Keystone Symposia Conference | Cardiovascular Development and Repair

Meeting Program

To view program in "24 hour" time (international) click here.

Sunday, February 28
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 8:30 PM	Keynote Address (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Grays/Longs Peaks
	* Michael Simons, Yale University, USA
	* Doris A. Taylor, University of Minnesota, USA
	Eric N. Olson, University of Texas Southwestern Medical Center, USA MicroRNA Control of Cardiovascular Development and Disease
Monday, March 1
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:15 AM	Cardiac Development as a Model for Repair Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Longs Peak
	* Doris A. Taylor, University of Minnesota, USA
	Richard P. Harvey, University of New South Wales, Victor Chang Cardiac Research Institute, Australia The Pericyte Continuum in Heart Development and Repair
	Paul R. Riley, University College London, UK Epicardium-Induced Coronary Development and Repair
	Nadia A. Rosenthal, European Molecular Biology Laboratory, Italy Epicardium: The Outer Limits of Stem Cells
	Gordon M. Keller, University Health Network, MaRS Centre, Canada Cardiovascular Development from Human Pluripotent Stem Cells
	Lucile Ryckebusch, U910 INSERM Faculté de Médecine, France Short Talk: Establishment of Anteroposterior Patterning of the Cardiac Field
	Santanu Chakraborty, Cincinnati Children's Research Foundation, USA Short Talk: Twist1 Overexpression Promotes Heart Valve Cell Proliferation and Alters Extracellular Matrix Remodeling whereas Tbx20 Overexpression Causes Abnormal Heart Valve Primordia Formation in vivo in Mice
Following Session is for Angiogenesis in Health and Disease (X1)
8:00 - 11:00 AM	Arterial Specification Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Grays Peak
	* Eli Keshet, Hebrew University, Israel
	Nathan Lawson, University of Massachusetts Medical School, USA Exploring Endothelial Diversity in the Zebrafish
	Michael Simons, Yale University, USA Arterial Specification Signaling Cascade
	Brian L. Black, University of California, San Francisco, USA A Combinatorial Transcriptional Code for Endothelial Development
	Tao P. Zhong, Vanderbilt University, USA Regulation of Arterial-Venous Cell Specification and Migration
	Xabier Lopez Aranguren, Katholieke Universiteit Leuven, Belgium Short Talk: The Nuclear Orphan Receptor COUP-TFII Plays an Essential Role in Establishing and Maintaining Venous and Lymphatic Endothelial Identity by Distinct Mechanisms
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Quandary Peak
1:00 - 10:00 PM	Poster Viewing	Quandary Peak
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Models of Successful Cardiac Repair Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Longs Peak
	* Nadia A. Rosenthal, European Molecular Biology Laboratory, Italy
	Eduardo Marbán, Cedars-Sinai Medical Center, USA Cardiac Cell Therapy: From Concept to Clinical Reality
	Kenneth Poss, Duke University Medical Center, USA Heart Regeneration in Zebrafish
	Walter J. Koch, Jefferson Medical College, USA Using Gene Therapy to Repair the Failing Heart
	Brandi L. Bailey†, San Deigo State University, USA Short Talk: Sca-1 Knockout Compromises the Stem Cell Pool in the Heart and Bone Marrow Causing an Impaired Cardiac Phenotype
	Maria Paola Santini, Heart Science Centre, NHLI, Imperial College London, UK Short Talk: Cells and Factors for Cardiac Regeneration: mIGF-1-Mediated Cross-Talk between the Heart and the Bone Marrow
Following Session is for Angiogenesis in Health and Disease (X1)
5:00 - 7:00 PM	Vascular Metabolomics Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Grays Peak
	* Kenneth Walsh, Boston University School of Medicine, USA
	Peter F. Carmeliet, University of Leuven, Belgium Modulation of Hypoxia Resistance
	Ulf P.E. Eriksson, Karolinska Institutet, Sweden Vascular Endothelial Growth Factor B Controls Endothelial Fatty Acid Uptake - Implications in Fatty Acid Metabolism
	Frank J. Giordano, Yale University, USA Role of HIFs in Metabolic Regulation
	Stéphane E. Germain, INSERM, France Short Talk: Protection Against Myocardial Infarction through Preservation of Vascular Endothelial Cell Barrier Integrity and Reduction of No-Reflow by Angiopoietin-like 4
7:15 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Quandary Peak
Tuesday, March 2
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:15 AM	Aging Cardiocytes and Matrix - Molecular Targets for Repair Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Longs Peak
	* Eduardo Marbán, Cedars-Sinai Medical Center, USA
	Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA TRPC Channels Underlie Muscle Degeneration and Hypertrophy in Response to Alterations in the ECM - Sarcolemma
	Jeffrey N. Keller, Pennington Biomedical Research Center, USA Aging and Diet Effects on Proteasome and Oxidative Stress in the Heart
