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LANGUAGE NOTE: This meeting will be conducted in English.
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Meeting Program

To view program in "24 hour" time (international) click here.


Sunday, January 9
3:00 - 7:30 PM Registration Chamisa Lobby
7:30 - 8:30 PM Keynote Address
Registered attendees for this meeting can view Abstracts for this session starting on 12/09/2010
Chamisa Ballroom 1
Fred H. Gage, The Salk Institute for Biological Studies, USA
The Paradox of the Dentate Gyrus
Monday, January 10
7:00 - 8:00 AM Breakfast Los Vaqueros
8:00 - 11:00 AM Neural Stem Cells, Niches and Fate Decision
Registered attendees for this meeting can view Abstracts for this session starting on 12/09/2010

NOTE: Self-renewal and neuronal fate determination are the earliest steps of adult neurogenesis. Neurogenic niches provide instructional signals that control proliferation and differentiation of the stem cell pool to ensure that neurogenesis continues throughout life. Current knowledge regarding the mechanisms that control the undifferentiated state and fate determination of adult neural stem cells in the hippocampus and olfactory bulb will be discussed.
Chamisa Ballroom 1
* Arturo Alvarez-Buylla, University of California, San Francisco, USA
Specification and Plasticity of Adult Neural Stem Cells
Jonas Frisén, Karolinska Institutet, Sweden
Neural Stem Cells and Neurogenesis in the Adult
Magdalena Götz, University of Munich, Germany
A Transcriptional Code for Neurogenesis and Neuronal Specification in the Adult Olfactory Bulb
Dieter Chichung Lie, Helmholtz Center Munich, Germany
Wnt Signaling in Adult Hippocampal Neurogenesis
9:20 - 9:40 AM Coffee Break Chamisa Lobby
11:00 AM- 1:00 PM Poster Setup Chamisa Ballroom 2
1:00 - 10:00 PM Poster Viewing Chamisa Ballroom 2
4:30 - 5:00 PM Coffee Available Chamisa Lobby
5:00 - 7:00 PM Regulation
Registered attendees for this meeting can view Abstracts for this session starting on 12/09/2010

NOTE: This topic covers the molecular pathways important for adult neurogenesis, including transcriptional and epigenetic regulatory factors, and signaling mechanisms, during physiological and pathological contexts.
Chamisa Ballroom 1
* Jenny Hsieh, University of Texas Southwestern Medical Center at Dallas, USA
Transcriptional and Epigenetic Regulation of Adult Hippocampal Neurogenesis
Angélique Bordey, Yale University School of Medicine, USA
Homeostatic Regulation of Postnatal SVZ Neurogenesis
Gerd Kempermann, Center for Regenerative Therapies, Germany
Physical Activity and Enriched Environments: Regulation of Adult Neurogenesis and Functional Consequences
7:00 - 8:00 PM Social Hour w/ Lite Bites Chamisa Ballroom 2
7:30 - 10:00 PM Poster Session 1
Registered attendees for this meeting can view Abstracts for this session starting on 12/09/2010
Chamisa Ballroom 2
Tuesday, January 11
7:00 - 8:00 AM Breakfast Los Vaqueros
8:00 - 11:00 AM Functional Integration
Registered attendees for this meeting can view Abstracts for this session starting on 12/09/2010

NOTE: Newborn neuron in the adult hippocampus and olfactory bulb differentiate and integrate within the existing neuronal circuitry. This topic will address how the impact of adult-born neurons in the hippocampal and olfactory bulb network is dictated by the extent that newborn neurons participate as part of the network and how their intrinsic properties compare to those of existing neurons generated during development.
Chamisa Ballroom 1
* Alejandro Fabian Schinder, Fundacion Instituto Leloir, Argentina
From Neural Stem Cells to Functional Neurons in the Adult Hippocampus
Hongjun Song, Johns Hopkins University School of Medicine, USA
Neuronal Activity-Dependent Regulation of Adult Neurogenesis
Adi Mizrahi, Hebrew University of Jerusalem, Israel
Dendritic Development and Plasticity of Adult-Born Neurons in the Mouse Olfactory Bulb
Amelia J. Eisch, University of Texas Southwestern Medical Center at Dallas, USA
Cell-Intrinsic Regulation of Adult Neurogenesis and Behavior
Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM Coffee Break Chamisa Lobby
11:00 AM- 1:00 PM Poster Setup Chamisa Ballroom 2
1:00 - 10:00 PM Poster Viewing Chamisa Ballroom 2
4:30 - 5:00 PM Coffee Available Chamisa Lobby
5:00 - 7:00 PM Functional Significance Olfactory Bulb
Registered attendees for this meeting can view Abstracts for this session starting on 12/09/2010

NOTE: Newly formed neurons incorporate into functional networks of the olfactory bulb suggesting important roles for adult neurogenesis in the olfactory sensory organ. This topic presents the current evidence regarding the functional roles that newborn granule neurons play in the olfactory bulb.
Chamisa Ballroom 1
* Pierre-Marie Lledo, Pasteur Institute, France
The Role of Olfactory Learning in Olfactory Bulb Neurogenesis
Ryoichiro Kageyama, Kyoto University, Japan
The Functional Significane of Neurogenesis in the Olfactory Bulb
Carlos Lois, Massachusetts Institute of Technology, USA
Sequential Formation of Synapses in Newborn Olfactory Bulb Neurons
7:00 - 8:00 PM Social Hour w/ Lite Bites Chamisa Ballroom 2
7:30 - 10:00 PM Poster Session 2
Registered attendees for this meeting can view Abstracts for this session starting on 12/09/2010
Chamisa Ballroom 2
Wednesday, January 12
7:00 - 8:00 AM Breakfast Los Vaqueros
8:00 - 11:00 AM Functional Significance Hippocampus
Registered attendees for this meeting can view Abstracts for this session starting on 12/09/2010

