Keystone Symposia Conference | Structural Genomics: Expanding the Horizons of Structural Biology

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Friday, January 8
3:00 - 7:30 PM	Registration	Foyer
6:15 - 7:15 PM	Refreshments	Foyer
7:15 - 7:30 PM	Orientation for New Attendees and New Investigators Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009 NOTE: Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a "What to Expect during your Attendance" for interested delegates.	Peaks 1-5
7:30 - 8:30 PM	Keynote Session (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-5
	* Alasdair C. Steven, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, USA
	* Ian A. Wilson, The Scripps Research Institute, USA
	William E. Moerner, Stanford University, USA Single-Molecule Approaches to Biomolecular Dynamics and Imaging of Cellular Superstructures
Saturday, January 9
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:15 AM	Pushing the Limits of Structural Biology I: New and Innovative Methods (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-5
	* Kurt Wüthrich, ETH Zurich/The Scripps Research Institute, Switzerland
	Andrej Sali, University of California, San Francisco, USA Integrative Determination of Macromolecular Structures
	John A. Tainer, The Scripps Research Institute, USA Short Talk: Proteomics Scale X-ray Solution Scattering (SAXS) to Shape Interactomes
	Ad Bax, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA Combining Novel Solution NMR Approaches with SAXS
	Wah Chiu, Baylor College of Medicine, USA Seeing Protein Backbone and Side-Chains in Molecular Machines by Cryo-EM
	Daniel J. Müller, University of Technology Dresden, Germany Force Probing How Membrane Proteins Regulate Molecular Mechanics of Cell Rounding
	Graham Johnson, The Scripps Research Institute, USA Short Talk: Automated Visualization of Subcellular Environments
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM- 1:00 PM	Poster Setup	Breckenridge Ballroom
11:15 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Breckenridge Ballroom
2:30 - 4:30 PM	Workshop 1: Advances in Methodologies and Tools for Structural Biology NOTE: This workshop will focus on new methodologies, technologies, instrumentation, devices, software and innovations for production, characterization, structure determination and analysis of biological macromolecules, including servers, databases and repositories.	Peak 5
	* Helen M. Berman, Rutgers University, USA
	* Andy May, Fluidigm Corporation, USA
	George N. Phillips, Jr., University of Wisconsin, CESG, USA Use of a Cell-Free Protein Production Platform for X-Ray Crystallography
	Cory J. Gerdts, Emerald BioSystems, USA Nanovolume Optimization of Protein Crystal Growth Using the Microcapillary Protein Crystallization System
	Andrei Kouranov, Protein Data Bank, USA PepcDB (Protein Expression Purification Crystallization DataBase): A Tool for Experimental Design
	Paolo Rossi, Rutgers University, USA Synergies of X-ray, NMR, and Rosetta in Protein Structure Determination
	Peter Minary, Stanford University, USA Conformational Optimization with Natural Degrees of Freedom: A Novel Stochastic Chain Closure Algorithm and its Applications
	Joshua M. Gilmore, Stowers Institute for Medical Research, USA Determining Protein Complex Architecture using a Probabilistic Deletion Network Derived from Quantitative Proteomics
	Gyorgy Babnigg, Argonne National Laboratory, USA Comparison of High-Throughput Techniques for the Expression of Protein Complexes
	Wladek Minor, University of Virginia, USA Application of the Ligand Screening Module in HKL-3000 for High-Throughput Identification of Bound Ligands in Protein Crystal Structures
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Advances in Protein and Nucleic Acid Production and Crystallization Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peak 5
	* Andrzej Joachimiak, Argonne National Laboratory, USA
	Scott A. Lesley, Genomics Institute of the Novartis Research Foundation, USA Applying Structural Genomics Principles to Biology-Centered Targets
	Yaeta Endo, Ehime University, Japan Advances in Cell Free Systems for Expression of Eukaryotic and Parasitic Proteins
	Robert T. Batey, University of Colorado, Boulder, USA Advances in Preparation and Crystallization of RNA
