Keystone Symposia Conference | Dynamics of Eukaryotic Transcription during Development

Meeting Program

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Wednesday, April 7
3:00 - 7:30 PM	Registration	Lower Atrium
6:30 - 7:30 PM	Refreshments	Lower Atrium
7:30 - 8:30 PM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 03/07/2010	Gallatin
	Richard A. Young, Whitehead Institute for Biomedical Research, USA Programming Embryonic Stem Cell State
Thursday, April 8
7:00 - 8:00 AM	Breakfast	Jefferson/Madison
8:00 - 11:00 AM	Genomic Approaches to Understanding Gene Expression Registered attendees for this meeting can view Abstracts for this session starting on 03/07/2010	Gallatin
	Frank Holstege, University Medical Center, Utrecht, The Netherlands Understanding Regulatory Circuitry through Expression-Profile Phenotypes
	Steven Henikoff, Fred Hutchinson Cancer Research Center, USA Mapping Genome-Wide Nucleosome Dynamics
	Jonathan Widom, Northwestern University, USA DNA-Encoded Nucleosome Organization of Eukaryotic Genomes
	B. Franklin Pugh, Pennsylvania State University, USA Global Interplay between the Transcription Machinery and Chromatin
	W. Lee Kraus, Cornell University, USA Short Talk: Exploring the Direct Estrogen-Regulated Transcriptome in Breast Cancer Cells Using GRO-Seq
9:20 - 9:40 AM	Coffee Break	Lower Atrium
11:00 AM-	On Own for Lunch and Recreation
11:00 AM- 1:00 PM	Poster Setup	Jefferson/Madison
1:00 - 10:00 PM	Poster Viewing	Jefferson/Madison
4:30 - 5:00 PM	Coffee Available	Lower Atrium
5:00 - 7:15 PM	Transcription Regulation in Stem Cells and during Development Registered attendees for this meeting can view Abstracts for this session starting on 03/07/2010	Gallatin
	Kenneth S. Zaret, University of Pennsylvania, USA Pioneer Transcription in Programming of Liver and Pancreas Progenitors: Lessons for Stem Cell Differentiation
	Susan E. Mango, Harvard University, USA Investigating the Transcriptional Mechanisms that Govern the Progression of C. elegans Development
	Stuart H. Orkin, Dana-Farber Cancer Institute, USA Epigenetic Regulation of Hematopoietic Stem Cells and mES Cell Pluripotency and Differentiation
	Fiona M. Watt, CRUK Cambridge Research Institute, UK Proliferation and differentiation of epidermal stem cells
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Jefferson/Madison
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 03/07/2010	Jefferson/Madison
Friday, April 9
7:00 - 8:00 AM	Breakfast	Jefferson/Madison
8:00 - 11:00 AM	Transcription Regulation - From Pol II Recruitment to Early Elongation Registered attendees for this meeting can view Abstracts for this session starting on 03/07/2010	Gallatin
	Jennifer F. Kugel, University of Colorado, Boulder, USA Regulation of Early Steps of Transcription by ncRNAs
	Laszlo Tora, Institut de Genetique et de Biologie Moleculaire et Cellulaire, France TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte
	Robert G. Roeder, Rockefeller University, USA Function of Diverse Transcriptional Coactivators in Animal Cells
	Marc Timmers, University Medical Centre Utrecht, The Netherlands Dynamic Regulation of the Basal Transcription Machinery
	Michel Werner†, CEA/Saclay, France Short Talk: In vivo Mechanism of Pol II Recruitment on Class-II Genes by the Mediator
9:20 - 9:40 AM	Coffee Break	Lower Atrium
11:00 AM-	On Own for Lunch and Recreation
11:00 AM- 1:00 PM	Poster Setup	Jefferson/Madison
1:00 - 10:00 PM	Poster Viewing	Jefferson/Madison
2:30 - 4:30 PM	Workshop 1: Genomic Approaches: Discovery of Transcription Modulators as Drug Targets and High-Throughput Techniques for Investigating Changes in Gene Expression NOTE: This workshop is designed to engage members of pharmaceutical industry using new techniques to identify transcription inhibitors, as well as companies that do high-throughput sequencing.	Gallatin
	James E. Bradner†, Dana-Farber Cancer Institute, USA Direct Inhibition of the Notch Transcription Factor Complex
	Jun Zhu†, Institute for Genome Sciences & Policy, USA The Landscape of Transcription Initiation in the Drosophila melanogaster Embryo
