Keystone Symposia Conference | Bioactive Lipids: Biochemistry and Diseases

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Meeting Program

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Sunday, June 6
3:00 - 7:30 PM	Registration	Mizuho Foyer
6:30 - 7:30 PM	Refreshments	Mizuho Foyer
7:30 - 8:30 PM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 05/06/2010	Mizuho Ballroom
	* Shuh Narumiya, Kyoto University, Japan
	Osamu Hayaishi, Osaka Bioscience Institute, Japan Prostaglandins and Sleep
Monday, June 7
7:30 - 8:30 AM	Breakfast	Mizuho Ballroom
7:30 - 8:30 AM	Poster Setup	Mizuho Ballroom
8:30 AM- 7:00 PM	Poster Viewing	Mizuho Ballroom
8:30 AM- 12:00 PM	Biochemistry of Lipid Metabolism I Registered attendees for this meeting can view Abstracts for this session starting on 05/06/2010	Mizuho Ballroom
	* Edward A. Dennis, University of California, San Diego, USA
	* Jesper Z. Haeggstrom, Karolinska Institute, Sweden
	Takao Shimizu, University of Tokyo, Japan Turnover of Glycerophospholipids by Deacylation-Reacylation Cycle
	Makoto Murakami, Tokyo Metropolitan Institute of Medical Science, Japan Biological Functions of sPLA2s
	Sasanka Ramanadham, Washington University School of Medicine, USA Involvement of Novel iPLA2beta-Dependent Mechanisms in beta-Cell Apoptosis
	William L. Smith, University of Michigan, USA Cyclooxygenase Homodimers Function as Conformational Heterodimers with Allosteric and Catalytic Subunits
	Michael H. Gelb, University of Washington, USA Short Talk: Phospholipase A2 Mediated Eicosanoid Generation During Inflammation
	Claude Wolf, Faculté de Médecine St Antoine, France Short Talk: Profiling of Liver Triglycerides Reveals Specific Molecular Species Associated with Fatty Liver in Mice
9:40 - 10:00 AM	Coffee Break	Mizuho Foyer
12:00 - 1:00 PM	Lunch	Mizuho Ballroom
12:30 - 3:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 05/06/2010	Mizuho Ballroom
2:45 - 3:00 PM	Coffee Available	Mizuho Foyer
3:00 - 5:30 PM	Biochemistry of Lipid Metabolism II Registered attendees for this meeting can view Abstracts for this session starting on 05/06/2010	Mizuho Ballroom
	* Takao Shimizu, University of Tokyo, Japan
	* William L. Smith, University of Michigan, USA
	Kikuko Watanabe, University of East Asia, Japan A Novel Type of PGF Synthase belonging to the Thioredoxin-Like Superfamily
	Jesper Z. Haeggstrom, Karolinska Institute, Sweden Structure and function of LTA4 hydrolase, LTC4 synthase, and related enzymes
	B. Therese Kinsella, University College Dublin, Ireland Biochemistry of the Human Prostacyclin Receptor
	Edward A. Dennis, University of California, San Diego, USA Short Talk: Lipidomics of Eicosanoids in Cell Signaling and Inflammation
	Toshiko Suzuki-Yamamoto, Okayama Prefectural University, Japan Short Talk: Localization of Prostaglandin F2alpha Synthase and Receptor FP in the Rat Cerebellum
	Marcia E. Newcomer, Louisiana State University, USA Short Talk: The Crystal Structure of Human 5-Lipoxygenase
5:30 PM-	On Own for Dinner
Tuesday, June 8
7:30 - 8:30 AM	Breakfast	Mizuho Ballroom
8:30 AM- 12:00 PM	Biochemistry of Lipid Metabolism III Registered attendees for this meeting can view Abstracts for this session starting on 05/06/2010	Mizuho Ballroom
	* Jerold J. Chun, The Scripps Research Institute, USA
	* Kikuko Watanabe, University of East Asia, Japan
	Robert C. Murphy, University of Colorado Denver, USA Transcellular Biosynthesis of Leukotrienes in vivo
	Alan R. Brash, Vanderbilt University Medical Center, USA Lipoxygenases, Essential Fatty Acids, and the Epidermis
	Helena Idborg, Karolinska Institute, Sweden Short Talk: Evaluation of Urinary Prostaglandin E2 Metabolite as a Biomarker of Inflammation
	Michal L. Schwartzman, New York Medical College, USA Cytochrome P450-Derived EETs and HETEs in Vascular Biology
	Junkin Aoki, Tohoku University, Japan Autotaxin and LPA Signaling in Cardiovascular Development
	Yutaka Yatomi, Graduate School of Medicine, The University of Tokyo, Japan Short Talk: Clinical Introduction of Plasma Lysophosphatidic Acid and Serum Autotaxin Assays