	Joseph R. Luft, Hauptman-Woodward Medical Research Institute, USA Short Talk: The Use of Empirically Derived Detergent Phase Boundaries to Crystallize Membrane Proteins
Following Session is for Structural Biology (J1)
5:00 - 7:00 PM	Macromolecular Complexes I Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-4
	* Christopher P. Hill, University of Utah, USA
	Eva Nogales, HHMI - University of California, Berkeley, USA Microtubule-Kinetochore Interactions
	Cynthia Wolberger, Johns Hopkins School of Medicine, USA Insights into the Unusual Chemistry of Sir2 Enzymes
	Justin L. P. Benesch, University of Cambridge, UK Short Talk: A Hybrid Approach for Determining the Structures of Protein Oligomers Comprising Heterogeneous Ensembles
	Angela M. Gronenborn, University of Pittsburgh, USA Synergy between cryo-EM and NMR - Novel Findings for HIV capsid Function
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Breckenridge Ballroom
Sunday, January 10
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:15 AM	Advances in Crystallography, Magnetic Resonance Spectroscopy and Computation Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peak 5
	* Robert M. Stroud, University of California, San Francisco, USA
	Soichi Wakatsuki, KEK IMSS Photon Factory, Japan Developments in Synchrotron Protein Crystallography for Targeted Structural Proteomics
	Kurt Wüthrich, ETH Zurich/The Scripps Research Institute, Switzerland NMR in Structural Genomics: New Strategic and Technical Challenges
	John L. Markley, University of Wisconsin, Madison, USA Short Talk: Advances in High-Throughput NMR Spectroscopy of Proteins
	Wayne A. Hendrickson, Columbia University, USA Structural Genomics of Membrane Proteins by X-ray Crystallography
	David Baker, University of Washington, USA Rapid Structure Determination from Sparse Experimental Data Sets using Rosetta
	Michael A. Kennedy, Miami University, USA Short Talk: EPR-Based Long-Range Distance Restraints for Structure Determination of Protein Complexes
Following Session is for Structural Biology (J1)
8:00 - 11:00 AM	Membrane-Associated Phenomena Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-4
	* Hartmut Luecke, University of California, Irvine, USA
	James H. Hurley, National Institutes of Health, USA The ESCRT Complexes in Membrane Scission and Budding
	Christopher P. Arthur, The Scripps Research Institute, USA Short Talk: Structure of Botulinum Neurotoxin Serotype B in a Lipid Bilayer at Multiple pH Levels
	Gabriel Waksman, Birkbeck College and University College London, UK Structural Biology of Type IV Secretion Systems
	Mark S.P. Sansom, University of Oxford, UK Multiscale Simulations of Membrane Proteins
	Jay T. Groves, University of California, Berkeley, USA Spatial and Mechanical Regulation of Signal Transduction in Cell Membranes
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM- 1:00 PM	Poster Setup	Breckenridge Ballroom
11:15 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Breckenridge Ballroom
2:30 - 4:30 PM	Workshop 2: Structural Genomics and Functional Proteomics of Biological Macromolecules NOTE: This workshop will focus on novel insights gained from study of the expanding protein universe, protein families, individual organisms, microbiomes, metagenomes, drug targets, pathogens, novel mechanisms, challenging proteins, including RNA, protein-protein complexes, membrane proteins and eukaryotic proteins.	Peak 5
	* Gaetano T. Montelione, Rutgers University, USA
	Marek Grabowski, University of Virginia, USA “Drugability” of Structural Genomics
	Parthasarathy Sampathkumar, Eli Lilly, USA Structures of Two PHR Domains from Mus musculus Phr1 (Mycbp2) Reveal a Novel Fold and Provide Insights into a C. elegans RPM-1 Loss of Function Mutation
	Werner Braun, University of Texas Medical Branch,, USA Allergen Structures in a Genomic Age
	Ashley M. Deacon, Stanford Synchrotron Radiation Laboratory, USA Structural and Functional Studies of the Bacterial Ancestors of Common Eukaryotic Protein Modules
	Liskin Swint-Kruse, University of Kansas Medical School, USA Comparing the Functional Roles of Nonconserved Sequence Positions in Homologous Transcription Repressors: Implications for Sequence/Function Analyses
	András Fiser, Albert Einstein College of Medicine, USA Structural Characteristics of Novel Protein Folds
