Keystone Symposia Conference | The Macrophage: Intersection of Pathogenic and Protective Inflammation

Meeting Program

To view program in "24 hour" time (international) click here.

Friday, February 12
3:00 - 7:30 PM	Registration	Van Horne Foyer
6:30 - 7:30 PM	Refreshments	Van Horne Foyer
7:30 - 8:30 PM	Keynote Address (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	Carl F. Nathan, Weill Cornell Medical College, USA Non-Resolving Inflammation: Disease, Defense and Therapy
Saturday, February 13
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:00 AM	Macrophages and Pathogens I Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	* De'Broski R. Herbert, Cincinnati Children's Research Foundation, USA
	Lalita Ramakrishnan, University of Washington, USA Macrophages and Infectious Granulomas
	Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA Activation of the NLR Family of Pathogen Detectors
	Sabine Ehrt, Weill Cornell Medical College, USA Mycobacterial Survival Strategies in the Macrophage Phagosome
	Alan Sher, NIAID, National Institutes of Health, USA Poly-IC Treatment Exacerbates Tuberculosis by the Pulmonary Recruitment of a Pathogen-permissive Monocyte/macrophage Population
Following Session is for Atherosclerosis (J7)
8:00 - 11:15 AM	Genetics and Functional Genomics of Atherosclerosis Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom C
	Sekar Kathiresan, Massachusetts General Hospital, USA Mapping Genes for Plasma Lipids and Myocardial Infarction in Humans

	Eric Schadt, Pacific Biosciences, USA Moving Toward a Systems Biology Understanding of Complex Human Diseases
	Karen Reue, University of California, Los Angeles, USA Identification of Novel Lipid Metabolism Genes from Spontaneous Mouse Mutants

	* Daniel J. Rader, University of Pennsylvania Medical Center, USA Functional Characterization of Novel Loci Associated with Plasma Lipids
	Yajaira Suárez, New York University School of Medicine, USA Short Talk: TNF-Induced microRNAs Regulate TNF-Induce Expression of E-Selectin and ICAM-1 in Human Endothelial Cells
	Johan Lars Markus Björkegren, Karolinska University Hospital, Sweden Short Talk: Multi-Organ Expression Profiling to Uncover Gene Networks and Modules of Importance to Coronary Artery Disease
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:00 AM-	On Own for Lunch and Recreation
11:00 AM- 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
2:30 - 4:30 PM	Workshop 1	Van Horne Ballroom A-B
	* Lalita Ramakrishnan, University of Washington, USA
	Jennifer A. Philips, NYU School of Medicine, USA Functional Genomics of the Host: Defining Macrophage Susceptibility to Mycobacterial Infection
	Dennis Montoya, University of California, Los Angeles, USA Plasticity of Macrophage Phagocytic and Antimicrobial Programs in Leprosy
	Hanne Gunda Schoenen, Institute for Clinical Microbiology and Hygiene, Germany Mincle is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analogue Trehalose-Dibehenate1
	Antoine Tinel, Harvard Medical School, USA A Crucial Role for SIRT1 in Host-Defense Mechanisms
	Sandra E. Nicholson, Walter and Eliza Hall Institute of Medical Research, Australia The SPRY Domain-containing SOCS Box Protein SPSB2 Targets iNOS for Ubiquitination and Proteasomal Degradation
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:15 PM	Signaling and Gene Expression (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	* Peter Tontonoz, University of California, Los Angeles, USA
	Ruslan M. Medzhitov, Yale University School of Medicine, USA Regulation of Inflammatory Gene Expression in Macrophages
	Linda K. Curtiss, The Scripps Research Institute, USA Atherosclerosis: An Unfortunate Mix of Lipids and Inflammation Whipped Up by Toll-Like Receptors
	Joachim Herz, University of Texas Southwestern Medical Center, USA Cell-Autonomous Atheroprotective Functions of LRP1 in the Vascular Wall
	Petra Keul, University of Duisburg-Essen, Germany Short Talk: Deletion of the S1P Receptor S1P3 Attenuates Macrophage-Driven Inflammation in Atherosclerotic Lesions of S1P3-/-/ApoE -/- Double Knockout Mice
	Jay W. Heinecke†, University of Washington School of Medicine, USA Short Talk: Demonstrating Proteomic Analysis of Macrophage Foam Cells
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Mezzanine 2
Sunday, February 14
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:00 AM	Understanding Human Macrophages Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	* Peter J. Murray, St. Jude Children's Research Hospital, USA
	Lionel Bohdan Ivashkiv, Hospital for Special Surgery, New York, USA Signal Integration during Macrophage Activation and Cytokine Production
	David Hume, University of Edinburgh, UK Transcriptional Networks in Macrophage Differentiation and Activation
	Menno Van Lookeren Campagne, Genentech, Inc., USA A Central Role for Complement and Liver Kupffer Cells in Host Defense
	Christopher L. Karp, Cincinnati Children's Hospital Research Foundation, USA Pathogen Contact with Human Macrophages
	Molly A. Ingersoll, Mount Sinai School of Medicine, USA Short Talk: Comparison of Gene Expression Profiles between Human and Mouse Monocyte Subsets
Following Session is for Atherosclerosis (J7)
8:00 - 11:15 AM	Immune Mechanisms and Atherosclerosis Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom C
	Göran K. Hansson, Karolinska University Hospital, Sweden Interplay of Innate and Adaptive Immune Mechanisms in Atherosclerosis
	* Joseph L. Witztum, University of California, San Diego, USA Oxidation-Specific Epitopes are a Major Target of Innate Immunity
	Ziad Mallat, Inserm U970, Paris Cardiovascular Research Center, France Regulatory T Cell Immunity in Atherosclerosis
	Gwendalyn J. Randolph, Mount Sinai School of Medicine, USA Fate of Monocyte-Derived Cells in Atherosclerotic Plaques versus Sites of Resolving Inflammation
	David Weismann, Center for Molecular Medicine of the Austrian Academy of Sciences, Austria Short Talk: Complement Factor H Binds to Malondialdehyde-Modified Proteins and Inhibits Foam Cell Formation
	Yue Zhao, University of Kentucky, USA Short Talk: The NR4A Orphan Nuclear Receptor NOR1 Mediates Monocyte Adhesion and Atherosclerosis Formation in Mice
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:00 AM-	On Own for Lunch and Recreation
11:00 AM- 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Macrophage Movement (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	* Gerald Krystal, British Columbia Cancer Research Center, Canada
	Israel F. Charo, Gladstone Institute of Cardiovascular Disease, USA Macrophage Movement in Atherosclerosis Lesions
	Frederic Geissmann, Kings College London, UK In vivo Monitoring of Monocyte/Macrophage Traffic
	Steven L. Kunkel, University of Michigan Medical School, USA Writers, Readers, and Erasers: Dynamic Epigenetic Regulation of the Macrophage Phenotype
	Andrea L. Hevener, University of California, Los Angeles, USA Short Talk: Myeloid-specific Deletion of Estrogen Receptor-alpha (ERalpha) Promotes Obesity and Insulin Resistance in Mice
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Mezzanine 2
Monday, February 15
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:00 AM	Sterile Inflammation and Cancer Inflammation Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	* Christopher L. Karp, Cincinnati Children's Hospital Research Foundation, USA
	Kenneth L. Rock, University of Massachusetts Medical School, USA The Sterile Inflammatory Response
	Vincenzo Bronte, Istituto Oncologico Veneto, Italy Myeloid-Derived Suppressor Cells
	Thorsten Hagemann, Bart's and the London Queen Mary's Medical School, UK Cancer-Related Inflammation
	Shigekazu Nagata, Kyoto University, Japan Activation of Innate Immune Reaction by Mammalian DNA that Escaped from Degradation
	Antonio Castrillo, Instituto Investigaciones Biomedicas CSIC, Spain Short Talk: LXR Nuclear Receptors Regulate Apoptotic Cell Clearance and Immune Tolerance
Following Session is for Atherosclerosis (J7)
8:00 - 11:15 AM	The Vulnerable Plaque Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom C