9:40 - 10:00 AM	Coffee Break	Mizuho Foyer
12:00 PM-	On Own for Lunch and Recreation
12:00 - 1:00 PM	Poster Setup	Mizuho Ballroom
1:00 - 9:30 PM	Poster Viewing	Mizuho Ballroom
3:45 - 4:00 PM	Coffee Available	Mizuho Foyer
4:00 - 6:30 PM	Immunoregulation Registered attendees for this meeting can view Abstracts for this session starting on 05/06/2010	Mizuho Ballroom
	* Andrew D. Luster, Massachusetts General Hospital, USA
	* Sarah Spiegel, Virginia Commonwealth University School of Medicine, USA
	Shuh Narumiya, Kyoto University, Japan Prostanoids and Immune Inflammation
	Kenji Chiba, Mitsubishi Tanabe Pharma Corporation, Japan Immunoregulation by the Sphingosine 1-Phosphate Receptor Modulator, FTY720
	Andreas Zimmer, University of Bonn, Germany Endocannabinoids and Immunoregulation
	Doina Ganea, Temple University School of Medicine, USA Short Talk: Dendritic Cells – A Crucial Target for the Anti-Inflammatory Effects of Docosahexaenoic Acid (DHA)
	Marc Stephan Lamphier, Eisai Research Institute, USA Short Talk: A Novel Antagonist of the Prostaglandin E2 Receptor EP4 Inhibits Th1 Differentiation and Th17 Expansion and is Orally Active in Arthritis Models
6:30 - 7:30 PM	Social Hour w/ Lite Bites	Mizuho Ballroom
7:00 - 9:30 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 05/06/2010	Mizuho Ballroom
Wednesday, June 9
7:30 - 8:30 AM	Breakfast	Mizuho Ballroom
8:30 AM- 12:00 PM	Allergy and Inflammation Registered attendees for this meeting can view Abstracts for this session starting on 05/06/2010	Mizuho Ballroom
	* Shuh Narumiya, Kyoto University, Japan
	* Colin D. Funk, Queen's University, Canada
	K. Frank Austen, Harvard Medical School, USA The Integrated Biology of the Cysteinyl Leukotrienes and their Receptors
	Andrew D. Luster, Massachusetts General Hospital, USA Lipid-Cytokine-Chemokine Cascades Control Leukocyte Trafficking in Disease
	Jilly F. Evans, Amira Pharmaceuticals, USA Development of FLAP Inhibitors
	Sarah Spiegel, Virginia Commonwealth University School of Medicine, USA Novel Intracellular Targets of Sphingosine-1-Phosphate
	Yumiko Imai, Akita University School of Medicine, Japan Short Talk: Hyper-Response of Innate Immune System Triggered by Oxidative Stress and Oxidized Phospholipids Controls the Severity of Acute Lung Injury
	Susanna Louise Lundström, Karolinska Institutet, Sweden Short Talk: Allergic Asthmatics Exhibit Altered Responses in Oxylipin Profile Compared to Healthy and Asthmatic Controls following Allergen Provocation
9:40 - 10:00 AM	Coffee Break	Mizuho Foyer
12:00 PM-	On Own for Lunch and Recreation
12:00 - 1:00 PM	Poster Setup	Mizuho Ballroom
1:00 - 9:30 PM	Poster Viewing	Mizuho Ballroom
3:45 - 4:00 PM	Coffee Available	Mizuho Foyer
4:00 - 5:50 PM	Nervous System Registered attendees for this meeting can view Abstracts for this session starting on 05/06/2010	Mizuho Ballroom
	* Garret A. FitzGerald, University of Pennsylvania, USA
	* Yoshihiro Urade, Osaka Bioscience Institute, Japan
	Jerold J. Chun, The Scripps Research Institute, USA Lysophospholipid Signaling in Disease
	Daniele Piomelli, University of California, Irvine, USA Endocannabinoids and the Brain
	Shuntaro Hara, Showa University, Japan Short Talk: Involvement of Microsomal Prostaglandin E Synthase-1 (mPGES-1) in Alzheimer’s Disease
	Fumiaki Kojima, Asahikawa Medical College, Japan Short Talk: Prostaglandin E2 Exacerbates Ischemic Brain Injury via the EP4 Receptor Subtype in Mice Subjected to a Middle Cerebral Artery Occlusion
5:50 - 6:30 PM	Cardiovascular Diseases I Registered attendees for this meeting can view Abstracts for this session starting on 05/06/2010	Mizuho Ballroom
	Shaun R. Coughlin, University of California, San Francisco, USA Sphingosine-1-Phosphate in the Plasma Compartment Regulates Basal and Stimulated Vascular Leak in Mouse
6:30 - 7:30 PM	Social Hour w/ Lite Bites	Mizuho Ballroom
7:00 - 9:30 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 05/06/2010	Mizuho Ballroom
Thursday, June 10
7:30 - 8:30 AM	Breakfast	Mizuho Ballroom
