Keystone Symposia
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LANGUAGE NOTE: This meeting will be conducted in English.
**Meeting has ended.**



Meeting Program

To view program in "24 hour" time (international) click here.


Wednesday, June 10
3:00 - 7:30 PM Registration Shavano Peak Foyer
6:30 - 7:30 PM Refreshments Shavano Peak Foyer
7:30 - 7:45 PM Welcome Remarks
Registered attendees for this meeting can view Abstracts for this session starting on 05/10/2009
Red Cloud/Crestone
Frank J. Slack, Yale University, USA
7:45 - 8:45 PM Keynote Address
Registered attendees for this meeting can view Abstracts for this session starting on 05/10/2009
Red Cloud/Crestone
Joan Massagué, Memorial Sloan-Kettering Cancer Center, USA
Deconstructing Metastasis
Thursday, June 11
7:30 - 8:30 AM Breakfast Shavano/Torreys
8:30 - 11:00 AM Regulation of Development by miRNAs
Registered attendees for this meeting can view Abstracts for this session starting on 05/10/2009
Red Cloud/Crestone
* Helge Großhans, Friedrich Miescher Institute (FMI), Switzerland
Alexander F. Schier, Harvard University, USA
MicroRNAs in Embryogenesis
Amy E. Pasquinelli, University of California, San Diego, USA
Regulation of Gene Expression by MicroRNAs in C. elegans
Eric C. Lai, Sloan-Kettering Institute, USA
Biogenesis and Function of Short Regulatory RNAs in Drosophila
Seogang Hyun, Seoul National University, South Korea
Short Talk: Functional Study on Conserved miR-8/200 Family in Flies and Mammals
Silvia Monticelli, Institute for Research in Biomedicine, Switzerland
Short Talk: MicroRNAs in Mast Cells
Debora Marks, Harvard Medical School, USA
Short Talk: Transfection of Small RNAs Globally Perturbs Gene Regulation by Endogeneous microRNAs
9:50 - 10:10 AM Coffee Break Shavano Peak Foyer
11:45 AM- On Own for Lunch
11:45 AM- 1:00 PM Poster Setup Shavano/Torreys
1:00 - 10:00 PM Poster Viewing Shavano/Torreys
2:30 - 4:30 PM Workshop 1: Bench to Bedside: Translating miRNA Discoveries into Clinical Applications
Red Cloud/Crestone
* Joanne B. Weidhaas, Yale University School of Medicine, USA
Doyel Mitra, University of Colorado Denver, USA
The Role of the Histone Demethylase JARID1b in the Regulation of miRNA Expression in Breast Cancer Cells
Helen M. Heneghan, National University of Ireland, Galway, Ireland
Circulating miRNAs as Novel Minimally Invasive Biomarkers for Breast Cancer
Galina Gabriely, Brigham and Women's Hospital, USA
The Role of Onco-MicroRNA miR-21 in Gliomagenesis
Stoil D. Dimitrov, Dana-Farber Cancer Institute, USA
Regulation of BRCA1 Expression by MicroRNA-545
Dalia Cohen, Rosetta Genomics, USA
Identification of Tumor Tissue Origin by a MicroRNA-based Molecular Assay
Kim A. Lennox, Integrated DNA Technologies, USA
A Direct Comparison of miRNA Antagonist Potency
Yan Li, National Eye Institute, USA
Characterization of a Corneal/Lens-Specific miRNA Gene, miR-184
Karen Angelica Cavassani, University of Michigan Medical School, USA
microRNA as Regulators of Tumor Growth in Post-Septic Hosts
4:30 - 5:00 PM Coffee Available Shavano Peak Foyer
5:00 - 7:00 PM Gene Regulation by Non-Coding RNAs
Registered attendees for this meeting can view Abstracts for this session starting on 05/10/2009
Red Cloud/Crestone
* Alla Grishok, Columbia University Medical Center, USA
John Mattick, University of Queensland, Australia
The Central Role of RNA Regulation in Evolution, Development and Cognition
George A. Calin, University of Texas - M.D. Anderson Cancer Center, USA
A Noncoding RNA Revolution in the Cancer Society
Mark A. Kay, Stanford University, USA
The Role of Small RNAs in Gene Regulation
Yong Sun Lee, University of Texas Medical Branch, USA
Short Talk: A Novel Class of Small RNAs, tRNA-Derived RNA Fragments (tRFs), is Highly Expressed in Proliferating Cells and Required for Cell Proliferation
7:00 - 8:00 PM Social Hour w/ Lite Bites Shavano/Torreys
7:30 - 10:00 PM Poster Session 1
Registered attendees for this meeting can view Abstracts for this session starting on 05/10/2009
Shavano/Torreys
Friday, June 12
7:30 - 8:30 AM Breakfast Shavano/Torreys
8:30 - 11:45 AM MicroRNAs in Cancer
Registered attendees for this meeting can view Abstracts for this session starting on 05/10/2009
Red Cloud/Crestone
* Scott M. Hammond, University of North Carolina at Chapel Hill, USA
