Meeting Program

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Friday, January 7
3:00 - 7:30 PM	Registration	Ballroom Lobby
7:30 - 7:45 PM	Opening Remarks Registered attendees for this meeting can view Abstracts for this session starting on 12/07/2010	Ballroom 2-3
	* Wanjun Chen, NIDCR, National Institutes of Health, USA
	Michael B. Sporn, Dartmouth Medical School, USA The Discovery of TGF-beta
7:45 - 8:45 PM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 12/07/2010	Ballroom 2-3
	Joan Massagué, Memorial Sloan-Kettering Cancer Center, USA TGF-beta Receptors, Mediators and Targets: The Next 25 Years
Saturday, January 8
7:00 - 8:00 AM	Breakfast	Golden Cliff/Eagles
8:00 - 11:00 AM	Basic Mechanisms of TGF-beta Signal Transduction Registered attendees for this meeting can view Abstracts for this session starting on 12/07/2010	Ballroom 2-3
	Rik Derynck, University of California, San Francisco, USA Smad-Dependent and -Independent TGF-beta Signaling Pathways
	Daniel B. Rifkin, New York University, USA TGF-beta Bioavailability: Latency and Activation
	Xin-Hua Feng, Baylor College of Medicine, USA Molecular Basis of Smad Signal Transduction and Termination
	Speaker to be Announced,
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Ballroom Lobby
11:00 AM- 1:00 PM	Poster Setup	Superior/Superior Lobby/Wasatch/Maybird
1:00 - 10:00 PM	Poster Viewing	Superior/Superior Lobby/Wasatch/Maybird
2:30 - 4:30 PM	Workshop 1: TGF-beta in B Cells: IgA and Other Antibodies	Ballroom 2-3
	Short Talks to be Chosen from Abstracts, ,
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby
5:00 - 7:00 PM	TGF-beta Regulation of T and B Cell Function Registered attendees for this meeting can view Abstracts for this session starting on 12/07/2010	Ballroom 2-3
	Richard A. Flavell, Yale University School of Medicine, USA TGF-beta in CD4 and CD8 T Cells
	Tim R. Mosmann, University of Rochester Medical Center, USA TGF-beta Regulation of Th1 and Th2 Cells
	Alexander Y. Rudensky, Memorial Sloan-Kettering Cancer Center, USA TGF-beta Regulation of T Cells: Treg-Dependent and -Independent Pathways
	Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Superior/Superior Lobby/Wasatch/Maybird
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 12/07/2010	Superior/Superior Lobby/Wasatch/Maybird
Sunday, January 9
7:00 - 8:00 AM	Breakfast	Golden Cliff/Eagles
8:00 - 11:00 AM	TGF-beta and Regulatory T Cells Registered attendees for this meeting can view Abstracts for this session starting on 12/07/2010	Ballroom 2-3
	Wanjun Chen, NIDCR, National Institutes of Health, USA TGF-beta and Foxp3
	Harald von Boehmer, Harvard Medical School, USA Prevention of Type 1 Diabetes by Negative (Treg) Vaccination with an Insulin Mimetope
	Ethan M. Shevach, NIAID, National Institutes of Health, USA Control of Immune Response by TGF-beta Induced Treg Cells
	Jeffrey A. Bluestone, University of California, San Francisco, USA Induced Treg Cells in Diabetes and Neuropathy Models
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Ballroom Lobby
11:00 AM- 1:00 PM	Poster Setup	Superior/Superior Lobby/Wasatch/Maybird
1:00 - 10:00 PM	Poster Viewing	Superior/Superior Lobby/Wasatch/Maybird
2:30 - 4:30 PM	Workshop 2: Interactions between TGF-beta and Other Immune Cytokines: Impact on Immunity and Tolerance	Ballroom 2-3
	Short Talks to be Chosen from Abstracts, ,
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby
5:00 - 7:00 PM	TGF-beta in Innate Immunity Registered attendees for this meeting can view Abstracts for this session starting on 12/07/2010	Ballroom 2-3
	Steven M. Albelda†, University of Pennsylvania, USA Polarization of Tumor-Associated Neutrophil Phenotype by TGF-b: Implications in Antitumor Immunity
	Yasmine Belkaid, NIAID, National Institutes of Health, USA Mucosal DCs and TGF-beta in Infection
	Peter M. Henson, National Jewish Medical and Research Center, USA Macrophage Response to Apoptotic Cells
	Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Superior/Superior Lobby/Wasatch/Maybird
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 12/07/2010	Superior/Superior Lobby/Wasatch/Maybird
Monday, January 10
7:00 - 8:00 AM	Breakfast	Golden Cliff/Eagles
8:00 - 11:00 AM	TGF-beta and Th17 Cells Registered attendees for this meeting can view Abstracts for this session starting on 12/07/2010	Ballroom 2-3
