Keystone Symposia Conference | Innate Immunity: Mechanisms Linking with Adaptive Immunity

Meeting Program

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Monday, June 7
3:00 - 7:30 PM	Registration	Lower Concourse
6:30 - 7:30 PM	Refreshments	Lower Concourse
7:30 - 8:30 PM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre
	Ruslan M. Medzhitov, Yale University School of Medicine, USA Innate Control of Adaptive Immunity
Tuesday, June 8
7:30 - 8:30 AM	Breakfast	Lodging Location
7:30 - 8:30 AM	Poster Setup	Beckett Rooms
8:30 AM- 3:00 PM	Poster Viewing	Beckett Rooms
8:30 - 11:30 AM	The Modulation of Innate and Adaptive Immune Responses by Innate Receptors Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre
	Shizuo Akira, Osaka University, Japan Talk Title to be Determined
	Alberto Mantovani, Istituto Clinico Humanitas, Italy Interplay between Cellular and Humoral Innate Immunity
	Julie Magarian Blander, Mount Sinai School of Medicine, USA Phagosomes and Antigen Presentation
	Mihai G. Netea, Radboud University Nijmegen Medical Centre, The Netherlands Modulation of Antifungal Immune Responses by Innate Receptors
	Short Talk(s) to be Chosen from Abstracts,
9:40 - 10:00 AM	Coffee Break	Lower Concourse
11:30 AM- 12:30 PM	Lunch	Lower Concourse
12:00 - 2:30 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Beckett Rooms
2:30 - 3:00 PM	Coffee Available	Lower Concourse
3:00 - 5:00 PM	Autoimmunity as a Consequence of Innate Immunity Defects Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre
	Carla Vanina Rothlin, Yale University, USA TAM Receptors and the Control of Innate Immunity
	Jos van der Meer, Nijmegen Centre for Molecular Life Sciences, The Netherlands Pathogenesis of Hereditary Autoinflammatory Fevers
	Averil I. Ma, University of California, San Francisco, USA Ubiquitination and Innate Immunity
	Short Talk to be Chosen from Abstracts,
5:00 PM-	On Own for Dinner
Wednesday, June 9
7:30 - 8:30 AM	Breakfast	Lodging Location
8:30 - 11:30 AM	Evolution of Innate and Adaptive Immunity Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre
	Max D. Cooper, Emory University, USA Evolution of the Adaptive Immune System
	Gary W. Litman, University of South Florida, USA The Evolution of Immune Receptor Diversity
	Jenny P. Ting, University of North Carolina at Chapel Hill, USA NLR Proteins: From Plants to Animals
	Neal Silverman, UMass Medical School, USA What the Fly has Taught us about Immunity
	Short Talk(s) to be Chosen from Abstracts,
9:40 - 10:00 AM	Coffee Break	Lower Concourse
11:30 AM- 12:30 PM	Lunch	Lower Concourse
11:30 AM- 12:30 PM	Poster Setup	Beckett Rooms
12:30 - 2:30 PM	Workshop	Burke Theatre
2:30 - 3:00 PM	Coffee Available	Lower Concourse
3:00 - 5:00 PM	The Role of Innate Receptors in Adjuvancy Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre
	Kingston H. G. Mills, Trinity College, Dublin, Ireland Enabling Adjuvancy by TLR Ligands by Manipulation of Signaling Pathways
	Alan Sher, NIAID, National Institutes of Health, USA Dictating T Cell Responses via Effects on Innate Receptors
	Bart N. Lambrecht, Ghent University, Belgium Molecular Basis for Alum Adjuvancy
	Short Talk to be Chosen from Abstracts,
5:00 - 6:00 PM	Social Hour w/ Lite Bites	Lower Concourse
5:30 - 8:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Beckett Rooms
Thursday, June 10
7:30 - 8:30 AM	Breakfast	Lodging Location
7:30 - 8:30 AM	Poster Setup	Beckett Rooms
8:30 AM- 3:00 PM	Poster Viewing	Beckett Rooms
8:30 - 11:30 AM	Control of T Cell Subsets by Innate Immune Signals Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre
	Laurence A. Turka, Beth Israel Deaconess/Harvard, USA Regulation of T Lymphocytes by "Innate Immune Pathways"
	Shimon Sakaguchi, Institute for Frontier Medical Sciences, Kyoto University, Japan Regulatory T Cells in Innate and Adaptive Immunity
	Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA Retinoic Acid and T Cell Regulation
	Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA Controlling Treg and Th17 Subsets
