Keystone Symposia Conference | Structural Biology

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Meeting Program

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Friday, January 8
3:00 - 7:30 PM	Registration	Foyer
6:15 - 7:15 PM	Refreshments	Foyer
7:15 - 7:30 PM	Orientation for New Attendees and New Investigators Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009 NOTE: Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a "What to Expect during your Attendance" for interested delegates.	Peaks 1-5
7:30 - 8:30 PM	Keynote Session (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-5
	* Alasdair C. Steven, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, USA
	* Ian A. Wilson, The Scripps Research Institute, USA
	William E. Moerner, Stanford University, USA Single-Molecule Approaches to Biomolecular Dynamics and Imaging of Cellular Superstructures
Saturday, January 9
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:15 AM	Pushing the Limits of Structural Biology I: New and Innovative Methods (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-5
	* Kurt Wüthrich, ETH Zurich/The Scripps Research Institute, Switzerland
	Andrej Sali, University of California, San Francisco, USA Integrative Determination of Macromolecular Structures
	John A. Tainer, The Scripps Research Institute, USA Short Talk: Proteomics Scale X-ray Solution Scattering (SAXS) to Shape Interactomes
	Ad Bax, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA Combining Novel Solution NMR Approaches with SAXS
	Wah Chiu, Baylor College of Medicine, USA Seeing Protein Backbone and Side-Chains in Molecular Machines by Cryo-EM
	Daniel J. Müller, University of Technology Dresden, Germany Force Probing How Membrane Proteins Regulate Molecular Mechanics of Cell Rounding
	Graham Johnson, The Scripps Research Institute, USA Short Talk: Automated Visualization of Subcellular Environments
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM- 1:00 PM	Poster Setup	Breckenridge Ballroom
11:15 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Breckenridge Ballroom
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Macromolecular Complexes I Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-4
	* Christopher P. Hill, University of Utah, USA
	Eva Nogales, HHMI - University of California, Berkeley, USA Microtubule-Kinetochore Interactions
	Cynthia Wolberger, Johns Hopkins School of Medicine, USA Insights into the Unusual Chemistry of Sir2 Enzymes
	Justin L. P. Benesch, University of Cambridge, UK Short Talk: A Hybrid Approach for Determining the Structures of Protein Oligomers Comprising Heterogeneous Ensembles
	Angela M. Gronenborn, University of Pittsburgh, USA Synergy between cryo-EM and NMR - Novel Findings for HIV capsid Function
Following Session is for Structural Genomics (J2)
5:00 - 7:00 PM	Advances in Protein and Nucleic Acid Production and Crystallization Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peak 5
	* Andrzej Joachimiak, Argonne National Laboratory, USA
	Scott A. Lesley, Genomics Institute of the Novartis Research Foundation, USA Applying Structural Genomics Principles to Biology-Centered Targets
	Yaeta Endo, Ehime University, Japan Advances in Cell Free Systems for Expression of Eukaryotic and Parasitic Proteins
	Robert T. Batey, University of Colorado, Boulder, USA Advances in Preparation and Crystallization of RNA

