| Friday, June 5 |
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3:00 - 7:30 PM
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Registration
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Shavano Peak Foyer
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6:30 - 7:30 PM
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Refreshments
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Shavano Peak Foyer
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7:30 - 8:30 PM
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Keynote Address
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Red Cloud Peak
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Kenneth A. Dill,
University of California, San Francisco
Protein Folding: Physical Approaches to Predicting Structures and Stabilities
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| Saturday, June 6 |
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7:00 - 8:00 AM
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Breakfast
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Crestone Peak
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8:00 - 11:00 AM
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Dynamics, Energy Landscapes and Evolutionary Selection
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Red Cloud Peak
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Hans Frauenfelder,
Los Alamos National Laboratory
A Unified Model of Protein Dynamics
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Cecilia Clementi,
Rice University
Prediction of Protein Functional States by Multi-Resolution Protein Modeling
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Michele Vendruscolo,
University of Cambridge
Advances in the use of NMR Spectroscopy to Characterize Free Energy Landscapes of Proteins
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Walter Englander,
University of Pennsylvania
Short Talk: How Proteins Fold
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Matthias Buck,
Case Western Reserve University, Medical School
Short Talk: Conformational Coupling in an Effector-GTPase Interaction:
Differences in the Complex Formation of the Plexin GTPase Binding Domain with Rac1 and Rnd1
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9:20 - 9:40 AM
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Coffee Break
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Shavano Peak Foyer
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11:00 AM -
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On Own for Lunch
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11:00 AM - 1:00 PM
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Poster Setup
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Crestone Peak
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1:00 - 10:00 PM
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Poster Viewing
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Crestone Peak
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2:30 - 4:30 PM
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Workshop
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Red Cloud Peak
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Ada Yonath,
Weizmann Institute of Science
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Chad M. Petit,
University of North Carolina
Entropically Modulated Function in a PDZ domain
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Miles A. Pufall,
University of California-San Francisco
Modulating Protein Function: DNA as an Allosteric Effector of Glucocorticoid Receptor Activity
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Paula Therese Lang,
University of California, Berkeley
Ghosts in the Machines: Using Novel X-Ray Crystallographic Methods to Identify Side Chain Polymorphism in Protein-Ligand Interactions
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Jianpeng Ma,
Baylor College of Medicine
Minimalist Network Model (MNM): A Novel Coarse-grained Normal Mode Analysis
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Eileen K. Jaffe,
Fox Chase Cancer Center
Dynamic Dissociating Homo-Oligomers and Allosteric Regulation
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Gail E. Fanucci,
University of Florida
Monitoring Motions and Flexibility of HIV-1 Protease with Pulsed EPR Spectroscopy
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Ahmet Bakan,
University of Pittsburgh
Effect of Inhibitor Binding on Protein Structure and Dynamics: Intrinsic Dynamics or Induced Dynamics?
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Michelle A. Markus,
Wyeth Pharmaceuticals
Identifying Novel, Non-Chelating Inhibitors of MMP-9 using Virtual Screening, NMR Spectroscopy, and X-Ray Crystallography
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4:30 - 5:00 PM
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Coffee Available
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Shavano Peak Foyer
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5:00 - 7:00 PM
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Catalysis and Allostery
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Red Cloud Peak
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Amnon Horovitz,
Weizmann Institute of Science
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Patrick Loria,
Yale University
Short and Long-Range Interactions and Motions and their Impact on Enzyme Function
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Sebastian Doniach,
Stanford University
Allostery and riboswitch function
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Susan S. Taylor,
University of California, San Diego
Dynamics of Signaling by PKA
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Andrea Mozzarelli,
University of Parma
Short Talk: Hemoglobin: Still the Paradigm for Allostery
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Crestone Peak
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7:30 - 10:00 PM
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Poster Session 1
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Crestone Peak
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| Sunday, June 7 |
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7:00 - 8:00 AM
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Breakfast
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Crestone Peak
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8:00 - 8:50 AM
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Keynote Address
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Red Cloud Peak
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Jean-Pierre Changeux,
Institut Pasteur
The Nicotinic Acetylcholine Receptor: A Membrane Allosteric Protein Engaged in Neuronal Communication
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8:50 - 11:15 AM
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Allosteric Events in Membrane Proteins
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Red Cloud Peak
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D. Peter Tieleman,
University of Calgary
Coupling between Nucleotide Binding and Transmembrane Domains in ABC Transporters
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Ivet Bahar,
University of Pittsburgh
Allosteric Dynamics of Glutamate Transporters: Insights from Multiscale Computations
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Heidi E. Hamm,
Vanderbilt University School of Medicine
Allosteric Connections from a G Protein-Coupled Receptor to the Nucleotide-Binding Pocket of a Heterotrimeric G Protein
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Ofer Yifrach,
Ben-Gurion University of the Negev
Short Talk: Principles Underlying Energetic Coupling Along an Allosteric Communication Trajectory of a Voltage-Activated K+ Channel
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Nikolaos G. Sgourakis,
Rensselaer Polytechnic Institute
Short Talk: Simulation of a Protein Tertiary Complex: Study of the Interaction Interface and Conformational Dynamics of Dark State Rhodopsin in Complex with Transducin
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9:20 - 9:40 AM
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Coffee Break
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Shavano Peak Foyer
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11:30 AM -
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On Own for Lunch
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11:30 AM - 1:00 PM
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Poster Setup
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Crestone Peak
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1:00 - 10:00 PM
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Poster Viewing
