Keystone Symposia Conference | Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics

Meeting Program

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Tuesday, February 22
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 9:30 PM	Keynote Session (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Longs/Grays Peak
	* Richard N. Kitsis, Albert Einstein College of Medicine, USA
	* Joseph M. Metzger, University of Minnesota, USA
	Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA Epigenetic Control of Embryonic Stem Cell Differentiation
	Robert J. Lefkowitz, HHMI/Duke University Medical Center, USA Pleiotropic Signaling from G Protein-Coupled Receptors
Wednesday, February 23
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	Genetic and Epigenetic Specification of Cardiac Structure and Function (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Longs/Grays Peak
	* Jeffrey Robbins, Cincinnati Children's Hospital Research Foundation, USA
	Christine E. Seidman, Harvard Medical School, USA Copy Number Variation as a Mechanism of Structural Heart Disease
	Elizabeth M. McNally, University of Chicago, USA Genetic Modifiers of Heart and Muscle Disease
	Stuart A. Cook, Imperial College, UK Systems Genetics Studies of Heart Disease
	Jean E. Schaffer, Washington University School of Medicine, USA Unexpected Regulators of Metabolic Stress
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Quandary Peak
1:00 - 10:00 PM	Poster Viewing	Quandary Peak
2:30 - 4:30 PM	Workshop 1: Early Independent Career Research Competition (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011 NOTE: Eligibility criteria for the Early Independent Career Research Competition will be provided prior to abstract submission. These criteria will be along the lines of graduate/medical students, postdoctoral fellows, residents/fellows, and faculty within two years of initial appointment. There will be no reference to age. Abstracts submitted to this competition will be rated by the 6 organizers. The 4 top submissions will be selected for oral presentation in this session in addition to poster sessions. The above referees will select a winner from the 4 presenters. The winner will be announced on the final night of the meeting. The difference between abstracts selected for “half-talks” and ones selected for the Early Independent Career Research Competition are as follows: (a) Abstracts selected for “half-talks” will be selected regardless of the presenters career stage. (b) Abstracts selected for “half-talks” will be thematically related to the session in which they are presented. (c) Abstracts that the presenter submits to the Early Independent Career Research Competition will first be considered for that competition. If not selected for the Early Independent Career Research Competition, the abstract will then be considered for a “half-talk” along with all the other abstracts.	Longs/Grays Peak
	* Leslie A. Leinwand, University of Colorado, USA
	Short Talks to be Chosen from Abstracts, ,
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Regulation of Cardiac Function Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Longs Peak
	* Eric N. Olson, University of Texas Southwestern Medical Center at Dallas, USA
	Howard A. Rockman, Duke University Medical Center, USA Beta-Arrestin Signaling and Cardiac Function
	Walter J. Koch, Jefferson Medical College, USA Role of GRKs in Cardiac Injury and Repair
	David Kass, Johns Hopkins Hospital, USA Nitric Oxide Signaling and Heart Failure
	Short Talk to be Chosen from Abstracts,
Following Session is for Cardiac Growth (X3)
5:00 - 7:00 PM	Cardiac Stress Responses Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Grays Peak
	* Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA
	Jeffrey Robbins, Cincinnati Children's Hospital Research Foundation, USA Protein-Induced Stress
	Ivor J. Benjamin, University of Utah, USA Heat Shock Proteins and Cardiac Stress
	Issei Komuro, Chiba University Graduate School of Medicine, Japan p53 as a Mediator of Cardiac Disease
	Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Quandary Peak
Thursday, February 24
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	New Insights into Cardiac Hypertrophy Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Longs Peak
	* Howard A. Rockman, Duke University Medical Center, USA