	Joseph R. Luft, Hauptman-Woodward Medical Research Institute, USA Short Talk: The Use of Empirically Derived Detergent Phase Boundaries to Crystallize Membrane Proteins
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Breckenridge Ballroom
Sunday, January 10
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:00 AM	Membrane-Associated Phenomena Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-4
	* Hartmut Luecke, University of California, Irvine, USA
	James H. Hurley, National Institutes of Health, USA The ESCRT Complexes in Membrane Scission and Budding
	Christopher P. Arthur, The Scripps Research Institute, USA Short Talk: Structure of Botulinum Neurotoxin Serotype B in a Lipid Bilayer at Multiple pH Levels
	Gabriel Waksman, Birkbeck College and University College London, UK Structural Biology of Type IV Secretion Systems
	Mark S.P. Sansom, University of Oxford, UK Multiscale Simulations of Membrane Proteins
	Jay T. Groves, University of California, Berkeley, USA Spatial and Mechanical Regulation of Signal Transduction in Cell Membranes
Following Session is for Structural Genomics (J2)
8:00 - 11:15 AM	Advances in Crystallography, Magnetic Resonance Spectroscopy and Computation Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peak 5
	* Robert M. Stroud, University of California, San Francisco, USA
	Soichi Wakatsuki, KEK IMSS Photon Factory, Japan Developments in Synchrotron Protein Crystallography for Targeted Structural Proteomics
	Kurt Wüthrich, ETH Zurich/The Scripps Research Institute, Switzerland NMR in Structural Genomics: New Strategic and Technical Challenges
	John L. Markley, University of Wisconsin, Madison, USA Short Talk: Advances in High-Throughput NMR Spectroscopy of Proteins
	Wayne A. Hendrickson, Columbia University, USA Structural Genomics of Membrane Proteins by X-ray Crystallography
	David Baker, University of Washington, USA Rapid Structure Determination from Sparse Experimental Data Sets using Rosetta
	Michael A. Kennedy, Miami University, USA Short Talk: EPR-Based Long-Range Distance Restraints for Structure Determination of Protein Complexes
9:20 - 9:40 AM	Coffee Break	Foyer
11:00 AM- 1:00 PM	Poster Setup	Breckenridge Ballroom
11:00 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Breckenridge Ballroom
2:30 - 4:30 PM	Special Session	Peaks 1-4
	* Alasdair C. Steven, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, USA
	Vitold E. Galkin, University of Virginia, USA Short Talk: High Resolution Structures of F-actin Yield New Insights into the Dynamics of Actin Filament
	Christian Biertümpfel, NIDDK, National Institutes of Health, USA Short Talk: Crystal Structure of T4 Endonuclease VII Resolving a Holliday Junction
	Pingwei Li, Texas A&M University, USA Short Talk: The Structural Basis of Viral RNA Recognition by RIG-I
	Mei-ting Wu, University of Washington, USA Short Talk: Nanobodies were Crucial for Solving Crystal Structures from a Key Protein of an RNA-Editing Complex from the Sleeping Sickness Parasite Trypanosoma brucei
	Donald L.D. Caspar, Florida State University, USA Special Lecture: Origins of Structural Biology and Trials and Errors in its History
Following Workshop is for Structural Genomics (J2)
2:30 - 4:30 PM	Workshop 2: Structural Genomics and Functional Proteomics of Biological Macromolecules Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009 This workshop will focus on novel insights gained from study of the expanding protein universe, protein families, individual organisms, microbiomes, metagenomes, drug targets, pathogens, novel mechanisms, challenging proteins, including RNA, protein-protein complexes, membrane proteins and eukaryotic proteins.	Peak 5
	* Gaetano T. Montelione, Rutgers University, USA
	Marek Grabowski, University of Virginia, USA “Drugability” of Structural Genomics
	Parthasarathy Sampathkumar, Eli Lilly, USA Structures of Two PHR Domains from Mus musculus Phr1 (Mycbp2) Reveal a Novel Fold and Provide Insights into a C. elegans RPM-1 Loss of Function Mutation
	Werner Braun, University of Texas Medical Branch,, USA Allergen Structures in a Genomic Age
	Ashley M. Deacon, Stanford Synchrotron Radiation Laboratory, USA Structural and Functional Studies of the Bacterial Ancestors of Common Eukaryotic Protein Modules
	Liskin Swint-Kruse, University of Kansas Medical School, USA Comparing the Functional Roles of Nonconserved Sequence Positions in Homologous Transcription Repressors: Implications for Sequence/Function Analyses
	András Fiser, Albert Einstein College of Medicine, USA Structural Characteristics of Novel Protein Folds
	Markus Fischer, Columbia University, USA MarkUs: A Server to Navigate Sequence-Structure-Function Space
	Margaret J. Gabanyi, PSI Structural Genomics Knowledgebase - Rutgers University, USA The PSI Structural Genomics Knowledgebase Technology Portal - an Online Resource for all Structural Biologists
	Andrew Ward, The Scripps Research Institute, USA Structural Basis of Drug Binding and Transport in P-glycoprotein
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:10 PM	Unfolded, Alternatively Folded, and Deliberately Folded Proteins Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-4
	* Mark R. Walter, University of Alabama, Birmingham, USA
	Joel L. Sussman, Weizmann Institute of Science, Israel Intrinsically Disordered Proteins (IDPs): A Role in Nervous System Development
	Alasdair C. Steven, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, USA Amyloid Polymorphisms from Cryo-Electron Microscopy
	Beat H. Meier, ETH Zurich, Switzerland Amyloid and Prion Structure by Solid-State NMR: What Can We Learn?
	Dorothee Kern, Brandeis University, USA Panorama of a Signaling Protein: Excursions in silico and in proteo
Following Session is for Structural Genomics (J2)
5:00 - 7:00 PM	Challenging Proteins Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peak 5

