Keystone Symposia Meeting

Meeting Details  

Developmental Origins and Epigenesis in Human Health and Disease (D1)

Organizer(s): Judith Swain, Peter D. Gluckman, Michael Meaney and Anne Ferguson-Smith
April 26 - 30, 2010
Swissotel The Stamford  ·  Singapore,
Abstract Deadline: December 28, 2009
Late Abstract Deadline: January 29, 2010
Scholarship Deadline: December 28, 2009
Early Registration Deadline: March 12, 2010

In collaboration with Agency for Science, Technology and Research (A*STAR)



This meeting took place in the 2010 season.

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Summary of Meeting
Developmental plasticity results from the interplay of fetal environment and genetic factors. There is considerable data to indicate that these interactions play an important role in the susceptibility of the individual to the development of chronic diseases such as diabetes, obesity, and to the cognitive capacity of that individual. Evidence suggests that gene/environment interactions may result in epigenetic changes that not only indicate susceptibility to chronic disease, but may play a causative role in the processes. The specific nature of the signaling pathways that dictate these susceptibilities and capacities are not known. This symposium is designed to explore experimental models of development, to understanding the role of epigenetics in regulating important signaling pathways, and to examine the relationship of the fetal environment to normal development and the susceptibility to chronic disease.

Monday, April 26
3:00 - 7:30 PM Registration Stamford Foyer
6:30 - 7:30 PM Refreshments Stamford Foyer
7:30 - 7:45 PM Opening Address and Welcoming Remarks Stamford Ballroom
* Judith L. Swain, Singapore Institute for Clinical Sciences
Chuan Poh Lim, Chairman, Agency for Science Technology and Research (A*STAR)
7:45 - 8:45 PM Keynote Address Stamford Ballroom
* Anne Ferguson-Smith, University of Cambridge
Adrian P. Bird, University of Edinburgh
Investigating the Molecular Basis of Rett Syndrome
Tuesday, April 27
8:00 - 9:00 AM Breakfast Stamford Ballroom
8:00 - 9:00 AM Poster Setup Stamford Foyer
9:00 AM - 12:00 PM Mechanisms of Developmental Plasticity Stamford Ballroom
* Anne Ferguson-Smith, University of Cambridge
Genomic Imprinting as an Adaptive Model of Developmental Plasticity
Stephen M. Cohen, Temasek Life Sciences Laboratory
MicroRNA Functions: Insights from Drosophila Genetics
Emma Whitelaw, Queensland Institute of Medical Research
Epigenetics and Transgenerational Effects
John S. Mattick, University of Queensland
RNA as the Regulator of Epigenetic Memory and the Mediator of Epigenome-Environment Interactions
Kian Peng Koh, Immune Disease Institute, Harvard Medical School
Short Talk: Tet1/Cxxc6 and Related Enzymes, a New Family of 5-Methylcytosine Hydroxylases, Modulate Pluripotency and Cell Lineage Specification in Mouse Embryonic Stem Cells
10:20 - 10:40 AM Coffee Break Stamford Foyer
12:00 - 1:00 PM Lunch Stamford Ballroom
12:00 - 5:00 PM Poster Viewing Stamford Foyer
12:00 - 2:30 PM Poster Session 1 Stamford Foyer
2:30 - 3:00 PM Coffee Available Stamford Foyer
3:00 - 5:00 PM Phenotypic Plasticity in Evolution Stamford Ballroom
* Russell D. Fernald, Stanford University
Social Control of the Brain
Hamish G. Spencer, University of Otago
The Evolution of Phenotypic Plasticity: Insights from Theory
Yijun Ruan, Genome Institute of Singapore
Short Talk: Estrogen Induced Chromatin Interaction and Transcription Regulation in Cancer Cells
Wednesday, April 28
8:00 - 9:00 AM Breakfast Stamford Ballroom
8:00 - 9:00 AM Poster Setup Stamford Foyer
9:00 AM - 12:00 PM Developmental Influences in Chronic Disease Stamford Ballroom
* Peter Gluckman, University of Auckland
The Developmental Contribution to the Risk of Chronic Disease
Caleb E. Finch, University of Southern California
Early Exposure to Infections Accelerates Aging
Joseph Nadeau, Case Western Reserve University
Transgenerational Epigenetic Control of Phenotypic Variation and Disease Risk
10:20 - 10:40 AM Coffee Break Stamford Foyer
12:00 - 1:00 PM Lunch Stamford Ballroom
12:00 - 5:00 PM Poster Viewing Stamford Foyer
12:30 - 2:30 PM Poster Session 2 Stamford Foyer
2:30 - 3:00 PM Coffee Available Stamford Foyer
3:00 - 5:00 PM Neural and Developmental Epigenetics Stamford Ballroom
* Michael Meaney, McGill University
Developmental Influences on Cognitive Processes
Yi Eve Sun, University of California, Los Angeles
DNA Methylation and Neural Cell Fate
Zhao Xu, Beth Israel Deaconess Medical Center
Short Talk: Pathway Discovery in Adipocyte Biology Using Epigenomics
Assam El-Osta, Baker Heart Research Institute
Short Talk: Persistent Changes in the Epigenetic Code Explaining Hyperglycemic Memory
Thursday, April 29
8:00 - 9:00 AM Breakfast Stamford Ballroom
9:00 - 11:40 AM Environmental Control of Tissue Differentiation Stamford Ballroom
Zofia Zukowska, Georgetown University
Gender-Specific Stress-Induced Programming for Obesity: Role of Neuropeptide Y and Adipose Stem Cells
Davor Solter, Institute of Medical Biology
Judy C. Sng, Singapore Institute of Clinical Sciences
Control of the Critical Period in Sensory Development
* Jonathan R. Seckl, University of Edinburgh School of Clinical Sciences & Community Health
Glucocorticoid 'Programming' of the Brain: From Stress to Liquorice
10:20 - 10:40 AM Coffee Break Stamford Foyer
2:45 - 3:00 PM Coffee Available Stamford Foyer
3:00 - 5:00 PM Environmental Factors and Developmental Plasticity Stamford Ballroom
Michael K. Skinner, Washington State University
The Environment and Epigenetics on Transgenerational Inheritance
Robert A. Waterland, Baylor College of Medicine
The Search for Human Metastable Epialleles
Corrado Spadafora, Istituto Superiore di Sanità (Italian National Institute of Health)
Short Talk: Retrotransposons, Reverse Transcriptase and the Genesis of New Genetic Information
5:00 - 7:00 PM Social Hour w/ Lite Bites Stamford Foyer
Friday, April 30
Departure
*Session Chair   †Speaker invited, not yet responded.



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