	Philippe Boucher, UMR CNRS 7213, University of Strasbourg, France PPAR-gamma Inhibits Vascular Calcification by Controlling an LRP1/beta-Catenin Signaling Pathway
	Peter Libby, Brigham and Women's Hospital, USA Extracellular Matrix Metabolism and Determinants of Plaque Stability
	Garret A. FitzGerald, University of Pennsylvania, USA Cardiovascular Complexity in the Prostanoid System
	* Ira Tabas, Columbia University, USA Mechanisms and Consequences of Macrophage Apoptosis in Atherosclerosis
	Kristiina Satu Susanna Rajamäki, Wihuri Research Institute, Finland Short Talk: Cholesterol Crystals Activate Inflammasome Signaling in Human Macrophages
	Walter S. Speidl, Medical University of Vienna, Austria Short Talk: The Complement Component C5a Induces the Expression of MMP-1 and MMP-9 in Human Macrophages
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:00 AM-	On Own for Lunch and Recreation
11:00 AM- 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
2:30 - 4:30 PM	Workshop 2	Van Horne Ballroom A-B
	* Steven L. Kunkel, University of Michigan Medical School, USA
	Jan Van den Bossche, Vrije Universiteit Brussel - VIB, Belgium Alternatively Activated Macrophages Engage in Homotypic and Heterotypic Interactions through IL-4 and Polyamine-Induced E Cadherin/Catenin Complexes
	Mark Gilchrist, Institute for Systems Biology, USA Sumo 1 Modification and Regulation of the Transcription Factor ATF3 in Macrophages
	Karin Reif, Genentech, Inc., USA A Novel Highly Specific Small Molecule Inhibitor for BTK Suppresses Fc Receptor Function in Macrophages and Prevents Inflammatory Arthritis
	Jacob Rachmilewitz, Goldyn Savad Institute for Gene Therapy, Israel Cells Exposed to Sub-Lethal Oxidative-Stress Attract Monocytes via a MYD88-Linked Receptor but do not Provoke the Release of Pro-Inflammatory Cytokines
	Jessica A. Hamerman, Benaroya Research Institute, USA ITAM Signaling Adapters Regulate Macrophage and Dendritic Cell Function and Homeostasis
	Amrom Obstfeld, Columbia University, USA Obesity Induced Hepatic Myeloid Cells Modulate Liver Steatosis
	Suneil K. Koliwad, Gladstone Institute of Cardiovascular Disease, USA Macrophage Triacylglycerol Storage as a Modulator of the Inflammatory and Metabolic Response to Dietary Fats
	Pavel Kovarik, University of Vienna, Austria Qualitative and Temporal Control of mRNA Decay during Inflammatory Response of Macrophages
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Deactivating Macrophage Activity (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	Peter J. Murray, St. Jude Children's Research Hospital, USA Cytokine-Mediated Deactivation of the Activated Macrophage
	Gerald Krystal, British Columbia Cancer Research Center, Canada The Role of SHIP in Macrophage Skewing and Activation
	* Christopher K. Glass, University of California, San Diego, USA PPAR and LXR-Dependent Repression Pathways that Regulate Inflammation
	Tim Ian Smallie, Kennedy Institute of Rheumatology Division, UK Short Talk: IL-10 Negatively Regulates Macrophage Activation by Inhibiting Transcription Elongation
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Mezzanine 2
Tuesday, February 16
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:00 AM	Macrophage and Pathogens II Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	* Sabine Ehrt, Weill Cornell Medical College, USA
	De'Broski R. Herbert, Cincinnati Children's Research Foundation, USA Alternatively Activated Macrophages Control Helminth-Driven Immunopathology
	Thomas A. Wynn, National Institutes of Health, USA The Role of IL-4/IL-13 Activated Macrophages in Fibrosis
	Judith E. Allen, University of Edinburgh, UK The Macrophage and the Worm
	Sara R. Cherry, University of Pennsylvania School of Medicine, USA Identification of Intrinsic Innate Immune Mechanisms
Following Session is for Atherosclerosis (J7)
8:00 - 11:15 AM	Cholesterol Homeostasis/Foam Cell Formation Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom C
	* Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center, USA Degradation of HMG CoA Reductase and Cholesterol Metabolism
	Alan R. Tall, Columbia University, USA Role of ABC Transporters in Atherosclerosis and Foam Cell Formation
	Kathryn J. Moore, New York University Medical Center, USA Micro-Managing Macrophage Cholesterol Metabolism