	Dan R. Littman, New York University School of Medicine, USA TGF-beta and RORgammaT in Murine and Human T Cells
	Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA TGF-beta in Th17 and Tregs
	Tobias Bopp, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany TGF-beta Promotes IRF4-dependent Development of IL-9-producing Th9 Cells
	Speaker to be Announced,
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Ballroom Lobby
11:00 AM- 1:00 PM	Poster Setup	Superior/Superior Lobby/Wasatch/Maybird
1:00 - 10:00 PM	Poster Viewing	Superior/Superior Lobby/Wasatch/Maybird
2:30 - 4:30 PM	Workshop 3: TGF-beta Effect on Anti-Tumor Immunity and Immunodeficiency	Ballroom 2-3
	Short Talks to be Chosen from Abstracts, ,
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby
5:00 - 7:00 PM	TGF-beta in Mucosal Immunity and Tolerance Registered attendees for this meeting can view Abstracts for this session starting on 12/07/2010	Ballroom 2-3
	Howard L. Weiner, Brigham and Women's Hospital, USA TGF-beta and Oral Tolerance
	Fiona M. Powrie, University of Oxford, UK Regulation of IBD by TGF-beta
	Warren Strober, National Institutes of Health, USA Membrane-Bound TGF-beta in Treg Function and Immune Tolerance
	Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Superior/Superior Lobby/Wasatch/Maybird
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 12/07/2010	Superior/Superior Lobby/Wasatch/Maybird
Tuesday, January 11
7:00 - 8:00 AM	Breakfast	Golden Cliff/Eagles
8:00 - 11:00 AM	TGF-beta in Autoimmunity, Inflammation and Transplantation Registered attendees for this meeting can view Abstracts for this session starting on 12/07/2010	Ballroom 2-3
	Dean Sheppard, University of California, San Francisco, USA Regulation of T Cell Differentiation by the alpha-v beta-8 Integrin on Dendritic Cells
	Herman Waldmann, University of Oxford, UK TGF-beta Signaling to T Cells in Long-Term Acceptance of Allografts
	Lucienne Chatenoud, INSERM, Hopital Necker, France CD3-Antibody, TGF-beta and Tregs in Type I Diabetes
	John J. O'Shea, NIAMS, National Institutes of Health, USA TGF-beta and Furin in T Cells
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	Ballroom Lobby
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby
5:00 - 7:00 PM	TGF-beta in Human Immune Cells and Diseases Registered attendees for this meeting can view Abstracts for this session starting on 12/07/2010	Ballroom 2-3
	Maria Grazia Roncarolo, San Raffaele Telethon Institute for Gene Therapy, Italy TGF-beta and IL-10 in Human T Cells
	Michael B. Sporn, Dartmouth Medical School, USA Synthetic Triterpenoids: Effects on Inflammation, T Cells and TGF-beta
	John M. McPherson, Genzyme Corporation, USA Safety Considerations for the Clinical Use of Anti-TGF-beta Antibodies for Treatment of Fibrotic Diseases and Cancer
	Short Talk to be Chosen from Abstracts,
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Ballroom 2-3
8:00 - 11:00 PM	Entertainment	Ballroom 2-3
Wednesday, January 12
	Departure
*=Session Chair     †=Speaker invited, not yet responded.

The recent discovery of TGF-beta as a key regulator in immune responses (particularly in regulatory T cell and Th17 cell differentiation) has put TGF-beta at the center stage of immunology, a position it deserves. Despite great progress in the field, key questions related to TGF-beta re-programming T cells are largely unknown. In this regard, it is imperative to understand the molecular mechanisms by which TGF-beta controls such a diverse T cell programming. Elucidation of these pathways would allow us to apply the knowledge and information acquired from basic studies to understand the pathogenesis of human immune-associated diseases and develop therapeutic practices in experimental and ultimately clinical settings. In addition, roles for TGF-beta in innate immunity, the mucosal immune system, autoimmunity and inflammation, anti-tumor immunity, and HIV-mediated immune deficiency have been gradually disclosed and appreciated. Thus, it is necessary to gather experts in the field together to discuss new findings and update the pivotal role of TGF-beta in the immune system, with the aim to lay out the critical and key questions and point out possible directions. The Keystone symposium is the ideal platform to reach this goal.