Keystone Symposia Conference | HIV Biology and Pathogenesis

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Tuesday, January 12
3:00 - 7:30 PM	Registration	Sweeney Ballroom Foyer
6:30 - 7:30 PM	Refreshments	Sweeney Ballroom A-D
7:30 - 8:30 PM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 12/12/2009	Sweeney Ballroom E-F
	Stephen P. Goff, Columbia University, USA HIV-1 Interactions with Host Proteins
8:30 - 8:45 PM	Orientation for New Attendees and New Investigators Registered attendees for this meeting can view Abstracts for this session starting on 12/12/2009 NOTE: Meeting Organizer, Dr. Thomas Hope, to lead discussion in a "What to Expect during your Attendance" for interested delegates.	Sweeney Ballroom E-F
Wednesday, January 13
7:00 - 8:00 AM	Breakfast	Sweeney Ballroom A-D
8:00 - 11:00 AM	HIV Transmission and Early Pathogenesis Registered attendees for this meeting can view Abstracts for this session starting on 12/12/2009	Sweeney Ballroom E-F
	* John P. Moore, Weill Medical College of Cornell University, USA
	Thomas J. Hope, Northwestern University, Feinberg School of Medicine, USA Defining the Mechanisms of HIV Entry and Interactions with the Female Genital Tract
	Beatrice H. Hahn, University of Alabama at Birmingham, USA Natural History of Simian Immunodeficiency Virus Infection in Wild-Living Chimpanzees
	Daniel C. Douek, NIAID, National Institutes of Health, USA Immune Aspects of HIV Disease Pathogenesis
	Guido Silvestri, University of Pennsylvania School of Medicine, USA SIV Infection of Sooty Mangabeys
	Jan Münch, University Clinic of Ulm, Germany Short Talk: Testing the Effect of Semen on HIV Infection
9:20 - 9:40 AM	Coffee Break	Sweeney Ballroom A-D
11:00 AM- 1:00 PM	Poster Setup	Sweeney Ballroom A-D
11:00 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Sweeney Ballroom A-D
2:30 - 4:30 PM	Workshop 1: Interplay of Viral and Cellular Proteins	Sweeney Ballroom E-F
	* Paula M. Cannon, University of Southern California, Keck School of Medicine, USA
	* David McDonald, Case Western Reserve University, USA
	Hillel Haim, Dana-Farber Cancer Institute, USA An Inherent ‘Ligand-Reactivity’ Property of the HIV-1 Envelope Glycoproteins Determines both Fusion Capacity and General Inhibitor Sensitivity
	Brian P. Doehle, University of Washington, USA HIV-1 Mediates Global Disruption of Innate Antiviral Signaling and Immune Defenses within Infected Cells
	Ed Campbell, Loyola University, USA p62/Sequestosome1 Associates with and Stabilizes the Expression of TRIM5alpha Proteins
	Jonathan Richard, Institut de Recherches Cliniques de Montréal, Canada HIV-1 Vpr Promotes NK Cell-Mediated Killing by Upregulating Expression of Ligands for the Activating NKG2D Receptor
	Amy J. Andrew, NIAID, National Institutes of Health, USA Functional Analysis of Bst-2/Tetherin Imposed Inhibition of HIV-1 Virus Release
	Elena Chertova, National Cancer Institute, National Institutes of Health, USA Denying the Denialists: Purification of SIV Particles from Highly Viremic Monkey Plasma
	Vincent Dussupt, NIAID, National Institutes of Health, USA Mutations of Basic Residues in the Nucleocapsid Region of HIV-1 Gag cause Budding Arrests