	Anthony Rosenzweig, Beth Israel Deaconess Medical Center, USA SGK1 in Cardiac Hypertrophy, Failure, and Arrhythmias
	Meredith Bond, University of Maryland School of Medicine, USA AKAPs in Healthy and Failing Heart
	Eric N. Olson, University of Texas Southwestern Medical Center at Dallas, USA MicroRNAs in Cardiac Hypertrophy
	Joan Heller Brown, University of California, San Diego, USA Ca++/CaM Protein Kinase II in Hypertrophy and Failure
	Short Talk(s) to be Chosen from Abstracts,
Following Session is for Cardiac Growth (X3)
8:00 - 11:00 AM	Directed Differentiation of Cardiac Progenitors Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Grays Peak
	* Gordon M. Keller, University Health Network, MaRS Centre, Canada
	Deepak Srivastava, Gladstone Institute of Cardiovascular Disease, USA MicroRNA Control of Cardiac Differentiation and Reprogramming
	Michael D. Schneider, Imperial College London, UK Differentiation of ES Cells to Cardiac Myocytes
	Christine L. Mummery, Leiden University Medical Center, Netherlands Pathways Controlling Cardiac Differentiation of Human ES Cells
	Benoit G. Bruneau, Gladstone Institute of Cardiovascular Disease, USA Epigenetic Regulation of Cardiogenesis
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Quandary Peak
1:00 - 10:00 PM	Poster Viewing	Quandary Peak
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Ca++ Dynamics and Heart Failure Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Longs Peak
	* Roger J. Hajjar, Mount Sinai School of Medicine, USA
	W. Jonathan Lederer, University of Maryland Medical Biotechnology Center, USA Ca++ Sparks, Blinks and Winks
	Joseph M. Metzger, University of Minnesota, USA New Ca++ Buffers for the Failing Heart
	Evangelia Kranias, University of Cincinnati College of Medicine, USA Ca++ and Heart Failure
	Short Talk to be Chosen from Abstracts,
Following Session is for Cardiac Growth (X3)
5:00 - 7:00 PM	Cardiac Death Programs Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Grays Peak
	* Gerald Dorn, Washington University School of Medicine, USA
	Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA Mechanisms of Necrosis
	Richard N. Kitsis, Albert Einstein College of Medicine, USA Toward a Unified Theory of Cell Death
	Junichi Sadoshima, University of Medicine & Dentistry of New Jersey, USA Apoptosis and Autophagy in Cardiac Remodeling
	Short Talk(s) to be Chosen from Abstracts,
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Quandary Peak
Friday, February 25
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	“Wntch” Signaling in Cardiogenesis and Repair (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Longs/Grays Peak
	* Charles E. Murry, University of Washington, USA
	Randall T. Moon, University of Washington School of Medicine, USA Wnt Signaling in Zebrafish Heart Regeneration
	Gordon M. Keller, University Health Network, MaRS Centre, Canada Wnt and Notch Signals Control Human Cardiac Differentiation
	Jonathan A. Epstein, University of Pennsylvania, USA Notch Signaling and Cardiovascular Development
	Juan Carlos Izpisúa-Belmonte, The Salk Institute, USA Talk Title to be Determined
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Quandary Peak
1:00 - 10:00 PM	Poster Viewing	Quandary Peak
2:30 - 4:30 PM	Workshop 2: Graduate Student and Postdoc Research Competition (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Longs/Grays Peak
	Short Talks to be Chosen from Abstracts, ,
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Nutrition, Energetics, and Signaling Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Longs Peak
	* Evangelia Kranias, University of Cincinnati College of Medicine, USA
	Leslie A. Leinwand, University of Colorado, USA Gender, Diet, and Cardiac Function
	David D. Thomas, University of Minnesota, USA Phospholamban Structure and Small-Molecule Screening
	Daniel P. Kelly, Sanford-Burnham at Lake Nona, USA Transcriptional Regulation of Cardiac Energetics
	Short Talk to be Chosen from Abstracts,
Following Session is for Cardiac Growth (X3)
5:00 - 7:00 PM	Translating the (Pluri)Potential into Therapy Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Grays Peak
	* Doris A. Taylor, University of Minnesota, USA
	Bernd K. Fleischmann, Universität Bonn, Germany The Physiological Basis for Cardiac Repair by Stem Cells
