| Saturday, February 27 |
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3:00 - 7:30 PM
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Registration
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Foyer
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6:30 - 7:30 AM
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Refreshments
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Foyer
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7:30 - 8:30 PM
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Keynote Address: The TCR
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Peak 5
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Lawrence E. Samelson,
National Institutes of Health
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Mark M. Davis,
Stanford University
T-Cell Receptor Signaling
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| Sunday, February 28 |
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7:00 - 8:00 AM
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Breakfast
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Summit Gallery
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8:00 - 11:15 AM
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Initiation of Antigen Receptor Signaling
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Peak 5
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*
Susan K. Pierce,
NIAID, National Institutes of Health
The Molecular Mechanisms Underlying the Initiation of BCR Signaling
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Phillip Anton van der Merwe,
University of Oxford
Molecular Mechanism of TCR Triggering
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Balbino Alarcón,
CSIC-Universidad Autonoma de Madrid
Intramolecular Mechanism for Transmission of the Conformational Change in the TCR
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Arup K. Chakraborty,
Massachusetts Institute of Technology
How T Cells “See” Antigen
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Nina C. Hartman,
University of California, Berkeley
Short Talk: The Regulation of Protein Spatial Sorting and its Effect on T Cell Signaling in the Immunological Synapse
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Mira Barda-Saad,
Bar Ilan University
Short Talk: THE NEGATIVE REGULATION MECHANISM OF THE
WISKOTT-ALDRICH SYNDROME PROTEIN
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9:20 - 9:40 AM
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Coffee Break
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Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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11:15 AM - 1:00 PM
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Poster Setup
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Peaks 1-4
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1:00 - 10:00 PM
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Poster Viewing
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Peaks 1-4
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4:30 - 5:00 PM
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Coffee Available
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Foyer
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5:00 - 7:00 PM
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Cell Biology of Lymphocyte Activation
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Peak 5
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Facundo D. Batista,
London Research Institute, Cancer Research UK
Interplay between the BCR and Cytoskeleton: A Mechanism to Regulate Lymphocyte Activation and Tonic Signaling?
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Gillian Griffiths,
Cambridge Institute for Medical Research
The Immunological Synapse: A Focal Point for Exocytosis and Endocytosis
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Matthew F. Krummel,
University of California, San Francisco
The Interplay of T Motility and Signaling
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Sarah Russell,
Swinburne University of Technology
Short Talk: Orchestratation of Lymphocyte Fate by the Polarity Network
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Peaks 1-4
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7:30 - 10:00 PM
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Poster Session 1
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Peaks 1-4
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| Monday, March 1 |
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7:00 - 8:00 AM
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Poster Setup
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Peaks 1-4
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7:00 - 8:00 AM
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Breakfast
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Summit Gallery
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8:00 - 11:15 AM
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Transcriptional Regulation and Chromatin Remodeling during Lymphocyte Activation
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Peak 5
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Anjana Rao,
Harvard Medical School
Ca Signaling and Transcription Regulation in Lymphocytes
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Steven L. Reiner,
University of Pennsylvania
Specifying the T Cell Fates Required for Immunity
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Joonsoo Kang,
University of Massachusetts Medical School
Transcriptional Regulation of alpha-beta vs. gamma-delta T Cell Lineage Commitment
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Casey T. Weaver,
University of Alabama at Birmingham
Gene Expression and the TH17 Response
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Michael J. Pazin,
National Institute of Aging, National Institutes of Health
Short Talk: The Chromatin Remodeling Landscape of T Helper Cell Differentiation
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Robert J. Johnston,
La Jolla Institute for Allergy & Immunology
Short Talk: Bcl6 and Blimp-1 are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation
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8:00 AM - 5:00 PM
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Poster Viewing
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Peaks 1-4
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9:20 - 9:40 AM
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Coffee Break
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Foyer