	Markus Fischer, Columbia University, USA MarkUs: A Server to Navigate Sequence-Structure-Function Space
	Margaret J. Gabanyi, PSI Structural Genomics Knowledgebase - Rutgers University, USA The PSI Structural Genomics Knowledgebase Technology Portal - an Online Resource for all Structural Biologists
	Andrew Ward, The Scripps Research Institute, USA Structural Basis of Drug Binding and Transport in P-glycoprotein
Following Workshop is for Structural Biology (J1)
2:30 - 4:30 PM	Special Session Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-4
	* Alasdair C. Steven, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, USA
	Vitold E. Galkin, University of Virginia, USA Short Talk: High Resolution Structures of F-actin Yield New Insights into the Dynamics of Actin Filament
	Christian Biertümpfel, NIDDK, National Institutes of Health, USA Short Talk: Crystal Structure of T4 Endonuclease VII Resolving a Holliday Junction
	Pingwei Li, Texas A&M University, USA Short Talk: The Structural Basis of Viral RNA Recognition by RIG-I
	Mei-ting Wu, University of Washington, USA Short Talk: Nanobodies were Crucial for Solving Crystal Structures from a Key Protein of an RNA-Editing Complex from the Sleeping Sickness Parasite Trypanosoma brucei
	Donald L.D. Caspar, Florida State University, USA Special Lecture: Origins of Structural Biology and Trials and Errors in its History
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Challenging Proteins Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peak 5
	Robert M. Stroud, University of California, San Francisco, USA Ratiocinative Screen of Eukaryotic Integral Membrane Protein Expression and Solubilization for Structure Determination
	Raymond C. Stevens, The Scripps Research Institute, USA Structure-Function of the Human G-Protein Coupled Receptor Family
	Aled M. Edwards, University of Toronto, Canada Advances in Structural Proteomics of Human Proteins
	Boguslaw Nocek, Argonne National Laboratory, USA Short Talk: Structure of the HK97-like Bacteriophage DNA Packaging Portal
Following Session is for Structural Biology (J1)
5:00 - 7:10 PM	Unfolded, Alternatively Folded, and Deliberately Folded Proteins Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-4
	* Mark R. Walter, University of Alabama, Birmingham, USA

	Joel L. Sussman, Weizmann Institute of Science, Israel Intrinsically Disordered Proteins (IDPs): A Role in Nervous System Development
	Alasdair C. Steven, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, USA Amyloid Polymorphisms from Cryo-Electron Microscopy
	Beat H. Meier, ETH Zurich, Switzerland Amyloid and Prion Structure by Solid-State NMR: What Can We Learn?
	Dorothee Kern, Brandeis University, USA Panorama of a Signaling Protein: Excursions in silico and in proteo
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Breckenridge Ballroom
Monday, January 11
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:15 AM	Pushing the Limits of Structural Biology II: Advances in Challenging Systems (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-5
	* Pamela J. Bjorkman, California Institute of Technology, USA
	Steven C. Almo, Albert Einstein College of Medicine, USA Sequence, Structure, Function, Immunity
	Roger W. Hendrix, University of Pittsburgh, USA The Virome and Evolutionary Relationships
	Andrew Ward, The Scripps Research Institute, USA
	Thomas Güttler, Max Planck Institute for Biophysical Chemistry, Germany Short Talk: Cargo Recognition by the Nuclear Export Receptor CRM1/Exportin1
	Erik W. Debler, Rockefeller University, USA Short Talk: Characterization of the Nup84 Complex - Paradigm for the Nuclear Pore Complex Structure
	Jamie H.D. Cate, University of California, Berkeley, USA Structures of the Bacterial Ribosome and the Mechanism of Translocation
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM- 1:00 PM	Poster Setup	Breckenridge Ballroom
11:15 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Breckenridge Ballroom
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 6:30 PM	Evolution of Structure and Function Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peak 5
	* Christine A. Orengo, University College London, UK
	Ian A. Wilson, The Scripps Research Institute, USA What have we Learned from Structural Genomics of Proteins of Unknown Function?
