Keystone Symposia Conference | Role of Inflammation in Oncogenesis

Meeting Program

To view program in "24 hour" time (international) click here.

Sunday, February 7
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 9:30 PM	Keynote Session (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010	Grays/Longs Peak
	* Nina Bhardwaj, New York University School of Medicine, USA
	* Dmitry I. Gabrilovich, University of South Florida, USA
	* Giorgio Trinchieri, National Cancer Institute at Frederick, USA
	Robert D. Schreiber, Washington University School of Medicine, USA Co-Evolution of Immunoediting on Oncogenesis during Tumor Formation
	Frances R. Balkwill, Queen Mary University of London, Barts and The London Medical School, UK Inflammatory Cytokines and Autocrine Tumor-Promoting Networks
Monday, February 8
7:00 - 8:00 AM	Breakfast	Rockies Ballroom
8:00 - 11:15 AM	Tumor Microenvironment and Immune Escape (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010	Grays/Longs Peak
	* Robert D. Schreiber, Washington University School of Medicine, USA
	Lisa M. Coussens, University of California, San Francisco, USA Role of Inflammation in Tumor Progression
	Claire E. Lewis, University of Sheffield Medical School, UK Role of Macrophages in Tumor Progression and Response to Therapy
	Arya Biragyn, National Institute of Aging, National Institutes of Health, USA Short Talk: Primary Breast Cancer Actively Generates Regulatory T and B Cells (Tregs and Bregs) to Facilitate Lung Metastasis
	Gerard I. Evan, University of California, San Francisco, USA Immune Function and Angiogenesis in Myc-Mediated Tumor Formation
	Hans Schreiber, University of Chicago, USA The Role of Tumor Stroma in Immune Escape of Cancer
	Alexander J. Muller, Lankenau Institute for Medical Research, USA Short Talk: IDO Contributes to Pathologies Associated with Chronic Inflammation
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Rockies Ballroom
1:00 - 10:00 PM	Poster Viewing	Rockies Ballroom
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Inflammation in the Tumor Microenvironment Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010	Grays Peak
	* Frances R. Balkwill, Queen Mary University of London, Barts and The London Medical School, UK
	Alberto Mantovani, Istituto Clinico Humanitas, Italy Tumor Microenvironment: Sculpting the Inflammatory Response during Tumor Formation
	Susan E. Erdman, Massachusetts Institute of Technology, USA Unifying Roles for Regulatory T Cells and Inflammation in Cancer
	Li Yang, National Cancer Institute, National Institutes of Health, USA Short Talk: TGFbeta, an Inflammation and Immune Suppressor in Tumor Progression
Following Session is for Immune Escape in Cancer (J6)
5:00 - 7:00 PM	Antigen-Specific Mechanisms of Tumor Escape Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010 This session will be focused on molecular and cellular mechanisms associated with role of antigens in tumor escape. Topics include tumor antigen diversity, molecular mechanisms of defective antigen presentation by tumor cells, dendritic cells and T cell tolerance.	Longs Peak
	* Hans Schreiber, University of Chicago, USA
	Thomas Blankenstein, Max Delbruck Center for Molecular Medicine, Germany No Escape
	Hyam I. Levitsky, Johns Hopkins School of Medicine, USA Mechanism of T-Cell Tolerance in Cancer
	Richard A. Flavell, Yale University School of Medicine, USA TGF-beta Signaling in Tumoral Immune Suppression
	Andrew D.M. Kaiser, Netherlands Cancer Institute, The Netherlands Short Talk: Low Tumor-Antigen Density Leads to PD-L1/PD-1 Mediated Suppression of Partially Exhausted CD8+ T Cells
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Rockies Ballroom
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010	Rockies Ballroom
Tuesday, February 9
7:00 - 8:00 AM	Breakfast	Rockies Ballroom
8:00 - 11:15 AM	Inflammation and Carcinogenesis Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010	Grays Peak
	* Alberto Mantovani, Istituto Clinico Humanitas, Italy
	Eva M. Hernando, New York University Cancer Center, USA miRNAs that Contribute to Melanoma Metastasis by Modulating Immune Evasion
	Yinling Hu, National Cancer Institute at Frederick, USA Role of IKKalpha in Skin Cancer
	Pauline M. Andreu, University of California San Francisco, USA Short Talk: FcRgamma Activation Regulates Inflammation-Associated Squamous Carcinogenesis
	Giorgio Trinchieri, National Cancer Institute at Frederick, USA Innate Resistance and Cancerogenesis
	Carlos Bais, Genentech, Inc., USA Stromal Cells and VEGF-Independent Angiogenesis
	Brendan J. Jenkins, Monash Institute of Medical Research, Australia Short Talk: Deregulated Cytokine Signaling as a Crucial Bridge Linking Pathogen-Driven Gastric Inflammation and Tumorigenesis
Following Session is for Immune Escape in Cancer (J6)
8:00 - 11:15 AM	Myeloid Cells in Immune Suppression and Tumor Progression Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010 This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells.	Longs Peak
	* Mario P. Colombo, Fondazione IRCCS Istituto Nazionale Tumori, Italy
	Dmitry I. Gabrilovich, University of South Florida, USA Regulation of Myeloid-Derived Suppressor Cells in Cancer
	Suzanne Ostrand-Rosenberg, University of Maryland, USA Myeloid Cells, Inflammation, and Anti-Tumor Immunity: Not an Auspicious Combination