	Edward A. Fisher, New York University School of Medicine, USA HDL and Atherosclerosis Regression: Effects on the Quantity and Quality of Monocyte-Derived Cells in Plaques
	Prakash Gopaldas Chandak, Institute of Molecular Biology and Biochemistry, Austria Short Talk: Adipose Triglyceride Lipase Deficiency Affects Macrophage Morphology and Function and Significantly Reduces Atherosclerosis in LDLR -/- Mice
	Shunxing Rong, Wake Forest University School of Medicine, USA Short Talk: High Polyunsaturated Fatty Acid (PUFA) Diet Unmasks Role of 12/15 Lipoxygenase in Lipid Metabolism and Atherosclerosis
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:00 AM-	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Metabolism and Macrophages at the Intersection of Metabolic Control (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/12/2010	Van Horne Ballroom A-B
	* Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center, USA
	* Ajay Chawla, Stanford University Medical Center, USA PPARs and Macrophage Activation in Health and Disease
	Peter Tontonoz, University of California, Los Angeles, USA Control of Cholesterol Homeostasis by LXRs
	Gökhan S. Hotamisligil, Harvard University School of Public Health, USA The Role of Endoplasmic Reticulum Stress in Atherosclerosis and its Regulation by Lipids
	Hwee Ying Lim, National University of Singapore, Singapore Short Talk: Ezetimibe Restores Lymphatic Vessel Function and Dendritic Cell Migration, in Hypercholesterolemic apoE-Deficient Mice
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
8:00 - 11:00 PM	Entertainment	Mezzanine 2
Wednesday, February 17
	Departure
*=Session Chair †=Speaker invited, not yet responded.

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We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI085791-01

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Recent insights into macrophage biology have focused on their prodigiously varied roles: as sensors, effectors and regulators of immunity; as cells central to tissue repair and homeostasis; as the host cell of diverse pathogens; and as cells pivotal to the pathogenesis of numerous inflammatory diseases. The conservation of underlying common mechanisms of macrophage activation and subsequent control forms the overall thematic organization of this meeting. A special focus will be on areas of macrophage biology that are often neglected, including the role of macrophages in inflammatory diseases not obviously linked to pathogens including atherosclerosis, cancer, metabolic diseases and other forms of ‘sterile’ inflammation. The meeting is intended to provide a state-of-the-art overview of macrophage biology, to highlight the translational implications of this work, to provide researchers with access to diverse model systems, topics and levels of investigation, and to help define the most important questions to be addressed.

The Macrophage: Intersection of Pathogenic and Protective Inflammation (J8)