Curtis C. Harris, National Institutes of Health, USA
MicroRNAs and Inflammatory Cytokines as Biomarkers of Cancer Diagnosis, Prognosis, and Therapeutic Outcome
Frank J. Slack, Yale University, USA
MicroRNAs and Cancer
Joshua Mendell, Johns Hopkins University, USA
MicroRNA Reprogramming in Cancer: Mechanisms and Therapeutic Opportunities
Carlo M. Croce, Ohio State University, USA
Role of microRNAs in Human Cancer
Mathijs Voorhoeve, Duke-NUS Graduate Medical School, Singapore
Short Talk: Genetic Dissection of the Role of microRNAs and Other ncRNAs in Cancer
Florian Kuchenbauer, Terry Fox Laboratory, Canada
Short Talk: Emerging Evidence of Differential Expression of miRNA*s and its Contribution to the Development of Acute Myeloid Leukemia
9:50 - 10:10 AM Coffee Break Shavano Peak Foyer
11:45 AM- On Own for Lunch
11:45 AM- 1:00 PM Poster Setup Shavano/Torreys
1:00 - 10:00 PM Poster Viewing Shavano/Torreys
4:30 - 5:00 PM Coffee Available Shavano Peak Foyer
5:00 - 7:00 PM Hot Topics in miRNA Research
Registered attendees for this meeting can view Abstracts for this session starting on 05/10/2009
Red Cloud/Crestone
* Lin He, University of California, Berkeley, USA
Hannele Ruohola-Baker, University of Washington, USA
microRNAs Regulate Human Embryonic Stem Cell Division
Eric G. Marcusson, Regulus Therapeutics, USA
Therapeutic Targeting of miRNA
Isidore Rigoutsos, International Business Machines Corporation, USA
Expanding the Role of miRNA Activity
Zain Paroo, University of Texas Southwestern Medical Center, USA
Short Talk: Phosphorylation of the Human Micro-RNA Generating Complex Mediates MAPK/Erk Signaling
7:00 - 8:00 PM Social Hour w/ Lite Bites Shavano/Torreys
7:30 - 10:00 PM Poster Session 2
Registered attendees for this meeting can view Abstracts for this session starting on 05/10/2009
Shavano/Torreys
Saturday, June 13
7:30 - 8:30 AM Breakfast Shavano/Torreys
8:30 - 11:45 AM Mechanisms of miRNA Form and Function
Registered attendees for this meeting can view Abstracts for this session starting on 05/10/2009
Red Cloud/Crestone
* George A. Calin, University of Texas - M.D. Anderson Cancer Center, USA
Jennifer A. Doudna, University of California, Berkeley, USA
Biogenesis of small regulatory RNAs
Marianthi Kiriakidou, University of Pennsylvania School of Medicine, USA
miRNA Function in Normal and Cancer Cells
Alla Grishok, Columbia University Medical Center, USA
Gene Expression Regulation by Endogenous RNAi and Rb in C. elegans
Elaine Fuchs, Howard Hughes Medical Institute, Rockefeller University, USA
MicroRNA Regulation in Skin Stem Cells: Fine Tuning the Balance between Growth and Differentiation
Liang Zhang, Rockefeller University, USA
Short Talk: Systematic Analysis of Dynamic miRNA-Target Interactions during C. elegans Development
Ulrich Tschulena, DKFZ, Germany
Short Talk: A Novel Large-Scale Screen to Identify Modulators of miR-21
9:50 - 10:10 AM Coffee Break Shavano Peak Foyer
11:45 AM- On Own for Lunch
11:45 AM- 1:00 PM Poster Setup Shavano/Torreys
1:00 - 10:00 PM Poster Viewing Shavano/Torreys
2:30 - 4:30 PM Workshop 2: Emerging Ideas and Technologies in Small RNAs
Red Cloud/Crestone
* Allison L. Abbott, Marquette University, USA
Carl D. Novina, Dana Farber Cancer Institute, USA
Identification of microRNA-Mediated Tumor Suppressive Activity in Melanoma
Angela Anderegg, Northwestern University, USA
The Role of MicroRNAs in Midbrain Dopaminergic Neurogenesis
Jennifer Young, Centenary Institute, Australia
Regulation of Angiogenesis by MicroRNAs
Lu Ping Tan, University Medical Center Groningen, the Netherlands
A High Throughput Experimental Approach to Identify miRNA Target Genes
Ivan Martinez, Yale University, USA
Rb-Dependent Cellular Senescence Induce the Expression of miR-29 and miR-30 that Target the Cell Cycle Regulatory Gene MYBL2
Aleishia Geraldine Harris, Stanford School of Medicine, USA
Epstein-Barr Virus Latent Membrane Protein 1 Modulates Host MicroRNAs in B Cell Lymphomas
Andrei Thomas-Tikhonenko, University of Pennsylvania, USA
Clusterin, an Inhibitor of Tumor Growth and Angiogenesis, is Negatively Regulated by c-Myc though miR-17-92 and the type II TGFbeta Receptor
4:30 - 5:00 PM Coffee Available Shavano Peak Foyer
5:00 - 7:00 PM Roles of Small RNAs in Cancer