	David R. Gibb, Virginia Commonwealth University, USA and

	Sheinei Jamal Saleem, Virginia Commonwealth University, USA Short Talk: A Novel Model of Myeloid-Derived Suppression of the Anti-Tumor Response: Overexpression of ADAM10 Promotes Myeloid-Derived Suppressor Cell Expansion in a Tumor-Free Environment
	Vincenzo Bronte, Istituto Oncologico Veneto, Italy Forced Myelopoiesis and Immune Deviation in Cancer
	Ling Qi, Cornell University, USA Short Talk: The Metabolic Function of Myeloid-Derived Suppressor Cells in Obesity
	Cong Yan, Indiana University School of Medicine, USA Short Talk: Apoptotic Inhibition of Myeloid Cells Causes MDSC Expansion and Lung Tumorigenesis
	Anna Wasiuk, Dartmouth College, USA Short Talk: Mast Cells as Regulators of Adaptive Immunity to Tumors
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Rockies Ballroom
1:00 - 10:00 PM	Poster Viewing	Rockies Ballroom
2:30 - 4:30 PM	Workshop: Inflammation and Carcinogenesis NOTE: This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment.	Grays Peak
	* Jacqueline Bromberg, Memorial Sloan Kettering Cancer Center, USA
	* Carlos Bais, Genentech, Inc., USA
	David G. DeNardo, University of Califonia, San Francisco, USA CD4+ T Lymphocytes Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing the Pro-Tumor Properties of Macrophages
	Mercedes B. Fuertes, University of Chicago, USA Host Type I IFN Signals Mediate Awareness of Tumor and Promote Spontaneous Adaptive Immune Responses Against Tumor-Associated Antigens
	Esther N. Arwert, Cambridge Research Institute (CR-UK), UK Tumor Formation Initiated by Nondividing Epidermal Cells via an Inflammatory Infiltrate
	Jack D. Bui, University of California, San Diego, USA Evidence for Macrophage-Mediated Cancer Immunoediting
	Sharon A. Glynn, National Cancer Institute, National Institutes of Health, USA Joint Expression of NOS2 and COX2 in ER-Negative Breast Cancer – Acquisition of a Poor Prognosis Phenotype
	Abby L. Geis, Johns Hopkins Medical Institute, USA A Human Commensal Promotes Colorectal Cancer in Min Mice: Role of the Treg / Th17 Balance in the colitis-Induced Carcinogenesis
	Maria Grazia Ruocco, Skirball, New York University School of Medicine, USA Stress-Induced Signals Facilitate T Cell Arrest and Lead to Tumor Eradication
	Michele W. Teng, Peter MacCallum Cancer Centre, Australia IL-23 Suppresses Innate Immune Response during Carcinogenesis and Metastasis
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Innate Resistance and Tumor Escape Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010	Grays Peak
	* Nina Bhardwaj, New York University School of Medicine, USA
	David H. Raulet, University of California, Berkeley, USA NKG2D, NKG2D Ligands and Spontaneous Malignancy
	Laurence Zitvogel, Institut Gustave Roussy, France NKp30/NCR3 Isoforms and Prognosis of Human Malignancies: Revisiting the DC/NK Cross Talk
	Mark J. Smyth, Peter MacCallum Cancer Centre, Australia Suppression and Innate Immune Surveillance
Following Session is for Immune Escape in Cancer (J6)
5:00 - 7:00 PM	Regulatory T and NKT Cells in Immune Escape Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010 This session is focused on molecular and cellular mechanisms of regulatory T cell function in cancers. Specific topics can include novel findings on the role of classical Treg in cancer, different types of Tregs, and role of NKT.	Longs Peak
	* Vincenzo Bronte, Istituto Oncologico Veneto, Italy