	Michael Levitt, Stanford University, USA The Protein Universe: A Current Snapshot
	Barry Honig, Columbia University / HHMI, USA Structural and Functional Relationships between Proteins with Different Global Topologies: Implications for Function Annotation Strategies
Following Session is for Structural Biology (J1)
5:00 - 7:00 PM	Structural Biology of Prokaryotic Cells Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-4
	* Elizabeth J. Goldsmith, University of Texas Southwestern Medical Center, USA
	Natalie Strynadka, University of British Columbia, Canada Piecing Together the Type III Secretion System of Pathogenic Bacteria



	Grant J. Jensen, California Institute of Technology, USA Bacterial Cryotomography

	Clara L. Kielkopf, University of Rochester Center for RNA Biology, USA Short Talk: Structural Mechanism of Prokaryotic NADH/NAD+ Redox Sensing
	Ohad Medalia, Ben-Gurion University, Israel Structural Insight into the Nuclear Pore Complex by Cryo-Electron Tomography
6:30 - 7:15 PM	Debate 1: Protein Folds: Fact or Fiction?? Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009
	* Ian A. Wilson, The Scripps Research Institute, USA
	Barry Honig, Columbia University / HHMI, USA
	Joel L. Sussman, Weizmann Institute of Science, Israel
	Andrej Sali, University of California, San Francisco, USA
	Michael Levitt, Stanford University, USA
	Adam Godzik, Burnham Institute for Medical Research, USA
	David Baker, University of Washington, USA
	Christine A. Orengo, University College London, UK
7:15 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
7:30 - 10:00 PM	Large-Scale Poster Session: World-Wide Structural Genomics and Structural Proteomics Centers NOTE: Structural genomic, structural proteomic and protein production centers and consortia highlight the platforms they have developed on new methods, technologies, databases, and computational tools that have spearheaded advances in protein production and structure determination for all classes of targets from bacterial to pathogens to human and on challenging macromolecules, such as membrane proteins, eukaryotic proteins and protein-protein complexes. Emphasis will be placed on what is applicable to the entire community, including single investigator laboratories to increase success and throughput in the study of biological macromolecules. An additional focus of this session will be on contributions of structural genomics to the structure and function of biological macromolecules. Megaposters are encouraged for general overviews from large and medium-sized centers. Normal sized posters are encouraged on specific aspects of structural genomics and structural proteomics, including structural and functional contributions to the study of biological macromolecules. *Click here for more information about this session.	Breckenridge Ballroom
Tuesday, January 12
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:00 AM	Proteomics and Protein Assemblies/Networks Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peak 5
	* Soichi Wakatsuki, KEK IMSS Photon Factory, Japan
	Christine A. Orengo, University College London, UK Identifying Novel Genes Implicated in Function Networks of Biological and Medical Significance
	Adam Godzik, Burnham Institute for Medical Research, USA Structural View of the Gut Microbial Surface Proteome: Implications for Host Immunity and Health
	Michael Washburn, Stowers Institute for Medical Research, USA Quantitative and Probabilistic Assembly of Human Protein Interaction Networks
	Janet Y. Huang, Rutgers University and Northeast Structural Genomics Consortium, USA Short Talk: Human Cancer Protein Interaction Network
	Hannes Braberg, University of California, San Francisco, USA Functional Insights from Protein-Protein and Genetic Interaction Maps
Following Session is for Structural Biology (J1)
8:00 - 11:15 AM	Macromolecular Interactions Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-4
	* Andrej Sali, University of California, San Francisco, USA
	James A. Wells, University of California, San Francisco, USA Trapping Allosteric Transitions in Enzymes

	Pamela J. Bjorkman, California Institute of Technology, USA Fc Receptors: From Molecules to Cells
	Tanja Kortemme, University of California, San Francisco, USA Prediction, Design and Engineering of Protein Interactions and Networks