	Robert M. Stroud, University of California, San Francisco, USA Ratiocinative Screen of Eukaryotic Integral Membrane Protein Expression and Solubilization for Structure Determination
	Raymond C. Stevens, The Scripps Research Institute, USA Structure-Function of the Human G-Protein Coupled Receptor Family
	Aled M. Edwards, University of Toronto, Canada Advances in Structural Proteomics of Human Proteins
	Boguslaw Nocek, Argonne National Laboratory, USA Short Talk: Structure of the HK97-like Bacteriophage DNA Packaging Portal
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Breckenridge Ballroom
Monday, January 11
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:00 AM	Pushing the Limits of Structural Biology II: Advances in Challenging Systems (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-5
	* Pamela J. Bjorkman, California Institute of Technology, USA
	Steven C. Almo, Albert Einstein College of Medicine, USA Sequence, Structure, Function, Immunity
	Roger W. Hendrix, University of Pittsburgh, USA The Virome and Evolutionary Relationships
	Andrew Ward, The Scripps Research Institute, USA
	Thomas Güttler, Max Planck Institute for Biophysical Chemistry, Germany Short Talk: Cargo Recognition by the Nuclear Export Receptor CRM1/Exportin1
	Erik W. Debler, Rockefeller University, USA Short Talk: Characterization of the Nup84 Complex - Paradigm for the Nuclear Pore Complex Structure
	Jamie H.D. Cate, University of California, Berkeley, USA Structures of the Bacterial Ribosome and the Mechanism of Translocation
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM- 1:00 PM	Poster Setup	Breckenridge Ballroom
11:15 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Breckenridge Ballroom
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Structural Biology of Prokaryotic Cells Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-4
	* Elizabeth J. Goldsmith, University of Texas Southwestern Medical Center, USA
	Natalie Strynadka, University of British Columbia, Canada Piecing Together the Type III Secretion System of Pathogenic Bacteria
	Grant J. Jensen, California Institute of Technology, USA Bacterial Cryotomography
	Clara L. Kielkopf, University of Rochester Center for RNA Biology, USA Short Talk: Structural Mechanism of Prokaryotic NADH/NAD+ Redox Sensing
	Ohad Medalia, Ben-Gurion University, Israel Structural Insight into the Nuclear Pore Complex by Cryo-Electron Tomography
Following Session is for Structural Genomics (J2)
5:00 - 6:30 PM	Evolution of Structure and Function Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peak 5
	* Christine A. Orengo, University College London, UK

