Keystone Symposia Conference | Adipose Tissue Biology

**Meeting has ended.**

View Current Meetings

Meeting Search

Contact Us

Meeting Program

To view program in "24 hour" time (international) click here.

Sunday, January 24
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 8:30 PM	Keynote Address (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Longs/Grays Peaks
	Jeffrey M. Friedman, Rockefeller University, USA Leptin and the Links Among Metabolism, Physiology and Behavior
Monday, January 25
7:00 - 8:00 AM	Breakfast	Torreys 1-3, Shavano, Red Cloud
8:00 - 11:15 AM	Circadian Control of Adiposity and Metabolism (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Grays/Longs Peaks
	* Martin G. Myers, Jr., University of Michigan, USA
	Joseph Bass, Northwestern University, USA Clock and Per: Gene Network Controls on Metabolism/Adiposity
	Julian Mercer, Rowett Research Institute, UK Effect of Rhythms, Diet and Feeding Patterns on Hypothalamic Gene Expression
	Georgios Paschos, University of Pennsylvania, USA Short Talk: Obesity and Metabolic Syndrome in Mice with Adipose Tissue-Specific Deletion of Bmal1
	Etienne Challet, CNRS, France Synchronization of Multiple Circadian Clocks by Feeding
	Clifford J. Rosen, Maine Medical Center, USA Short Talk: Nocturnin, a Circadian Clock Gene, Stimulates Adipogenesis by Promoting Nuclear Transport of PPARgamma
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 - 11:30 AM	NIDDK Discussion of Funding Issues Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Grays/Longs Peak
	Philip F. Smith, NIDDK, National Institutes of Health, USA
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Torreys 1-3, Shavano, Red Cloud
1:00 - 10:00 PM	Poster Viewing	Torreys 1-3, Shavano, Red Cloud
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Angiogenesis and Adipose Mass: Factors and Regulation Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Longs Peak
	* Anna Krook, Karolinska Institutet, Sweden
	Silvia Corvera, University of Massachusetts Medical School, USA Depot-Specific Differences in Adipose Tissue Angiogenesis and the Development of Insulin Resistance in Humans
	H. Roger Lijnen, University of Leuven, Belgium Role of Proteolysis in Development of Adipose Tissue
	Zofia Zukowska, Georgetown University, USA Stress-induced Epigenetic Programming for Adipogenesis: Role of Neuropeptide Y
	Dong-Hoon Kim, University of Cincinnati, USA Short Talk: Differential Adipose Tissue Remodeling Related to Angiogenesis and Inflammation in Young Obesity-Prone C57Bl/6 Mice and Obesity-Resistant FVB/N Mice
	James E. Minchin, University of North Carolina at Chapel Hill, USA Short Talk: Real-Time Imaging of Adipose Depot Morphogenesis in Zebrafish
Following Session is for Neuronal Control of Appetite (J4)
5:00 - 7:00 PM	Molecular Programming of Hypothalamic Circuitry Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Grays Peak
	* Kevin L. Grove, Oregon National Primate Research Center, USA
	Joel K. Elmquist, University of Texas Southwestern Medical Center, USA Cellular and Molecular Mechanisms Regulating Energy Balance and Glucose Homeostasis
	Richard B. Simerly, Children's Hospital Los Angeles, USA Perinatal Programming of Hypothalamic Connectivity
	I. Sadaf Farooqi, University of Cambridge, UK Mutations of Hypothalamic Circuits in Humans
	Yi-Chun Loraine Tung, University of Cambridge Metabolic Research Laboratories, UK Short Talk: Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats
7:15 - 8:00 PM	Social Hour w/ Lite Bites	Torreys 1-3, Shavano, Red Cloud
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Torreys 1-3, Shavano, Red Cloud
Tuesday, January 26
7:00 - 8:00 AM	Breakfast	Torreys 1-3, Shavano, Red Cloud
8:00 - 11:15 AM	Fat (R)evolution - The Brown vs. White Fat Debate Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Longs Peak
	* Sheila Collins, Burnham Institute and Hamner Institutes of Health
	Jan Nedergaard, Stockholm University, Sweden State of the New Evidence for Active Adult Human Brown Adipose Tissue and its Possible Metabolic Significance
	Saverio Cinti, University of Ancona, Italy Histological and Morphological Features: Precursor Cell Origins
	Bruce M. Spiegelman, Harvard Medical School, USA Transcriptional Control of Brown and White Adipocytes
	Karsten Kristiansen, University of Copenhagen, Denmark Single Gene Mutations that Promote Brown Adipocyte Differentiation
	Marika Charalambous, University of Cambridge, UK Short Talk: Impaired Thermogenesis and Persistent Hypothyroidism caused by Altered Dosage of Imprinted Genes
	Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School, USA Short Talk: Identification of Brown Fat Progenitors in Mouse Skeletal Muscle
Following Session is for Neuronal Control of Appetite (J4)
8:00 - 11:15 AM	Nutrient Sensing in the Brain Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Grays Peak