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11:30 AM - 12:30 PM
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Lunch
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12:30 - 2:30 PM
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Poster Session 2
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Peaks 1-4
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2:30 - 4:30 PM
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Workshop 1: Early Events in Lymphocyte Activation
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Peak 5
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*
Arthur Weiss,
University of California, San Francisco
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Melania Capasso,
MRC Toxicology Unit
Control of B Cell Activation and Metabolism by the Voltage-Gated Proton Channel HVCN1
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Olga Anna Ksionda,
NIMR
The Role of the Localization of Vav1 during T Cell Activation
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Aaron J. Marshall,
University of Manitoba
The Phosphoinositide 3-Kinase Effector Molecule Bam32/DAPP1 Promotes B Cell Adhesion and Formation of Polarized Conjugates with T Cells
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David Oh,
Stanford University
Ca2+ Signaling and the Regulation of Thymocyte Mobility during Negative Selection in Thymic Slices
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Hanne L. Ostergaard,
University of Alberta
Regulation of the Tyrosine Kinase Pyk2 By Calcium in Cytotoxic T Lymphocytes
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Bruno Silva-Santos,
University of Lisbon
Differential Requirements on TCR/ CD27 versus TLR Signaling for Activation of Discrete Pro-Inflammatory gamma-delta T Cell Subsets
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Neetu Gupta,
Cleveland Clinic Foundation
Regulation of Antigen-Dependent B Cell Activation by Tyrosine and Threonine Phosphorylation of the ERM Family Protein Ezrin
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Steve R. Roffler,
Academia Sinica
Mechanical Forces Acting on the T Cell Receptor Complex Can Trigger TCR Signaling
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4:30 - 5:00 PM
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Coffee Available
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Foyer
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5:00 - 7:00 PM
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Downstream Pathways of Antigen Receptor Signaling I
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Peak 5
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Doreen A. Cantrell,
University of Dundee
The Function of Protein Kinase B/Akt in Peripheral T Cells
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Pamela L. Schwartzberg,
NHGRI, National Institutes of Health
Altered T Cell Function in Mice Deficient in SAP, a Model for X-Linked Lymphoproliferative Disease
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Bernard Malissen,
Centre d'Immunologie de Marseille-Luminy
Th2 Lymphoproliferative Disorders Resulting from Defective LAT Signalosomes
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Debbie A. Yablonski,
Technion - Israel Institute of Technology
Short Talk: Regulatory Interactions within the SLP-76-Nucleated Complex
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Morgan Huse,
Sloan-Kettering Cancer Center
Short Talk: Probing Inhibitory Signaling Dynamics in NK Cells by Photostimulation
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Michelle Krogsgaard,
New York University School of Medicine
Short Talk:
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7:00 PM -
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On Own for Dinner
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Peaks 1-4
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| Tuesday, March 2 |
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7:00 - 8:00 AM
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Breakfast
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Summit Gallery
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8:00 - 11:15 AM
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Downstream Pathways of Antigen Receptor Signaling II
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Peak 5
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Arthur Weiss,
University of California, San Francisco
Turning T Cells Off and On with Small Molecule Inhibitors of Tyrosine Kinases
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Andrey S. Shaw,
Washington University School of Medicine
Imaging T Cell Activation
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Juergen Wienands,
Georg August University of Goettingen
Short Talk: Composition and Dynamic Assembly of B Cell Signalosomes as Revealed by Functional Proteomics
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Gary A. Koretzky,
University of Pennsylvania School of Medicine
Role of SLP-76 in Immune Cell Development and Function
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Bridget S. Wilson,
University of New Mexico School of Medicine
High Resolution Imaging of Fc[epislon]RI Organization and Receptor Dynamics: Immobilization is not a Requirement for Signal Initiation
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Stephen C. Bunnell,
Tufts University School of Medicine
Short Talk: VLA-4 Inhibits the Centralization of SLP-76 Microclusters by Resisting the Contraction of Myosin IIA Filaments
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9:20 - 9:40 AM
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Coffee Break
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Foyer
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11:15 AM - 1:00 PM
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Poster Setup
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Peaks 1-4
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11:15 AM -
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On Own for Lunch and Recreation
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1:00 - 10:00 PM
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Poster Viewing
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Peaks 1-4
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4:30 - 5:00 PM
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Coffee Available
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Foyer
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5:00 - 7:00 PM