	Ian A. Wilson, The Scripps Research Institute, USA What have we Learned from Structural Genomics of Proteins of Unknown Function?
	Michael Levitt, Stanford University, USA The Protein Universe: A Current Snapshot
	Barry Honig, Columbia University / HHMI, USA Structural and Functional Relationships between Proteins with Different Global Topologies: Implications for Function Annotation Strategies
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Breckenridge Ballroom
Tuesday, January 12
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:15 AM	Macromolecular Interactions Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-4
	* Andrej Sali, University of California, San Francisco, USA
	James A. Wells, University of California, San Francisco, USA Trapping Allosteric Transitions in Enzymes
	Pamela J. Bjorkman, California Institute of Technology, USA Fc Receptors: From Molecules to Cells
	Tanja Kortemme, University of California, San Francisco, USA Prediction, Design and Engineering of Protein Interactions and Networks
	Peter Kasson, Stanford University, USA Short Talk: Simulations Yield New Insight into the Mechanism of Viral Membrane Fusion
	Gideon Schreiber, Weizmann Institute, Israel Building a Forcefield for Protein Interface Design
	Steffen Lindert, Vanderbilt University, USA Short Talk: BCL::EM-Fold: Protein Folding Tool for Medium Resolution Density Maps
Following Session is for Structural Genomics (J2)
8:00 - 11:00 AM	Proteomics and Protein Assemblies/Networks Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peak 5
	* Soichi Wakatsuki, KEK IMSS Photon Factory, Japan

	Christine A. Orengo, University College London, UK Identifying Novel Genes Implicated in Function Networks of Biological and Medical Significance
	Adam Godzik, Burnham Institute for Medical Research, USA Structural View of the Gut Microbial Surface Proteome: Implications for Host Immunity and Health
	Michael Washburn, Stowers Institute for Medical Research, USA Quantitative and Probabilistic Assembly of Human Protein Interaction Networks
	Janet Y. Huang, Rutgers University and Northeast Structural Genomics Consortium, USA Short Talk: Human Cancer Protein Interaction Network
	Hannes Braberg, University of California, San Francisco, USA Functional Insights from Protein-Protein and Genetic Interaction Maps

9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM-	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Macromolecular Complexes II Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peaks 1-4
	* R. Andrew Byrd, National Cancer Institute, National Institutes of Health, USA
	Albert J.R. Heck, Utrecht University, The Netherlands Native Mass Spectrometry Applied to Virus Structure and Assembly
	John (Jack) E. Johnson, The Scripps Research Institute, USA Biophysical Studies of Virus Particles and their Maturation: Insights into Elegantly Programmed Nano-Machines
	G. Marius Clore, National Institute of Diabetes and Digestive and Kidney Diseases, USA Short Talk: Detecting and Visualizing Sparsely Populated Protein States
	Richard W. Kriwacki, St. Jude Children's Research Hospital, USA Short Talk: PUMA-Induced Dimerization of BCL-xL Releases Cytoplasmic p53 and Promotes p53-Dependent Apoptosis
Following Session is for Structural Genomics (J2)
5:00 - 6:30 PM	Exploiting Structure for Function Registered attendees for this meeting can view Abstracts for this session starting on 12/08/2009	Peak 5
	* Stephen K. Burley, Eli Lilly and Company, USA
	Nobutaka Hirokawa, University of Tokyo, Japan Kinesin Superfamily Molecular Motors, KIFs and Intracellular Transport: Mechanism of Motility
	Susan S. Taylor, University of California, San Diego, USA Conserved Architecture and Assembly of an Active Protein Kinase
	Peter J. Myler, Seattle Biomedical Research Institute, USA Structural Genomics of Infectious Disease
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
8:00 - 11:00 PM	Entertainment	Breckenridge Ballroom
Wednesday, January 13
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grants for this conference provided by:

National Institutes of Health
National Institute of General Medical Sciences (NIGMS)
National Cancer Institute (NCI)
Grant No. 1R13GM088916-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

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Static depictions are appearing in ever-increasing numbers of the detailed structures of individual macromolecules. A key challenge for structural biology is how to parlay this reservoir of fundamental information into a comparably detailed understanding of how functional complexes assemble; what ranges of alternative conformations they may assume at successive stages of their functional cycles; how they recognize each other; and how their propensities to bind small molecules, cofactors and other macromolecules are specified; and how they behave in cells. This meeting will explore ongoing developments in structural biology on several fronts including the following: the frontier between in vitro and in situ observations; the frontier between traditional experimental approaches and newly emerging complementary ones; and the frontier represented by computational structural biology as a means to analyze, integrate, and unify information emerging from diverse experimental sources.

Structural Biology (J1)