	Harald von Boehmer, Harvard Medical School, USA In vivo Induction of Antigen-Specific Regulatory T Cells to Prevent Unwanted Immunity
	Rong-Fu Wang, Baylor College of Medicine, USA Immunosuppressive gammadelta Treg and other Immune Cells and their Functional Regulation through Innate Immune Signaling
	Mario P. Colombo, Fondazione IRCCS Istituto Nazionale Tumori, Italy OX40 Costimulation in Treg Functions
	Jay A. Berzofsky, National Cancer Institute, National Institutes of Health, USA Short Talk: Tipping the Balance in the NKT Cell Regulation of Tumor Immunity
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Rockies Ballroom
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010	Rockies Ballroom
Wednesday, February 10
7:00 - 8:00 AM	Breakfast	Rockies Ballroom
8:00 - 11:15 AM	Transcriptional Regulation of Immune Escape (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010	Grays/Longs Peak
	Hua E. Yu, Beckman Research Institute, City of Hope, USA STATs in Cancer Inflammation and Immune Escape: A Leading Role for Stat3
	Erwin F. Wagner, Spanish National Cancer Research Centre, Spain Functions of AP-1 (Fos/Jun) in Inflammation and Cancer
	Mitsugu Fujita, University of Pittsburgh Cancer Institute, USA Short Talk: Type-1 Interferons Play a Pivotal Role in Anti-glioma Immunosurveillance
	Thomas F. Gajewski, University of Chicago, USA T Cell Dysfunction in the Tumor Microenvironment as a Mechanism of Tumor Escape
	Michael Karin, University of California, San Diego, USA NF-kappaB in Inflammation, Progression and Immune Response
	Jahan Khalili, MD Anderson Cancer Center, USA Short Talk: The Role of B-raf V600E Mutation on PD-1 Ligand Expression in Melanocytic nevi
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Rockies Ballroom
1:00 - 10:00 PM	Poster Viewing	Rockies Ballroom
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Innate Receptors, Cancer and Inflammation Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010	Grays Peak
	* Mark J. Smyth, Peter MacCallum Cancer Centre, Australia
	Xiaoxia Li, Cleveland Clinic Foundation, USA SIGIRR-Mediated Tumor Suppression
	Felix Yarovinsky, University of Texas Southwestern Medical Center, USA Short Talk: A Novel Transgenic Mouse Model for Chronic Inflammation: Linking Toll-like Receptor (TLR) Responses with Carcinogenesis
	Nina Linde, German Cancer Research Center (DKFZ), Germany Inflammation in Epithelial Skin Tumors
	Irving Coy Allen, University of North Carolina at Chapel Hill, USA Short Talk: NLRP3 is an Essential Regulator of Interleukin-1beta and Interleukin-18 during Inflammation Driven Colon Tumorigenesis
Following Session is for Immune Escape in Cancer (J6)
5:00 - 7:00 PM	Immune Inhibitory Receptors in Cancer Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010	Longs Peak
	* Augusto C. Ochoa, Louisiana State University Health Sciences Center, USA
	Lieping Chen, Johns Hopkins School of Medicine, USA Co-Stimulatory Control of Tumor Immunity and Autoimmunity
	Drew M. Pardoll, Johns Hopkins School of Medicine, USA Mechanism of T-Cell Tolerance in Cancer Mediated by Inhibitory Receptors
	Michael R. Shurin, University of Pittsburgh, USA Dendritic Cells in Immune Escape in Cancer
	Daniel Hirschhorn-Cymerman, Memorial Sloan-Kettering Cancer Center, USA Short Talk: OX40 Engagement and Chemotherapy Combination Provides Potent Anti-Tumor Immunity with Concomitant Regulatory T Cell Apoptosis
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Rockies Ballroom