4:30 - 5:00 PM	Coffee Available	Sweeney Ballroom A-D
5:00 - 7:15 PM	HIV Entry Registered attendees for this meeting can view Abstracts for this session starting on 12/12/2009	Sweeney Ballroom E-F
	* Jeremy Luban, University of Geneva, Switzerland
	Gregory B. Melikian, University of Maryland, USA Biophysics of HIV Entry
	David McDonald, Case Western Reserve University, USA Cell Biology of HIV Trans-Infection
	Anna Cereseto, Scuola Normale Superiore, Italy Visualization of the Pre-Integration Complex
	Benjamin Dale, Mount Sinai School of Medicine, USA Short Talk: The Virological Synapse Promotes HIV-1 Transfer into Fusion-Permissive Compartments
	Andrea Polacchini-Oliveira Jordan, University of Pennsylvania School of Medicine, USA Short Talk: Pathological Correlates of Attenuation for SIVmac239 Containing a Mutation in a Tyr-Dependent Trafficking Motif in the Envelope Transmembrane Cytoplasmic Tail
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Sweeney Ballroom A-D
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 12/12/2009	Sweeney Ballroom A-D
Thursday, January 14
7:00 - 8:00 AM	Breakfast	Sweeney Ballroom A-D
8:00 - 11:00 AM	Innate Restriction of HIV Infection Registered attendees for this meeting can view Abstracts for this session starting on 12/12/2009	Sweeney Ballroom E-F
	* Wesley I. Sundquist, University of Utah School of Medicine, USA
	Michael H. Malim, King's College London School of Medicine, UK Mechanism of HIV-1 Inhibition by APOBEC3G
	Jeremy Luban, University of Geneva, Switzerland TRIM5 is a Receptor for Retroviral Capsid that Contributes to the Antiviral State
	Paula M. Cannon, University of Southern California, Keck School of Medicine, USA Tetherin Restriction and its Ablation by Diverse Viral Proteins
	Mark Yeager, The Scripps Research Institute, USA Structural Studies of HIV Capsid and TRIM5 alpha
	Robert A. Barnitz, NIAID, National Institutes of Health, USA Short Talk: Protein Kinase A Phosphorylation Activates HIV-1 Vpr Cell Cycle Arrest
9:20 - 9:40 AM	Coffee Break	Sweeney Ballroom A-D
11:00 AM- 1:00 PM	Poster Setup	Sweeney Ballroom A-D
11:00 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Sweeney Ballroom A-D
2:30 - 4:30 PM	Workshop 2: Towards Understanding How HIV Causes AIDS	Sweeney Ballroom E-F
	* Richard A. Koup, National Institutes of Health, USA
	* Galit Alter, Massachusetts General Hospital, USA
	Boris Dominik Jülg, Ragon Institute, Massachusetts General Hospital, USA Strong Antiviral CD8 T Cell Function in-vitro Correlates with Better Disease Outcome in HIV Elite Controllers Lacking Protective HLA Class I Alleles
	Benjamin C. Chaon, University of Iowa, USA Simultaneous ex vivo Expression of the PD-1/PD-L1 Axis, a Potential Mediator of T-T Cell Interactions, Characterizes HIV-Specific CD4+ T Cells
	Donald L. Sodora, Seattle Biomedical Research Institute, USA Double Negative T Cells (CD3+/CD4-/CD8-) with Potential CD4 T Cell Function during Natural SIV Infection of Sooty Mangabeys
	Lena Al-Harthi, Rush University, USA CD4dimCD8bright T-Cells have Potent Anti-HIV-Specific Responses and their Phenotype is Induced in a beta-Catenin-Dependent Manner