8:30 AM- 12:00 PM	Cardiovascular Diseases II Registered attendees for this meeting can view Abstracts for this session starting on 05/06/2010	Mizuho Ballroom
	* Shaun R. Coughlin, University of California, San Francisco, USA
	* Michal L. Schwartzman, New York Medical College, USA
	Garret A. FitzGerald, University of Pennsylvania, USA Cardiovascular Biology of the Prostanoids
	Colin D. Funk, Queen's University, Canada Eicosanoids in Cardiovascular Disease
	Paola Patrignani, G. D'Annunzio University, Italy Role of Prostanoids in Endothelial Biology
	Alison M. Strack, Merck & Co., USA Niacin and DP1 Antagonists: Studies in Mouse Models of Atherosclerosis
	Barry Rubin, Toronto General Hospital, Canada Short Talk: Lack of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) in Bone Marrow Derived Leucocytes Impairs Left Ventricular Remodelling and Increases Mortality After Myocardial Infarction
	Yoshinori Katsumata, Keio University, Japan Short Talk: Prostaglandin D2 Transduces Signals into Cardiomyocytes Independently of Canonical PGD2 Receptor
9:40 - 10:00 AM	Coffee Break	Mizuho Foyer
12:00 PM-	On Own for Lunch and Recreation
3:45 - 4:00 PM	Coffee Available	Mizuho Foyer
4:00 - 6:30 PM	Immunomodulation by Lipid Mediators and Related Drugs Registered attendees for this meeting can view Abstracts for this session starting on 05/06/2010	Mizuho Ballroom
	* Jilly F. Evans, Amira Pharmaceuticals, USA
	* Alison M. Strack, Merck & Co., USA
	Suzanne Ostrand-Rosenberg, University of Maryland, USA Prostaglandin E2 Drives Immune Suppression in the Tumor Microenvironment
	Yoshihiro Urade, Osaka Bioscience Institute, Japan PGD2 in Neuroinflammation and Muscular Dystrophy
	Takayuki Maruyama, Ono Pharmaceutical Co.Ltd., Japan Possibilities of EP Agonists and Antagonists for Novel Therapies
	David F. Woodward, Allergan, Inc., USA Short Talk: Design of Antagonists for PGF2alpha-Ethanolamide and PGE2-Glyceryl Ester by Using a Single Oxabicycloheptane Scaffold
	Masataka Majima, Kitasato University School of Medicine, Japan Short Talk: Recruitment of Mast Cells to the Tumor Microenvironment via the High Affinity Leukotriene B4 Receptor Regulates Tumor Stromal Profiles and Tumor-Associated Angiogenesis
6:30 - 7:30 PM	Social Hour w/ Lite Bites	Mizuho Ballroom
6:30 - 8:30 PM	Entertainment	Mizuho Ballroom
Friday, June 11
	Departure
*=Session Chair †=Speaker invited, not yet responded.

Keystone Symposia would like to thank the sponsors of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:



	Nacalai Tesque, Inc.


	Asubio Pharma Co., Ltd.
Journal of Lipid Research	Minase Research Institute, Ono Pharmaceutical Co. Ltd.
Ono Pharmaceutical Co.Ltd.

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI088818-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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The world of lipid mediators is expanding. New and unexpected biological functions, biosynthetic pathways and receptors are being revealed for lipids as appreciation grows for their complex interactions with protein and the genome. New actions are still being added to classic mediators such as prostaglandins and leukotrienes. Lipid mediators are now recognized to influence a broad swath of biology from inflammation to allergy, immunity, cardiovascular diseases, cancer and behavior. Advances in lipidomics enable us to monitor dynamics of a variety of lipid mediators simultaneously. In this symposium we invite distinguished scientists to share their progress in this expanding field and to present a comprehensive view on what lipid mediators do in our body. We also invite scientists interested in the translation of such basic science from model systems to an understanding of the role of lipids in human physiology, disease and drug action. Expansion of our understanding of the role of lipid mediators affords the opportunity for novel therapeutic opportunities, examples of which will be discussed in the symposium.

Bioactive Lipids: Biochemistry and Diseases (D2)