NOTE: The discovery of adult neurogenesis has fundamentally changed our idea of how our brain can adapt to physiological and environmental stimuli. This topic describes our current understanding of neurogenesis, along with other forms of brain plasticity, which may help us fully understand learning and memory function in the hippocampus.
Chamisa Ballroom 1
* Nora Abrous, INSERM U862, France
Spatial Learning Requires Adult Hippocampal Neurogenesis
Paul W. Frankland, University of Toronto, Canada
Integration of adult-generated granule cells into hippocampal memory circuits
Martin Wojtowicz, University of Toronto, Canada
Hippocampal Neurogenesis in Memory Function
Janet Wiles, University of Queensland, Australia
Computational Influence of Adult Neurogenesis on Memory
9:20 - 9:40 AM Coffee Break Chamisa Lobby
11:00 AM- 1:00 PM Poster Setup Chamisa Ballroom 2
1:00 - 10:00 PM Poster Viewing Chamisa Ballroom 2
4:30 - 5:00 PM Coffee Available Chamisa Lobby
5:00 - 7:00 PM Comparative Neurogenesis
Registered attendees for this meeting can view Abstracts for this session starting on 12/09/2010

NOTE: To fully understand adult neurogenesis, it is important to consider the functional and adaptive significance, and evaluate the comparative nature of neurogenesis across diverse species and in natural populations. This topic will cover recent data regarding adult neurogenesis in songbirds, zebrafish, and in natural populations of mammals.
Chamisa Ballroom 1
* Steven Goldman, University of Rochester Medical Center, USA
Neuronal Addition in the Adult Songbird Brain
Günther K.H. Zupanc, Jacobs University, Germany
Adult Neurogenesis in the Teleost Fish
Hans-Peter Lipp, University of Zürich, Switzerland
Adult Neurogenesis in Natural Populations of Mammals
7:00 - 8:00 PM Social Hour w/ Lite Bites Chamisa Ballroom 2
7:30 - 10:00 PM Poster Session 3
Registered attendees for this meeting can view Abstracts for this session starting on 12/09/2010
Chamisa Ballroom 2
Thursday, January 13
7:00 - 8:00 AM Breakfast Los Vaqueros
8:00 - 11:00 AM Neurological Disorders and Repair
Registered attendees for this meeting can view Abstracts for this session starting on 12/09/2010

NOTE: Recent studies have shown that a wide variety of stimuli, including seizures, stress, stroke, and chronic antidepressant treatment, can profoundly affect adult neurogenesis. Moreover, neurodegenerative disease states are often associated with diminished neurogenesis. This topic will address whether failure of a normal reparative process, i.e., adult neurogenesis, contributes to the development of disease, and/or whether enhancing neurogenesis could be used as a therapeutic strategy in some of these disorders.
Chamisa Ballroom 1
* Olle Lindvall, University of Lund, Sweden
Adult Neurogenesis after Stroke
Frank M. La Ferla, University of California, Irvine, USA
Neural Stem Cells in Alzheimer’s Disease
Jürgen Winkler, Universitätsklinikum Erlangen, Germany
Cellular Repair Strategies in Parkinson's Disease
Rene Hen, Columbia University, USA
Hippocampal Neurogenesis and Depression
Short Talk(s) to be Chosen from Abstracts,
9:20 - 9:40 AM Coffee Break Chamisa Lobby
4:30 - 5:00 PM Coffee Available Chamisa Lobby
5:00 - 7:00 PM Future of Neural Repair
Registered attendees for this meeting can view Abstracts for this session starting on 12/09/2010

NOTE: Neural stem cell differentiation and reprogramming has many potential therapeutic applications in the treatment of neurological disease. This topic will cover new strategies and technologies in translating neural stem/progenitor cells towards the clinic.
Chamisa Ballroom 1
Carrolee Barlow, Brain Cells Inc., USA
Profiling Neurogenic Compounds to Treat CNS Disorders
Anders Haegerstrand, NeuroNova AB, Sweden
Identification and Clinical Application of Neural Progenitor Cell Proliferating Drugs
Anders Bjorklund, Lund University, Sweden
Transplantation of Dopamine-Producing Neurons
7:00 - 8:00 PM Social Hour w/ Lite Bites Chamisa Ballroom 2
8:00 - 11:00 PM Entertainment Chamisa Ballroom 2
Friday, January 14
Departure
      *=Session Chair     †=Speaker invited, not yet responded.



Keystone Symposia would like to thank the sponsor of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:


We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Institute of Neurological Disorders and Stroke (NINDS)

Grant No. 1R13NS071629-01


The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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The ability to generate new neurons in the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the hippocampal dentate gyrus provides the adult mammalian brain an important level of plasticity for maintaining cellular homeostasis under physiological conditions, and potentially underlies an injury response under pathological contexts. Yet a full understanding of the neural stem cell niche, basic molecular mechanisms that ultimately dictate the fate of neural stem/progenitor cells, and intrinsic properties that guide the functional integration of newborn neurons in the existing circuitry is still in its infancy. The goal of this Keystone symposium is, by presenting novel mechanistic insights into the regulation and functional implications of adult neurogenesis, both the speakers and audience will gain further understanding, initiate extensive discussion, and promote scientific collaboration regarding the control of self-renewal, survival, and fate specification of neural stem cells in the adult mammalian brain.