	Kelly M. Fahrbach, Northwestern University, USA Enhanced Cellular Responses and Environmental Sampling in Inner Foreskin Explants: Evidence for the Foreskin's Role in HIV Transmission
	Victor H. Ferreira, McMaster University, Canada The Effect of Co-Infection on HIV-1 Replication in the Female Genital Tract
	Tara Edmonds, University of Alabama, Birmingham, USA Infectious Molecular Clones of Transmitted/Founder HIV-1 Infect Monocyte-Derived Macrophages Less Efficiently Than Highly Macrophage Tropic Viruses
	Steven E. Bosinger, University of Pennsylvania, USA Global Genomic Analysis Reveals Rapid Control of a Robust Innate Response in SIV-Infected Sooty Mangabeys
4:30 - 5:00 PM	Coffee Available	Sweeney Ballroom A-D
5:00 - 7:15 PM	Immune Responses to HIV Infection Registered attendees for this meeting can view Abstracts for this session starting on 12/12/2009	Sweeney Ballroom E-F
	* Anna Aldovini, Children's Hospital Boston and Harvard Medical School, USA
	Galit Alter, Massachusetts General Hospital, USA NK Cells in HIV Infection
	Richard A. Koup, National Institutes of Health, USA Interplay of HIV and the Immune Response
	Timothy W. Schacker, University of Minnesota, USA Mechanisms of Lymphoid Tissue Fibrosis and its Consequences in HIV Infection
	Judith Angeline Briant, NIAID, National Institutes of Health, USA Short Talk: Infant African Green Monkeys are Resistant to SIVagm Infection
	Leonid Margolis, National Institutes of Health, USA Short Talk: HIV Interactions with Other Viruses: And How to Exploit Them
7:15 - 8:00 PM	Social Hour w/ Lite Bites	Sweeney Ballroom A-D
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 12/12/2009	Sweeney Ballroom A-D
Friday, January 15
7:00 - 8:00 AM	Breakfast	Sweeney Ballroom A-D
8:00 - 11:00 AM	Regulation of HIV Integration and Gene Expression Registered attendees for this meeting can view Abstracts for this session starting on 12/12/2009	Sweeney Ballroom E-F
	* Anna Cereseto, Scuola Normale Superiore, Italy
	Frederic D. Bushman, University of Pennsylvania School of Medicine, USA Integration of HIV DNA: Mechanism and Consequences
	Peter P. Cherepanov, Imperial College London, UK Structural Basis for Retroviral Preintegration Complex Assembly
	Katherine A. Jones, The Salk Institute, USA Tat and Cellular Stress Induce the HIV-1 Core Promoter via Distinct Mechanisms
	Qiang Zhou, University of California, Berkeley, USA Novel Cellular Cofactors and Mechanism for Tat-Activation of HIV-1 Transcriptional Elongation
	Ivan D'Orso, University of California, San Francisco, USA Short Talk: Proteomic Study of HIV-host Transcription Complexes Relevant to Infection
9:20 - 9:40 AM	Coffee Break	Sweeney Ballroom A-D
11:00 AM- 1:00 PM	Poster Setup	Sweeney Ballroom A-D
11:00 AM-	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Sweeney Ballroom A-D
1:30 - 4:30 PM	NIAID Workshop: The Next Challenge: Elimination of HIV Reservoirs	Sweeney Ballroom E-F
	Janet Siliciano, Johns Hopkins University, USA Issues in HIV-1 Persistence and Latency
	Carl H. June, University of Pennsylvania, USA Exploring the Potential of Gene Modified CD4 T Cells to Target the HIV-1 Reservoir
	Olaf Kutsch, University of Alabama at Birmingham, USA HIV-1 Latency – Does Site of Integration Matter?
