Keystone Symposia Conference | Stem Cells, Cancer and Metastasis

Meeting Program

To view program in "24 hour" time (international) click here.

Sunday, March 6
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 8:30 PM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 02/06/2011	Longs/Grays Peak
	Robert A. Weinberg, Whitehead Institute for Biomedical Research, USA
Monday, March 7
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	Stem Cells in Cancer Pathogenesis I: The Controversy of Cancer Origins Registered attendees for this meeting can view Abstracts for this session starting on 02/06/2011 NOTE: Aim: To discuss the controversy surrounding the candidate cell of origin of cancer and the relation to stem cells.	Longs/Grays Peak
	John E. Dick, Toronto General Research Institute, University Health Network, Canada Stem Cells in Leukemia
	Robert J. Wechsler-Reya, Duke University Medical Center, USA The Road from Stem Cell to Cancer Progenitor: A Study in Medulloblastoma
	Michael A. Dyer, St. Jude Children's Research Hospital, USA Mature Cells: A Hotbed of Cancer Susceptibility?
	Richard J. Gilbertson, St. Jude Children's Research Hospital, USA Adult Tissue Stem Cells: A Hotbed of Cancer Susceptibility?
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Quandary Peak
1:00 - 10:00 PM	Poster Viewing	Quandary Peak
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Stem Cells in Cancer Pathogenesis II: Niches and the Metastatic Cascade Registered attendees for this meeting can view Abstracts for this session starting on 02/06/2011 NOTE: Aim: To discuss the connection between stem cells, niches and metastases.	Longs/Grays Peak
	Richard O. Hynes, Massachusetts Institute of Technology, USA Extracellular Matrix Niches in Cancer Progression
	Dorothy A. Sipkins, University of Chicago, USA The Leukemic Stem Cell Niche
	David C. Lyden, Weill Cornell Medical College, USA Priming the Soil: The Pre-Metastatic Niche
	Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 02/06/2011	Quandary Peak
Tuesday, March 8
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	Genomic Analyses: Reading the Genome in Cancer Stem Cells and Metastatic Precursors Registered attendees for this meeting can view Abstracts for this session starting on 02/06/2011 NOTE: Aim: To highlight how high-end genomic technologies are being used to inform regarding the deregulation of stem cells in cancer.	Longs/Grays Peak
	Charles G. Mullighan, St. Jude Children's Research Hospital, USA Unmasking the Origins of Leukemia with Genomics
	Robert H. Blelloch, University of California, San Francisco, USA miRNAS and the Regulation of Stem Cell Differentiation in Normal and Cancerous Tissues
	Joan Massagué, Memorial Sloan-Kettering Cancer Center, USA Mechanisms of the Metastatic Process
	Sridhar Ramaswamy, Massachusetts General Hospital Cancer Center / Harvard Medical School, USA Spontaneous Cancer Cell Quiescence
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Quandary Peak
1:00 - 10:00 PM	Poster Viewing	Quandary Peak
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Imaging and Tracking Cancer Stem Cells and Metastatic Precursors Registered attendees for this meeting can view Abstracts for this session starting on 02/06/2011 NOTE: Aim: To bring highlight technological advances in stem cell tracking, isolation and imaging.	Longs/Grays Peak
	Peter Kuhn, The Scripps Research Institute, USA High Definition Circulating Tumor Cells in Carcinoma Patients
	Daniel A. Haber, Massachusetts General Hospital, USA Molecular Analysis of Circulating Tumor Cells Using Microfluidic Chip
	Michael R.H. White, University of Liverpool, UK Systems Analysis in Single Cells
	Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 02/06/2011	Quandary Peak
Wednesday, March 9
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	Cancer Stem Cells, Metastasis and Cancer Therapy Registered attendees for this meeting can view Abstracts for this session starting on 02/06/2011 NOTE: Aim: To discuss current and ongoing efforts to develop new therapies against cancer stem cells and metastatic disease.	Longs/Grays Peak
	Max S. Wicha, University of Michigan, USA Therapeutic Implication of Stem Cells in Breast Cancer
	Margaret Read, Infinity Pharmaecuticals, Inc., USA Drug Discovery in the Cancer Stem Cell Era
	Frederic J. de Sauvage, Genentech, Inc., USA Developmental Regulatory Pathways and Cancer Drug Discovery
	Joan S. Brugge, Harvard Medical School, USA Genes that Regulate Migration and Invasion
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Quandary Peak
1:00 - 10:00 PM	Poster Viewing	Quandary Peak
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Breast Cancer Registered attendees for this meeting can view Abstracts for this session starting on 02/06/2011	Longs/Grays Peak
	Jane E. Visvader, Walter and Eliza Hall Institute of Medical Research, Australia Stem Cells in Breast and Breast Cancer
	Rama Khokha, Ontario Cancer Institute, Canada 'Regulation of the Mammary Stem Cell Niche
	Charlotte Kuperwasser, Tufts University School of Medicine, New England, USA Normal and Cancer Stem Cell Heterogeneity and Metastasis
	Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 02/06/2011	Quandary Peak
Thursday, March 10
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	Epithelial Cancers and Stem Cells Registered attendees for this meeting can view Abstracts for this session starting on 02/06/2011	Longs/Grays Peak
	Hans C. Clevers, Hubrecht Institute, Netherlands Intestinal Stem Cells and Cancer
	Elaine Fuchs, HHMI/Rockefeller University, USA Stem Cells and Cancer in the Skin
	Courtney W. Houchen, University of Oklahoma Health Sciences Center, USA Skin Stem Cells and Colon Cancer
	Carla Kim, Children's Hospital, Boston, USA Stem Cells in Normal Lung and Lung Cancer
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 5:45 PM	Closing Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 02/06/2011	Longs/Grays Peak
	Sean J. Morrison, HHMI/University of Michigan, USA Stem Cells and Cancer: Where Are We Now?
5:45 - 7:00 PM	Roundtable: Cancer Stem Cells in Metastasis: Insights and Controversies Registered attendees for this meeting can view Abstracts for this session starting on 02/06/2011	Longs/Grays Peak
	* Richard J. Gilbertson, St. Jude Children's Research Hospital, USA
	* Daniel A. Haber, Massachusetts General Hospital, USA
	Sean J. Morrison, HHMI/University of Michigan, USA
	Robert A. Weinberg, Whitehead Institute for Biomedical Research, USA
	Hans C. Clevers, Hubrecht Institute, Netherlands
	Elaine Fuchs, HHMI/Rockefeller University, USA
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
8:00 - 11:00 PM	Entertainment	Quandary Peak
Friday, March 11
	Departure
*=Session Chair †=Speaker invited, not yet responded.