	R. John Solaro, University of Illinois at Chicago, USA Quantitative Comparison of Sarcomeric Phosphoproteomes of Neonatal and Adult Rat Hearts
	Kyoko Imanaka-Yoshida, Mie University, Graduate School of Medicine, Japan Tenascin-C as a Target for Regulation of Cardiac Remodeling
	Arti Anushka Ramkisoensing, Leiden University Medical Center, The Netherlands Short Talk: Embryonic and Fetal Mesenchymal Stem Cells do Undergo Cardiac Differentiation in Contrast to their Adult Counterparts: The Younger the Better
	C. Travis Cottage†, San Diego State University, USA Short Talk: Pim-1 Activation Modulates the Shelterin Complex to Preserve Telomere Length
Following Session is for Angiogenesis in Health and Disease (X1)
8:00 - 11:15 AM	Endothelial Cell-Tissue Interactions Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Grays Peak
	* Peter F. Carmeliet, University of Leuven, Belgium
	Eli Keshet, Hebrew University, Israel On-Site Education by VEGF of Recruited Monocytes
	Kenneth Walsh, Boston University School of Medicine, USA Paracrine Endothelium-Myocyte Interactions
	Didier Y. R. Stainier, University of California, San Francisco, USA Endothelial Cell-Tissue Interactions during Zebrafish Organogenesis
	Maija Bry, University of Helsinki, Finland VEGF-B Induces VEGFR-1 and Bmx Tyrosine Kinase-Mediated Cardiac Hypertrophy and Strong Coronary Arteriogenesis in Rats
	Christiana Ruhrberg, University College London, UK Macrophages Act as Cellular Chaperones for Vascular Anastomosis
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Quandary Peak
1:00 - 10:00 PM	Poster Viewing	Quandary Peak
2:30 - 4:30 PM	Workshop: Conversations on Deriving and Differentiating Stem Cells for Cardiac Repair	Longs Peak
	* Doris A. Taylor, University of Minnesota, USA
2:30 - 3:30 PM	Deriving Stem Cells	Longs Peak
	Stefan Braam, Leiden University Medical Center, The Netherlands Isolation and Characterization of Multipotent Human NKX2-5 Cardiovascular Progenitors
	Xuejun Huang Parsons, University of California, Riverside, USA Deriving Cardiac Elements from Pluripotent Human Embryonic Stem Cells for Heart Reconstitution
	Alexander Ruvantha Pinto, EMBL, Italy Tissue Resident CX3CR1-Positive Macrophages and Dendritic Cells in the Injured and Uninjured Heart
	Linda W. van Laake, University Medical Center Utrecht, The Netherlands Reporter-Based Isolation of Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Limited Gene Expression Variance
3:30 - 4:30 PM	Differentiating Stem/Progenitor Cells	Longs Peak
	Miriam Brodt-Ivenshitz†, Weizmann Institute of Science, Israel BMP-Mediated Inhibition of FGF Signaling Lies at the Heart of Differentiation
	Maria Grazia Perino, National Institutes of Health, USA Ascorbic Acid Promotes Cardiomyogenesis in Mouse Embryonic Stem Cells via Modulation of SMADs
	Antoine J.P. Bondue, Université Libre de Bruxelles, Belgium Deciphering the Cellular and Transcriptional Hierarchy Acting during the Earliest Step of Multipotent Cardiovascular Progenitor Specification
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Cardiac Stem Cell Sources and Niches Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Longs Peak
	* Calum A. MacRae, Brigham & Women's Hospital, USA
	Edward E. Morrisey, University of Pennsylvania, USA Regulation of Cardiac Progenitor Expansion and Differentiation by Wnt Signaling
	Matt Robertson, University of Minnesota, USA LV-Derived Stem Cells: Is it a Feasible Goal from Humans?
	Andre Terzic†, Mayo Clinic College of Medicine, USA Talk Title to be Determined
	Adriana C. Gittenberger-de Groot, Leiden University Medical Center, The Netherlands Short Talk: From Cardiogenesis to Cardiac Regeneration. Focus on Epicardium Derived Cells
	Elaine L. Shelton, Vanderbilt University, USA Short Talk: The Omentum: A Source of Vascular Smooth Muscle Cells for Development and Repair
Following Session is for Angiogenesis in Health and Disease (X1)
5:00 - 7:00 PM	Vascular Development and Collaterals Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Grays Peak
	* Michael Simons, Yale University, USA
	Anne C. Eichmann, College de France, France Development of Collaterals
	James E. Faber, University of North Carolina at Chapel Hill, USA Development and Genetics of Collateral Formation and Remodeling
	Eleni Tzima, University of North Carolina, USA Angiogenic Effects of tRNA Synthetases
	Suk-Won Jin, University of North Carolina Chapel Hill, USA Short Talk: Heterogeneity of Developing Vessels: A Unique Role for BMP in Developing Veins
7:15 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Quandary Peak
Wednesday, March 3
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	Cardiovascular Genetics (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Grays/Longs Peaks
	* William C. Sessa, Yale University School of Medicine, USA
	* Brian H. Annex, University of Virginia, USA