	Peter Kasson, Stanford University, USA Short Talk: Simulations Yield New Insight into the Mechanism of Viral Membrane Fusion
	Gideon Schreiber, Weizmann Institute, Israel Building a Forcefield for Protein Interface Design
	Steffen Lindert, Vanderbilt University, USA Short Talk: BCL::EM-Fold: Protein Folding Tool for Medium Resolution Density Maps
9:20 - 9:40 AM	Coffee Break	Foyer
11:00 AM-	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 6:30 PM	Exploiting Structure for Function Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peak 5
	* Stephen K. Burley, Eli Lilly and Company, USA
	Nobutaka Hirokawa, University of Tokyo, Japan Kinesin Superfamily Molecular Motors, KIFs and Intracellular Transport: Mechanism of Motility
	Susan S. Taylor, University of California, San Diego, USA Conserved Architecture and Assembly of an Active Protein Kinase
	Peter J. Myler, Seattle Biomedical Research Institute, USA Structural Genomics of Infectious Disease
Following Session is for Structural Biology (J1)
5:00 - 7:00 PM	Macromolecular Complexes II Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-4
	* R. Andrew Byrd, National Cancer Institute, National Institutes of Health, USA
	Albert J.R. Heck, Utrecht University, The Netherlands Native Mass Spectrometry Applied to Virus Structure and Assembly
	John (Jack) E. Johnson, The Scripps Research Institute, USA Biophysical Studies of Virus Particles and their Maturation: Insights into Elegantly Programmed Nano-Machines

	G. Marius Clore, National Institute of Diabetes and Digestive and Kidney Diseases, USA Short Talk: Detecting and Visualizing Sparsely Populated Protein States

	Richard W. Kriwacki, St. Jude Children's Research Hospital, USA Short Talk: PUMA-Induced Dimerization of BCL-xL Releases Cytoplasmic p53 and Promotes p53-Dependent Apoptosis
6:30 - 7:15 PM	Debate 2: Can We Really Determine Function from Structure? Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009
	* Stephen K. Burley, Eli Lilly and Company, USA
	Aled M. Edwards, University of Toronto, Canada
	Andrzej Joachimiak, Argonne National Laboratory, USA
	Christine A. Orengo, University College London, UK
	Gaetano T. Montelione, Rutgers University, USA
7:15 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
8:00 - 11:00 PM	Entertainment	Breckenridge Ballroom
Wednesday, January 13
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM088949-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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Structural Biology continues to be one of the most prolific and informative ways to make biological and biomedical discoveries at the turn of the millennium, and provides fundamental molecular level insights into the underlying biological and biochemical functions. Structural genomics has been at the forefront of these developments as a major contributor to the advances of high throughput (HT) technologies and methodologies that span the gene to structure process by both crystallography and NMR. In parallel, the rapid expansion of the genome sequencing projects is substantially increasing the complexity and size of the known protein universe, and providing structural biologists with a wealth of new opportunities and challenges to explore, the diversity of biological macromolecules and their relationships to, function, evolution and disease. The goal of this Keystone Symposia meeting is to explore how we can best harness the current approaches from high throughput structural genomics to tackle present and future challenges in structural biology and how we can directly apply these methods to topical and important problems in structural, molecular, cellular and chemical biology. We will focus on approaches that are applicable not only for large consortia, but also for single investigator laboratories and smaller scale projects. Using such methodologies and technologies, we can then keep pace with the genome sequencing efforts and continue to make significant contributions to the constantly increasing discoveries on the intricacies and vagaries of complex biological processes – such as mammalian proteomes, microbial pathogens and cellular and signaling networks / systems. In this way, structural biology will continue to lead the way in making innovative discoveries in biological, chemical, and biomedical research.

Structural Genomics: Expanding the Horizons of Structural Biology (J2)