Keystone Symposia would like to thank the sponsors of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:


OncoMed Pharmaceuticals, Inc.

We gratefully acknowledge the organizations that provide Keystone Symposia with additional support, such as marketing and advertising...

Click here to view these companies

Several concepts regarding the origins of cancer and metastasis have converged in recent years. In particular, special interest has focused on the possibility that tissue specific stem cells and cancer cells displaying the properties of these cells play fundamental roles in the malignant process. These concepts have been supported by studies of mouse models in which predictable patterns of tumor spread and access to both primary and metastatic lesions has allowed molecular analyses. With regard to primary tumors, emerging evidence suggests that important cancers, including those in the colon and brain, may arise directly from mutated progenitor cells that display deviant differentiation within "stem cell-niches". Tumors appear also to contain stem-like cancer cells that are both necessary and required to propagate the disease. These findings overlap with observations of metastasis that suggest tumor dissemination may be driven by critical changes in tumor cell differentiation, including epithelial to mesenchymal transition (EMT), and the migration of malignant stem cells to "pre-metastatic niches". We believe the time is ripe for a joint conference that will bring together scientists and clinicians with interests in stem cell biology, cancer and metastasis. The meeting will provide a forum for exchange of information and insights between these rapidly moving fields. In addition to increasing the sharing of key scientific approaches we believe this conference will galvanize collaborative efforts among disparate research communities to address several key outstanding questions: (i) What is the relationship between normal and malignant tissue stem cells? (ii) What is the relationship between cancer stem cells and the so-called "metastatic precursor", that is capable of indefinite proliferation at the new metastatic site? (iii) What are the interactions between stromal and stem-like cancer cells in primary and metastatic disease sites? How do these interactions facilitate disease propagation and metastatic spread? (iv) How should we monitor in vivo the biology of stem-like cells in primary tumors and metastasis? (v) What are the optimal approaches to target therapeutically stem-like cancer cells in primary and metastatic disease? By focusing on these questions, we aim to elicit exciting fundamental biological discussions with significant translational application.

Stem Cells, Cancer and Metastasis (C4)