Keystone Symposia Conference | Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics

Meeting Program

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Saturday, January 15
3:00 - 7:30 PM	Registration	BC Foyer
6:30 - 7:30 PM	Refreshments	BC Foyer
7:30 - 8:30 PM	Keynote Address (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	British Columbia Ballroom
	Anthony S. Fauci, National Institutes of Health, USA Tuberculosis in 2011: Major Challenges and Unprecedented Opportunities
Sunday, January 16
7:00 - 8:00 AM	Breakfast	Vancouver Island, etc.
8:00 - 11:00 AM	Environmental Sensing, Signaling and Stress Response Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	Columbia Ballroom
	Sarah M. Fortune, Harvard School of Public Health, USA Esx Secretion and TB Virulence
	Miriam Braunstein, University of North Carolina Chapel Hill, USA The Accessory SecA2 Export System
	Sandhya S. Visweswariah, Indian Institute of Science, India Cyclic AMP in Mycobacteria
	Stewart H. Shuman, Memorial Sloan-Kettering Institute, USA Mechanisms of Mycobacterial dsDNA Break Repair
Following Session is for TB Immunology & Vaccine Design (J3)
8:00 - 11:00 AM	TB Immunology: Bench to Clinic Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	British Ballroom
	Joyoti Basu, Bose Institute, India Virulence Factor-Mediated Immune Responses
	Andrea M. Cooper, Trudeau Institute, Inc., USA T Cell Subsets in Tuberculosis
	Federica Sallusto, Institute for Research in Biomedicine, Switzerland Human T Cell Responses to Bacteria
	Daniel L. Barber, NIAID, National Institutes of Health, USA IRIS in Tuberculosis
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	BC Foyer
11:15 AM- 1:00 PM	Poster Setup	Pacific Ballroom
1:00 - 10:00 PM	Poster Viewing	Pacific Ballroom
2:30 - 4:30 PM	Workshop 1: Tools for TB Pathogenesis and Discovery of Novel Intervention Measures (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010
	Short Talks to be Chosen from Abstracts, ,
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	Phagocyte Defense Mechanisms and Bacterial Evasion Strategies (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	Columbia Ballroom
	Kenneth L. Rock, University of Massachusetts Medical School, USA Endosomal Fate of Particles and Inflammasome Activation
	Eric J. Brown, Genentech, Inc, USA Mycobacterial Interactions with the Inflammasome
	Thierry Soldati, University of Geneva, Switzerland Interactions of Pathogenic Mycobacteria with Dictyostelium
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Pacific Ballroom
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	Pacific Ballroom
Monday, January 17
7:00 - 8:00 AM	Breakfast	Vancouver Island, etc.
8:00 - 11:00 AM	Molecular and Evolutionary Determinants of TB Pathogenicity Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	Columbia Ballroom
	Sebastien Gagneux, Medical Research Council, National Institute for Medical Research, UK Genetic Diversity in M. tuberculosis: An Evolutionary Perspective
	Roland Brosch, Institut Pasteur, France Virulence Traits of Tubercle bacilli: Insights from a (Patho)genomic Perspective
	Tim Stinear, University of Melbourne, Australia Evolution of Mycobacterial Pathogenicity
	Olivier Neyrolles, IPBS, CNRS-University of Toulouse, France Mycobacteria Interactions with Host Cells
	Short Talk(s) to be Chosen from Abstracts,
Following Session is for TB Immunology & Vaccine Design (J3)
8:00 - 11:00 AM	Fundamentals of Persistance and Granuloma Formation Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	British Ballroom
	Anne O'Garra, National Institute for Medical Research, UK Protective versus Permissive Immune Responses
	John D. MacMicking, Yale University, USA Native Immunity to TB: Host Genetics of the IFN-gamma Response
	Anca Dorhoi, Max Planck Institute for Infection Biology, Germany Orchestration of Innate Immunity of TB
	Peter J. Peters, Netherlands Cancer Institute, Netherlands Virulence of Mycobacteria is Determined by ESX-1 Secretion System Mediated Translocation to the Cytosol
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	BC Foyer
11:00 AM- 1:00 PM	Poster Setup	Pacific Ballroom
1:00 - 10:00 PM	Poster Viewing	Pacific Ballroom
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	Capacity Building for Clinical Trials (Drugs, Vaccines and Diagnostics) and Raising Public Awareness (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	Columbia Ballroom
	Alimuddin Zumla, University College London, Windeyer Institute of Medical Sciences, UK Sustainability of Clinical Trial Sites in Developing Countries
	Ajit Lalvani†, Imperial College London, UK Talk Title to be Determined
	Mark Harrington, Treatment Action Group, USA Talk Title to be Determined
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Pacific Ballroom
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	Pacific Ballroom
Tuesday, January 18
7:00 - 8:00 AM	Breakfast	Vancouver Island, etc.
8:00 - 11:00 AM	Persistence Strategies Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	Columbia Ballroom
	Kyu Y. Rhee, Weill Cornell Medical College, USA Metabolomic Adaptations of M. tuberculosis and Implications for Pathogenesis
	Christopher M. Sassetti, University of Massachusetts Medical School, USA Genetic Tools to Dissect M. tuberculosis Virulence and Utilization of Cholesterol
	Joeli Marrero, Weill Cornell Medical College, USA Carbon Metabolism in M. tuberculosis during Infection
	Marcel A. Behr, McGill University Health Center, Canada Mechanisms of Mycobacterial Immunogenicity
	Short Talk(s) to be Chosen from Abstracts,
Following Session is for TB Immunology & Vaccine Design (J3)
8:00 - 11:00 AM	Diagnosis and Vaccines Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	British Ballroom
	Madhukar Pai, McGill University, Canada TB Diagnostics: The Good, the Bad and the Ugly
	Gerhard Walzl, Stellenbosch University, South Africa Biomarkers in Different Forms of TB
	Anneke C. Hesseling, Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, South Africa Childhood TB, Pathogenesis, Diagnosis and Prevention
	Helen McShane, University of Oxford, UK Challenges of TB Vaccination
	Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM	Coffee Break	BC Foyer
11:00 AM- 1:00 PM	Poster Setup	Pacific Ballroom
1:00 - 10:00 PM	Poster Viewing	Pacific Ballroom
2:30 - 4:30 PM	Workshop 2: Bioinformatics and Systems Biology (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010
	Short Talks to be Chosen from Abstracts, ,
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	The Host-Pathogen Interfaction (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	Columbia Ballroom
	John Chan, Albert Einstein College of Medicine, USA Talk Title to be Determined
	Joel D. Ernst, New York University School of Medicine, USA Limitations and Consequences of Adaptive Immunity in Tuberculosis
	Kevin B. Urdahl, University of Washington, USA Regulation and Memory in TB
	Marc K. Jenkins, University of Minnesota Medical School, USA How CD4+ T Cells Remember Infections
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Pacific Ballroom
7:30 - 10:00 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	Pacific Ballroom
Wednesday, January 19
7:00 - 8:00 AM	Breakfast	Vancouver Island, etc.
8:00 - 11:00 AM	Physiology and Intervention Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	Columbia Ballroom
	Stewart T. Cole, École Polytechnique Fédérale de Lausanne, Switzerland Multidisciplinary Approaches to Drug Development
	John S. Blanchard, Albert Einstein College of Medicine, USA Biochemistry as a Tool for TB Drug Discovery
	David L. Pompliano, GlaxoSmithKline, USA Challenges of Antibacterial Drug Discovery
	D. Branch Moody, Brigham and Women's Hospital, USA Scanning the M. tuberculosis Lididome for New Virulence Pathways
	Short Talk(s) to be Chosen from Abstracts,
Following Session is for TB Immunology & Vaccine Design (J3)
8:00 - 11:00 AM	Cellular and Genetic Mechanisms of Host Responses Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	British Ballroom
	Philippe Gros, McGill University, Canada Human Genetc Studies of Susceptibility to Leprosy and Tuberculosis
	David Tobin, University of Washington, USA Talk Title to be Determined

