Keystone Symposia Conference | Molecular Basis for Chromatin Structure and Regulation

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Sunday, January 17
3:00 - 7:30 PM	Registration	Chamisa Lobby
6:30 - 7:30 PM	Refreshments	Chamisa Lobby
7:30 - 9:30 PM	Keynote Session Registered attendees for this meeting can view Abstracts for this session starting on 12/17/2009	Chamisa Ballroom 1
	* Jonathan Widom, Northwestern University, USA
	Roger D. Kornberg, Stanford University, USA Chromatin Structure and Transcription
	C. David Allis, Rockefeller University, USA Beyond the Double Helix: Writing and Reading the Histone Code
Monday, January 18
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Transcription Factor and Chromatin Dynamics in vivo Registered attendees for this meeting can view Abstracts for this session starting on 12/17/2009	Chamisa Ballroom 1
	Timothy J. Stasevich, National Institutes of Health, USA Dissecting the Binding Mechanism of the Linker Histone in Live Cells: An Integrated FRAP Analysis
	John T. Lis, Cornell University, USA Very Rapid and Locus-Wide Changes in Chromatin Caused by Activation of a Potentiated Gene
	X. Sunney Xie, Harvard University, USA Transcription Factor and Chromatin Dynamics in vivo
	Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland The Role of Nucleosome Remodelers in the Positioning and Dynamics of DNA during Expression and Repair
	Hinrich Boeger, University of California, Santa Cruz, USA Short Talk: The Kinetics of Stochastic Fluctuations in Chromatin Structure and Gene Expression
	Maya M. Kasowski, Yale University, USA Short Talk: Analyzing Variation in Gene Regulation in Humans: Global Analysis of NF-kappaB and Polii Binding using CHIP-SEQ
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Chamisa Ballroom 2
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 2
3:30 - 4:30 PM	Workshop Panel NOTE: To be geared toward helping women (and men, if interested) graduate students, postdocs, and junior faculty address the challenges of balancing an academic career and family.	Chamisa Ballroom 1
	* Geeta J. Narlikar, University of California, San Francisco, USA
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Functional Elements Registered attendees for this meeting can view Abstracts for this session starting on 12/17/2009	Chamisa Ballroom 1
	* Gary Felsenfeld, National Institutes of Health, USA Insulators and Enhancer Blockers
	Stavros Lomvardas, University of California, San Francisco, USA Molecular Mechanisms of Olfactory Receptor Choice
	Robert E. Kingston, Massachusetts General Hospital, USA Nucleosome Occupancy and Transcriptional Regulation
	JJ L. Miranda, University of California, San Francisco, USA Short Talk: Molecular Architecture of CTCF and the Insulatosome
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 12/17/2009	Chamisa Ballroom 2
Tuesday, January 19
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Chromatin Assembly and Modification Registered attendees for this meeting can view Abstracts for this session starting on 12/17/2009	Chamisa Ballroom 1
	* Karolin Luger, Colorado State University, USA Histone Chaperone Mechanisms in Chromatin Assembly and Disassembly
	Geneviève Almouzni, Centre National de la Recherche Scientifique, France Histone Chaperones, Chromatin Assembly and the Challenges of Cell Cycle
	James T. Kadonaga, University of California, San Diego, USA Chromatin Assembly and DNA Dynamics
	Shelley L. Berger, University of Pennsylvania, USA Histone Covalent Modifications in Genome Regulation
	Song Tan, Pennsylvania State University, USA Short Talk: Structural Basis for Nucleosome Recognition by the RCC1 Chromatin Factor
	Michael A. Shogren-Knaak, Iowa State University, USA Short Talk: Acetylation-Dependent Multimerization of the Yeast SAGA Coactivator Complex in Inducible Gene Transcription
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Chamisa Ballroom 2
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 2
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Histone Code Modules and Enzyme Mechanism Registered attendees for this meeting can view Abstracts for this session starting on 12/17/2009	Chamisa Ballroom 1
	* Dinshaw J. Patel, Memorial Sloan-Kettering Cancer Center, USA
	Or P. Gozani, Stanford University, USA Role of Protein Lysine Methylation Signaling in Health and Disease
	Cheryl Arrowsmith, University of Toronto, Canada Structural and Chemical Biology of Histone Code Modules
	Philip A. Cole, Johns Hopkins School of Medicine, USA Chemical Approaches to Mechanisms of Histone Modifying Enzymes
	Alexander J. Ruthenburg, Rockefeller University, USA Short Talk: Multivalent Interactions Interpret the Histone Code at the Nucleosome Level
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 12/17/2009	Chamisa Ballroom 2
Wednesday, January 20
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Dynamic Transitions and ATP-Dependent Remodeling Registered attendees for this meeting can view Abstracts for this session starting on 12/17/2009	Chamisa Ballroom 1
	* Bradley R. Cairns, Huntsman Cancer Institute, University of Utah, USA DNA Translocation by the RSC Chromatin Remodeler in ‘Tethered’ Formats
