Keystone Symposia Conference | Viral Immunity

Meeting Program

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Sunday, March 21
3:00 - 7:30 PM	Registration	Van Horne Foyer
6:15 - 7:15 PM	Refreshments	Van Horne Foyer
7:15 - 7:30 PM	Orientation for New Attendees and New Investigators Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010 NOTE: Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a "What to Expect during your Attendance" for interested delegates.	Van Horne Ballroom
7:30 - 9:30 PM	Keynote Session (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Van Horne Ballroom
	Bruce D. Walker, Massachusetts General Hospital, USA Durable Control of HIV Infection: Implications for Vaccine Design
	Peter C. Doherty, University of Melbourne, Australia Anti-Viral Immunity: Lessons from Influenza Virus
Monday, March 22
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	Innate Recognition of Virus Infection Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Van Horne Ballroom C
	* Herbert (Skip) W. Virgin IV, Washington University School of Medicine, USA
	Ruslan M. Medzhitov, Yale University School of Medicine, USA Innate Recognition of Endogenous Retroviruses
	Nelson Cesar Di Paolo, University of Washington, USA Short Talk: Adenovirus Binding to beta3 Integrins Activates Innate Antiviral Immunity Independently of the Virus DNA Recognition by Intracellular Sensors
	Michael J. Gale Jr., University of Washington, USA Regulation of Pathogen Recognition Receptor Signaling and Innate Immunity by Hepatitis C Virus
	Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA NLRs in Innate Immunity to Influenza Virus
	Sammy Bedoui, University of Melbourne, Australia Short Talk: Priming of CD8 T Cell Immunity to Herpes Simplex Virus Type 1 Requires Cognate TLR3 Expression in vivo
	Akiko Iwasaki, Yale University School of Medicine, USA Toll Like Receptors in Viral Immunity
Following Session is for HIV Vaccines (X5)
8:00 - 11:00 AM	Adaptive Immunity/T- and B-Cell Responses Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Van Horne Ballroom A-B
	* Marcus Altfeld, Massachusetts General Hospital, USA
	Kim J. Hasenkrug, NIAID, National Institutes of Health, USA T Cell and B Cell Memory in Protection against Mouse Retrovirus Infection
	Richard A. Koup, National Institutes of Health, USA Adaptive Immunity to HIV
	Barbara L. Shacklett, University of California, Davis, USA Mucosal Immune Responses to HIV Infection
	Barton F. Haynes, Duke University Medical Center, USA B-Cell Immune Responses to Acute HIV Infection
	Hendrik Streeck, Massachusetts General Hospital, Harvard Medical School, USA Short Talk: Increased Control of Viral Replication by HIV-1-Specific CD8+ T Cells Mediated by HIV-Specific CD4+ T Helper Signals


9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Innate Immunity to Viruses Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Van Horne Ballroom C
	* Akiko Iwasaki, Yale University School of Medicine, USA
	Herbert (Skip) W. Virgin IV, Washington University School of Medicine, USA 'Virus-Host Susceptibility Gene' Interactions Control Chronic Inflammatory Disease
	Doris Wilflingseder, Innsbruck Medical University, Austria Short Talk: Complement as an Endogenous Adjuvant for Dendritic Cell-Mediated Induction of Retrovirus-Specific CTLs
	Ofer Mandelboim, Hebrew University of Jerusalem, Israel Cellular and Viral microRNAs Controlling Immune Response to Stress
	Wayne M. Yokoyama, Washington University School of Medicine, USA NK Cells, CTLs, and Virus Infection: Missing-Self in Action?