	Elizabeth M. McNally, University of Chicago, USA Dissecting Modifier Genes for Heart and Muscle Disease
	Arya Mani, Yale University, USA The Genetic Link between Coronary Artery Disease and Metabolic Risk Factors
	Calum A. MacRae, Brigham & Women's Hospital, USA Genetic Basis of Atrial Fibrillation
	Jonathan G. Seidman, Harvard Medical School, USA Genetic Mechanisms of Hypertrophic Cardiomyopathy
	Christian Kupatt, University of Munich, Germany Short Talk: Pathophysiological Consequences of Chronic Endothelial Angiopoietin-2 Overexpression
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM-	On Own for Lunch and Recreation
11:00 AM- 1:00 PM	Poster Setup	Quandary Peak
1:00 - 10:00 PM	Poster Viewing	Quandary Peak
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Lessons from Cardiac Hypertrophy and Autophagy Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Longs Peak
	* Jonathan G. Seidman, Harvard Medical School, USA
	Leslie A. Leinwand, University of Colorado, USA Sex Differences in Cardiac Hypertrophy: Are they Relevant for Repair?
	Joseph A. Hill, University of Texas Southwestern Medical Center, USA Autophagy in Cardiac Plasticity and Disease
	Francis G. Spinale, Medical University of South Carolina, USA Regulation and Control of the Matrix in Hypertrophy/Failure: Relevance to Cell and Regenerative Repair
	Yulia Anatolevna Chudinovskikh†, Russian Cardiovascular Scientific Center, Russia Short Talk: New Aspects of the Morphological Features and Pathogenesis of Hypertrophic Cardiomyopathy
Following Session is for Angiogenesis in Health and Disease (X1)
5:00 - 7:15 PM	Micro RNAs in the Endothelium Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Grays Peak
	* Anne C. Eichmann, College de France, France
	William C. Sessa, Yale University School of Medicine, USA Regulation of Vascular Function by miRNAs
	Ralf H. Adams, Max-Planck-Institute for Molecular Biomedicine, Germany Molecular Regulation of the Angiogenic Endothelial Phenotype
	Deepak Srivastava, Gladstone Institute of Cardiovascular Disease, USA microRNA Regulation of Signaling and Transcriptional Networks during Cardiogenesis
	Amparo Acker-Palmer, University Frankfurt, Germany EphrinB2 Regulates VEGFR2 Function in Developmental and Tumour Angiogenesis
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Quandary Peak
Thursday, March 4
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	Mechanisms in Cardiac Repair Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Longs Peak
	* Brian H. Annex, University of Virginia, USA
	Michael J. Galko, University of Texas M.D. Anderson Cancer Center, USA The Drosophila Open Circulatory System as a Source of Cells and Signals for Tissue Repair
	Nikolaos G. Frangogiannis, Baylor College of Medicine, USA The Role of the Inflammatory Response in Cardiac Repair
	* Howard A. Rockman, Duke University Medical Center, USA Genetics versus Genes
	Roger J. Hajjar, Mount Sinai School of Medicine, USA Short Talk: Myocardial Delivery of AAV1.SERCA2a in Patients with Advanced Heart Failure: A Phase I/II Clinical Trial
Following Session is for Angiogenesis in Health and Disease (X1)
8:00 - 11:00 AM	Therapeutic Interventions Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Grays Peak
	* Frank J. Giordano, Yale University, USA
	John Martin, University College London, UK Gene Therapy or Stem Cell Therapy: Which is the Future for Angiogenesis
	Ryan J. Watts, Genentech, Inc., USA Antibodies Targeting Vascular and Neuronal Pathways: Understanding Antibodies and the BBB
	Donald M. McDonald, University of California, San Francisco, USA Angiogenesis Inhibitors: Risk and Return
	Victor Kotelianski, Alnylam Pharmaceuticals Inc., USA Development of RNAi Therapeutics
	Kory J. Lavine, Washington University School of Medicine, USA Short Talk: Hedgehog Signaling in Coronary Development, Growth, and Disease
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM-	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	The Future of Cardiac Repair Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Longs Peak
	* Roger J. Hajjar, Mount Sinai School of Medicine, USA
	Speaker to be Announced,
	Doris A. Taylor, University of Minnesota, USA Re-Endothelialization of Decellularized Heart Reduces Vascular Thrombogenicity
	Brian H. Annex, University of Virginia, USA Systems Biology Consideration in Angiogenesis and Cell Therapy: Bench to Bedside
Following Session is for Angiogenesis in Health and Disease (X1)
5:00 - 7:00 PM	Phospholipid Signaling and Late-Breaking Science Registered attendees for this meeting can view Abstracts for this session starting on 01/28/2010	Grays Peak
	* Donald M. McDonald, University of California, San Francisco, USA
	Timothy T. Hla, Weill Medical College of Cornell University, USA S1P Signaling in the Vascular System
	Mariona Graupera, Institut d´Investigació Biomèdica de Bellvitge, Spain PI3K Signaling in Angiogenesis