	Geeta J. Narlikar, University of California, San Francisco, USA Structure and Mechanisms of ATP-Dependent Chromatin Remodeling Motors
	Michelle D. Wang, Cornell University, USA The Dynamics of Accessing DNA
	Xiaowei Zhuang, Harvard University, USA Single Molecule Studies of Chromatin Remodeling Enzymes
	Gregory D. Bowman, Johns Hopkins University, USA Short Talk: Crystal Structure of the Chd1 Remodeler Reveals that Chromodomains can Directly Regulate the ATPase Motor
	Hua-Ying Fan, Fox Chase Cancer Center, USA Short Talk: UV-Induced Association of the CSB Remodeling Protein with Chromatin Requires ATP-Dependent Relief of N-Terminal Autorepression
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Chamisa Ballroom 2
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 2
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Chromatin Structure Registered attendees for this meeting can view Abstracts for this session starting on 12/17/2009	Chamisa Ballroom 1
	* Geeta J. Narlikar, University of California, San Francisco, USA
	Eran Segal, Weizmann Institute of Science, Israel EMBO Young Investigator Lecture: Toward Understanding the Code of Chromatin Regulation
	Timothy J. Richmond, ETH Zürich, Switzerland Structure and Interactions of the Chromatin Remodeling Factor ISW1a
	John van Noort, Universiteit Leiden, The Netherlands Unraveling Chromatin Higher Order Structure with Magnetic Tweezers
	Yvonne N. Fondufe-Mittendorf, Northwestern University, USA Short Talk: Nucleosome Positioning and Dynamic Nucleosome Repositioning in Transcription Regulation
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 12/17/2009	Chamisa Ballroom 2
Thursday, January 21
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Silencing and Dosage Compensation Registered attendees for this meeting can view Abstracts for this session starting on 12/17/2009	Chamisa Ballroom 1
	* Danesh Moazed, Harvard Medical School, USA In Vitro Reconstitution of Heterochromatin-Dependent Transcriptional Gene Silencing
	Shiv I. S. Grewal, National Institutes of Health, USA RNAi-Mediated Epigenetic Control of the Genome
	Barbara J. Meyer, University of California, Berkeley, USA X-Chromosome-Wide Gene Regulation
	Jeannie T. Lee, Massachusetts General Hospital, USA Separating Repressive and Activating Chromatin Domains at the X-Inactivation Center
	Joanna Wysocka, Stanford School of Medicine, USA Short Talk: Coordinated Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells
	Yali Dou, University of Michigan, USA Short Talk: The Heterodimer of Non-SET Domain Proteins Ash2L and RbBP5 has Intrinsic Histone Methyltransferase Activity that Synergizes with the MLL1 SET Domain in H3 K4 Methylation
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM-	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Protein Chemistry Registered attendees for this meeting can view Abstracts for this session starting on 12/17/2009	Chamisa Ballroom 1
	* Tom W. Muir, Rockefeller University, USA A Synthetic ‘Kiss of Death’
	Dinshaw J. Patel, Memorial Sloan-Kettering Cancer Center, USA A Structural Perspective of How Chromatin-Binding Modules Interpret Histone Modifications
	Jennifer J. Ottesen, Ohio State University, USA Short Talk: Ligation Strategies to Probe Histone Modifications in the Nucleosome Core
	Benjamin A. Garcia, Princeton University, USA Short Talk: Next Generation Quantitative Proteomic Tools for Analyzing Histone Modifications
	Daniele Canzio, University of California, San Francisco, USA Short Talk: Polymerizable Chromodomain "Sticky Ends" in HP1 Couple H3K9me3 Recognition to Nucleosome Arrangement in Heterochromatin Assembly
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
8:00 - 11:00 PM	Entertainment	Chamisa Ballroom 2
Friday, January 22
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:

The Directors' Fund

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Chromatin structure and dynamics underlie every aspect of genome function. The past several years have seen an exponential growth in our knowledge of facts, ranging from catalogs of histone protein posttranslational modifications to complete genome sequences of many organisms to atomic resolution structures of many key molecular players. But our mechanistic understanding lags far behind. New reagents, methodologies and concepts are needed. This meeting will bring together leading experts in diverse areas of chromatin biology who are developing and applying new approaches to develop a concrete mechanistic link between chromatin structure and chromatin function. The topics covered include: fundamental in vivo physical chemical studies of transcription factor binding; real-time single molecule in vivo imaging; state-of-the-art methods for discovery, characterization, and manipulation of histone- and nucleosome-modifying enzymes and for the synthesis and characterization of their specifically-modified histone and nucleosome substrates; single molecule biophysics studies of molecular mechanisms; atomic resolution structural studies; and locus- and chromosome-wide phenomena such as heterochromatin formation and dosage compensation.

Molecular Basis for Chromatin Structure and Regulation (A8)