalysis and Allostery Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009	Red Cloud Peak
	* Amnon Horovitz, Weizmann Institute of Science, Israel
	Patrick Loria, Yale University, USA Short and Long-Range Interactions and Motions and their Impact on Enzyme Function
	Sebastian Doniach, Stanford University, USA Allostery and riboswitch function
	Susan S. Taylor, University of California, San Diego, USA Dynamics of Signaling by PKA
	Andrea Mozzarelli, University of Parma, Italy Short Talk: Hemoglobin: Still the Paradigm for Allostery
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Crestone Peak
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009	Crestone Peak
Sunday, June 7
7:00 - 8:00 AM	Breakfast	Crestone Peak
8:00 - 8:50 AM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009	Red Cloud Peak
	Jean-Pierre Changeux, Institut Pasteur, France The Nicotinic Acetylcholine Receptor: A Membrane Allosteric Protein Engaged in Neuronal Communication
8:50 - 11:15 AM	Allosteric Events in Membrane Proteins Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009	Red Cloud Peak
	D. Peter Tieleman, University of Calgary, Canada Coupling between Nucleotide Binding and Transmembrane Domains in ABC Transporters
	Ivet Bahar, University of Pittsburgh, USA Allosteric Dynamics of Glutamate Transporters: Insights from Multiscale Computations
	Heidi E. Hamm, Vanderbilt University School of Medicine, USA Allosteric Connections from a G Protein-Coupled Receptor to the Nucleotide-Binding Pocket of a Heterotrimeric G Protein


	* Ofer Yifrach, Ben-Gurion University of the Negev, Israel Short Talk: Principles Underlying Energetic Coupling Along an Allosteric Communication Trajectory of a Voltage-Activated K+ Channel
	Nikolaos G. Sgourakis, Rensselaer Polytechnic Institute, USA Short Talk: Simulation of a Protein Tertiary Complex: Study of the Interaction Interface and Conformational Dynamics of Dark State Rhodopsin in Complex with Transducin
9:20 - 9:40 AM	Coffee Break	Shavano Peak Foyer
11:30 AM-	On Own for Lunch
11:30 AM- 1:00 PM	Poster Setup	Crestone Peak
1:00 - 10:00 PM	Poster Viewing	Crestone Peak
4:30 - 5:00 PM	Coffee Available	Shavano Peak Foyer
5:00 - 7:15 PM	Dynamics and Biomolecular Machines Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009	Red Cloud Peak
	* David A. Agard, University of California, San Francisco, USA
	Ada Yonath, Weizmann Institute of Science, Israel Ribosomal Machinery: Peptide Bond Formation, Chaperone Assistance, and Antibiotics Inactivation
	Devarajan Thirumalai, University of Maryland, USA Structural Basis of Allosteric Transitions in Biological Machines: Common Themes
	Amnon Horovitz, Weizmann Institute of Science, Israel Linking Allostery in Chaperonins to Protein Folding
	Lars Skjaerven, Universitetet i Bergen, Norway Short Talk: Discovering the Intrinsic Dynamical Abilities of the GroEL Subunit by Molecular Dynamics Simulation
	David P. Giedroc, Indiana University, USA Short Talk: Structure and Energetics of Metal-induced Allosteric Regulation of DNA binding by ArsR Family Metal Sensor Proteins
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Crestone Peak
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009	Crestone Peak
Monday, June 8
7:00 - 8:00 AM	Breakfast	Crestone Peak
8:00 - 11:15 AM	Signal Propagation in Molecular and Cellular Systems I Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009	Red Cloud Peak
	* Rama Ranganathan, University of Texas Southwestern Medical Center, USA
	Vincent J. Hilser, University of Texas Medical Branch, USA Allostery in an Ensemble
	Kevin Donald Ridge, University of Texas, Houston, USA Signaling via Structure Change: NMR Analysis of GPCR and G Protein Activation
	Michael Grabe, University of Pittsburgh, USA Insight into the Nature of Voltage Sensing in Voltage-gated Potassium Channels
	Lila M. Gierasch, University of Massachusetts Amherst, USA The Mechanism of Allostery in an Hsp70 Molecular Chaperone
	Jeffrey W. Peng, University of Notre Dame, USA Short Talk: Towards Establishing Flexibility-Activity-Relationships for Dynamic Protein-Ligand Interactions
	Akash Bhattacharya, University of Michigan, USA Short Talk: A Comprehensive View of Allostery in the Hsp70 Chaperone Proteins