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010	Rockies Ballroom
Thursday, February 11
7:00 - 8:00 AM	Breakfast	Rockies Ballroom
8:00 - 11:00 AM	Dendritic Cells and Macrophages in Cancer Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010	Grays Peak
	* Laurence Zitvogel, Institut Gustave Roussy, France
	Nina Bhardwaj, New York University School of Medicine, USA Modulating Inflammatory Dendritic Cell Responses against Cancer
	Shannon J. Turley, Dana Farber Cancer Institute, Harvard Medical School, USA Novel Aspects of Tolerance in the Tumor Microenvironment
	Miriam Merad, Mount Sinai Medical Center, USA Functional Diversity of Tumor Infiltrating Dendritic Cells
	Ana Carrizosa Anderson, Harvard Medical School, USA New Roles for TIM Family Members in Immune Regulation
	Emmanuelle Godefroy, New York University, School of Medicine, USA Short Talk: MMP-2 Conditions Dendritic Cells to Prime Inflammatory TH2 Cells via an IL-12 and OX40L-Dependent Pathway
Following Session is for Immune Escape in Cancer (J6)
8:00 - 11:15 AM	Metabolic Pathways Involved in Immune Escape Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010 This session will be focused on the role of metabolism of carbohydrates, lipids, arginine, tryptophan, and exosomes in tumor escape.	Longs Peak
	* Drew M. Pardoll, Johns Hopkins School of Medicine, USA
	David H. Munn, Medical College of Georgia, USA Indoleamine 2,3-Dioxygenase in Tumor Immune Escape
	Gabriel A. Rabinovich, Instituto de Biologia y Medicina Experimental, Argentina 'Turning Sweet' on Immunity: Galectin-Glycan Interactions in T-Cell and Dendritic Cell Physiology
	Linglin Yang, University of Maryland, Baltimore County, USA Short Talk: Indoleamine 2,3-Dioxygenase (IDO) Contributes to Myeloid-Derived Suppressor Cell- Mediated Tumor Suppression through Interleukin-6 Signaling Pathway
	Augusto C. Ochoa, Louisiana State University Health Sciences Center, USA Arginine Depletion by MDSC in vivo, a Mechanism of Tumor Escape
	Licia Rivoltini, Fondazione IRCCS Istituto Nazionale Tumori, Italy Tumor-Derived Microvesicles and Immune Defects in Human Cancer
	Jonathan D. Silk, University of Oxford, UK Short Talk: A Novel Amino Acid Transporter Induced by Expression of Indoleamine 2,3 Dioxygenase in Tumors
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM-	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Cytokines in the Tumor Microenvironment Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010	Grays Peak
	* Giorgio Trinchieri, National Cancer Institute at Frederick, USA
	Jacqueline Bromberg, Memorial Sloan Kettering Cancer Center, USA The IL-6/Stat3 Signaling Pathway Promotes Mammary Tumorigenesis and Metastases
	Martin Oft, Merck, USA Switching Tumor Promoting Inflammation into Tumor Immune Surveillance
	Charles Drake, Johns Hopkins University, USA Th17 Cells in Tumors
	Jiyoung Park, University of Texas Southwestern Medical Center, USA Short Talk: Peripheral Leptin Promotes Mammary Tumor Progression and Metastasis through Activation of the Jak2/STAT3 Pathway in vivo
Following Session is for Immune Escape in Cancer (J6)
5:00 - 7:15 PM	Therapeutic Development to Correct Immune Escape in Cancer Registered attendees for this meeting can view Abstracts for this session starting on 01/07/2010 This session will discuss preclinical and clinical development of different approaches to counter immune suppressive mechanisms in cancer.	Longs Peak
	* Hyam I. Levitsky, Johns Hopkins School of Medicine, USA