	* Roger D. Cone, Vanderbilt University, USA
	Martin G. Myers, Jr., University of Michigan, USA Neurotensin and Orexin as Mediators of Lateral Hypothalamic Leptin Action
	Michael A. Cowley, Monash University, Australia Melanocortins and Glucose Homeostasis
	Michael Rosenbaum, Columbia University Medical College, USA Leptin and Energy Homeostasis in Humans
	Tamas L. Horvath, Yale University School of Medicine, USA Fuel Utilization by Neurons: A Determinant of “Nutrient Sensing"
	Dong Kong, Beth Israel Deaconess Medical Center, Harvard Medical School, USA Short Talk: Glucose Sensing by MCH Neurons Regulates Glucose Homeostasis and is Inhibited by UCP2
	Hong Wang, University of Colorado Health Science Center, USA Short Talk: Neuron-Specific Lipoprotein Lipase Deficiency Perturbs the Regulation of Energy Balance and Leads to Obesity by Modifying the Expression of the Orexigenic Neuropeptides AgRP and NPY
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Torreys 1-3, Shavano, Red Cloud
1:00 - 10:00 PM	Poster Viewing	Torreys 1-3, Shavano, Red Cloud
2:30 - 4:30 PM	Workshop 1: New Aspects of Adipogenesis, Lipid Droplets and Triglyceride Metabolism Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Grays/Longs Peaks
	* Sheila Collins, Burnham Institute for Medical Research of Lake Mona, USA
	Cristina M. Rondinone, Roche, USA Introductory 'In Memoriam' for Dean Londos
	Chris E. Lowe, University of Cambridge Metabolic Research Laboratories, UK The ATF6alpha Pathway of the Unfolded Protein Response is Required for Adipogenesis
	Ana G. Cristancho, University of Pennsylvania School of Medicine, USA Transcription Factor 7-like 1 (TCF7L1) is required for PPARgamma2 Expression during Adipogenesis
	Kai Ge, NIDDK, National Institutes of Health, USA Epigenetic Regulation of Adipogenesis
	Susanne Mandrup, University of Southern Denmark, Denmark MED14 Tethers the Mediator to the N-Terminal Domain of PPARgamma and is Required for Full Transcriptional Activity and Adipogenesis
	Charles Harris, Gladstone Institute for Cardiovascular Disease, USA DGAT Enzymes Are Required for Triglyceride Synthesis and Lipid Droplet Formation But Not for Other Aspects of Adipogenesis
	Cynthia Smas, University of Toledo, USA Functional Analysis of FSP27 Protein Regions for Lipid Droplet Localization, Caspase-Dependent Apoptosis and Dimerization with CIDEA
	Lise Madsen†, University of Copenhagen, Denmark Transdifferentiation of White into Brown Adipose Tissue Requires Cyclooxygenases
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Insights from Model Organisms (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Grays/Longs Peak
	* Karsten Kristiansen, University of Copenhagen, Denmark
	Roger D. Cone, Vanderbilt University, USA Zebrafish: A Model System for Forward Genetic Analysis of Energy Homeostasis
	Sri Devi Narasimhan, University of Massachusetts Medical School, USA Identifying Phosphatases that Modulate the Insulin/IGF-1 Signaling Pathway
	Sean M. Oldham, Burnham Institute for Medical Research, USA Role of Nutrient Sensing TOR Pathway in High Fat Diet-Induced Obesity
	Biao Wang, The Salk Institute, USA Short Talk: Drosophila Salt Inducible Kinase (SIK) Suppresses Brummer–Dependent Lipolysis through FOXO during Feeding
	Christine Könner, Institute for Genetics, University of Cologne, Germany Short Talk: Conserved Role for Insulin Receptor Signaling in Catecholaminergic Cells in Control of Energy Homeostasis
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Torreys 1-3, Shavano, Red Cloud
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Torreys 1-3, Shavano, Red Cloud
Wednesday, January 27
7:00 - 8:00 AM	Breakfast	Torreys 1-3, Shavano, Red Cloud
8:00 - 11:15 AM	Immune Signals and Energy Homeostasis/Body Composition (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Grays/Longs Peak
	* Randy J. Seeley, University of Cincinnati, USA
	Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA Obesity, Inflammation and Insulin Resistance (Basic and Clinical Issues)
	Ajay Chawla, Stanford University Medical Center, USA Macrophage Activation in Obesity and Insulin Resistance
	Carey N. Lumeng, University of Michigan, USA Short Talk: MGL1 Promotes Adipose Tissue Inflammation and Insulin Resistance by Regulating 7/4hi Monocytes in Obesity
	Umut Ozcan, Children's Hospital Boston, Harvard Medical School, USA The ER Stress and Leptin Resistance
	Daniel Lee Marks, Oregon Health & Science University, USA Cachexia and Wasting - Cytokine Actions in the Brain
	Jose Manuel Garcia, Michael E. DeBakey Veterans Affairs Medical Center, USA Short Talk: The Effects of Peripheral Ghrelin Administration on the Adipocyte are Primarily Mediated through Changes in Food Intake in a Model of Cachexia
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Torreys 1-3, Shavano, Red Cloud
1:00 - 10:00 PM	Poster Viewing	Torreys 1-3, Shavano, Red Cloud
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Bariatric Surgery and the Treatment of Metabolic Disease Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Longs Peak
	* Mitchell A. Lazar, University of Pennsylvania School of Medicine, USA
	John W. Newcomer, Washington University School of Medicine, USA
	Francesco Rubino, Weill Cornell Medical College, USA Resolution of Diabetes and Bariatric Surgery
	Paul O'Brien, Monash University, Australia Appetite Control and Bariatric Surgery
	Randy J. Seeley, University of Cincinnati, USA Bariatric Surgery: Beyond Restriction and Malabsorption
	Thomas Alexander Lutz, Institute of Veterinary Physiology, Switzerland Short Talk: Roux-en-Y Gastric Bypass Increases Energy Expenditure and Affects Taste Perception in Rats
	Jocelyne Magré, INSERM, France Genetics of Congenital Lipodystrophy
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Torreys 1-3, Shavano, Red Cloud
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Torreys 1-3, Shavano, Red Cloud
Thursday, January 28
7:00 - 8:00 AM	Breakfast	Torreys 1-3, Shavano, Red Cloud
8:00 - 11:15 AM	Adipose Stem Cells: Biology and Application (Bone Marrow vs. Adipose Tissue; Characteristics/Signaling that Promote their Differentiation; Plastics/Reconstructive, Tissue Engineering Aspects) Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Longs Peak
	* Barbara Cannon, Stockholm University, Sweden
	Hei Sook Sul, University of California, Berkeley, USA Pref-1: Role in Adipogenesis and Mesenchymal Cell Fate
	Rei Ogawa, Nippon Medical School, Japan Application of Adipose Stem Cells for Plastic Surgery - In Particular about Cartilage Regeneration
	Ormond A. MacDougald, University of Michigan, USA Regulation of Adipocyte Differentiation and Metabolism by Wnt Signaling
	Ez-Zoubir E. Amri, Centre National de la Recherche Scientifique, Université Nice, France Short Talk: Human Multipotent Adipose-Derived Stem Cells Differentiate into Functional Brown Adipocytes
	Daniel R. Zeve, University of Texas Southwestern Medical Center at Dallas, USA Short Talk: Defining Developmentally Important Genes within the White Adipose Progenitor Cells
	Maryam Ahmadian, University of California, Berkeley, USA Short Talk: Adipose-Specific Phospholipase A2 (AdPLA) Ablation Prevents Diet-Induced and Genetic Obesity: A Novel Lipodystrophy Model
Following Session is for Neuronal Control of Appetite (J4)
8:00 - 11:15 AM	Thinking Outside of the Hypothalamus Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Grays Peak
	* Daniel Lee Marks, Oregon Health & Science University, USA
	Marta Korbonits, Barts and The London, Queen Mary's School of Medicine and Dentistry, UK Cross-Talk of Endocannabinoids and Ghrelin
	Darren Opland, University of Michigan, USA Short Talk: VTA Leptin Receptor Neurons Specifically Project to and Regulate CART Neurons of the Extended Central Amygdala
	Alastair V. Ferguson, Queen's University, Canada Sensory Circumventricular Organs: Integrative Control Centers Regulating Energy Balance?

