Keystone Symposia Conference | RNA Silencing: Mechanism, Biology and Application

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Thursday, January 14
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 9:30 PM	Keynote Session Registered attendees for this meeting can view Abstracts for this session starting on 12/14/2009	Longs/Quandary Peaks
	James C. Carrington, Oregon State University, USA Small RNA-Directed Silencing Pathways in Plants
	V. Narry Kim, Seoul National University, South Korea The Making of a MicroRNA
Friday, January 15
7:00 - 8:00 AM	Breakfast	Grays/Torreys Peaks
8:00 - 11:00 AM	Structure and Regulation of Small RNAs Registered attendees for this meeting can view Abstracts for this session starting on 12/14/2009	Longs/Quandary Peaks
	Jennifer A. Doudna, University of California, Berkeley, USA Dicer and Beyond: Mechanisms of Regulatory RNA Processing and Targeting
	Rachel J. Senturia, University of California, Los Angeles, USA Short Talk: Crystallographic and Cellular Studies of the DGCR8 Dimerization Domain: A Platform for Interaction with Heme
	Dinshaw J. Patel, Memorial Sloan-Kettering Cancer Center, USA A Structural Perspective of Recognition and Cleavage Events in RNA Silencing
	Nina Schürmann, University of Heidelberg, Germany Short Talk: Directed Molecular Evolution of Chimeric Argonaute Proteins as Potent New Approach to Elucidate Structure-Function Relationships of Human RISC
	Martijn Kedde, Netherlands Cancer Institute, The Netherlands Short Talk: A Pumilio-Induced RNA Structure Switch in p27-3’UTR Controls miR-221&222 Accessibility
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM-	On Own for Lunch and Recreation
11:00 AM- 1:00 PM	Poster Setup	Grays/Torreys Peaks
1:00 - 10:00 PM	Poster Viewing	Grays/Torreys Peaks
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Regulation of Small RNA Pathways Registered attendees for this meeting can view Abstracts for this session starting on 12/14/2009	Longs/Quandary Peaks
	Brenda L. Bass, University of Utah, USA A Role for Dicer's Helicase Domain
	Brandi N. Davis, Tufts Medical Center, USA Short Talk: Smad Proteins Bind a Conserved RNA Sequence to Promote microRNA Maturation by Drosha
	Olivier Voinnet, Institut de Biologie Moléculaire des Plantes, France Function and Regulation of miRNA Pathways in Plants
	Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA Genetic Analysis Reveals the Complexity of the C. elegans RNA Silencing Pathways
	Guillaume Jannot, Laval University Cancer Research Centre, Canada Short Talk: Conserved Function of a Ribosomal Protein RACK1 in the microRNA Pathway
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Grays/Torreys Peaks
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 12/14/2009	Grays/Torreys Peaks
Saturday, January 16
7:00 - 8:00 AM	Breakfast	Grays/Torreys Peaks
8:00 - 11:15 AM	miRNA Biogenesis and Function Registered attendees for this meeting can view Abstracts for this session starting on 12/14/2009	Longs/Quandary Peaks
	Xuemei Chen, University of California, Riverside, USA Three Polymerases in siRNA-Directed Transcriptional Gene Silencing
	Elisa Izaurralde, MPI for Developmental Biology, Germany A Role for PABPC1 in the miRNA Pathway
	Demian E. Cazalla, Yale University, USA Short Talk: Herpesvirus saimiri U RNAs Affect the Expression of Cellular microRNAs in Latently Infected T Cells
	David P. Bartel, Massachusetts Institute of Technology, USA MicroRNAs and Other Small Regulatory RNAs
	Victor Ambros, University of Massachusetts, USA MicroRNA Pathways and Cofactors in C. elegans
	Catherine A. Reinke, Northwestern University, USA Short Talk: Elucidation of the miRNA Pathway through the Identification and Characterization of Genes Identified in a Forward Genetics Study of miRNA Function in Drosophila melanogaster
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Grays/Torreys Peaks
1:00 - 10:00 PM	Poster Viewing	Grays/Torreys Peaks
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:30 PM	Small RNA Therapeutics Registered attendees for this meeting can view Abstracts for this session starting on 12/14/2009	Longs/Quandary Peaks
	Priti Kumar, Yale School of Medicine, USA Targeting siRNAs to T-Cells for Anti-Viral Therapy
	Daniel G. Anderson, Massachusetts Institute of Technology, USA Combinatorial Development of Synthetic siRNA Delivery Systems
	Mark A. Kay, Stanford University, USA Mechanism of MicroRNA Mediated Transgene Silencing
	Lukas Jeker, University of California San Francisco, USA Short Talk: miR-10a in Regulatory T Cells
	Sakari Kauppinen, Santaris Pharma, Denmark Targeting of microRNAs for Therapeutics
7:30 - 8:30 PM	Social Hour w/ Lite Bites	Grays/Torreys Peaks
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 12/14/2009	Grays/Torreys Peaks
Sunday, January 17
7:00 - 8:00 AM	Breakfast	Grays/Torreys Peaks
8:00 - 11:15 AM	Small RNAs and RNAi I Registered attendees for this meeting can view Abstracts for this session starting on 12/14/2009	Longs/Quandary Peaks