	Robert J. Wilkinson, University of Cape Town, South Africa Talk Title to be Determined
	David M. Lewinsohn, Portland VA Medical Center, USA Talk Title to be Determined
	Short Talk(s) to be Chosen from Abstracts,
9:00 - 9:20 AM	Coffee Break	BC Foyer
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	Systems Biology (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 12/15/2010	Columbia Ballroom
	Luis Serrano Pubull, Centre for Genomic Regulation, Spain Systems Biology Analysis of a Small Prokaryote Reveals Unexpected Complexity in Prokaryotes
	Ronald N. Germain, NIAID, National Institutes of Health, USA Systems Immunology Approaches to Infectious Disease
	Speaker to be Announced,
8:00 - 11:00 PM	Entertainment	Pacific Ballroom
Thursday, January 20
	Departure
*=Session Chair †=Speaker invited, not yet responded.

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Tuberculosis (TB) remains a major global disease, worsened by its dangerous synergy with HIV/AIDS and increasing incidences of multi-drug and extensively-drug-resistant strains. More aggressive strains such as the East-Asian/Beijing genotype family are conquering the globe and immune reconstitution inflammatory syndrome (IRIS) increasingly occurs in HIV/M. tuberculosis co-infected individuals under antiretroviral therapy. To reverse this negative trend, increased efforts are needed within academia and industry. Recently, targeted activities have started to translate basic findings into the formulation of drug, vaccine and diagnostic candidates that are entering field trials. However, these efforts are stymied by enormous gaps in our knowledge about specific mechanisms that underlie the relationship between host, pathogen and environment in TB. This Keystone Symposium on TB will focus on these relationships covering basic and clinical research. Topics include the molecular genetics and biochemistry of the pathogen with emphasis on unique lineage and growth state-specific features and the immunology and molecular genetics of the host during latency, reactivation and active disease. Because the outcomes of TB are influenced by genetic, epigenetic and environmental influences on both host and pathogen, the meeting will highlight research on host-pathogen crosstalk at the basic cellular and molecular level as well as human studies that determine the basis of susceptibility to and severity of tuberculosis. Finally, the most recent results on clinical trials of drug and vaccine candidates will be discussed in depth. It is hoped that this meeting will provide not only deeper insights into the complex crosstalk between host and pathogen, but also information on novel measures for TB control including pre- and post-exposure vaccination strategies, combat of extensively drug-resistant strains and novel therapeutic stratagems to avoid IRIS.

Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics (J4)