Registered attendees for this meeting can view Abstracts for this session starting on 05/10/2009
Red Cloud/Crestone
* Joshua Mendell, Johns Hopkins University, USA
Aurora Esquela-Kerscher, Eastern Virginia Medical School, USA
The Role of miRNAs during Development and Cancer Progression
Bryan R. Cullen, Duke University Medical Center, USA
Viral microRNAs and Cancer
Judy Lieberman, Harvard Medical School, USA
miRNAs and Breast Cancer also Small RNAs as Therapeutics
Joel Neilson, Massachusetts Institute of Technology, USA
Short Talk: 3' UTR Dynamics in Cellular Activation and Transformation
7:00 - 8:00 PM Social Hour w/ Lite Bites Shavano/Torreys
7:30 - 10:00 PM Poster Session 3
Registered attendees for this meeting can view Abstracts for this session starting on 05/10/2009
Shavano/Torreys
Sunday, June 14
7:30 - 8:30 AM Breakfast Shavano Peak
8:30 - 11:45 AM MiRNAs as Diagnostics and Therapeutics
Registered attendees for this meeting can view Abstracts for this session starting on 05/10/2009
Red Cloud/Crestone
* Aurora Esquela-Kerscher, Eastern Virginia Medical School, USA
Michele A. Cleary, Rosetta Inpharmatics LLC, USA
Molecular Profiling-Based Approaches to Understanding microRNA Function and Targets
Lin He, University of California, Berkeley, USA
miRNAs in Cancer
Joanne B. Weidhaas, Yale University School of Medicine, USA
A MicroRNA Binding Site Polymorphism as a Biomarker of Cancer Risk
Scott M. Hammond, University of North Carolina at Chapel Hill, USA
MicroRNAs in Development and Disease
Sónia A. Melo, IDIBELL - PEBC Program Barcelona/GABBA Program Portugal, Spain
Short Talk: Impairment of microRNA Machinery in Human Cancer
Alexander Pertsemlidis, University of Texas Southwestern Medical Center, USA
Short Talk: miR-337 Modulates Sensitivity to Paclitaxel in Non-Small Cell Lung Cancer
9:50 - 10:10 AM Coffee Break Shavano Peak Foyer
11:45 AM- On Own for Lunch
4:30 - 5:00 PM Coffee Available Shavano Peak Foyer
5:00 - 7:00 PM Lessons from Developmental Biology
Registered attendees for this meeting can view Abstracts for this session starting on 05/10/2009
Red Cloud/Crestone
* Eric C. Lai, Sloan-Kettering Institute, USA
Allison L. Abbott, Marquette University, USA
Genetic Analysis of microRNA Functions in C. elegans Development
Helge Großhans, Friedrich Miescher Institute (FMI), Switzerland
Life and Death of MicroRNAs
David Brown, Asuragen, Inc., USA
Therapeutic Applications of a Tumor Suppressor miRNA
Eric Alexander Miska, University of Cambridge, UK
Short Talk: Genetic Analysis in C. elegans Reveals New Insights into miRNA Mechanism
7:00 - 7:15 PM Closing Remarks
Registered attendees for this meeting can view Abstracts for this session starting on 05/10/2009
Red Cloud/Crestone
Amy E. Pasquinelli, University of California, San Diego, USA
7:15 - 8:15 PM Social Hour w/ Lite Bites Shavano Peak
8:00 - 11:00 PM Entertainment Shavano Peak
Monday, June 15
Departure
      *=Session Chair     †=Speaker invited, not yet responded.



We gratefully acknowledge support for this conference from:












Asuragen, Inc.


The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Cancer Institute (NCI)

Grant No. 1R13CA139690-01


The contents of this program are solely the responsibility of the Conference Organizers and their speakers and do not necessarily represent the official views of the National Institutes of Health.


We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

Click here to view these companies

MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently mis-expressed in human disease states, in particular cancer. MicroRNAs act to promote or repress cell proliferation, migration and apoptosis during development, all processes that can go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. Their small size and molecular properties make miRNAs amenable as targets and therapeutics in cancer treatment. While hundreds of human microRNAs are known, relatively little is known about their roles and targets. This meeting will focus on the exciting biology of microRNAs in controlling developmental and cancer processes like cell proliferation, differentiation, cell cycle, apoptosis and metastasis. It will also focus on the latest efforts to harness the power of these small RNAs as agents in the fight against cancer.