	Attila Molnar, University of Cambridge, UK Small RNAs are Mobile and Trigger DNA Methylation in Distant Tissue
	Sarah C.R. Elgin, Washington University, USA Targeting Heterochromatin Formation in Drosophila
	Hanbang Zhang, Stanford University, USA Short Talk: Antisense Small RNAs with 5’-Polyphosphate Termini Regulate Gene Expression in the Deep Branching Eukaryote Entamoeba Histolytica
	Phillip A. Sharp, Massachusetts Institute of Technology, USA Small RNA Function in Mammals
	Elaine Fuchs, Howard Hughes Medical Institute, Rockefeller University, USA MicroRNAs and Stem Cells
	Shouhong Guang, University of Wisconsin, Madison, USA Short Talk: Small RNAs Mediate Transcription Termination
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Grays/Torreys Peaks
1:00 - 10:00 PM	Poster Viewing	Grays/Torreys Peaks
2:30 - 4:30 PM	Workshop: piRNA Biogenesis and Function	Longs/Quandary Peaks
	Craig C. Mello, University of Massachusetts Medical School, USA piRNAs in Worms: The Same, but Different
	Mikiko C. Siomi, Keio University School of Medicine, Japan piRNAs in the Fly Germ Line
	Gregory J. Hannon, Cold Spring Harbor Laboratory, USA Understanding piRNA Biology
	Phillip D. Zamore, University of Massachusetts Medical School, USA Small RNAs and Genomic Defense
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Small RNAs and RNAi II Registered attendees for this meeting can view Abstracts for this session starting on 12/14/2009	Longs/Quandary Peaks
	René F. Ketting, Hubrecht Institute, The Netherlands Small RNAs in Germline Development and Function
	Danesh Moazed, Harvard Medical School, USA Small RNAs that Trigger Heterochromatin Assembly and RNAi
	Shiv I. S. Grewal, National Institutes of Health, USA RNAi and Heterochromatin Factors Suppress Antisense RNAs
	Stephan Emmerth, Friedrich Miescher Institute, Switzerland Short Talk: Nuclear Retention of Fission Yeast Dicer Ensures Accurate Gene Expression and Heterochromatin Assembly
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Grays/Torreys Peaks
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 12/14/2009	Grays/Torreys Peaks
Monday, January 18
7:00 - 8:00 AM	Breakfast	Grays/Torreys Peaks
8:00 - 11:00 AM	Small RNAs, Disease and Development Registered attendees for this meeting can view Abstracts for this session starting on 12/14/2009	Longs/Quandary Peaks
	Alexander Y. Rudensky, Memorial Sloan Kettering Cancer Center, USA Role of miRNAs in T-Cell Function
	Beverly L. Davidson, University of Iowa, USA Small RNAs on the Brain
	Mark P. Boldin, Regulus Therapeutics, USA Short Talk: Myeloproliferative Disease, Autoimmunity and Cancer in Mice with Targeted Deletion of miR-146a Gene
	Deepak Srivastava, Gladstone Institute of Cardiovascular Disease, USA microRNA Regulation of Cardiac Cell Fate, Morphogenesis and Function
	Magnus Blø, University of Bergen, Norway Short Talk: Flow Cytometric-Based Functional Selection of RNA Interference Triggers for epi-allelic Analysis
	Tudor Alexandru Fulga, Harvard Medical School, USA Short Talk: Defining microRNA Function with Precise Spatiotemporal Resolution in Intact Organisms
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM-	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Small RNAs in Stem Cells and Germ Cells Registered attendees for this meeting can view Abstracts for this session starting on 12/14/2009	Longs/Quandary Peaks
	Gene W. Yeo, University of California, San Diego, USA MicroRNAs and Targets in Human Pluripotent Stem Cells
	Dasaradhi Palakodeti, University of Connecticut Health Center, USA Small RNAs in the Planarian Schmidtea mediterranea
	Colin C. Conine, University of Massachusetts Medical School, USA Short Talk: The Ago-Class Argonautes TZK-1 and TZK-2 Bind 26G-RNAs to Promote Male Fertility in C. elegans
	Alex Bortvin, Carnegie Institution of Washington, USA Short Talk: Maelstrom and Mammalian Meiosis
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Grays/Torreys Peaks
8:00 - 11:00 PM	Entertainment	Grays/Torreys Peaks
Tuesday, January 19
	Departure
*=Session Chair †=Speaker invited, not yet responded.

Keystone Symposia would like to thank the sponsors of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Grant No. 1R13HD063228-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs, various types of siRNAs and piRNAs. These classes differ in their biogenesis, modes of target regulation and in the biological pathways they regulate. However, there is also a growing realization that these distinct small RNA pathways are interconnected. These pathways functions in RNA-based immunity, developmental gene regulation, transcriptional silencing, and genomic stability. The aim of this meeting is to explore the similarities and differences between RNA silencing pathways, to probe their underlying molecular mechanisms, to learn—by illustrative examples—the logic behind RNA-guided regulation of gene expression, and to explore new methods for harnessing these mechanisms for gene discovery and therapeutics applications.

RNA Silencing: Mechanism, Biology and Application (A7)