	Gordana V. Vunjak-Novakovic, Columbia University, USA Myocardial Regeneration through Tissue Engineering
	Jane S. Lebkowski, Geron Corporation, USA Clinical Trials of Human ES Cells: Spinal Cord, Heart and Beyond
	Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Quandary Peak
Saturday, February 26
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	Intercellular and Intracellular Communication Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Longs Peak
	* Michael D. Schneider, Imperial College London, UK
	Kenneth Walsh, Boston University School of Medicine, USA Signaling between Cardiac Myocytes and Endothelial Cells
	Richard T. Lee, Harvard University, USA Paracrine Signaling between Fibroblasts and Myocytes
	Gerald Dorn, Washington University School of Medicine, USA Crosstalk between ER and Mitochondria
	Yibin Wang, University of California, Los Angeles, USA Phosphatases in Cardiac Function
	Short Talk(s) to be Chosen from Abstracts,
Following Session is for Cardiac Growth (X3)
8:00 - 11:00 AM	Identification and Manipulation of Progenitor Cells Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Grays Peak
	* Deepak Srivastava, Gladstone Institute of Cardiovascular Disease, USA
	Charles E. Murry, University of Washington, USA iPS Cells as Models of Human Development and Disease
	Sylvia M. Evans, University of California, San Diego, USA Epicardial Progenitors: The Third Heart Field?
	Daniel J. Garry, University of Minnesota, USA Nkx2-5 Transcriptional Networks and Cardiogenesis
	Bernhard Kühn, Children's Hospital, Boston, USA Cell Division in Adult Mammalian Cardiomyocytes
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Bench to Bedside: Experimental Therapeutics Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Longs Peak
	* Anthony Rosenzweig, Beth Israel Deaconess Medical Center, USA
	Eva van Rooij, Miragen Therapeutics, USA Prospects for microRNA-Based Cardiac Therapeutics
	Roger J. Hajjar, Mount Sinai School of Medicine, USA Manipulating SERCA2a in Heart Failure: Basic Mechanisms to Clinical Applications
	Bruce E. Markham, Phrixus Pharmaceuticals, USA Membrane Repair, Triblock Polymers and Heart Failure
	Short Talk to be Chosen from Abstracts,
Following Session is for Cardiac Growth (X3)
5:00 - 7:00 PM	Cardiac Rebirth and Renewal Registered attendees for this meeting can view Abstracts for this session starting on 01/22/2011	Grays Peak
	* Jonathan A. Epstein, University of Pennsylvania, USA
	Loren J. Field, Indiana University, School of Medicine, USA Can Resident Cardiac Progenitors Repopulate the Heart?
	Jonas Frisén, Karolinska Institutet, Sweden Evidence for Cardiac Myocyte Repopulation in Health and Disease
	Doris A. Taylor, University of Minnesota, USA Cells, Molecules and Matrix: New Tools for Regeneration
	Short Talk(s) to be Chosen from Abstracts,
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
8:00 - 11:00 PM	Entertainment	Quandary Peak
Sunday, February 27
	Departure
*=Session Chair †=Speaker invited, not yet responded.

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Cardiovascular disease is the major cause of death in the world. Although advances have been made in our understanding of cardiac biology and pathobiology, significant conceptual and practical gaps remain. These two symposia address that gap by focusing on fundamental mechanisms that regulate cardiac structure, function, and repair and how they relate to human disease. The major consideration in the design of these two symposia was integration. Accordingly, each symposium was designed in a very unconventional manner. All six organizers participated in the design of each symposium. Only after all sessions were designed was each “assigned” to one meeting or the other. Consequently, integration exists at multiple levels: the science, the speakers, and hopefully the attendees. With respect to the science, the subject matter of the two symposia is linked at both the fundamental and medical level. The speakers themselves are linked with both symposia by virtue of their scientific interests and conference duties: e.g., some are even speaking in one symposium and moderating in the other. The attendees will be linked to both symposia by virtue of scientific interests and the multiple joint sessions.

Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics (X4)