Following Session is for HIV Vaccines (X5)
5:00 - 7:00 PM	Control of HIV Infection Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Van Horne Ballroom A-B
	* Andrew J. McMichael, John Radcliffe Hospital, UK Vaccine Design: Lessons from Acute HIV-1 Infection
	R. Paul Johnson, Harvard Medical School, USA Lessons from Live Attenuated SIV
	Guido Silvestri, University of Pennsylvania School of Medicine, USA Nonpathogenic Natural SIV Infections
	Mark Brockman, Simon Fraser University, Canada Short Talk: Reduced Replication Capacity of Recombinant Viruses Encoding Acute/Early HIV-1 Gag-Protease Sequences from Individuals Expressing Protective HLA Class I Alleles
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Mezzanine 2
Tuesday, March 23
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	T-Cell Immunity to Viruses Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Van Horne Ballroom C
	* Jack R. Bennink, National Institutes of Health, USA
	Nicole L. La Gruta, University of Melbourne, Australia Dissection of CTL Immunodominance Determinants Following Viral Infection
	Guna Karupiah, John Curtin School of Medical Research, Australian National University, Australia Short Talk: The Biological Significance of Proliferation-Independent Expansion of Antigen-Specific CD8+ T Cells through Receptor Sharing
	Andrea Lynn Cox, Johns Hopkins University, USA Analysis of T cells Chasing Hepatitis C Virus Escape Variants
	Ann B. Hill, Oregon Health & Science University, USA CD8+ T Cells and Cytomegalovirus: A Dangerous Obsession?
	Linda S. Cauley, University of Connecticut Health Center, USA Short Talk: Cause and Effects of Prolonged Lymph Node Hypertrophy after Influenza Infection
	J. Lindsay Whitton, The Scripps Research Institute, USA CD8+ T Cell Responses To Infection: A Tale Of Two Viruses
Following Session is for HIV Vaccines (X5)
8:00 - 11:45 AM	Neutralizing Antibody Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Van Horne Ballroom A-B
	Eric Hunter, Emory University, USA Recently Transmitted HIV and the Early Neutralizing Antibody Response
	Cynthia A. Derdeyn, Emory University, USA Recently Transmitted HIV and the Early Neutralizing Antibody Response
	Peter D. Kwong, Vaccine Research Center, National Institutes of Health, USA Antibody VRC01: To Be or Not To Be Like CD4

	Quentin J. Sattentau, Sir William Dunn School of Pathology, UK Inducing Mucosal HIV-1 Antibodies in an Anti-Inflammatory Environment
	* Lynn Morris, National Institute for Communicable Diseases, South Africa How Does Neutralization Breadth Develop in HIV Infection
	Ann J. Hessell, The Scripps Research Institute, USA Short Talk: A Non-Fucosylated Variant of the Anti-HIV-1 MAb b12 Results in Greatly Increased ADCC and ADCVI and Binds FcgammaRIIIa with Higher Affinity than Wild-Type b12
	Joseph Joyce, Merck & Co., Inc., USA Short Talk: Vaccination with Peptide Mimetics of the gp41 Pre-Hairpin Fusion Intermediate Yields Neutralizing Antisera Against HIV-1 Isolates
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
2:30 - 4:30 PM	Workshop 1: Anti-Viral CD8 T Cell Responses	Van Horne Ballroom C
2:30 - 3:30 PM	Workshop 1A: CD8 T Cell Memory
	* Tania H. Watts, University of Toronto, Canada
	* David C. Tscharke, Australian National University, Australia
	Jeffrey C. Nolz, University of Iowa, USA Multiple Antigen Encounters Decrease the Protective Capacity of the Ensuing Memory CD8 T Cell Population Against Chronic LCMV Infection
	John Rutigliano, St. Jude Children's Research Hospital, USA Development and Differentiation of Memory CD8+ T Cells in Influenza Infection
	Hélène Decaluwe, Pasteur Institute, France Gamma c Deficiency Precludes CD8+ T Cell Memory Despite Formation of Potent Anti-Viral T Cell Effectors
	Amol Suryawanshi, University of Tennessee, USA Galectin-9/TIM-3 Interaction Regulates Virus-Specific Primary and Memory CD8+T Cell Response
Following Workshop is for HIV Vaccines (X5)
2:30 - 4:30 PM	Workshop 2: Novel Vector and Adjuvant Development Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Van Horne Ballroom A-B
	* Gerald H. Voss, GlaxoSmithKline Biologicals, Belgium