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Crestone Peak
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4:30 - 5:00 PM
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Coffee Available
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Shavano Peak Foyer
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5:00 - 7:15 PM
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Dynamics and Biomolecular Machines
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Red Cloud Peak
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David A. Agard,
University of California, San Francisco
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Ada Yonath,
Weizmann Institute of Science
Ribosomal Machinery: Peptide Bond Formation,
Chaperone Assistance, and Antibiotics Inactivation
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Devarajan Thirumalai,
University of Maryland
Structural Basis of Allosteric Transitions in Biological Machines: Common Themes
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Amnon Horovitz,
Weizmann Institute of Science
Linking Allostery in Chaperonins to Protein Folding
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Lars Skjaerven,
Universitetet i Bergen
Short Talk: Discovering the Intrinsic Dynamical Abilities of the GroEL Subunit by Molecular Dynamics Simulation
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David P. Giedroc,
Indiana University
Short Talk: Structure and Energetics of Metal-induced Allosteric Regulation of DNA binding by ArsR Family Metal Sensor Proteins
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Crestone Peak
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7:30 - 10:00 PM
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Poster Session 2
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Crestone Peak
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| Monday, June 8 |
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7:00 - 8:00 AM
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Breakfast
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Crestone Peak
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8:00 - 11:15 AM
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Signal Propagation in Molecular and Cellular Systems I
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Red Cloud Peak
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9:20 - 9:40 AM
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Coffee Break
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Shavano Peak Foyer
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11:15 AM -
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On Own for Lunch
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11:15 AM - 1:00 PM
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Poster Setup
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Crestone Peak
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1:00 - 10:00 PM
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Poster Viewing
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Crestone Peak
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4:30 - 5:00 PM
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Coffee Available
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Shavano Peak Foyer
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5:00 - 7:15 PM
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Signal Propagation in Molecular and Cellular Systems II
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Red Cloud Peak
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Susan S. Taylor,
University of California, San Diego
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Rama Ranganathan,
University of Texas Southwestern Medical Center
The Evolutionary Design of Proteins
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David A. Agard,
University of California, San Francisco
Conformational Dynamics, Structure and Mechanism of Hsp90 Chaperones
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Andrew Hopkins,
University of Dundee
Pharmacological Approaches to Biological Network Perturbation and Allosteric Modulation
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Giorgio Colombo,
Istituto di Chimica del Riconoscimento Molecolare
Short Talk: Modeling Signal Propagation Mechanisms and Ligand-Based Conformational Dynamics of the Hsp90 Molecular Chaperone Full Length Dimer
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Saskia Neher,
University of California at San Francisco
Short Talk: Signal Sequences Activate the Catalytic Switch of SRP RNA
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Crestone Peak
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7:30 - 10:00 PM
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Poster Session 3
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Crestone Peak
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| Tuesday, June 9 |
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7:00 - 8:00 AM
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Breakfast
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Crestone Peak
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8:00 - 11:00 AM
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Novel Methods for Dynamics and Allostery
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Red Cloud Peak
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Patrick Loria,
Yale University
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G. Marius Clore,
National Institute of Diabetes and Digestive and Kidney Diseases
Visualizing Transient Lowly-Populated Regions of the Free Energy Landscape of Macromolecules and their Complexes by Paramagnetic Relaxation Enhancement
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Ruben Abagyan,
The Scripps Research Institute
Induced Fit in Ligand Docking and Drug Discovery
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Ad Bax,
NIDDK, National Institutes of Health
Proteins, Lipids, and their Dynamic Interaction Viewed by NMR
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Justin L. P. Benesch,
University of Cambridge
Short Talk: Thermo-Dynamically Controlled Chaperone Function of the Small Heat Shock Proteins
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Aron W. Fenton,
University of Kansas Medical Center
Short Talk: Mapping Individual Residues within the N-Terminus that are Energetically Coupled to Allosteric and Active Site Functions of Human Liver Pyruvate Kinase
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9:20 - 9:40 AM
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Coffee Break
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Shavano Peak Foyer
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11:00 AM -
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On Own for Lunch
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4:30 - 5:00 PM
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Coffee Available
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Shavano Peak Foyer
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5:00 - 6:45 PM
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Novel Methods for Equilibrium Fluctuations
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Red Cloud Peak
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Ad Bax,
NIDDK, National Institutes of Health
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Elliot L. Elson,
Washington University School of Medicine
Chemical Reaction Fluxes in Non-Equilibrium Steady State Systems
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Patrice Vachette,
IBBMC
Synchrotron SAXS Study of Quaternary Structure Equilibrium for Wild-Type and Mutant Forms of Allosteric Aspartate Transcarbamoylase
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Brian M. Baker,
University of Notre Dame
Short Talk: T Cell Receptor Cross-Reactivity Triggered by Peptide-Specific Conformational Dynamics in an Unligated Peptide/MHC Complex
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6:45 - 7:15 PM
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Closing Remarks
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Ivet Bahar,
University of Pittsburgh
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Lila M. Gierasch,
University of Massachusetts Amherst
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Crestone Peak
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8:00 - 11:00 PM
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Entertainment
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Crestone Peak
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| Wednesday, June 10 |
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Departure
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