	Short Talk(s) to be Chosen from Abstracts,
9:40 - 10:00 AM	Coffee Break	Lower Concourse
11:30 AM- 12:30 PM	Lunch	Buttery Food Court
12:00 - 2:30 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Beckett Rooms
2:30 - 3:00 PM	Coffee Available	Lower Concourse
3:00 - 5:00 PM	Innate Immune Mechanisms: Molecular and Structural Aspects Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre
	Luke A.J. O'Neill, Trinity College Dublin, Ireland Signal Transduction during Innate Immunity and Inflammation
	Kate A. Fitzgerald, University of Massachusetts Medical School, USA Inflammasomes and Anti-Viral Responses
	Eicke Latz, University of Massachusetts Medical School, USA Regulation of NLRP3 and AIM2 Inflammasome Signaling
	Short Talk to be Chosen from Abstracts,
5:00 PM-	On Own for Dinner
Friday, June 11
7:30 - 8:30 AM	Breakfast	Lodging Location
8:30 - 11:30 AM	Therapeutic Manipulation of Innate Immunity in Inflammatory Diseases Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre
	John Bertin, GlaxoSmithKline, USA Targeting NLR Signaling Complexes with Small-Molecule Inhibitors
	Robert L. Coffman, Dynavax Technologies, USA Targeting TLR7 and TLR9 in Autoimmune Disease
	Sudhir Agrawal, Idera Pharmaceuticals, USA Synthetic Agonists and Antagonists of Toll-Like Receptors 7,8, and 9
	Andrew E. Parker, Opsona Therapeutics, Ireland Targeting TLR2 in Inflammatory Diseases
	Short Talk(s) to be Chosen from Abstracts,
9:40 - 10:00 AM	Coffee Break	Lower Concourse
11:00 AM-	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Lower Concourse
5:00 - 7:15 PM	Pathogen-Specific Responses Registered attendees for this meeting can view Abstracts for this session starting on 05/07/2010	Burke Theatre
	Tracy Hussell, Imperial College London, UK The Role of Innate Immunity in Host Defense against Respiratory Pathogens
	Douglas Golenbock, University of Massachusetts Medical School, USA Innate Immune Mechanisms in Malaria
	Stefanie N. Vogel, University of Maryland, USA The Role of Innate Immunity in the Response to Tularemia
	Andrew G. Bowie, Trinity College Dublin, Ireland Viral Modulation of Host Defense
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Grand Dining Hall
8:15 - 11:00 PM	Entertainment	Grand Dining Hall
Saturday, June 12
	Departure
*=Session Chair †=Speaker invited, not yet responded.

Keystone Symposia would like to thank the sponsor of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:



	Opsona Therapeutics

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In the past 5 years there have been remarkable advances in our understanding of the molecular basis of innate immunity. We now have considerable detail on the major classes of innate immune receptors that sense pathogens and provoke immune and inflammatory responses. These include the Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs). The role these receptors play in host defense against microbes has been studied, their signaling pathways elucidated, and their roles in infectious and inflammatory diseases examined in detail. As well as stimulating innate immunity via induction of various effector mechanisms, these receptors also participate in the establishment of adaptive immunity. This occurs via the induction of key cytokines to promote T and B cell development and activation, and also via the induction of co-stimulatory molecules on the surface of dendritic cells, notably CD80 and CD86. A final aspect concerns adjuvancy – microbial or synthetic agents that activate these receptors act as powerful adjuvants required for the establishment of memory responses. This conference will bring together scientists working on innate immune mechanisms activated by these receptors, and will have as a key focus the ability of these receptors and the responses they elicit to promote adaptive immunity. The conference will therefore be of interest to many investigators interested in immunity and the role the immune system plays in disease.

Innate Immunity: Mechanisms Linking with Adaptive Immunity (D3)