	John K. Rose†, Yale University School of Medicine, USA Strong Protection Against SIVsmE660 Mucosal Challenge Conferred by a Novel, Heterologous, Prime-Boost Vaccine Regimen
	Mauricio A. Martins, University of Wisconsin-Madison, USA Recombinant Yellow Fever Vaccine Virus 17D Expressing SIVmac239 Gag Induces SIV-Specific CD8+ T Cell Responses in Rhesus Macaques
	* Nancy L. Haigwood, Oregon Health and Science University, USA Novel VLPs Rapidly Induce High Titer Neutralizing Antibodies when Combined with DNA Vaccines in Rabbits
	Adrian McDermott†, International AIDS Vaccine Initiative, USA Control of Pathogenic SIVmac239 Following Electroporated DNA + IL-12 Prime and Adenovirus 5 Boost in a Study Designed to Compare Priming Strategies in the NHP Model
	Magdalini Moutaftsi, Infectious Disease Research Institute, USA Glucopyranosyl Lipid A (GLA), a Synthetic TLR4 Vaccine Adjuvant, Induces Potent Th1-Promoting Immune Responses
	Anna Bershteyn, Massachusetts Institute of Technology, USA Versatile Lipid-Based Vaccine Carriers Elicit CTL and Antibody Responses to Surface-Conjugated or Encapsulated Antigen
	Ben Berkhout, University of Amsterdam, Academic Medical Center, The Netherlands Live Attenuated SIV: Characterising the Role of Vaccine Persistence in Protection
	Tomas Hanke, Weatherall Institute of Molecular Medicine, UK Long Peptides Induce Polyfunctional Macaque T Cells Against Conserved Regions of HIV-1 with Superior Breadth to Single-Gene Vaccines
3:30 - 4:30 PM	Workshop 1B: Virus Specific CD8 T Cells
	Alice E. Denton, University of Melbourne, Australia Epigenetic Regulation in CD8+ T Cell Differentiation
	Bailey E. Freeman, Oregon Health & Science University, USA Cytokine-Mediated Regulation of CD8+ T Cell Responses during LCMV Infection
	Lila Ann Farrington†, Oregon Health and Sciences University, USA Virus-Infected Cells are Extremely Resistant to CTL-Mediated Killing
	Silvia Ariotti, Netherlands Cancer Institute, The Netherlands In vivo Imaging of Target Localization by Virus-Specific Cytotoxic T Lymphocytes
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Routes of Antigen Presentation Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Van Horne Ballroom C
	* Nicole L. La Gruta, University of Melbourne, Australia
	William R. Heath, University of Melbourne, Australia Viral Antigen Presentation to Naïve and Memory CD8+ T Cells
	Margarita Del Val, Instituto de Salud Carlos III, Spain Short Talk: Furin-Processed Antigens Targeted to the Secretory Route Elicit Functional TAP1-/- CD8+ T Lymphocytes in vivo
	Sylvie Le Gall, Massachusetts General Hospital, Harvard Medical School, USA Deciphering HIV Epitope Production: Implications for Immunogen Design
	Laurence C. Eisenlohr, Thomas Jefferson University, USA A Proteasome- and TAP-Dependent MHC Class II-Restricted Presentation Pathway that Stimulates a Substantial Portion of the Antiviral CD4+ T Cell Response: Part 2
Following Session is for HIV Vaccines (X5)
5:00 - 7:00 PM	Innate Immunity Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Van Horne Ballroom A-B
	* Bali Pulendran, Emory University, USA

	Marcus Altfeld, Massachusetts General Hospital, USA Natural Killer Cells in HIV-1 Infection
	Mariapia A. Degli-Esposti, LEI, University of Western Australia, Australia NK/DC Crosstalk and Regulation of Adaptive Immunity
	Jay A. Berzofsky, National Cancer Institute, National Institutes of Health, USA Short Talk: Innate and Adaptive Immune Correlates of Vaccine-Induced Control of Mucosal Transmission of SIV in Macaques
	Silke Paust, Harvard Medical School, USA Short Talk: Critical Role for CXCR6 in NK Cell Mediated Adaptive Immunity to Viruses
	Veronica Anna Sofia Tjomsland, University of Linköping, Sweden Short Talk: Receptors and Pathways Utilized by Dendritic Cells for Antigen Presentation of Free and Complement Opsonized HIV
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Mezzanine 2
Wednesday, March 24
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	Vaccines: Immunologic Mechanisms of Action (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Van Horne Ballroom