	Tae-Kyung Kim, University of Texas Southwestern, USA Widespread Transcription at Thousands of Enhancers during Activity-Dependent Gene Expression in Neurons
	Marta Radman-Livaja, University of Massachusetts Medical School, USA Gene Inactivation and Epigenetic Inheritance
	Pao-Shu Wu, Wellcome Trust/CRUK Gurdon Institute, UK Genome-Wide Analysis of Temporal Transcription Factor Regulatory Circuitry and their Roles in Drosophila Neural Stem Cell Competence regulation
	Michael P. Schnetz, Case Western Reserve University, USA CHD7 Targets Active Gene Enhancer Elements to Modulate ES Cell-Specific Gene Expression
	Michael D. Wilson, Cambridge Research Institute, UK Five Vertebrate ChIP-seq Reveals the Genetic Mechanisms of Rapid Transcription Factor Binding Divergence
4:30 - 5:00 PM	Coffee Available	Lower Atrium
5:00 - 7:00 PM	Regulation of Transcription Elongation Registered attendees for this meeting can view Abstracts for this session starting on 03/07/2010	Gallatin
	Karen Adelman, NIEHS, National Institutes of Health, USA Regulation of Immune-Responsive Pathways by Pol II Stalling
	Hiroshi Handa, Tokyo Institute of Technology, Japan The Role of Transcription Elongation Factors in Genome Expression
	David S. Gilmour, Pennsylvania State University, USA Biochemical and In Vivo Analysis of Promoter Proximal Pausing
	Ryan Baugh, Duke University, USA Short Talk: Nutritional Control of Pol II Pausing during C. elegans Development
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Jefferson/Madison
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 03/07/2010	Jefferson/Madison
Saturday, April 10
7:00 - 8:00 AM	Breakfast	Jefferson/Madison
8:00 - 11:15 AM	The Effects of Chromatin Structure on Transcription Registered attendees for this meeting can view Abstracts for this session starting on 03/07/2010	Gallatin
	Ali Shilatifard, Stowers Institute for Medical Research, USA Histone Methylation Pathways
	Jessica K. Tyler, University of Colorado Health Sciences Center, USA Chromatin Assembly and Disassembly
	Jane Mellor, University of Oxford, UK Histone Modifications, Transcription Factors, ncRNA and Gene Loops in Transcription.
	Danny F. Reinberg, NYU-School of Medicine, USA How Histone Modifications Affect Gene Expression
	Xiaole Shirley Liu, DFCI/HSPH, USA Short Talk: Using Histone Mark Dynamics to Infer the Transcription Regulatory Network in Intestine Development
	Marc D. Meneghini, University of Toronto, Canada Global Histone Demethylation Controls Spore Differentiation Timing During Budding Yeast Gametogenesis.
9:20 - 9:40 AM	Coffee Break	Lower Atrium
11:00 AM-	On Own for Lunch and Recreation
11:00 AM- 1:00 PM	Poster Setup	Jefferson/Madison
1:00 - 10:00 PM	Poster Viewing	Jefferson/Madison
2:30 - 4:30 PM	Workshop 2: New and Noteworthy	Gallatin
	Maria Ciofani, Skirball Institute of Biomolecular Medicine, NYUSOM, USA Transcriptional Regulatory Network Underlying CD4+ T Helper 17 (Th17) Lineage Specification
	Suming Huang†, University of Florida, USA Serine Phosphorylation on TAL1 Regulates its Interaction with Histone Demethylase LSD1 during Hematopoiesis
	Miguel Garcia-Diaz, Stony Brook University, USA A Unique DNA Binding Mode Enables Human mterf1 to Regulate Mitochondrial Transcription
	Bijan Sobhian, Institute of human genetics, France HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP
	Akihiko Yokoyama, National Cancer Center Research Institute, Japan Mechanisms of MLL-Dependent Transcriptional Maintenance in Normal and Cancer Cells
	Madeline M. Wong, National Cancer Institute, NIH, USA Promoter Bound p300 Complexes Facilitate Transmission of Molecular Memory Across the Cell Cycle
	Ines de Santiago, MRC - Clinical Sciences Centre, UK Genome-Wide Mapping of RNA Polymerase II Phosphorylation Elucidates the CTD Code in Embryonic Stem Cells
	Olivier Cuvier†, LBME- CNRS, France Deciphering the Discrete Stages of Insulator-encoded Nucleosome-Positioning: The Road towards Transcriptional Competence