	Jason E. Fish, Gladstone Institute, USA Short Talk: A Novel Slit/Robo/microRNA-218 Signaling Axis Regulates VEGF-Mediated Endocardial Migration and Heart Tube Formation
	John Chappell, University of North Carolina, USA Short Talk: A Novel Form of Vessel Sprout Guidance Requires Soluble Flt-1 (VEGFR-1)
	Lydia S. Glaw, University of Virginia, USA Short Talk: PDGF-B Produced by Bone Marrow-Derived Cells Is Required for Normal Perivascular Coverage after Hypoxia-Induced Angiogenesis
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
8:00 - 11:00 PM	Entertainment	Quandary Peak
Friday, March 5
	Departure
*=Session Chair †=Speaker invited, not yet responded.

Keystone Symposia would like to thank the sponsor of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:

American Heart Association's Council on Basic Cardiovascular Sciences

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL099225-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

Click here to view these companies

During fetal development, cardiocytes and vascular progenitors proliferate, coalesce and organize to form a nascent organ. Yet during adult mammalian life, these same cells are incapable of responding to repair injured heart. This Keystone Symposia meeting is designed: 1) to expose scientists in the field of cardiac and vascular repair to models of successful cardiac repair in lower vertebrates, 2) to discuss repair in the context of cardiac development and 3) to begin to ask what cues and targets from each may be applicable in the adult mammal. As a companion to and overlapping with an Angiogenesis meeting, it will provide meeting-goers access to both preclinical and clinical components of cardiac and vascular repair using cells, genes and small molecules.

Cardiovascular Development and Repair (X2)