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Downstream Pathways of Antigen Receptor Signaling III
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Peak 5
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Leslie J. Berg,
University of Massachusetts Medical Center
Tec Kinases in T Cell Differentiation
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Lawrence E. Samelson,
National Institutes of Health
Signaling at the TCR
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Richard S. Lewis,
Stanford University School of Medicine
Molecular Mechanisms for Activation and Inactivation of Calcium Channels in T Cells
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Patrick G. Hogan,
Harvard Medical School
Short Talk: Minimal Requirement for Store-Operated Calcium Entry: STIM1 Gates ORAI1 Channels in vitro
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Peaks 1-4
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7:30 - 10:00 PM
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Poster Session 3
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Peaks 1-4
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| Wednesday, March 3 |
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7:00 - 8:00 AM
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Breakfast
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Summit Gallery
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8:00 - 11:15 AM
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Visualization of Lymphocyte Activation
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Peak 5
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Ellen A. Robey,
University of California, Berkeley
Visualizing Thymic Selection in situ
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Michael L. Dustin,
New York University School of Medicine
Immunological Synapse Formation in Normal and Pathological Immune Responses
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Ronald N. Germain,
NIAID, National Institutes of Health
Cell Dynamics during the Initiation and Effector Phases of Adaptive Immune Responses
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Takashi Saito,
RIKEN Center for Allergy and Immunology
Molecular Dynamics for T-Cell Activation and Co-stimulation
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Daniel M. Davis,
Imperial College London
Short Talk: Membrane Nanotubes Support Sub-Micron Scale Immune Synapses and Aid Cytolysis of Distant Target Cells
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Philippe Bousso,
Institute Pasteur
Short Talk: Intravital Imaging Reveals Distinct Dynamics of NK Cells and CD8+ T Cells during Effector Function in Solid Tumors
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9:20 - 9:40 AM
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Coffee Break
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Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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2:30 - 4:30 PM
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Workshop 2: Late Events in Lymphocyte Activation
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Peak 5
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*
Pamela L. Schwartzberg,
NHGRI, National Institutes of Health
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Mark R. Boothby,
Vanderbilt University Medical Center
Stage-Specific Essential Roles of Rictor, a Mammalian Target of Rapamycin Complex 2 (mTORC2) Subunit, in T Cell Differentiation Define a Bifurcation in the Signal Relay
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Jennifer L. Cannons,
National Institutes of Health
A Multi-Stage T:B Lymphocyte Adhesion Process is Required for Germinal Centre Responses
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Greg M. Delgoffe,
Johns Hopkins University School of Medicine
The mTOR Signaling Complexes TORC1 and TORC2 Selectively Regulate CD4+ T Cell Differentiation
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Guo Fu,
The Scripps Research Institute
Themis Regulates Thymocyte Signaling
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Katrina L. Randall,
John Curtin School of Medical Research
DOCK8 Mutations Cripple B Cell Immune Synapse Formation, Germinal Centers and Long-Lived Antibody Production
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Yuri K. Sykulev,
Thomas Jefferson University
Kinetics of Early TCR Signaling Influences the Path of Granule Delivery by CTL
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Bazarragchaa Damdinsuren,
National Institute on Aging, National Institutes of Health
Single-Round of Antigen Receptor Signaling Programs Naive B Cells to Receive T Cell Help
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Vanessa Hubbard,
Albert Einstein College Of Medicine
Macroautophagy Regulates CD4+ T Cell Function
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4:30 - 5:00 PM
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Coffee Available
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Foyer
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5:00 - 7:00 PM
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Regulation of the Immune Response by microRNA
Session supported in part by the Juvenile Diabetes Research Foundation
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Peak 5
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*
Matthias Merkenschlager,
Imperial College London
Cohesins and Gene Expression: From Proof-of-Principle Towards Cell Lineage- and Developmental Stage-Specific Regulation
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Carola G. Vinuesa,
Australian National University
Role of Bcl-6 in Specializing the Function of T Follicular Helper Cells
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Li-Fan Lu,
Memorial Sloan-Kettering Cancer Center
Short Talk: Function of miR-146a in Controlling Treg Cell-Mediated Regulation of TH1 Responses
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Anna Barbara Stittrich,
German Arthritis Research Center
Short Talk: MicroRNA-182 Promotes Clonal Expansion of Activated T Helper Cells
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Peaks 1-4
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8:00 - 11:00 PM
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Entertainment
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Peaks 1-4
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| Thursday, March 4 |
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Departure
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