	Jedd D. Wolchok, Memorial Sloan-Kettering Cancer Center, USA Therapeutic Regulation of Immune Responses in Cancer Patients Using CTLA-4 Antibodies
	Elizabeth M. Jaffee, Johns Hopkins University, USA Vaccine Induced Immune Responses and the Pancreatic Tumor Microenvironment
	Jeffrey Weber, H. Lee Moffitt Cancer Center, USA Regulation of Immune Responses in Cancer via Checkpoint Blockade of Negative Receptors in Melanoma
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Rockies Ballroom
8:00 - 11:00 PM	Entertainment	Rockies Ballroom
Friday, February 12
	Departure
*=Session Chair †=Speaker invited, not yet responded.

Keystone Symposia would like to thank the sponsors of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grants for this conference provided by:

National Institutes of Health
National Cancer Institute (NCI)
National Institute of Environmental Health Sciences (NIEHS)
Grant No. 1R13CA144225-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

Click here to view these companies

Cancer is characterized by accelerated and uncontrolled growth, dysregulation of apoptosis, invasion and metastasis. While genetic and epigenetic mechanisms may underlie transformation, the tumor microenvironment promotes the neoplastic process. Chronic inflammation and infection, in particular, are linked to the development of cancer. Examples include the association between inflammatory bowel disease and colon cancer, Helicobacter pylori infection with gastric cancer and HPV with cervical cancer. Recent studies have linked the innate immune system, through production of inflammatory cytokines, with cancer progression. Factors such as TNF alpha, IL-6, and TGF beta, produced by macrophages and dendritic cells amongst other cells, enhance tumor growth, invasion, metastasis, and angiogenesis, while simultaneously impairing anti-tumor immune mechanisms. There have been several advances in our understanding of the influences of inflammation on tumorigenesis. However, critical elements of the involved inflammatory pathways that modulate tumor progression still remain to be identified. The complex interrelationship between inflammatory vs. immune suppressive cytokines and their effects on the neoplastic process remain to be defined. The association between DNA damage and inflammation and the link between pathogen associated molecular patterns (PAMPs) and novel pattern recognition molecules (TLRs and NOD like receptors) in driving tumor development require further characterization. How cancer associated inflammation might actively dysregulate the innate immune system, in particular of dendritic cell, NK and NKT cell anti-tumor function, is also an area of interest and intense speculation. This meeting will focus specifically on mechanisms of inflammation-induced carcinogenesis, and will bring together investigators with diverse interests and expertise - immunology, signal transduction, cancer biology and therapeutics. It is anticipated that the pairing with the concurrent Keystone Symposia meeting on Immune Escape in Cancer will attract a large body of scientists who share a common interest in cancer pathogenesis, inflammation and mechanisms underlying immune evasion. The goal of the meeting is to enhance discussion, foster collaborations, report on new paradigms, and ultimately to develop approaches that will modulate inflammation-associated tumor progression.

Role of Inflammation in Oncogenesis (J5)