Meeting Program

To view program in "24 hour" time (international) click here.

Sunday, January 30
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 9:30 PM	Keynote Session Registered attendees for this meeting can view Abstracts for this session starting on 12/30/2010	Longs/Grays Peak
	David M. Livingston, Dana-Farber Cancer Institute, USA Genomic Instability and Breast Cancer
	Stephen J. Elledge, Harvard-Partners Center for Genetics and Genomics, USA Talk Title to be Determined
Monday, January 31
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	DNA Damage Signaling: Networks and Systems Approaches Registered attendees for this meeting can view Abstracts for this session starting on 12/30/2010	Longs/Grays Peak
	Stephen P. Jackson, Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, UK Early Events in DNA Damage Signaling and DNA Repair
	Yosef Shiloh, Tel Aviv University, Israel System Biology Investigation of DNA Damage Response
	Galit Lahav, Harvard Medical School, USA Temporal Dynamics of Biological Signals
	Trey Ideker, University of California, San Diego, USA Widespread Induction of Genetic Networks in Response to DNA Damage
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Quandary Peak
1:00 - 10:00 PM	Poster Viewing	Quandary Peak
2:30 - 4:30 PM	Workshop 1: Checkpoint Controls	Longs/Grays Peak
	Short Talks to be Chosen from Abstracts, ,
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Mechanism of DNA Damage Signaling and DNA Repair Registered attendees for this meeting can view Abstracts for this session starting on 12/30/2010	Longs/Grays Peak
	Simon J. Boulton, London Research Institute, Clare Hall Laboratories, UK Novel Sensors and Players Involved in DNA Replication Stress
	Daniel Durocher, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Canada The Control of Genome Stability
	Junjie Chen, University of Texas MD Anderson Cancer Center, USA DNA damage signaling and DNA repair
	Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 12/30/2010	Quandary Peak
Tuesday, February 1
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	Advance in DNA Damage Response Registered attendees for this meeting can view Abstracts for this session starting on 12/30/2010	Longs/Grays Peak
	Alan D. D'Andrea, Dana-Farber Cancer Institute, USA New Insights from Fanconi Anemia
	Ivan Dikic, Goethe University Medical School, Germany Ubiquitin Signaling in Diverse Cellular Processes
	Karlene A. Cimprich, Stanford University, USA Checkpoint Activation and Signaling
	Speaker to be Announced,
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Quandary Peak
1:00 - 10:00 PM	Poster Viewing	Quandary Peak
2:30 - 4:30 PM	Workshop 2: DNA Repair	Longs/Grays Peak
	Short Talks to be Chosen from Abstracts, ,
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	DNA Repair, Stem Cells, Senescence and Aging Registered attendees for this meeting can view Abstracts for this session starting on 12/30/2010	Longs/Grays Peak
	Michael F. Clarke, Stanford University, USA Impact of Genomic Instability on Self-Renewal Pathways
	David A. Sinclair, Harvard Medical School, USA Roles of SIRT1 in Calorie Restriction and Lifespan Extension
	Judith Campisi, Buck Institute for Age Research, USA Genome maintenance, aging and cancer
	Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 12/30/2010	Quandary Peak
Wednesday, February 2
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	Models of DNA Damage Repair and Therapy Registered attendees for this meeting can view Abstracts for this session starting on 12/30/2010	Longs/Grays Peak
	André Nussenzweig, National Institutes of Health, USA Mechanisms of DNA Damage Detection and Repair in Lymphocytes
	Maria Jasin, Memorial Sloan-Kettering Cancer Center, USA Homologous Recombination and Chromosomal Translocation
	Michael T. Hemann, Massachusetts Institute of Technology, USA Modeling Tumor Development and Drug Response Using in vivo RNAi
	Helen Piwnica-Worms, Washington University School of Medicine, USA Exploiting Cell Cycle Checkpoint Control in Cancer Therapy
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM- 1:00 PM	Poster Setup	Quandary Peak
1:00 - 10:00 PM	Poster Viewing	Quandary Peak
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Expanding Dimensions of Genomic Instability and Cancer Therapy Registered attendees for this meeting can view Abstracts for this session starting on 12/30/2010	Longs/Grays Peak
	Judy Lieberman, Harvard Medical School, USA miRNAs that Regulate Cell Cycle Progression and the DNA Damage Response
	Andrei Thomas-Tikhonenko, Children's Hospital of Philadelphia & Univ of Pennsylvania, USA A MicroRNA Component of the Myc-p53 Axis
	Laura J. Niedernhofer, University of Pittsburgh Cancer Institute, USA Genomic Maintenance in Aging
	Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 12/30/2010	Quandary Peak
Thursday, February 3
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	Posttranslational Regulation and Modifications Involved in DNA Damage Response Registered attendees for this meeting can view Abstracts for this session starting on 12/30/2010	Longs/Grays Peak
	Michele Pagano, New York University School of Medicine, USA Role of SCF Ubiquitin Ligases in the Maintenance of Genomic Stability
	Michael B. Yaffe, Massachusetts Institute of Technology, USA Modular Domains Mediate the Assembly of Signaling Complexes
	J. Wade Harper, Harvard Medical School, USA Genetic and Proteomic Analysis of Damage-Signaling Systems
	Rene H. Medema, University Medical Center Utrecht, Netherlands Phosphoproteomic Analysis of Checkpoint Recovery
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
2:30 - 4:30 PM	Workshop 3: Study of DNA Damage Response at Organism Level	Longs/Grays Peak
	Short Talks to be Chosen from Abstracts, ,
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Genomic Instability, Cancer and Therapy Registered attendees for this meeting can view Abstracts for this session starting on 12/30/2010	Longs/Grays Peak
	Michael Stratton, Wellcome Trust Sanger Institute, UK Breast Cancer Susceptibility and Treatment
	Thomas Helleday, University of Oxford, UK PARP Inhibitors in Cancer Treatment: Beyond Inherited Mutations in BRCA1 and BRCA2
	Michael B. Kastan, St. Jude Children's Research Hospital, USA Modulation of ATM and p53 for Clinical Benefit
	Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
8:00 - 11:00 PM	Entertainment	Quandary Peak
Friday, February 4
	Departure
*=Session Chair     †=Speaker invited, not yet responded.

The maintenance of genomic integrity following DNA damage depends on the coordination of DNA repair, cell cycle progression, transcriptional and post-transcriptional regulation and apoptosis. The integrity of the DNA damage response pathways plays a critical role in human health. This meeting will present the most recent advance in the field and reveal how a complex network of signaling transduction pathways are involved in DNA damage response. The topics include early detection of DNA lesions, DNA damage checkpoint control, DNA repair, genotoxic damage in cancer stem cells, modulation of DNA damage signaling by microRNAs, systems biology approaches to DNA damage and the use of cutting edge technologies in the study of DNA damage responses.