	* Kim J. Hasenkrug, NIAID, National Institutes of Health, USA
	Bali Pulendran, Emory University, USA Lessons from Yellow Fever Vaccine
	Ian H. Frazer, University of Queensland, Australia Lessons from Human Papillomavirus Vaccines
	Shane Crotty, La Jolla Institute for Allergy and Immunology, USA Lessons from the Smallpox Vaccine: Follicular Helper CD4+ T Cell (Tfh) Differentiation and Neutralizing Antibodies
	M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA Lessons from the STEP Trial and the Current Clinical Pipeline
	Mark Stephen de Souza, AFRIMS, Thailand Short Talk: Immunogenicity of the Thai Phase III (RV144) HIV Vaccine Regimen
	Monica Vaccari†, National Cancer Institute, USA Short Talk: HIV/SIV Vaccine Efficacy Dependent on the Dose of SIVmac251 Challenge Exposure in Macaques
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Imaging of the Antiviral Immune Response (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Van Horne Ballroom
	* Jonathan W. Yewdell, National Institutes of Health, USA
	Heather D. Hickman, DHHS, NIH, NIAID, USA Intravital Imaging of the CD8+ T Cell Response to Virus
	Ronald N. Germain, NIAID, National Institutes of Health, USA Intravital Imaging of Adaptive Immune Effector Activity
	Ashley T. Haase, University of Minnesota, USA In Vivo Imaging of the Cellular Immune Response to Viral Infections
	Matteo Iannacone, Harvard Medical School, USA Short Talk: Lymph Node Subcapsular Sinus Macrophages Confer Resistance to CNS Invasion Upon Peripheral Infection With a Neurotropic Virus
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Mezzanine 2
Thursday, March 25
7:00 - 8:00 AM	Breakfast	Mezzanine 2
7:00 - 8:00 AM	Poster Setup	Mezzanine 2
8:00 - 11:15 AM	Immunity to Chronic and Persistent Viral Infections Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Van Horne Ballroom C
	* Peter C. Doherty, University of Melbourne, Australia
	Marcia A. Blackman, Trudeau Institute, USA Immune Control of Gamma-Herpesvirus Latency
	Ilhem Messaoudi, Oregon Health & Science University, USA Short Talk: Elucidating the Role of T Cell Immunity in the Control of VZV Replication using a Novel Nonhuman Primate Model
	Emmanuel J. Wiertz, University Medical Center Utrecht, The Netherlands Herpesvirus Interference with T-Cell Immunity
	Elina I. Zuniga, University of California, San Diego, USA Short Talk: Sustained-Cell-Intrinsic Transforming Growth Factor-beta Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence in vivo
	Barbara Rehermann, National Institutes of Health, USA Immunity to Hepatitis C Virus
	Francis V. Chisari, The Scripps Research Institute, USA Induction and Evasion of the Innate Host Response to HCV
Following Session is for HIV Vaccines (X5)
8:00 - 11:15 AM	Novel Vaccine Approaches Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Van Horne Ballroom A-B
	Wayne C. Koff, International AIDS Vaccine Initiative, USA Future Directions in AIDS Vaccine Development
	Gerald H. Voss, GlaxoSmithKline Biologicals, Belgium AS01, an Adjuvant System Potentiating Vaccines against Complex Pathogens


	Bette T. Korber, Los Alamos National Laboratory, USA HIV Antigen Designs to Address HIV Variability
	* Louis J. Picker, Oregon Health & Science University, USA Cytomegalovirus Vectors
	Dan H. Barouch, Beth Israel Deaconess Medical Center, USA Short Talk: Heterologous Rare Serotype Adenovirus Vectors for HIV-1 +
	Brad Jones, University of Toronto, Canada Short Talk: Comprehensive Elimination of Globally Diverse HIV Primary Isolate Infections by HERV-K-Specific CD8+ T Cells
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:15 AM- 12:00 PM	Lunch	Mezzanine 2
12:00 - 2:30 PM	Poster Session 4 Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Mezzanine 2
2:30 - 4:30 PM	Workshop 2: Anti-Viral T and B-Cells and Viral Evolution	Van Horne Ballroom C
2:30 - 3:30 PM	Workshop 2A: Anti-Viral CD4 and CD8 T Cell Responses
	* Connie C. Bergmann, Cleveland Clinic Foundation, USA
	* Kevin L. Legge, University of Iowa Carver College of Medicine, USA
	Anna Haas, Swiss Federal Institute of Technology, Switzerland HIV-1 Replication Activates CD4+ T Cells with Specificities for Persistent Herpes Viruses