	Vicente Planelles, University of Utah, USA The Role of NFAT in HIV-1 Latency: New Insights from a Central Memory T-Cell Model
	Javier Martinez-Picado, ICREA & irsiCaixa Foundation, Spain HIV-1 Replication and Immune Dynamics are Impacted by Raltegravir Intensification of HAART-Suppressed Patients
	Sarah E. Palmer, Karolinska Institute, Sweden Characterizing Persistent HIV Viremia
	Jeffrey C. Laurence, Weill Cornell Medical College, USA Proving the Concept: The First Well-Documented Functional, and Probably Complete, Case of HIV Eradication
	* Diana Finzi, NIAID, National Institutes of Health, USA Wrap-Up and Discussion
	* Janet Siliciano, Johns Hopkins University, USA Wrap Up and Discussion
2:45 - 3:15 PM	Coffee Break	Sweeney Ballroom A-D
4:30 - 5:00 PM	Coffee Available	Sweeney Ballroom A-D
5:00 - 7:00 PM	Treatment and Prevention of HIV Infection Registered attendees for this meeting can view Abstracts for this session starting on 12/12/2009	Sweeney Ballroom E-F
	* Dana H. Gabuzda, Dana Farber Cancer Institute, USA
	Steven G. Deeks, University of California, San Francisco, USA HIV-Association Inflammation as a Cause of Accelerated Aging
	John P. Moore, Weill Medical College of Cornell University, USA Small Molecule CCR5 Inhibitors as Vaginal Microbicides
	Jerome H. Kim, Walter Reed Army Institute of Research, USA Understanding the Results of the Thai Vaccine Trial
	Christopher Aiken, Vanderbilt University School of Medicine, USA Short Talk: Inhibition of HIV-1 Infection by Small Molecule Destabilization of the Viral Capsid
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Sweeney Ballroom A-D
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 12/12/2009	Sweeney Ballroom A-D
Saturday, January 16
7:00 - 8:00 AM	Breakfast	Sweeney Ballroom A-D
8:00 - 11:00 AM	HIV Latency and Reservoirs Registered attendees for this meeting can view Abstracts for this session starting on 12/12/2009	Sweeney Ballroom E-F
	* Vineet N. KewalRamani, National Cancer Institute, National Institutes of Health, USA
	Eric M. Verdin, University of California, San Francisco, USA Epigenetic Regulation of HIV Latency by DNA Methylation
	Anna Aldovini, Children's Hospital Boston and Harvard Medical School, USA Tat-mediated Gene Modulation in HIV Target Cells
	Dana H. Gabuzda, Dana Farber Cancer Institute, USA NeuroAIDS and HIV Reservoirs
	Bette T. Korber, Los Alamos National Laboratory, USA Exploring HIV Immune Escape in Acute Infection with Ultradeep Sequencing
	Wendy Burgers, University of Cape Town, South Africa Short Talk: Immune Activation during Early HIV Infection Associates with the Rate of Disease Progression and is not Due to Microbial Translocation
9:20 - 9:40 AM	Coffee Break	Sweeney Ballroom A-D
11:00 AM-	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Sweeney Ballroom A-D
5:00 - 7:15 PM	HIV Interactions with the Cell and Host Registered attendees for this meeting can view Abstracts for this session starting on 12/12/2009	Sweeney Ballroom E-F
	* Michael H. Malim, King's College London School of Medicine, UK
	Frank Kirchhoff, University of Ulm, Germany Role of Nef and Vpu in Primate Lentiviral Pathogenesis and Transmission
	Wesley I. Sundquist, University of Utah School of Medicine, USA HIV Assembly and Budding
	Vineet N. KewalRamani, National Cancer Institute, National Institutes of Health, USA CA Modulation of HIV-1 Interactions with the Nuclear Pore
	Marc C. Johnson, University of Missouri, Columbia, USA Short Talk: The Minimal Requirements for Viral Pseudotyping
	Greg J. Towers, University College London, UK Short Talk: A Role for the Nuclear Pore Protein Nup358 (RANBP2) in Capsid Dependent Nuclear Entry of Lentiviruses
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Sweeney Ballroom A-D
8:00 - 11:00 PM	Entertainment	Sweeney Ballroom A-D
Sunday, January 17
	Departure
*=Session Chair †=Speaker invited, not yet responded.

Keystone Symposia would like to thank the sponsors of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI087256-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

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The Keystone Symposia Meeting on HIV Biology and Pathogenesis emphasizes key aspects of the basic virological, cell and molecular biological, and disease aspects of HIV. The focus will be to highlight recent advances in our understanding of HIV/AIDS ranging from the earliest events of transmission, to treatments for infected individuals, to interventions to prevent viral transmission. The goal of the meeting is to emphasize the basic mechanisms of viral replication and the interplay of the virus with the immune system leading to the development of AIDS.

HIV Biology and Pathogenesis (A6)