9:20 - 9:40 AM	Coffee Break	Shavano Peak Foyer
11:15 AM-	On Own for Lunch
11:15 AM- 1:00 PM	Poster Setup	Crestone Peak
1:00 - 10:00 PM	Poster Viewing	Crestone Peak
4:30 - 5:00 PM	Coffee Available	Shavano Peak Foyer
5:00 - 7:15 PM	Signal Propagation in Molecular and Cellular Systems II Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009	Red Cloud Peak
	* Susan S. Taylor, University of California, San Diego, USA
	Rama Ranganathan, University of Texas Southwestern Medical Center, USA The Evolutionary Design of Proteins
	David A. Agard, University of California, San Francisco, USA Conformational Dynamics, Structure and Mechanism of Hsp90 Chaperones
	Andrew Hopkins, University of Dundee, UK Pharmacological Approaches to Biological Network Perturbation and Allosteric Modulation
	Giorgio Colombo, Istituto di Chimica del Riconoscimento Molecolare, Italy Short Talk: Modeling Signal Propagation Mechanisms and Ligand-Based Conformational Dynamics of the Hsp90 Molecular Chaperone Full Length Dimer
	Saskia Neher, University of California at San Francisco, USA Short Talk: Signal Sequences Activate the Catalytic Switch of SRP RNA
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Crestone Peak
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009	Crestone Peak
Tuesday, June 9
7:00 - 8:00 AM	Breakfast	Crestone Peak
8:00 - 11:00 AM	Novel Methods for Dynamics and Allostery Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009	Red Cloud Peak
	* Patrick Loria, Yale University, USA
	G. Marius Clore, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA Visualizing Transient Lowly-Populated Regions of the Free Energy Landscape of Macromolecules and their Complexes by Paramagnetic Relaxation Enhancement


	Ruben Abagyan, The Scripps Research Institute, USA Induced Fit in Ligand Docking and Drug Discovery
	Ad Bax, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA Proteins, Lipids, and their Dynamic Interaction Viewed by NMR

	Justin L. P. Benesch, University of Cambridge, UK Short Talk: Thermo-Dynamically Controlled Chaperone Function of the Small Heat Shock Proteins
	Aron W. Fenton, University of Kansas Medical Center, USA Short Talk: Mapping Individual Residues within the N-Terminus that are Energetically Coupled to Allosteric and Active Site Functions of Human Liver Pyruvate Kinase
9:20 - 9:40 AM	Coffee Break	Shavano Peak Foyer
11:00 AM-	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Shavano Peak Foyer
5:00 - 6:45 PM	Novel Methods for Equilibrium Fluctuations Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009	Red Cloud Peak
	* Ad Bax, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA
	Elliot L. Elson, Washington University School of Medicine, USA Chemical Reaction Fluxes in Non-Equilibrium Steady State Systems

	Patrice Vachette, IBBMC, France Synchrotron SAXS Study of Quaternary Structure Equilibrium for Wild-Type and Mutant Forms of Allosteric Aspartate Transcarbamoylase
	Brian M. Baker, University of Notre Dame, USA Short Talk: T Cell Receptor Cross-Reactivity Triggered by Peptide-Specific Conformational Dynamics in an Unligated Peptide/MHC Complex
6:45 - 7:15 PM	Closing Remarks Registered attendees for this meeting can view Abstracts for this session starting on 05/05/2009
	Ivet Bahar, University of Pittsburgh, USA
	Lila M. Gierasch, University of Massachusetts Amherst, USA
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Crestone Peak
8:00 - 11:00 PM	Entertainment	Crestone Peak
Wednesday, June 10
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM087771-01

The contents of this program are solely the responsibility of the Conference Organizers and their speakers and do not necessarily represent the official views of the National Institutes of Health.

We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

Click here to view these companies

With recent progress in exploring biomolecular systems dynamics, an emerging view is that of the ‘intrinsic ability’ of biomolecular systems to populate an ensemble of fluctuating conformations, or alternative states, which include, in particular, the functional forms stabilized upon ligand/substrate binding or protein-protein interactions. Allosteric changes in conformations, or signal transduction mechanisms, thus emerge as properties encoded by the structure and energy landscape, which are evolutionarily selected due to their functional predisposition. Of particular interest is to elucidate the mechanisms of information flow, not only at the level of residue interactions, but also between the components of biomolecular machines or cell signaling networks. This Keystone Symposia meeting will provide a forum for researchers from diverse fields to explore the basic principles underlying allosteric responses at the molecular level, and their higher (cellular) level consequences, and to exchange expertise on methods to illuminate key dynamic properties of biomolecular systems.

Protein Dynamics, Allostery and Function (E3)