	Mickael J. Ploquin, National Institute for Medical Research, UK B Cells Shape the T Helper Response to Retroviral Infection
	David E. Verhoeven, University of Maryland at Baltimore, USA Memory CD4+ T-Cells Mediate Enhanced Immunopathology during Influenza Infection
	Jennifer Bomberger, Dartmouth Medical School, USA The Pseudomonas aeruginosa Toxin Cif Reduces MHC Class I Antigen Presentation and Viral Immunity
Following Workshop is for HIV Vaccines (X5)
2:30 - 4:30 PM	Workshop 3: HIV Pathogenesis to Inform Vaccine Design Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	The Theatre
	* David I. Watkins, University of Wisconsin-Madison, USA
	* Barbara L. Shacklett, University of California, Davis, USA
	Srinika R.F. Ranasinghe, Weatherall Institute of Molecular Medicine, UK The Antiviral Efficacy of HIV-specific CD8+ T-cells to a Conserved Epitope is Heavily Dependent on the Infecting HIV-1 Isolate
	Anne-Sophie M. Dugast, Ragon Institute, Massachusetts General Hospital, USA Significant Impairment in Innate Immune Cells Recruitment by Chronic Untreated Antibodies to Mediate ADCC
	Matthew R. Reynolds, University of Wisconsin-Madison, USA Macaques Vaccinated with SIVmac239∆nef Delay Acquisition and Control Replication after Repeated Low Dose Heterologous SIV Challenge
	Todd M. Allen, Massachusetts General Hospital, USA Ultra-Deep Sequencing During Acute HIV Infection Reveals the Earliest Adaptive Changes to Host Selection Pressures
	Qingsheng Li, University of Minnesota, USA Maturation of Virus-specific Antibodies in Cervicovaginal Tissues in SIVmac239∆nef-vaccinated Macaques
	Suzanne English, University of Oxford, UK Sexual Transmission of Highly-Distinct HIV-1 Variants from a Single Donor to Two Recipients on the Same Night: Divergent Immune-Recognition and Clinical Outcomes
	Suresh Pallikkuth, University of Miami, USA Recombinant IL-21 Induces Cytotoxic Molecule Granzyme B in Lymph Nodes of Chronic SIV Infected Rhesus Macaques
	Adam D. Burgener, National Microbiology Lab, Canada HIV-1-Resistant Sex Workers Overexpress Novel Antiproteases and Antiviral Factors in their Cervical Mucosa. Protective Milieu Against HIV-1 Infection?
3:30 - 4:30 PM	Workshop 2B: B Cell Responses to Viruses
	Matthew R. Vogt, Washington University School of Medicine, USA Non-neutralizing Antibodies Protect against Lethal West Nile Virus Infection via Fc-gamma Receptor and Complement–dependent Mechanisms
	Michael Kuligowski, Harvard Medical School, USA Directed Trafficking of Influenza Antigens into LNs via Follicular Conduits
	Denise A. Kaminski, University of Rochester, USA Antiviral Activity of Influenza Nucleoprotein-Specific Antibodies
	Luis J. Sigal, Fox Chase Cancer Center, USA Not just Neutralizing Abs: Prevention and Cure of a Viral Disease by Antibodies that Block the Biological Function of a Virulence Factor
2:30 - 3:30 PM	Workshop 3: Innate Immunity to Virus Infection	Van Horne Ballroom A-B
2:30 - 3:30 PM	Workshop 3A: Immunity to Viruses
	* Adolfo Garcia-Sastre, Mount Sinai School of Medicine, USA
	Maulik Patel, Fred Hutchinson Cancer Research Center, USA Evolution as a Guide to Molecular Mechanisms of Pathogen Resistance
	Helene Minyi Liu, University of Washinton, Seattle, USA RIG-I Membrane-Association Controls Innate Antiviral Immunity
	Alina Baum, Mount Sinai School of Medicine, USA Characterization of Endogenous RIG-I Substrates from Virus Infected Cells
	Irving Coy Allen, University of North Carolina at Chapel Hill, USA NLRX1 is a Regulator of the Innate Immune Response to Influenza A Virus Infection
Following Workshop is for HIV Vaccines (X5)
2:30 - 4:30 PM	Workshop 3: HIV Pathogenesis to Inform Vaccine Design Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	The Theatre
	* David I. Watkins, University of Wisconsin-Madison, USA
	* Barbara L. Shacklett, University of California, Davis, USA
	Srinika R.F. Ranasinghe, Weatherall Institute of Molecular Medicine, UK The Antiviral Efficacy of HIV-specific CD8+ T-cells to a Conserved Epitope is Heavily Dependent on the Infecting HIV-1 Isolate