	Hans-Rudolf Berthoud, Pennington Biomedical Research Center, USA Hedonic, Emotional, Cognitive, and Metabolic Controls of Appetite and Energy Balance: Who is The Boss?
	Lora K. Heisler, University of Cambridge, UK Serotonin Influences Melanocortin Pathways to Affect Energy Balance
	Matthew R. Hayes, University of Pennsylvania, USA Short Talk: Endogenous Leptin Signaling in the NTS is Required for Energy Balance Regulation
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM-	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Drug Development: Treating the Brain and Beyond (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/24/2009	Grays/Longs Peaks
	* Michael A. Cowley, Monash University, Australia
	Eduardo Dunayevich, Orexigen Therapeutics, Inc., USA The Combination of Bupropion and Naltrexone in the Treatment of Obesity: From Bench to Pivotal Trials
	Donald J. Marsh, Merck Research Laboratories, USA New Neuropeptide Target Systems
	Michael Culler, Ipsen/Biomeasure, USA Novel Peptide Ligands of the Melanocortin Type 4 Receptor for the Treatment of Obesity and Metabolic Disease
	Lee M. Kaplan, Massachusetts General Hospital, USA Short Talk: Roux-en-Y Gastric Bypass Activates Brown Adipose Tissue and Increases Energy Expenditure in Obese Mice
	Alan Koncarevic, Acceleron Pharma, USA Short Talk: Induction of a Thermogenic Program in White Adipose Tissue of HFD-Fed Mice Treated with a Soluble ActRIIB
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Torreys 1-3, Shavano, Red Cloud
8:00 - 11:00 PM	Entertainment	Torreys 1-3, Shavano, Red Cloud
Friday, January 29
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grants for this conference provided by:

National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
National Institute on Aging (NIA)
Grant No. 1R13DK084688-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

Click here to view these companies

The study of adipose tissue has evolved over the years from merely being a passing note in most physiology texts to now playing center stage in the etiology of most metabolic diseases. This shift was assisted by early studies exploring the molecular signals and gene expression changes that dictate the differentiated state of a cell, for which the adipocyte was a model. Such studies led to the discovery of PPARgamma as one of those key regulators of adipogenesis, and later the realization that it was the pharmacologic target of the glitazone class of anti-diabetic agents. Further seminal studies from The Jackson Laboratories on mouse genetics of obesity paved the way for the discovery of adipocyte-derived regulatory hormones (“adipokines”) such as leptin and its receptor. These in turn ushered in the current state of vigorous investigation dissecting the molecular pathways of satiety and other aspects of signaling cross-talk between adipose tissue and other organs. The updated view of adipose tissue as a bona fide endocrine organ has been further extended to include it as a potential reservoir of stem cells for tissue engineering and an integral player in inflammatory status and insulin resistance. This meeting will cover these and other topics of the adipose biology field, including the role of angiogenesis in adipose tissue expansion; the white fat-brown fat debate; the contribution of the circadian clock to the hormonal and neural signals that coordinate food intake and activity for metabolic balance; and the connections between central and peripheral signals involved in the unanticipated lipodystrophic disorders resulting from such therapeutic regimens as antipsychotics and anti-retrovirals. A series of hot-topic sessions and short talks from submitted abstracts are also planned.

Adipose Tissue Biology (J3)