4:30 - 5:00 PM	Coffee Available	Lower Atrium
5:00 - 7:00 PM	Activators and Co-Regulatory Complexes Registered attendees for this meeting can view Abstracts for this session starting on 03/07/2010	Gallatin
	Joan W. Conaway, Stowers Institute for Medical Research, USA Mechanisms for Recruiting Chromatin Remodeling Complexes to Their Targets
	Michael S. Levine, University of California, Berkeley, USA Gene Activation during Development and Differentiation in Drosophila
	Barbara Panning, University of California, San Francisco, USA Tip60-p400 as a Regulator of Embryonic Stem Cell Identity
	Michael Meisterernst, Institute of Molecular Tumor Biology, Germany Short Talk: Transcription Cofactor PC4 is Critical for Cellular Proliferation and Early Development of Mammals
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Jefferson/Madison
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 03/07/2010	Jefferson/Madison
Sunday, April 11
7:00 - 8:00 AM	Breakfast	Jefferson/Madison
8:00 - 11:00 AM	Co- and Post-Transcriptional RNA Processing Registered attendees for this meeting can view Abstracts for this session starting on 03/07/2010	Gallatin
	Stephen Buratowski, Harvard Medical School, USA Connecting Transcription to Chromatin and mRNA Processing
	Katherine A. Jones, The Salk Institute, USA Co-Transcriptional Activities of the Spt6:Iws1 Complex on the RNAPII CTD
	Kevin Struhl, Harvard Medical School, USA An Epigenetic Switch that Links Inflammation to Cancer
	Sukesh R. Bhaumik, Southern Illinois University School of Medicine, USA Short Talk: A Novel Regulatory Pathway of Eukaryotic Transcriptional Activation by mRNA Cap-Binding Complex in vivo
9:20 - 9:40 AM	Coffee Break	Lower Atrium
4:30 - 5:00 PM	Coffee Available	Lower Atrium
5:00 - 7:00 PM	Imaging and Probing Global Nuclear Architecture Registered attendees for this meeting can view Abstracts for this session starting on 03/07/2010	Gallatin
	John T. Lis, Cornell University, USA New Views of Local and Genome-Wide Transcription Activation in Vivo
	Wendy A. Bickmore, MRC Human Genetics Unit, UK Ring1B Compacts Chromatin Structure, and Represses Gene Expression, Independent of Histone Ubiquitination
	Bas van Steensel, Netherlands Cancer Institute, The Netherlands Architecture and Function of Genome - Nuclear Lamina Interactions
	Jie Yao, Howard Hughes Medical Institute, USA Short Talk: Coordinate Re-Positioning of Genes and Core Promoter Selectivity Factors during Myogenesis
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Jefferson/Madison
8:00 - 11:00 PM	Entertainment	Jefferson/Madison
Monday, April 12
	Departure
*=Session Chair †=Speaker invited, not yet responded.

We gratefully acknowledge support for this conference from:

National Institute of Environmental Health Sciences

Funding for this conference was made possible, in part, by funding from the National Institute of Environmental Health Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

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Gene expression in eukaryotes is regulated primarily at the level of transcription. Although much is known about the basic building blocks required to recruit RNA polymerase II to a gene promoter and establish a pre-initiation complex, recent data reveals that a great deal of regulation occurs during transcription elongation, and involves dynamic interactions between the transcription machinery and chromatin structure. This meeting is intended to explore these recently appreciated mechanisms for gene regulation and to showcase the novel techniques that have permitted these advances. Of particular interest are the use of comprehensive, genomic approaches, and their use towards understanding the different patterns of gene expression in different model systems, including stem cells and developing tissues, as well as the application of novel molecular probing and cell imaging techniques to investigate the global nuclear architecture and its impact on gene expression.

Dynamics of Eukaryotic Transcription during Development (C4)