	Anne-Sophie M. Dugast, Ragon Institute, Massachusetts General Hospital, USA Significant Impairment in Innate Immune Cells Recruitment by Chronic Untreated Antibodies to Mediate ADCC
	Matthew R. Reynolds, University of Wisconsin-Madison, USA Macaques Vaccinated with SIVmac239∆nef Delay Acquisition and Control Replication after Repeated Low Dose Heterologous SIV Challenge
	Todd M. Allen, Massachusetts General Hospital, USA Ultra-Deep Sequencing During Acute HIV Infection Reveals the Earliest Adaptive Changes to Host Selection Pressures
	Qingsheng Li, University of Minnesota, USA Maturation of Virus-specific Antibodies in Cervicovaginal Tissues in SIVmac239∆nef-vaccinated Macaques
	Suzanne English, University of Oxford, UK Sexual Transmission of Highly-Distinct HIV-1 Variants from a Single Donor to Two Recipients on the Same Night: Divergent Immune-Recognition and Clinical Outcomes
	Suresh Pallikkuth, University of Miami, USA Recombinant IL-21 Induces Cytotoxic Molecule Granzyme B in Lymph Nodes of Chronic SIV Infected Rhesus Macaques
	Adam D. Burgener, National Microbiology Lab, Canada HIV-1-Resistant Sex Workers Overexpress Novel Antiproteases and Antiviral Factors in their Cervical Mucosa. Protective Milieu Against HIV-1 Infection?
3:30 - 4:30 PM	Workshop 3B: Innate Cellular Responses to Viruses
	Karyl Kopaskie, University of Chicago, USA Evasion of the Immune Response by Retroviriuses
	Mark T. Orr, University of California, San Francisco, USA “Unlicensed” NK Cells Dominate the Response to Cytomegalovirus Infection
	Stephen A. McCartney, Washington University School of Medicine, USA Distinct Functions of MDA5 and TLR3 in poly-I:C-mediated Activation of Murine NK Cells
	Stephanie Jost, Ragon Institute of MGH, MIT and Harvard, USA Modulation of 2B4 and NKp46 Expression at the Surface of NK Cells in Response to Influenza Virus
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Antigenic Variation (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/21/2010	Van Horne Ballroom
	* Wayne C. Koff, International AIDS Vaccine Initiative, USA
	David I. Watkins, University of Wisconsin-Madison, USA The Effect of Vaccine-Induced SIV-Specific Immune Response on Viral Acquisition and Replication
	Arnaud Moris, UPMC - Hôpital Pitié-Salpêtrière, France Short Talk: The Antiviral Factor APOBEC3G Improves CTL Recognition of HIV-Infected T Cells: Linking Intrinsic and Adaptive Immune Responses
	Dennis R. Burton, The Scripps Research Institute, USA HIV Env and Approaches to Neutralizing Abs
	Jonathan W. Yewdell, National Institutes of Health, USA Still Drifting: Mechanisms of Influenza A Virus Hemagglutinin Immune Escape
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
8:00 - 11:00 PM	Entertainment	Mezzanine 2
Friday, March 26
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

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We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI085598-01

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The most exciting recent advances in viral immunity include the increased understanding of the role of innate immune mechanisms, interaction between innate and adaptive immunity, pathogen manipulation of host responses, and activation of immune responses and generation of immune memory. Despite these advances, basic mechanisms of anti-viral immunity are poorly characterized particularly for chronic infections. Efforts are also required to exploit recent research advances to improve vaccine design and therapeutic intervention. This meeting will include both innate and adaptive immunity and juxtapose animal models with human studies as it attempts to foster collaborative efforts between attending viral immunologists and the HIV vaccine researchers in the joint meeting. Expert talks in plenary sessions will encompass the latest in critical areas of viral immunity. Workshops and additional presentations will cover provocative and cutting-edge results from attendees. The meeting objective is to accelerate progress in understanding and manipulating anti-viral immunity to improve human health.

Viral Immunity (X6)